Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 32, Issue 3, 2008, Pages 715-725

  Xu, Qun ^a   Yi, Li Tao ^a   Pan, Ying ^a   Wang, Xing ^a   Li, Yu Cheng ^a   Li, Jian Mei ^a   Wang, Cai Ping ^a   Kong, Ling Dong ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Behavioral despair models of depression; Chronic mild stress; Hypothalamic pituitary adrenal axis; Platelet adenylyl cyclase; Serotonergic system; The mixture of honokiol and magnolol

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; ADENYLATE CYCLASE; CORTICOSTERONE; CYCLIC AMP; FLUOXETINE; HONOKIOL; MAGNOLIA OFFICINALIS EXTRACT; MAGNOLOL; SEROTONIN;

5 HYDROXYINDOLEACETIC ACID BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; CHRONIC STRESS; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; EXPERIMENTAL TEST; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION; LOCOMOTION; MAGNOLIACEAE; MALE; MOUSE; NONHUMAN; SEROTONIN BRAIN LEVEL;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BIPHENYL COMPOUNDS; CORTICOSTERONE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; EXPLORATORY BEHAVIOR; HINDLIMB SUSPENSION; HYDROXYINDOLEACETIC ACID; LIGNANS; MAGNOLIA; MALE; MICE; MICE, INBRED ICR; PHYTOTHERAPY; RATS; RATS, WISTAR; SEROTONIN; STRESS; SWIMMING;

EID: 39749181656     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2007.11.020     Document Type: Article

References (76)

1. Abdel-Razaq W., Bates T.E., and Kendall D.A. The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system. Biochem Pharmacol 73 (2007) 1995-3
2. Alfonso J., Frasch A.C., and Flugge G. Chronic stress, depression and antidepressants: effects on gene transcription in the hippocampus. Rev Neurosci 16 (2005) 43-56
3. Arango V., Underwood M.D., and Mann J.J. Serotonin brain circuits involved in major depression and suicide. Prog Brain Res 136 (2002) 443-453
4. Archer J. Tests for emotionality in rats and mice: a review. Anim Behav 21 (1973) 205-235
5. Ayensu W.K., Pucilowski O., Mason G.A., Overstreet D.H., Rezvani A.H., and Janowsky D.S. Effects of chronic mild stress on serum complement activity, saccharin preference, and corticosterone levels in Flinders lines of rats. Physiol Behav 57 (1995) 165-169
6. Azpiroz A., Fano E., Garmendia L., Arregi A., Cacho R., Beitia G., et al. Effects of chronic mild stress (CMS) and imipramine administration, on spleen mononuclear cell proliferative response, serum corticosterone level and brain norepinephrine content in male mice. Psychoneuroendocrinology 24 (1999) 345-361
7. Bekris S., Antoniou K., Daskas S., and Papadopoulou D.Z. Behavioural and neurochemical effects induced by chronic mild stress applied to rat strains. Behav Brain Res 161 (2005) 45-59
8. Best L.C., Martin T.J., Russell R.G., and Preston F.E. Prostacyclin increases cyclic AMP levels and adenylate cyclase activity in platelets. Nature 267 (1977) 850-852
9. Bijak M., and Papp M. The effect of chronic treatment with imipramine on the responsiveness of hippocampal CA1 neurons to phenylephrine and serotonin in a chronic mild stress model of depression. Eur Neuropsychopharmacol 5 (1995) 43-48
10. Borsini F., and Meli A. Is the forced swimming test a suitable model for revealing antidepressant activity?. Psychopharmacology 94 (1988) 147-160
11. Cannon D.M., Ichise M., and Rollis D. Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [(11)C] DASB; comparison with bipolar disorder. Biol Psychiatry 62 (2007) 870-877
12. Chaouloff F. Physiopharmacological interactions between stress hormones and central serotonergic systems. Brain Res Rev 18 (1993) 1-32
13. Cowburn R.F., Marcusson J.O., Eriksson A., Wiehager B., and O'Neill C. Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims. Brain Res 633 (1994) 297-304
