Regulation of VSMC behavior by the cadherin-catenin complex

Frontiers in Bioscience

Volumn 16, Issue 2, 2011, Pages 644-673

  Lyon, Cressida ^a   Mill, Carina ^a   Tsaousi, Aikaterini ^a   Williams, Helen ^a   George, Sarah ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Apoptosis; Beta catenin; Cadherin; Migration; Proliferation; Review; Vascular smooth muscle cell; Wnt

Indexed keywords

BETA CATENIN; CADHERIN; CATENIN; WNT PROTEIN;

ANIMAL; APOPTOSIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL MOTION; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECT; HUMAN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; APOPTOSIS; ATHEROSCLEROSIS; BETA CATENIN; CADHERINS; CATENINS; CELL MOVEMENT; CELL PROLIFERATION; HUMANS; MUSCLE, SMOOTH, VASCULAR; PLAQUE, ATHEROSCLEROTIC; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 79955031204     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3711     Document Type: Article

References (109)

1. S Peterson, V Peto, M Rayner, European cardiovascular disease statistics. British Heart Foundation, ed. Edition London. (2005)
2. S Allender, V Peto, P Scarborough, A Kaur, M Rayner, Coronary heart disease statistics. British Heart Foundation, ed. edition. 2008, London.
3. AC Newby, SJ George: Proliferation, migration, matrix turnover and death of smooth muscle cells in native coronary and vein graft atherosclerosis. Curr Opin Cardiol 11, 574-582 (1996) (Pubitemid 26401805)
4. SM Schwartz, D deBlois, ERM O'Brien: The intima. Soil for atherosclerosis and restenosis. Circ Res 77, 3 445-465 (1995)
5. GK Owens, MS Kumar, BR Wamhoff: Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84, 767-801 (2003)
6. AW Clowes, MA Reidy, MM Clowes: Mechanisms of stenosis after arterial injury. Lab Invest 53, 513-520 (1983)
7. EW Raines, R Ross: Smooth Muscle Cells and the Pathogenesis of the Lesions of Atherosclerosis. Br Heart J 69, 1 Suppl. S30-S37 (1993) (Pubitemid 23035604)
8. S Peykar, DJ Angiolillo, TA Bass, MA Costa: Saphenous vein graft disease. Minerva Cardioangiol 52, 5 379-90 (2004) (Pubitemid 39457519)
9. F Saia, A Marzocchi, A Branzi: Review: The safety of drug-eluting stents. Therapeutic Advances in Cardiovascular Disease 2, 1 43-52 (2008)
10. EW Raines: The extracellular matrix can regulate vascular cell migration, proliferation, and survival: relationships to vascular disease. Int J Exp Pathol 81, 3 173-182 (2000) (Pubitemid 30485816)
11. MM Kavurma, R Bhindi, HC Lowe, C Chesterman, LM Khachigian: Vessel wall apoptosis and atherosclerotic plaque instability. J Thromb Haemost 3, 465-472 (2005) (Pubitemid 41632871)
12. M Clarke, N Figg, J Maguire, A Davenport, M Goddard, TD Littlewood, MR Bennett: Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis. Nature Med 12, 9 1075-1080 (2006) (Pubitemid 44353389)
13. JH von der Thusen, BJM van Vlijmen, RC Hoeben, MM Kockx, LM Havekes, TJC van Berkel, EAL Biessen: Induction of atherosclerosis plaque rupture in apolipoprotein E-/-mice after adenovirus-mediated transfer of p53. Circulation 105, 2064-2070 (2002) (Pubitemid 34465269)
14. EL Henderson, Y-J Geng, GK Sukhova, AD Whittemore, J Knox, P Libby: Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms. Circulation 99, 96-104 (1999) (Pubitemid 29035963)
