Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors

Journal of Ethnopharmacology

Volumn 124, Issue 3, 2009, Pages 421-425

  Koetter, Uwe ^a   Barrett, Marilyn ^b   Lacher, Svenja ^c   Abdelrahman, Aliaa ^c   Dolnick, Deanne ^d  

^a Dr Koetter Consulting   (Switzerland)

^b Pharmacognosy Consulting   (United States)

^c UNIVERSITY OF BONN   (Germany)

^d Next Pharmaceuticals   (United States)

Author keywords

Adenosine; Chinese herbal; Drug; GABAA; Magnolia; Plant extracts; Receptors; Ziziphus

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ADENOSINE A1 RECEPTOR; BENZODIAZEPINE RECEPTOR; DOPAMINE 5 RECEPTOR; DOPAMINE RECEPTOR; DOPAMINE TRANSPORTER; MAGNOLIA OFFICINALIS EXTRACT; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; SEDITOL; SEROTONIN 1B RECEPTOR; SEROTONIN 6 RECEPTOR; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG; ZIZIPHUS SPINOSA EXTRACT;

ANIMAL CELL; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; JUJUBE; NONHUMAN; PROTEIN INTERACTION; ZIZIPHUS SPINOSA;

ADENOSINE; CENTRAL NERVOUS SYSTEM; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DRUG COMBINATIONS; GAMMA-AMINOBUTYRIC ACID; HUMANS; HYPNOTICS AND SEDATIVES; MAGNOLIA; MEDICINE, EAST ASIAN TRADITIONAL; MUSCLE RELAXANTS, CENTRAL; PLANT EXTRACTS; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A1; RECEPTORS, DOPAMINE; RECEPTORS, GABA-A; RECEPTORS, NEUROTRANSMITTER; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SLEEP; ZIZIPHUS;

MAGNOLIA; MAGNOLIA OFFICINALIS; MAGNOLIACEAE; RHAMNACEAE; ZIZIPHUS;

EID: 67650655608     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.05.040     Document Type: Article

References (31)

