Honokiol and magnolol increase the number of [3H]muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites

Neurochemical Research

Volumn 24, Issue 12, 1999, Pages 1593-1602

  Squires, Richard F ^a   Ai, Jinglu ^b   Witt, Michael Robin ^b   Kahnberg, Pia ^b   Saederup, Else ^a   Sterner, Olov ^c   Nielsen, Mogens ^b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b Sct Hans Hospital   (Denmark)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Anxiolytic; Diflunisal; GABA(A) receptors; Honokiol; Magnolol; Propofol; Sedative

Indexed keywords

3ALPHA HYDROXY 16 IMINO 5BETA 17 AZAANDROSTAN 11 ONE; 4 AMINOBUTYRIC ACID; DIFLUNISAL; HONOKIOL; MAGNOLOL; MUSCIMOL; PROPOFOL;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FOREBRAIN; GABAERGIC TRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; TRANQUILIZING ACTIVITY;

ANIMALIA; MAGNOLIA; MAGNOLIA OFFICINALIS; MUS;

EID: 0032752149     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021116502548     Document Type: Article

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