15. A Lopez-Candales, D Holmes, S Liao, M Scott, S Wickline, T RW: Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms. Am J Pathol 150, 993-1007 (1997) (Pubitemid 27106171)
16. S Kondo, N Hashimoto, H Kikuchi, F Hazama, I Nagata, H Kataoka, WI Rosenblum: Apoptosis of Medial Smooth Muscle Cells in the Development of Saccular Cerebral Aneurysms in Rats Stroke 29, 181-189 (1998) (Pubitemid 28046962)
17. Y-X Wang, B Martin-McNulty, V da Cunha, J Vincelette, X Lu, Q Feng, M Halks-Miller, M Mahmoudi, M Schroeder, B Subramanyam, J-L Tseng, GD Deng, S Schrim, A Johns, K Kauser, WP Dole, DR Light: Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdmoninal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis. Circulation 111, 2219-2226 (2005) (Pubitemid 40632438)
18. D Yamanouchi, S Morgan, K Kato, J Lengfeld, F Zhang, B Liu: Effects of caspase inhibitor on angiotensin II-induced abdominal aortic aneurysm in Apolipoprotein Edeficient mice. Arterioscler Thromb Vasc Biol 30, 4 702-707 (2010)
19. J Golledge, J Muller, A Daugherty, P Norman: Abdominal aortic aneurysm-Pathogenesis and implications for management. Arteriosclerosis Thrombosis and Vascular Biology 26, 12 2605-2613 (2006)
20. D Allard, N Figg, MR Bennett, TD Littlewood: Akt Regulates the Survival of Vascular Smooth Muscle Cells via Inhibition of FoxO3a and GSK3. J. Biol. Chem. 283, 28 19739-19747 (2008)
21. H-Z Bai, MJ Pollman, Y Inishi, GH Gibbons: Regulation of vascular smooth muscle cell apoptosis. Modulation of bad by a phosphatidylinositol 3-kinasedependent pathway. Circ Res 85, 229-237 (1999) (Pubitemid 29377294)
22. OP Blanc-Brude, J Yu, H Simosa, MS Conte, WC Sessa, DC Altieri: Inhibitor of apoptosis protein survivin regulates vascular injury. Nature Medicine 8, 9 987-994 (2002) (Pubitemid 35033703)
23. MS McMurtry, SL Archer, DC Altieri, S Bonnet, A Haromy, G Harry, S Bonnet, L Puttagunta, ED Michelakis: Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. The Journal of Clinical investigation 115, 6 1479-1491 (2005) (Pubitemid 40814657)
24. J-B Michel: Anoikis in the cardiovascular system. Known and unknown extracellular mediators. Arterioscler Thromb Vasc Biol 23, (2003)
25. E Koutsouki, CA Beeching, SC Slater, OW Blaschuk, GB Sala-Newby, SJ George: N-cadherin-dependent cellcell contacts promote human saphenous vein smooth muscle cell survival. Arterioscler Thromb Vasc Biol 25, 982-988 (2005) (Pubitemid 40627843)
26. H Williams, J Johnson, C Jackson, S White, S George: MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis. Cardiovasc Res 87, 137-46, (2010)
27. AP Burke, FD Kolodgie, A Farb, DK Weber, GT Malcom, J Smialek, R Virmani: Healed plaque ruptures and sudden coronary death. Evidence that subclinical rupture has a role in plaque progression. Circulation 103, 934-940 (2001) (Pubitemid 32183797)
28. J Johnson, K Carson, H Williams, S Karanam, A Newby, G Angelini, S George, C Jackson: Plaque rupture after short periods of fat-feeding in the Apolipoprotein E knockout mouse: model characterisation, and effects of pravastatin treatment. Circulation 111, 2 1422-1430 (2005) (Pubitemid 40396809)
29. S Miyatani, K Shimamura, M Hatta, A Nagafuchi, A Nose, M Matsunaga, K Hatta, M Takeichi: Neural cadherin: Role in selective cell-cell adhesion. Science 245, 631-635 (1989) (Pubitemid 19213339)
30. SM Troyanovsky: Mechanism of cell-cell adhesion complex assembly. Curr Opin Cell Biol 11, 5 561-566 (1999) (Pubitemid 29460396)