14. Curzon G., and Green A.R. Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain. Br J Pharmacol 39 (1970) 653-655
15. Daszuta A., Ban M.S., and Soumier A. Depression and neuroplasticity: implication of serotoninergic systems. Therapies 60 (2005) 461-468
16. Federman A.D., Conklin B.R., Schrader K.A., Reed R.R., and Bourne H.R. Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. Nature 356 (1992) 159-161
17. Feng C.D., Dai T.J., Zeng Y.M., and Yang J.P. Effects of enflurane on the activity of adenylate cyclase and phosphodiestrases in cortex hippocampus and brain stem of rats. J Jiangsu Clin Med 3 (2005) 54-57
18. Grippo A.J., Sullivan N.R., and Damjanoska K.J. Chronic mild stress induces behavioral and physiological changes, and may alter serotonin 1A receptor function, in male and cycling female rats. Psychopharmacol 179 (2005) 769-780
19. Grippo A.J., Beltz T.G., and Weiss R.M. The effects of chronic fluoxetine treatment on chronic mild stress-induced cardiovascular changes and anhedonia. Biol Psychiatry 59 (2006) 309-316
20. Gronli J., Fiske E., Murison R., Bjorvatn B., Sorensen E., Ursin R., et al. Extracellular levels of serotonin and GABA in the hippocampus after chronic mild stress in rats. A microdialysis study in an animal model of depression. Behav Brain Res 181 (2007) 42-51
21. Guo Y.S., Kong L.D., Wang Y.M., and Huang Z.Q. Antidepressant evaluation of polysaccharides from a Chinese herbal medicine Banxia-houpu decoction. Phytother Res 18 (2004) 24-27
22. Habib K.E., Gold P.W., and Chrousos G.P. Neuroendocrinology of stress. Endocrinol Metab Clin N Am 30 (2001) 695-728
23. Hines L.M., and Tabakoff B. Platelet adenylyl cyclase activity: a biological marker for major depression and recent drug use. Biol Psychiatry 58 (2005) 955-962
24. Hsieh M.T., Chueh F.Y., and Lin M.T. Magnolol decreases body temperature by reducing 5-hydroxytryptamine release in the rat hypothalamus. Clin Exp Pharmacol Physiol 25 (1998) 813-817
25. Ieda F.O.S., Lucas P., Silvia R.C.P., Vany P., Alfredo J.A.B., Vivian A.A.F., et al. Age-related deficit in behavioral extinction is counteracted by long-term ethanol consumption: correlation between 5-HIAA/5HT ratio in dorsal raphe nucleus and cognitive parameters. Behav Brain Res 180 (2007) 226-234
26. Ikarashi Y., Yuzurihara M., Sakakibara I., Nakai Y., Hattori N., and Maruyama Y. Effects of the extract of the bark of Magnolia obovata and its biphenolic constituents magnolol and honokiol on histamine release from peritoneal mast cells in rats. Planta Med 67 (2001) 709-713
27. Kentarou U., Hiromi S., Yuki S., Hideto T., Satoru K., Shun H., et al. Chronopharmacological study of antidepressants in forced swimming test of mice. J Pharm Exp Therapeutics 315 (2005) 764-770
28. Kulkarni S.K., and Dhir A. Effect of various classes of antidepressants in behavioral paradigms of despair. Prog Neuropsychopharmacol Biol Psychiatry 31 (2007) 1248-1254
29. Kuribara H., Stavinoha W.B., and Maruyama Y. Behavioural pharmacological characteristics of honokiol, an anxiolytic agent present in extracts of Magnolia bark, evaluated by an elevated plus-maze test in mice. J Pharm Pharmacol 50 (1998) 819-826
30. Kuribara H., Kishi E., Hattori N., Yuzurihara M., and Maruyama Y. Application of the elevated plus-maze test in mice for evaluation of the content of honokiol in water extracts of magnolia. Phytother Res 13 (1999) 593-596
31. Kuribara H., Stavinoha W.B., and Maruyama Y. Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice. J Pharm Pharmacol 51 (1999) 97-103
32. LeCorre S., Sharp T., Young A.H., and Harrison P.J. Increase of 5-HT7 (serotonin-7) and 5-HT1A (serotonin-1A) receptor mRNA expression in rat hippocampus after adrenalectomy. Psychopharmcol 130 (1997) 368-374
