Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin α(IIb)β3

EMBO Journal

Volumn 15, Issue 21, 1996, Pages 5760-5771

  Holmbäck, Kenn ^a   Danton, Mary Jo S ^a   Suh, Theodore T ^a   Daugherty, Cynthia C ^a   Degen, Jay L ^a  

^a CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

Adhesion; Fibrinogen; Gene targeting; Integrin; Platelet

Indexed keywords

FIBRINOGEN; INTEGRIN; MUTANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLEEDING; BLOOD CLOTTING TIME; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FIBRINOGEN BLOOD LEVEL; GENE TARGETING; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT;

ANIMALIA;

EID: 0029906976     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00962.x     Document Type: Article

References (53)

1. Beacham, D.A., Wise, R.J., Turci, S.M. and Handin, R.I. (1992) Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesis. J. Biol. Chem., 267, 3409-3415.
2. Bertagnolli, M.E. and Beckerle, M.C. (1993) Evidence for the selective association of a subpopulation of GPIIb-IIIa with the cytoskeletons of thrombin-activated platelets. J. Cell Biol., 121, 1329-1342.
3. Bi, L., Lawler, A.M., Antonarakis, S.E., High, K.A., Gearhart, J.D. and Kazazian, H.H. (1995) Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A. Nature Genet., 10, 119-121.
4. Bugge, T.H., Flick, M.J., Daugherty, C.C. and Degen, J.L. (1995) Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes Dev., 9, 794-807.
5. Bugge, T.H. et al. (1996) Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Prof. Natl Acad. Sci. USA, 93, 6258-6263.
6. Caen, J.P. and Rosa, J.-P. (1995) Platelet-vessel wall interaction: from bedside to molecules. Thromb. Haemost., 74, 18-24.
7. Calvete, J.J. (1994) Clues for understanding the structure and function of a prototypic human integrin: The platelet glycoprotein IIb/IIIa complex. Thromb. Haemost., 72, 1-15.
8. Carr, E.,Jr, Carr, S.L., Hantgan, R.R. and Braaten, J. (1995) Glycoprotein IIb/IIIa blockade inhibits platelet-mediated force development and reduces gel elastic modulus. Thromb. Haemost., 73, 499-505.
9. Charo, I.F., Kieffer, N. and Phillips, D.R. (1994) Platelet Membrane Glycoproteins. In Coleman, R.W., Hirsh, J., Marder, V.J. and Salzman, E.W. (eds), Hemostasis and Thrombosis: Basic Principles and Clinical Practice. J.B.Lippincott Company, Philadelphia. PA, pp. 489-507.
10. Cheresri, D.A., Berliner, S.A., Vicente, V. and Ruggeri, Z.M. (1989) Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells. Cell, 58, 945-953.
11. Cherny, R.C., Honan, M.A. and Thiagarajan, P. (1993) Site-directed mutagenesis of the arginine-glycine-aspartic acid in vitronectin abolishes cell adhesion. J. Biol. Chem., 268, 9725-9729.
12. Chung, D.W. and Davie, E.W. (1981) γ and γ′ chains of human fibrinogen are produced by alternative mRNA processing. Biochemistry, 23, 4232-4236.
13. Crabtree, G.R. and Kant, J.A. (1982) Organization of the rat gamma fibrinogen gene: alternative mRNA splice patterns produce the gamma A and gamma B (gamma′) chains of fibrinogen. Cell, 31, 159-166.
14. Doolittle, R.F. (1994) The molecular biology of fibrin. In Stamatoyannopoulos, G.S., Nienhuis, A.W., Majerus, P.W. and Varmus, H. (eds), The Molecular Basis of Blood Diseases. W.B.Saunders Co., Philadelphia, PA. pp. 701-723.
15. Farrell, D.H. and Thiagarajan, P. (1994) Binding of recombinant fibrinogen mutants to platelets. J. Biol. Chem., 269, 226-231.
