The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA A receptors

Neuropharmacology

Volumn 62, Issue 8, 2012, Pages 2507-2514

  Alexeev, Mikhail ^b   Grosenbaugh, Denise K ^a   Mott, David D ^a   Fisher, Janet L ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Anxiolytic; GABA; Magnolia; Natural product

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR BETA3; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; HONOKIOL; MAGNOLOL;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; EMBRYO; GABAERGIC TRANSMISSION; GRANULE CELL; HIPPOCAMPUS; HUMAN; HUMAN CELL; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; SYNAPSE;

ANIMALS; BIPHENYL COMPOUNDS; DRUGS, CHINESE HERBAL; GABA AGENTS; HEK293 CELLS; HIPPOCAMPUS; HUMANS; INHIBITORY POSTSYNAPTIC POTENTIALS; LIGNANS; NEURONS; RATS; RECEPTORS, GABA-A; SYNAPTIC TRANSMISSION;

EID: 84859734048     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.03.002     Document Type: Article

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