33. Leonard B.E. The HPA and immune axes in stress: the involvement of the serotonergic system. Eur Psychiatr 20 Suppl 3 (2005) S302-S306
34. Lesch K.P. Serotonergic gene expression and depression: implications for developing novel antidepressants. J Affect Disord 62 (2001) 57-76
35. Li X.Q., and Xu J. Amitriptyline effect on the adenylyl cyclase activity in CMS rats frontal cortex. Basic Med Sci Clin 4 (2002) 372-373
36. Li Y.F., Gong Z.H., Zhang H.T., and Luo Z.P. Effect of antidepressants on adenylate cyclase activity of rat cerebral cortex. Bull Acad Military Med Sci 2 (1999) 18
37. Li J.M., Kong L.D., Wang Y.M., Cheng C.H.K., Zhang W.Y., and Tan W.Z. Behavioral and biochemical studies on chronic mild stress models in rats treated with a Chinese traditional prescription Banxia-houpu decoction. Life Sci 74 (2003) 55-73
38. Li J.M., Yang C., Zhang W.Y., and Kong L.D. The effects of banxia houpu decoction on a chronic mild stress model of depression. Zhongguo Zhong Yao Za Zhi 28 (2003) 55-59
39. Li S., Wang C., Wang M.W., Murakami Y., and Matsumoto K. Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress. Pharmacol Biochem Behav 83 (2006) 186-193
40. Li S., Wang C., Wang M.W., Wei L., Matsumoto K., and Tang Y.Y. Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sci 80 (2007) 1373-1381
41. Lin Y.R., Chen H.H., Ko C.H., and Chan M.H. Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage. Eur J Pharmacol 537 (2006) 64-69
42. Lingjaerde O. Blood platelets as a model system for studying serotonergic dysfunction and effects of antidepressants. Pharmacol Toxicol 66 (1990) 61-68
43. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 193 (1951) 265-275
44. Martinez A.L., Dominguez F., Orozco S., Chavez M., Salgado H., Gonzalez M., et al. Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice. J Ethnopharmacol 106 (2006) 250-255
45. Maruyama Y., Kuribara H., Morita M., Yuzurihara M., and Weintraub S.T. Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine. J Nat Prod 61 (1998) 135-138
46. Matsui N., Nakashima H., Ushio Y., Tada T., Shirono A., Fukuyama Y., et al. Neurotrophic effect of magnolol in the hippocampal CA1 region of senescence-accelerated mice (SAMP1). Biol Pharm Bull 28 (2005) 1762-1765
47. Matsumoto M., and Yoshioka M. Intracellular signal transduction mediated via 5-HT and NA receptors. Nippon Rinsho 59 (2001) 1450-1456
48. McAllister-Williams R.H., Ferrier I.N., and Young A.H. Mood and neuropsychological function in depression: the role of corticosteroids and serotonin. Psychol Med 28 (1998) 573-584
49. Menninger J.A., and Tabakoff B. Forskolin-stimulated platelet adenylyl cyclase activity is lower in persons with major depression. Biol Psychiatry 42 (1997) 30-38
50. Mikkelsen J.D., Hay-Schmidt A., and Kiss A. Serotonergic stimulation of the rat hypothalamo-pituitary-adrenal axis: interaction between 5-HT1A and 5-HT2A receptors. Ann N Y Acad Sci 1018 (2004) 65-70
51. Muñoz C., and Papp M. Alnespirone (S 20499), an agonist of 5-HT1A receptors, and imipramine have similar activity in a chronic mild stress model of depression. Pharmacol Biochem Behav 63 (1999) 647-653
52. Muscat R., and Willner P. Suppression of sucrose drinking by chronic mild unpredictable stress: a methodological analysis. Neurosci Biobehav Rev 16 (1992) 507-517
53. Nakazawa T., Yasuda T., and Ohsawa K. Metabolites of orally administered Magnolia officinalis extract in rats and man and its antidepressant-like effects in mice. J Pharm Pharmacol 55 (2003) 1583-1591
54. Pan Y., Kong L.D., Xia X., Zhang W.Y., Xia Z.H., and Jiang F.X. Antidepressant-like effect of icariin and its possible mechanism in mice. Pharmacol Biochem Behav 82 (2005) 686-694
