Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts antiepileptic effects via the GABA/benzodiazepine receptor complex in mice

British Journal of Pharmacology

Volumn 164, Issue 5, 2011, Pages 1534-1546

  Chen, C R ^a   Tan, R ^a   Qu, W M ^a   Wu, Z ^a   Wang, Y ^a   Urade, Y ^b   Huang, Z L ^a  

^a FUDAN UNIVERSITY   (China)

^b OSAKA BIOSCIENCE INSTITUTE   (Japan)

Author keywords

EEG; epileptiform activity; flumazenil; GABA; magnolol; pentylenetetrazol; seizure

Indexed keywords

4 AMINOBUTYRIC ACID; BENZODIAZEPINE RECEPTOR; FLUMAZENIL; MAGNOLOL; PENTETRAZOLE; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BARK; BRAIN CORTEX; BRAIN ELECTROPHYSIOLOGY; BRAIN REGION; BRAIN SLICE; CLONIC SEIZURE; COMPLEX FORMATION; CONTROLLED STUDY; DENTATE GYRUS; DISEASE SEVERITY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG STRUCTURE; ELECTROCARDIOGRAPHY; EPILEPTIC DISCHARGE; HIPPOCAMPAL CA1 REGION; IN VIVO STUDY; LATENT PERIOD; MAGNOLIA OFFICINALIS; MAGNOLIACEAE; MORTALITY; MOUSE; MYOCLONUS SEIZURE; NONHUMAN; ONSET AGE; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRIFORM CORTEX;

ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; BIPHENYL COMPOUNDS; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; LIGNANS; MAGNOLIA; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR STRUCTURE; PLANT BARK; RECEPTORS, GABA-A; SEIZURES;

EID: 80054024231     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01456.x     Document Type: Article

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