16. Frenette, P.S., Johnson, R.C., Hynes, R.O. and Wagner, D.D. (1995) Platelets roll on stimulated endothelium in vivo: An interaction mediated by endothelial P-selectin. Proc. Natl Acad. Sci. USA, 92, 7450-7454.
17. Gartner, T.K. and Bennett, J.S. (1985) The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets. J. Biiol. Chem., 260, 11891-11894.
18. Gartner, T.K. and Ogilvie, M.L. (1988) Peptides and monoclonal antibodies which bind to platelet glycoprotein IIb and/or IIIa inhibit clot retraction. Thromb. Res., 49, 43-53.
19. George, J.N., Caen, J.P. and Nurden, A.T. (1990) Glanzmann's thrombasthenia: The spectrum of clinical disease. Blood, 75, 1383-1395.
20. Ginsberg, M.H., Du, X., O'Toole, T.E. and Loftus, J.C. (1995) Platelet integrins. Thromb. Haemost., 74, 352-359.
21. Glanzmann, E. (1918) Hereditäre hämorragishe thrombasthenie. Ein beitrag zur Pathologie der Blutplättchen. Jahr Kinderh., 88, 113-118.
22. Hantgan, R.R. (1988) Localization of the domains of fibrin involved in binding to platelets. Biochim. Biophys. Acta, 968, 36-44.
23. Haverstick, D.M., Cowan, J.F., Yamada, K.M. and Santoro, S.A. (1985) Inhibition of platelet adhesion to fibronectin, fibrinogen and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell binding domain of fibronectin. Blood, 66, 946-952.
24. Hooper, M.L., Hardy, K., Handyside, A., Hunter, S. and Monk, M. (1987) HPRT-deficient [Lesch-Nyhan] mouse embryos derived from germline colonization by cultured cells. Nature, 326, 292-295.
25. Kirschbaum, N.E., Mosesson, M.W. and Amrani, D.L. (1992) Characterization of the y chain platelet binding site on fibrinogen fragment D. Blood, 79, 2643-2648.
26. Kloczewiak, M., Timmons, S., Lukas, T.J. and Hawiger, J. (1984) Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the y chain. Biochemistry, 23, 1767-1774.
27. Kuyas, C., Haeberli, A., Walder, P. and Straub, P.W. (1990) Isolation of human fibrinogen and its derivatives by affinity chromatography on Gly-Pro-Arg-Lys-Fractogel. Thromb. Haemost., 63, 439-444.
28. Lefebvre, R., White, M.D., Krumweide, I. and Cohen, I. (1993) Role of actin in platelet function. Eur. J. Cell Biol., 62, 194-204.
29. Li, H. et al. (1994) Gsh-4 encodes a LIM-type homeodomain, is in the developing nervous system and is required for early postnatal survival. EMBO J., 13, 2876-2885.
30. Lind, S.E. (1995) The hemostatic system. In Handin, R.I., Stossel, T.P. and Lux, S.E. (eds), Blood: Principles and Practice of Hematotogy. J.B.Lippincott Co., Philadelphia, PA. pp. 949-972.
31. McDonagh, J., Carrell, N. and Lee, M.H. (1994) Dysfibrinogenemias and other disorders of fibrinogen structure and function. In Colman, R.W., Hirsh, J., Marder, V.J. and Salzman, E.W. (eds), Hemostasis and Thrombosis, Basic Principles and Clinical Practice. J.B.Lippincott Co., Philadelphia. PA, pp. 314-334.
32. Murakawa, M., Okamura, T., Kamura, T., Shibuya, T., Harada, M. and Niho, Y. (1993) Diversity of the primary structures of the carboxy-terminal regions of mammalian fibrinogen Aα chains. Thromb. Haemost., 69, 351-360.
33. 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Cell Regulat., 1, 883-893.
34. Plow, E.F., Pierschbacher, M.D., Ruoslahti, E., Marguerie, G.A. and Ginsberg, M.H. (1985a) The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets. Proc. Natl Acad. Sci. USA, 82, 8057-8061.