31. B Nagar, M Overduin, M Ikura, J Rini: Structural basis of calcium induced E-cadherin rigidification and dimerisation. Nature 380, 360-364 (1996) (Pubitemid 26097119)
32. V Noe, J Willems, J Vandekerckhove, F Van Roy, E Bruyneel, M Mareel: Inhibition of adhesion and induction of epithelial cell invasion by HAV-containing E-cadherin specific peptides. J Cell Sci 112, 127-135 (1999) (Pubitemid 29043840)
33. B Zhu, S Chappuis-Flament, E Wong, IE Jensen, BM Gumbiner, D Leckband: Functional Analysis of the Structural Basis of Homophilic Cadherin Adhesion. Biophys J 84, 6 4033-4042 (2003) (Pubitemid 36637895)
34. H Aberle, H Schwartz, R Kemler: Cadherin-catenin complex: Protein interactions and their implications for cadherin function. Journal of Cellular Biochemistry 61, 4 514-523 (1996) (Pubitemid 26240128)
35. PZ Anastasiadis, AB Reynolds: The p120 catenin family: complex roles in adhesion, signaling and cancer. J Cell Sci 113, 1319-1334 (2000) (Pubitemid 30240551)
36. WJ Nelson, R Nusse: Convergence of Wnt, betacatenin and cadherin pathways. Science 303, 1483-1487 (2004) (Pubitemid 38314410)
37. F Rijsewijk, M Schuermann, E Wagenaar, P Parren, D Weigel, R Nusse: The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 50, 4 649-57 (1987)
38. AJ Chien, WH Conrad, RT Moon: A Wnt Survival Guide: From Flies to Human Disease. J Invest Dermatol (2009)
39. I Oishi, H Suzuki, N Onishi, R Takada, S Kani, B Ohkawara, I Koshida, K Suzuki, G Yamada, GC Schwabe, S Mundlos, H Shibuya, S Takada, Y Minami: The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8, 7 645-54 (2003) (Pubitemid 36880848)
40. AJ Mikels, R Nusse: Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLos Biology 4, 4 e115 (2006)
41. B Rubinfeld, I Albert, E Porfiri, C Fiol, S Munemitsu, P Polakis: Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272, 5264 1023-6 (1996) (Pubitemid 26259322)
42. J Zhurinsky, M Shtutman, A Ben-Ze'ev: Plakoglobin and beta-catenin: protein interactions, regulation and biological roles. J Cell Sci 113, 18 3127-3139 (2000)
43. O Tetsu, F McCormick: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 6726 422-426 (1999) (Pubitemid 29180374)
44. T-C He, A Sparks, C Rago, H Hermeking, L Zawel, L da Costa, P Morin, K Kinzler: Identification of c-myc as a target of the APC pathway. Science 281, 1509-1512 (1998) (Pubitemid 28425575)
45. T Brabletz, A Jung, S Dag, F Hlubek, T Kirchner: Beta-catenin regulates the expression of MMP-7 in human colorectal cancer. Am J Pathol 155, 1033-1038 (1999) (Pubitemid 29488909)
46. PJ Morin: Beta-catenin signaling and cancer. Bioessays 21, 1021-1030 (1999)
47. S Gilbertson-Beadling, C Fisher: A potential role for N-cadherin in mediating endothelial cell-smooth muscle cell interactions in the rat vasculature. Lab Invest 69, 203-209 (1993) (Pubitemid 23262500)
48. W-J Cai, S Koltai, E Kocsis, D Scholz, W Schaper, J Schaper: Connexin37, not Cx40 and Cx43, is induced in vascular smooth muscle cells during coronary arteriogenesis. J Mol Cell Cardiol 33, 957-967 (2001) (Pubitemid 32545330)
49. O Kocher, F Gabbiani, G Gabbiani, MA Reidy, MS Cokay, H Peters, I Huttner: Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening. Biochemical and morphologic studies. Lab Invest 65, 4 459-470 (1991)