1. Adham N., Zgombick J.M., Bard J., and Branchek T.A. Functional characterization of the recombinant human 5-hydroxytryptamine7(a) receptor isoform coupled to adenylate cyclase stimulation. Journal of Pharmacology and Experimental Therapeutics 287 (1998) 508-514
2. Ai J., Wang X., and Nielsen M. Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro. Pharmacology 63 (2001) 34-41
3. Baburin I., Beyl S., and Hering S. Automated fast perfusion of Xenopus oocytes for drug screening. Pflugers Archiv 453 (2006) 117-123
4. Basheer R., Strecker R.E., Thakkar M.M., and McCarley R.W. Adenosine and sleep-wake regulation. Progress in Neurobiology 73 (2004) 379-396
5. Giles H., Lansdell S.J., Bolofo M.L., Wilson H.L., and Martin G.R. Characterization of a 5-HT1B receptor on CHO cells: functional responses in the absence of radioligand binding. British Journal of Pharmacology 117 (1996) 1119-1126
6. Inoue T., Izumi T., Li X.B., Kitaichi Y., Nakagawa S., and Koyama T. Effect of a dopamine D1/5 receptor antagonist on haloperidol-induced inhibition of the acquisition of conditioned fear. European Journal of Pharmacology 519 (2005) 253-258
7. Khom S., Baburin I., Timin E.N., Hohaus A., Sieghart W., and Hering S. Pharmacological properties of GABAA receptors containing gamma1 subunits. Molecular Pharmacology 69 (2006) 640-649
8. Kim H.J., Baburin I., Khom S., Hering S., and Hamburger M. HPLC-based activity profiling approach for the discovery of GABAA receptor ligands using an automated two microelectrode voltage clamp assay on Xenopus oocytes. Planta Medica 74 (2008) 521-526
9. Kohen R., Metcalf M.A., Khan N., Druck T., Huebner K., Lachowicz J.E., Meltzer H.Y., Sibley D.R., Roth B.L., and Hamblin M.W. Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor. Journal of Neurochemistry 66 (1996) 47-56
10. Kuribara H., Kishi E., Hattori N., Okada M., and Maruyama Y. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. Journal of Pharmacy and Pharmacology 52 (2000) 1425-1429
11. Kuribara H., Kishi E., Hattori N., Yuzurihara M., and Maruyama Y. Application of the elevated plus-maze test in mice for evaluation of the content of honokiol in water extracts of magnolia. Phytotherapy Research 13 (1999) 593-596
12. Kuribara H., Stavinoha W.B., and Maruyama Y. Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice. Journal of Pharmacy and Pharmacology 51 (1999) 97-103
13. Li Y.J., and Bi K.S. Study on the therapeutic material basis of traditional chinese medicinal preparation suanzaoren decoction. Chemical and Pharmaceutical Bulletin (Tokyo) 54 (2006) 847-851
14. Liao J.F., Jan Y.M., Huang S.Y., Wang H.H., Yu L.L., and Chen C.F. Evaluation with receptor binding assay on the water extracts of ten CNS-active Chinese herbal drugs. Proceedings of the National Science Council Republic of China B 19 (1995) 151-158
15. Luo L., Nong W.J., Kong L.D., Jiang Q.G., and Tan R.X. Antidepressant effects of Banxia Houpu decoction, a traditional Chinese medicinal empirical formula. Journal of Ethnopharmacology 73 (2000) 277-281
16. Mialet J., Berque-Bestel I., Eftekhari P., Gastineau M., Giner M., Dahmoune Y., Donzeau-Gouge P., Hoebeke J., Langlois M., Sicsic S., Fischmeister R., and Lezoualc'h F. Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines. British Journal of Pharmacology 129 (2000) 771-781
17. Missale C., Nash S.R., Robinson S.W., Jaber M., and Caron M.G. Dopamine receptors: from structure to function. Physiological Reviews 78 (1998) 189-225
18. Müller C.E., Schumacher B., Brattstrom A., Abourashed E.A., and Koetter U. Interactions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptors. Life Sciences 71 (2002) 1939-1949
19. Newman-Tancredi A., Verriele L., and Millan M.J. Differential modulation by GTPgammaS of agonist and inverse agonist binding to h5-HT(1A) receptors revealed by [3H]-WAY100,635. British Journal of Pharmacology 132 (2001) 518-524
20. Peng W.H., Hsieh M.T., Lee Y.S., Lin Y.C., and Liao J. Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety. Journal of Ethnopharmacology 72 (2000) 435-441
21. Pristupa Z.B., Wilson J.M., Hoffman B.J., Kish S.J., and Niznik H.B. Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding. Molecular Pharmacology 45 (1994) 125-135
22. Runyon S.P., and Carroll F.I. Dopamine transporter ligands: recent developments and therapeutic potential. Current Topics in Medicinal Chemistry 6 (2006) 1825-1843
23. Schellenberg R., Sauer S., Abourashed E.A., Koetter U., and Brattstrom A. The fixed combination of valerian and hops (Ze91019) acts via a central adenosine mechanism. Planta Medica 70 (2004) 594-597
24. Speth R.C., Wastek G.J., and Yamamura H.I. Benzodiazepine receptors: temperature dependence of [3H]flunitrazepam binding. Life Sciences 24 (1979) 351-357
25. Squires R.F., Ai J., Witt M.R., Kahnberg P., Saederup E., Sterner O., and Nielsen M. Honokiol and magnolol increase the number of [3H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites. Neurochemical Research 24 (1999) 1593-1602
26. 1. Nature 350 (1991) 614-619
27. Tatarczynska E., Klodzinska A., Stachowicz K., and Chojnacka-Wojcik E. Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression. Behavioural Pharmacology 15 (2004) 523-534
28. Tatsumi M., Jansen K., Blakely R.D., and Richelson E. Pharmacological profile of neuroleptics at human monoamine transporters. European Journal of Pharmacology 368 (1999) 277-283
29. Wang L.E., Bai Y.J., Shi X.R., Cui X.Y., Cui S.Y., Zhang F., Zhang Q.Y., Zhao Y.Y., and Zhang Y.H. Spinosin, a C-glycoside flavonoid from semen Zizhiphi Spinozae, potentiated pentobarbital-induced sleep via the serotonergic system. Pharmacology, Biochemistry and Behaviour 90 (2008) 399-403
30. Wesolowska A., and Nikiforuk A. Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 52 (2007) 1274-1283
31. Zhou Q.Y., Grandy D.K., Thambi L., Kushner J.A., Van Tol H.H., Cone R., Pribnow D., Salon J., Bunzow J.R., and Civelli O. Cloning and expression of human and rat D1 dopamine receptors. Nature 347 (1990) 76-80