35. Plow, E.F., McEver, R.P., Coller, B.S., Woods, V.L., Marguerie, G.A. and Ginsberg, M.H. (1985b) Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor and thrombospondin on thrombin-stimulated platelets. Blood, 66, 724-727.
36. Plow, E.F., Pierschbacher, M.D., Ruoslahti, E., Marguerie, G. and Ginsberg, M.H. (1987) Arginyl-Glycyl-Aspartic acid sequences and fibrinogen binding to platelets. Blood, 70, 110-115.
37. Pytela, R., Pierschbacher, M.D., Ginsberg, M.H., Plow, E.F. and Ruoslahti, E. (1986) Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg/Gly/Asp-specific adhesion receptors. Science, 231, 1559-1562.
38. Rooney, M.M., Parise, L.V. and Lord, S.T. (1996) Dissecting clot retraction and platelet aggregation. J. Biol. Chem., 271, 8553-8555.
39. Ruggeri, Z.M. (1995) The role of von Willebrand factor and fibrinogen in the initiation of platelet adhesion to thrombogenic surfaces. Thromb. Haemost., 74, 460-463.
40. Ruggeri, Z.M., De Marco, L., Gatti, L., Bader, R. and Montgomery, R.R. (1983) Platelets have more than one receptor for von Willebrand factor. J. Clin. Invest., 72, 1-12.
41. Savage, B. and Ruggeri, Z.M. (1991) Selective recognition of adhesive sites in surface bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets. J. Biol. Chem., 266, 11227-11233.
42. Savage, B., Saldivar, E. and Ruggeri, Z.M. (1996) Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. Cell, 84, 289-297.
43. 3 (platelet glycoprotein IIb/IIIa) and cellular retraction of fibrin polymers. J. Biol. Chem., 269, 32479-32487.
44. Shattil, S.J., Ginsberg, M.H. and Brugge, J.S. (1994) Adhesive signaling in platelets. Curr. Opin. Cell Biol., 6, 695-704.
45. Shivadasani, R.A., Rosenblatt, M.F., Zucker-Franklin, D., Jackson, C.W., Hunt, P., Saris, C.J. and Orkin, S.H. (1995) Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell, 81, 695-704.
46. Sims, P.J., Ginsberg, M.H., Plow, E.F. and Shattil, S.J. (1991) Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex. J. Biol. Chem., 266, 7345-7352.
47. Sixma, J.J., van Zanten, H.G., Saelman, E.U.M., Verkleij, M., Lankhof, H., Niewenhuis, H.K. and deGroot, P.G. (1995) Platelet adhesion to collagen. Thromb. Haemmt., 74, 454-459.
48. Strong, D.D., Moore, M., Cottrell, B.A., Bonohus, V.L., Pontes, M., Evans, B., Riley, M. and Doolittle, R.F. (1985) Lamprey fibrinogen γ chain: cloning, cDNA sequencing, and general characterization. Biochemistry, 24, 92-101.
49. Suh, T.T., Holmbäck, K., Jensen, N.J., Daugherty, C.C., Small, K., Simon, D.I., Potter, S.S. and Degen, J.L. (1995) Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Genes Dev. 9, 2020-2038.
50. α (300-312) inhibit fibrinogen binding, clot retraction, and platelet adhesion to multiple ligands. Proc. Soc. Exp. Biol. Med., 205, 35-43.
51. Ugarova, T.P., Budzynski, A.Z., Shattil, S.J., Ruggeri, Z.M., Ginsberg, M.H. and Plow, E.F. (1993) Conformational changes in fibrinogen elicited by its interaction with the platelet membrane glycoprotein GPIIb-IIIa. J. Biol. Chem., 268, 21080-21087.
52. van der Lugt, N., Maandag, E.R., teRiele, H., Laird, P.W. and Berns, A. (1991) A pgk-hprt fusion as selectable marker for targeting genes in mouse embryonic stem cells: disruption of the T-cell receptor 5-chain encoding gene. Gene, 105, 263-267.
53. Witke, W., Sharpe, A.H., Hartwig, J.H., Azuma, T., Stossel, T.P. and Kwiatkowski, D.J. (1995) Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell, 81, 41-51.