50. EB Uglow, S Slater, GB Sala-Newby, CM Aguilera-Garcia, GD Angelini, AC Newby, SJ George: Dismantling of cadherin-mediated cell-cell contacts modulates smooth muscle proliferation. Circ Res 92, 1314-1321 (2003) (Pubitemid 36773473)
51. H Quasnichka, SC Slater, CA Beeching, M Boehm, GB Sala-Newby, SJ George: Regulation of smooth muscle cell proliferation by beta-catenin/TCF signaling involves modulation of cyclin D1 and p21 expression. Circ Res 99, 12 1329-1337 (2006) (Pubitemid 44949668)
52. SC Slater, E Koutsouki, CL Jackson, RC Bush, GD Angelini, AC Newby, SJ George: R-cadherin:betacatenin complex and its association with vascular smooth muscle cell proliferation. Arterioscler Thromb Vasc Biol 24, 1204-1210 (2004) (Pubitemid 38880009)
53. X Wang, Y Xiao, Y Mou, Y Zhao, M Blankesteijn, J Hall: A role for the beta-catenin / T-cell factor signalling cascade in vascular remodelling. Circ Res 90, 240-247 (2002)
54. A Bedel, A Negre-Salvayre, S Heeneman, M-H Grazide, J-C Thiers, R Salvayre, F Maupas-Schwalm: Ecadherin/beta-catenin/T-cell factor pathway is involved in smooth muscle cell proliferation elicited by oxidized lowdensity lipoprotein. Circ Res 103, 7 694-701 (2008)
55. M Maher, A Flozak, A Hartsell, S Russell, R Beri, O Peled, C Gottardi: Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7. Biology Direct 4, 1 5 (2009)
56. P Marambaud, J Shioi, G Serban, G Georgakopoulos, S Sarner, V Nagy, L Baki, P Wen, S Efthimiopoulos, Z Shao, T Wisniewski, NK Robakis: A presenilin-1/gammasecretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J 21, 8 1948-1956 (2002) (Pubitemid 34437192)
57. J Rios-Doria, KC Day, R Keufer, MG Rashid, AM Chinnaiyan, MA Rubin, ML Day: The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells. J Biol Chem 278, 2 1372-1379 (2003) (Pubitemid 36790823)
58. F Ryniers, C Stove, M Goethals, L Brackenier, V Noe, M Bracke, J Vanderkerckhove, M Mareel, E Bruyneel: Plasmin produces an E-cadherin fragment that stimulated cancer cell invasion. Biol Chem 383, 159-165 (2002) (Pubitemid 34224038)
59. A Dwivedi, SJ George: Cadherins, MMPs and proliferation. Trends Cardiovasc Med 14, 3 100-105 (2004)
60. A Dwivedi, S Slater, S George: MMP-9 and-12 cause N-cadherin shedding and thereby beta-catenin signalling and vascular smooth muscle cell proliferation. Cardiovasc Res 81, 1 178-186 (2008)
61. JM Mei, GL Borchert, SP Donald, JM Phang: Matrix metalloproteinase (s) mediate (s) NO-induced dissociation of beta-catenin from membrane bound E-cadherin and formation of nuclear beta-catenin/LEF-1 complex. Carcinogenesis 23, 12 2119-2122 (2002) (Pubitemid 36104962)
62. B Herren, B Levkau, EW Raines, R Ross: Cleavage of beta-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases. Mol Biol Cell 9, 1589-1601 (1998) (Pubitemid 28303499)
63. EB Uglow, S Slater, GB Sala-Newby, CM Aguilera-Garcia, GD Angelini, AC Newby, SJ George: Dismantling of Cadherin-Mediated Cell-Cell Contacts Modulates Smooth Muscle Cell Proliferation. Circ Res 92, 12 1314-1321 (2003) (Pubitemid 36773473)
64. X Wang, N Adhikari, Q Li, JL Hall: The LDL receptor related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 287, H2376-H2383 (2004) (Pubitemid 39557105)
65. J Ezan, L Leroux, L Barandon, P Dufourcq, B Jaspard, C Moreau, C Allieres, D Daret, T Couffinhal, C Duplaa: FrzA/sFRP-1, a secreted antagonist of the Wnt-Frizzled pathway, controls vascular cell proliferation in vitro and in vivo. Cardiovasc Res 63, 731-738 (2004) (Pubitemid 39078687)