55. Pan Y., Kong L.D., Li Y.C., Xia X., Kung H.F., and Jiang F.X. Icariin from Epimedium brevicornum attenuates chronic mild stress-induced behavioral and neuroendocrinological alterations in male Wistar rats. Pharmacol Biochem Behav 87 (2007) 130-140
56. Porsolt R.D., Le P.M., and Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 266 (1977) 730-732
57. Porsolt R.D., Anton G., Blavet N., and Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47 (1978) 379-391
58. Porter R., Gallagher P., Watson S., and Young A. Corticosteroid-serotonin interactions in depression: a review of the human evidence. Psychopharmacol 173 (2004) 1-17
59. Reiach J.S., Li P.P., Warsh J.J., Kish S.J., and Young L.T. Reduced adenylyl cyclase immunolabeling and activity in postmortem temporal cortex of depressed suicide victims. J Affect Disord 56 (1999) 141-151
60. Song L., Che W., and Wu M.W. Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress. Pharmacol Biochem Behav 83 (2006) 186-193
61. Staley J.K., Malison R.T., and Innis R.B. Imaging of the serotonergic system: interactions of neuroanatomical and functional abnormalities of depression. Biol Psychiatry 44 (1998) 534-549
62. Steru L., Chermat R., and Thierry B. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl) 85 (1985) 367-370
63. Taiwo Y.O., and Levine J.D. Mediation of serotonin hyperalgesia by the cAMP second messenger system. Neuroscience 48 (1992) 479-483
64. Teng C.M., Chen C.C., Ko F.N., Lee L.G., Huang T.F., Chen Y.P., et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 50 (1988) 757-765
65. Tsai T.H., Lee T.F., Chen C.F., and Wang L.C. Modulatory effects of magnolol on potassium-stimulated 5-hydroxytryptamine 5-HT release from rat cortical and hippocampal slices. Neurosci Lett 186 (1995) 49-52
66. Wadman I.A., Farndale R.W., and Martin B.R. Evidence for regulation of human platelet adenylate cyclase by phosphorylation. Inhibition by ATP and guanosine 5′-[beta-thio]diphosphate occur by distinct mechanisms. Biochem J 276 (1991) 621-630
67. Wang Y.M., Kong L.D., and Chen Y. Behavioural and biochemical effects of fractions prepared from Banxia Houpu decoction in depression models in mice. Phytother Res 19 (2005) 526-529
68. Watanabe K., Watanabe H., Goto Y., Yamaguchi M., Yamamoto N., and Hagino K. Pharmacological properties of magnolol and honokiol extracted from Magnolia officinalis: central depressant effects. Planta Med 49 (1983) 103-108
69. Willner P. Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berl) 134 (1997) 319-329
70. Willner P. Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52 (2005) 90-110
71. Willner P., and Mitchell P.J. The validity of animal models of predisposition to depression. Behav Pharmacol 13 (2002) 169-188
72. Willner P., Towell A., Sampson D., Sophokleous S., and Muscat R. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology 93 (1987) 358-364
73. Wu Y.T., Lin L.C., and Tsai T.H. Simultaneous determination of honokiol and magnolol in Magnolia officinalis by liquid chromatography with tandem mass spectrometric detection. Biomed Chromatogr 20 (2006) 1076-1081
74. Xia X., Pan Y., Zhang W.Y., Cheng G., and Kong L.D. Ethanolic extracts from Curcuma longa attenuates behavioral, immune and neuroendocrine alterations in a rat chronic mild stress model. Biol Pharm Bull 29 (2006) 938-944
75. Xu Y., Ku B.H., Tie L., Yao H.Y., Jiang W.G., Ma X., et al. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Res 1122 (2006) 56-64
76. Young E.A., Altemus M., Lopez J.F., Kocsis J.H., Schatzberg A.F., DeBattista C., et al. HPA axis activation in major depression and response to fluoxetine: a pilot study. Psychoneuroendocrinology 29 (2004) 1198-1204