Agonist-dependent single channel current and gating in α 4β2δ and α1β 2γ2S GABAA receptors

Journal of General Physiology

Volumn 131, Issue 2, 2008, Pages 163-181

  Keramidas, Angelo ^a   Harrison, Neil L ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; GABOXADOL; RECEPTOR SUBUNIT;

CHANNEL GATING; CONFERENCE PAPER; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; MEMBRANE CONDUCTANCE; MEMBRANE CURRENT; PATCH CLAMP;

ANIMALS; CELL LINE; COMPUTER SIMULATION; ELECTROPHYSIOLOGY; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; ION CHANNEL GATING; ISOXAZOLES; KINETICS; MEMBRANE POTENTIALS; MICE; MODELS, CHEMICAL; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 38749143963     PISSN: 00221295     EISSN: 00221295     Source Type: Journal    
DOI: 10.1085/jgp.200709871     Document Type: Conference Paper

References (48)

1. A receptors containing the α4 subunit by GABA and pentobarbital. J. Physiol. 556:387-399.
2. Auerbach, A., and C.J. Lingle. 1986. Heterogeneous kinetic properties of acetylcholine receptor channels in Xenopus myocytes. J. Physiol. 378:119-140.
3. Barry, P.H. 1994. JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurements. J. Neurosci. Methods. 51:107-116.
4. A receptors. Insight into the absolute arrangement. J. Biol. Chem. 277:46020-46025.
5. A receptors. J. Physiol. 497:753-759.
6. A receptors. Br. J. Pharmacol. 136:965-974.
7. 1β glycine receptors: an attempt to detect a conformational change before the channel opens. J. Neurosci. 24:10924-10940.
8. A receptor. J. Neurosci. 16:5415-5424.
9. Cobb, S.R., E.H. Buhl, K. Halasy, O. Paulsen, and P. Somogyi. 1995. Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons. Nature. 378:75-78.
10. Colquhoun, D. 2007. What have we learned from single ion channels? J. Physiol. 581:425-427.
11. Colquhoun, D., and A.G. Hawkes. 1995. The principles of the stochastic interpretation of ion-channel mechanisms. In Single-Channel Recordings. Second edition. Plenum Press, NY. 397-482.
12. A receptor gene family. Cell. Mol. Neurobiol. 25:607-624.
13. Del Castillo, J., and B. Katz. 1957. Interaction at end-plate receptors between different choline derivatives. Proc. R. Soc. Lond. B. Biol. Sci. 146:369-381.
14. Edmonds, B., and D. Colquhoun. 1992. Rapid decay of averaged single-channel NMDA receptor activations recorded at low agonist concentration. Proc. R. Soc. Lond. B. 250:279-286.
15. A receptor gating kinetics on the α-subunit isoform: implications for structure-function relations and synaptic transmission. J. Physiol. 489:529-543.
16. Hamill, O.P., A. Marty, E. Neher, B. Sakmann, and F.J. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391:85-100.
17. Hardie, J.B., and R.A. Pearce. 2006. Active and passive membrane properties and intrinsic kinetics shape synaptic inhibition in hippocampal CA1 pyramidal neurons. J. Neurosci. 26:8559-8569.
18. A receptor mediates tonic inhibition in thalamic VB neurons. J. Neurophysiol. 94:4491-4501.
19. A receptors in the thalamus. J. Neurosci. 28 (1): 106-115.
20. A channel responses to brief agonist pulses. Neuron. 15:181-191.
21. Keramidas, A., A.J. Moorhouse, K.D. Pierce, P.R. Schofield, and P.H. Barry. 2002. Cation-selective mutations in the M2 domain of the inhibitory glycine receptor channel reveal determinants of ioncharge selectivity. J. Gen. Physiol. 119:393-410.
22. A receptor. J. Physiol. 575:11-22.
23. A receptors α4β2γ2 and α6β2γ2. Mol. Pharmacol. 50:1253-1261.
24. A receptor channels are dependent on α-subunit isoform. Biophys. J. 73:2518-2526.
25. A receptor gating. J. Physiol. 572:183-200.
26. A receptors. Mol. Pharmacol. 69:2015-2026.
27. Maconochie, D.J., and J.H. Steinbach. 1998. The channel opening rate of adult- and fetal-type mouse muscle nicotinic receptors activated by acetylcholine. J. Physiol. 506:53-72.
28. A receptors open? Neuron. 12:61-71.
29. A -receptor subtypes really occur in the brain? Trends Neurosci. 19:139-143.
30. Milone, M., H.L. Wang, K. Ohno, R. Prince, T. Fukudome, X.M. Shen, J.M. Brengman, R.C. Griggs, S.M. Sine, and A.G. Engel. 1998. Mode switching kinetics produced by a naturally occurring mutation in the cytoplasmic loop of the human acetylcholine receptor epsilon subunit. Neuron. 20:575-588.
31. A receptors responsible for tonic and phasic conductances. Neurochem. Res. 26:907-913.
32. A receptor ion channels by full and partial agonists. J. Physiol. 557:389-413.
33. A receptors underlies potentiation at hippocampal inhibitory synapses. Nature. 395:172-177.
34. Pless, S.A., M.I. Dibas, H.A. Lester, and J.W. Lynch. 2007. Conformational variability of the glycine receptor M2 domain in response to activation by different agonists. J. Biol. Chem. 282:36057-36067.
35. Plested, A.J., P.J. Groot-Kormelink, D. Colquhoun, and L.G. Sivilotti. 2007. Single-channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors. J. Physiol. 581:51-73.
36. Popescu, G., and A. Auerbach. 2004. The NMDA receptor gating machine: lessons from single channels. Neuroscientist. 10:192-198.
37. Popescu, G., A. Robert, J.R. Howe, and A. Auerbach. 2004. Reaction mechanism determines NMDA receptor response to repetitive stimulation. Nature. 430:790-793.
38. Purohit, Y., and C. Grosman. 2006. Estimating binding affinities of the nicotinic receptor for low-efficacy ligands using mixtures of agonists and two-dimensional concentration-response relationships. J. Gen. Physiol. 127:719-735.
39. Schofield, C.M., and J.R. Huguenard. 2007. GABA affinity shapes IPSCs in thalamic nuclei. J. Neurosci. 27:7954-7962.
40. A receptor subtypes. Curr. Top. Med. Chem. 2:795-816.
41. A receptor function. Biochem. Soc. Trans. 34:868-871.
42. A receptor is concentrated in synaptic junctions containing the α1 and β2/3 subunits in hippocampus, cerebellum and globus pallidus. Neuropharmacology. 35:1425-1444.
43. A receptor channel gating by pentobarbital. J. Physiol. 537:715-733.
44. A receptor in rat thalamus. Mol. Pharmacol. 56:110-115.
45. Swanson, G.T., S.K. Kamboj, and S.G. Cull-Candy. 1997. Single-channel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition. J. Neurosci. 17:58-69.
46. A receptor α1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons. J. Neurosci. 21:3009-3016.
47. A receptor. J. Neurosci. 24:2733-2741.
48. A receptor α4 subunit expressed in Xenopus laevis oocytes. Mol. Pharmacol. 50:1364-1375.