66. C Mao, T-BO Malek, ME Pueyo, PG Steg, F Soubrier: Differentitial expression of rat frizzled-related frzb-1 and frizzled receptor fz1 and fz2 genes in the rat aorta after balloon injury. Arterioscler Thromb Vasc Biol 20, 43-51 (2000) (Pubitemid 30048345)
67. A Willis, D Pierre-Paul, BE Sumpio, V Gahtan: Vascular smooth muscle cell migration: current research and clinical implications. Vasc Endovasc Surg 38, 1 11-23 (2004) (Pubitemid 38140268)
68. M Jones, PJ Sabatini, FS Lee, MP Bendeck, BL Langille: N-cadherin upregulation and function in response of smooth muscle cells to arterial injury. Arterioscler Thromb Vasc Biol 22, 1972-1977 (2002) (Pubitemid 36025201)
69. C Lyon, E Koutsouki, C Aguilera, O Blaschuk, S George: Inhibition of N-cadherin retards smooth muscle cell migration and intimal thickening via induction of apoptosis. J Vasc Surg (in press), (2010)
70. R Blindt, A-K Bosserhoff, J Dammers, N Krott, L Demircan, R Hoffmann, P Hanrath, C Weber, F Vogt: Downregulation of N-cadherin in the neointima stimulates migration of smooth muscle cells by RhoA deactivation. Cardiovasc Res 62, 212-222 (2004) (Pubitemid 38326827)
71. P Sabatini, M Zhang, R Silverman-Gavrila, M Bendeck, BL Langille: Homotypic and endothelial cell adhesions via N-cadherin regulate polarity and migration of vascular smooth muscle cells. Circ Res 103, 4 405-412 (2008)
72. R Hou, NES Sibinga: Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells. J Biol Chem 284, 11 6955-6965 (2009)
73. L Rosano, F Spinella, V Di Castro, MR Nicotra, S Dedhar, AG de Herreros, PG Natali, A Bagnato: Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells. Cancer Res 65, 24 11649-11657 (2005) (Pubitemid 41821725)
74. M Maeda, KR Johnson, MJ Wheelock: Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition. J Cell Sci 118, 5 873-887 (2005) (Pubitemid 40484880)
75. G Christofori: Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression. EMBO 22, 10 2318-2323 (2003) (Pubitemid 36604971)
76. KM Rieger-Christ, P Lee, R Zagha, M Kosakowski, A Moinzadeh, J Stoffel, A Ben-Ze'ev, JA Libertino, IC Summerhayes: Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway. Oncogene 27, 4745-4753 (2004) (Pubitemid 38859462)
77. HC Crawford, BM Fingleton, LA Rudolph-Owen, KJ Heppner Goss, B Rubinfeld, P Polakis, LM Matrisian: The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene 18, 2883-2891 (1999) (Pubitemid 29250878)
78. M Rahmani, J Read, J Carthy, Z Luo, H Luo, X Si, A Wallace, P Rennie, B McManus: Versican promoter is a target for the beta-catenin/TCF-4 transcription factor via protein kinase B/glycognen synthase kinase-3-beta signaling in vascular smooth muscle cells. Cardiovasc Pathol 13, S56 (2004)
79. F Hlubek, S Spaderna, A Jung, T Kirchner, T Brabletz: Beta-catenin activates a coordinated expression of the proinvasive factors laminin-5 ψ2 chain and MT1-MMP in colorectal carcinomas. Int J Cancer 108, 321-326 (2004) (Pubitemid 37541790)
80. MA Utton, B Eickholt, FV Howell, J Wallis, P Doherty: Soluble N-cadherin stimulates fibroblast growth factor receptor dependent neurite outgrowth and N-cadherin and the fibroblast growth factor receptor cocluster in cells. J Neurochem 76, 1421-1430 (2001) (Pubitemid 32198247)
