Serum autoantibodies that bind citrullinated fibrinogen are frequently found in patients with rheumatoid arthritis

Journal of Rheumatology

Volumn 33, Issue 11, 2006, Pages 2115-2119

  Hill, Jonathan A ^a   Al Bishri, Jamal ^b   Gladman, Dafna D ^c   Cairns, Ewa ^a   Bell, David A ^a,d  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d ST JOSEPH S HEALTH CENTRE   (Canada)

Author keywords

Citrullinated fibrinogen; Cyclic citrullinated peptide; Rheumatoid arthritis; Rheumatoid factor

Indexed keywords

AUTOANTIBODY; CITRULLINE; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; FIBRINOGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; RHEUMATOID FACTOR;

ADOLESCENT; ADULT; AGED; ANTIBODY DETECTION; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOPATHOGENESIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PSORIATIC ARTHRITIS; RECEIVER OPERATING CHARACTERISTIC; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS; SENSITIVITY AND SPECIFICITY; SEROPREVALENCE;

EID: 33750991895     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Vossenaar ER, van Venrooij WJ. Anti-CCP antibodies, a highly specific marker for (early) rheumatoid arthritis. Clin Appl Immunol 2004;4:239-62.
2. van Venrooij WJ, Hazes JM, Visser H. Anticitrullinated protein/-peptide antibody and its role in the diagnosis and prognosis of early rheumatoid arthritis. Neth J Med 2002;60:383-8.
3. Masson-Bessiere C, Sebbag M, Girbal-Neuhauser E, et al. The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin. J Immunol 2001;166:4177-84.
4. Chang X, Yamada R, Suzuki A, et al. Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis. Rheumatology Oxford 2005;44:40-50.
5. Vossenaar ER, Nijenhuis S, Helsen MM, et al. Citrullination of synovial proteins in murine models of rheumatoid arthritis. Arthritis Rheum 2003;48:2489-500.
6. Vossenaar ER, Despres N, Lapointe E, et al. Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin. Arthritis Res Ther 2004;6:R142-50.
7. Menard HA, Lapointe E, Rochdi MD, Zhou ZJ. Insights into rheumatoid arthritis derived from the Sa immune system. Arthritis Res Ther 2000;2:429-32.
8. Newkirk MM. Rheumatoid factors: host resistance or autoimmunity? Clin Immunol 2002;104:1-13.
9. Dorner T, Egerer K, Feist E, Burmester GR. Rheumatoid factor revisited. Curr Opin Rheumatol 2004;16:246-53.
10. Hill JA, Wehrli B, Jevnikar AM, Bell DA, Cairns E. Citrullinated fibrinogen induces arthritis in HLA-DRB1*0401 transgenic mice [abstract]. Arthritis Rheum 2003;48 Suppl:S348.
11. Doyle HA, Mamula MJ. Post-translational protein modifications in antigen recognition and autoimmunity. Trends Immunol 2001;22:443-9.
12. Monneaux F, Muller S. Epitope spreading in systemic lupus erythematosus: identification of triggering peptide sequences. Arthritis Rheum 2002;46:1430-8.
13. Bonifacio E, Lampasona V, Bernasconi L, Ziegler AG. Maturation of the humoral autoimmune response to epitopes of GAD in preclinical childhood type I diabetes. Diabetes 2000;49:202-8.
14. Hill JA, Southwood S, Sette A, Jevnikar AM, Bell DA, Cairns E, Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J Immunol 2003;171:538-41.
15. Mamula MJ, Gee RJ, Elliott JI, et al. Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins. J Biol Chem 1999;274:22321-7.
16. Goodnow CC, Crosbie J, Adelstein S, et al. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 1998;334:676-82.
17. Hartley SB, Crosbie J, Brink TK, Kantor AB, Basten A, Goodnow CC. Elimination from peripheral lymphoid tissues of self-reactive B-lymphocytes recognizing membrane-bound antigens. Nature 1991;353:765-9.
18. Ferry H, Jones M, Vaux DJ, Roberts IS, Cornall RJ. The cellular location of self-antigen determines the positive and negative selection of autoreactive B cells. J Exp Med 2003;198:1415-25.
19. Fulcher DA, Basten A. Reduced life span of anergic self-reactive B cells in a double-transgenic model. J Exp Med 1994;179:125-34.
20. Cooke MP, Heath AW, Shokat KM, et al. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med 1994;179:425-38.