81. MT Nieman, RS Prudoff, KR Johnson, MJ Wheelock: N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol 147, 3 631-643 (1999) (Pubitemid 29523468)
82. U Cavallaro, J Niedermeyer, M Fuxa, G Christofori: N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling. Nature Cell Biol 3, 650-657 (2001) (Pubitemid 32624421)
83. E-J Williams, G Williams, FV Howell, SD Skaper, FS Walsh, P Doherty: Identification of an N-cadherin motif that can interact with the fibroblast growth factor receptor and is required for axonal growth. J Biol Chem 276, 47 43879-43886 (2001)
84. SJ Grille, A Bellacosa, J Upson, AJ Klein-Szanto, F van Roy, W Lee-Kwon, M Donowitz, PN Tsichlis, L Larue: The Protein Kinase Akt Induces Epithelial Mesenchymal Transition and Promotes Enhanced Motility and Invasiveness of Squamous Cell Carcinoma Lines. Cancer Res 63, 9 2172-2178 (2003) (Pubitemid 36538623)
85. J Peluso: Putative mechanism through which NCadherin-mediated cell contact maintains calcium homeostasis and thereby prevents ovarian cells from undergoing apoptosis. Biochem Pharmacol 54, 847-853 (1997) (Pubitemid 27404591)
86. S Skaper, L Facci, G Williams, E-J Williams, F Walsh, P Doherty: A dimeric version of the short N-Cadherin binding motif HAVDI promotes neuronal cell survival by activating an N-Cadherin/fibroblast growth factor receptor signalling cascade. Mol Cell Neurosci 26, 17-23 (2004) (Pubitemid 38581019)
87. A Makrigiannakis, G Coukos, M Christofidou-Solomidou, B Gour, G Radice, O Blaschuk, C Coutifaris: N-Cadherin mediated human granulosa cell adhesion prevents apoptosis. Am J Pathol 154, 5 1391-1406 (1999)
88. CA Lyon, JL Johnson, H Williams, GB Sala-Newby, SJ George: Soluble N-Cadherin Overexpression Reduces Features of Atherosclerotic Plaque Instability. Arterioscler Thromb Vasc Biol 29, 2 195-201 (2009)
89. J-H Pang, A Kraemer, S Stehbens, M Frame, A Yap: Recruitment of phophoinositide-3 kinase defines a positive contribution of tyrosine kinase signalling to E-cadherin function. J Biol Chem 280, 4 3043-3050 (2005) (Pubitemid 40189414)
90. G Li, K Satyamoorthy, M Herlyn: N-Cadherinmediated intercellular interactions promote survival and migration of melanoma cells. Cancer Res 61, 3819-3825 (2001) (Pubitemid 32694999)
91. N Tran, D Adams, R Vaillancourt, R Heimark: Signal Transduction from N-Cadherin increases Bcl-2. J Biol Chem 277, 36 32905-32914 (2002)
92. K Rieger-Christ, P Lee, R Zagha, M Kosakowski, A Moinzadeh, J Stoffel, J Libertino, I Summerhayes: Novel expression of N-Cadherin elicits in vitro bladder cell invasion via the Akt signalling pathway. Oncogene 23, 4745-4753 (2004) (Pubitemid 38859462)
93. S Byers, E Amaya, S Munro, O Blaschuk: Fibroblast growth factor receptors contain a conserved HAV region common to cadherins and influenza strain a hemagglutinins: A role for protein-protein interactions? Dev Biol 152, 2 411-414 (1992)
94. E-J Williams, G Williams, FV Howell, S Skaper, F Walsh, P Doherty: Identification of an N-Cadherin motif that can interact with the fibroblast growth factor receptor and is required for axonal growth. J Biol Chem 276, 43879 (2001)
95. N Erez, E Zamir, B Gour, O Blaschuk, B Geiger: Induction of apoptosis in cultured endothelial cells by a cadherin antagonist peptide: involvement of fibroblast growth factor receptor-mediated signalling. Exp Cell Res 294, 366-378 (2004) (Pubitemid 38326737)
96. K Kim, KM Pang, M Evans, ED Hay: Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol Biol Cell 11, 3509-3523 (2000)
97. SJ Chen, DC Guttridge, Z You, Z Zhang, A Fribley, MW Mayo, J Kitajewski, C-Y Wang: Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factormediated transcription. J Cell Biol 152, 1 87-96 (2001) (Pubitemid 32102439)
98. ME van Gijn, F Snel, JPM Cleutjens, JFM Smits, M Blankesteijn: Overexpression of components of the frizzled-dishevelled cascade results in apoptotic cell death, mediated by beta-catenin. Exp Cell Res 265, 46-53 (2001) (Pubitemid 32989062)
99. S Monga, H Monga, X Tan, K Mule, P Pediaditakis, G Michalopoulos: Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis and lineage specification. Gastroenterology 124, 202-216 (2003) (Pubitemid 36055352)
100. K Orford, C Orford, S Byers: Exogenous expression of beta-catenin regulates contact inhibition anchorageindependent growth, anoikis, and radiation-induced cell cycle arrest. J Cell Biol 146, 4 855-867 (1999) (Pubitemid 29408910)
101. X Wang, Y Xiao, Y Mou, Y Zhao, M Blankesteijn, JL Hall: A role for the beta-catenin/T-cell factor signaling cascade in vascular remodeling. Circ Res 90, 340-347 (2002) (Pubitemid 34633936)
102. L Lv, Z Zhou, X Huang, Y Zhao, L Zhang, Y Shi, M Sun, J Zhang: Inhibition of peptidyl-prolyl cis/trans isomerase Pin1 induces cell cycle arrest and apoptosis in vascular smooth muscle cells. Apoptosis 15, 1 41-54
103. Y Bobryshev, R Lord, T Watanabe, T Ikezawa: The cell adhesion molecule E-cadherin is widely expressed in human atherosclerotic lesions. Cardiovasc Res 40, 1 191-205 (1998) (Pubitemid 28435444)
104. F Sigala, G Vourliotakis, S Georgopoulos, N Kavantzas, E Papalambros, M Agapitos, E Bastounis: VE-cadherin expression in human atherosclerotic plaque and its relationship with plaque morphology and clinical data. Eur J Vasc Endovasc Surg 26, 523-528 (2003) (Pubitemid 37362095)
105. MA Christman, II, DJ Goetz, E Dickerson, KD McCall, CJ Lewis, F Benencia, MJ Silver, LD Kohn, R Malgor: Wnt5a is expressed in murine and human atherosclerotic lesions. Am J Physiol Heart Circ Physiol 294, 6 H2864-2870 (2008)
106. A Mani, J Radhakrishnan, H Wang, A Mani, M-A Mani, C Nelson-Williams, KS Carew, S Mane, H Najmabadi, D Wu, RP Lifton: LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors. Science 315, 5816 1278-1282 (2007) (Pubitemid 46364265)
107. R Sarzani, F Salvi, M Bordicchia, F Guerra, I Battistoni, G Pagliariccio, L Carbonari, P Dessì-Fulgheri, A Rappelli: Carotid artery atherosclerosis in hypertensive patients with a functional LDL receptor-related protein 6 gene variant. Nutrition, Metabolism and Cardiovascular Diseases epub Oct 13 2009, (2009)
108. K Magoori, MJ Kang, MR Ito, H Kakuuchi, RX Ioka, A Kamataki, DH Kim, H Asaba, S Iwasaki, YA Takei, M Sasaki, S Usui, M Okazaki, S Takahashi, M Ono, M Nose, J Sakai, T Fujino, TT Yamamoto: Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E. J Biol Chem 278, 13 11331-6 (2003) (Pubitemid 36792690)
109. T Ueland, K Otterdal, T Lekva, B Halvorsen, A Gabrielsen, WJ Sandberg, G Paulsson-Berne, TM Pedersen, L Folkersen, L Gullestad, E Oie, GK Hansson, P Aukrust: Dickkopf-1 enhances inflammatory interaction between platelets and endothelial cells and shows increased expression in atherosclerosis. Arterioscler Thromb Vasc Biol 29, 8 1228-34 (2009)