Leukocyte engagement of fibrin(ogen) via the integrin receptor αMβ2/Mac-1 is critical for host inflammatory response in vivo

Journal of Clinical Investigation

Volumn 113, Issue 11, 2004, Pages 1596-1606

  Flick, Matthew J ^a   Du, XinLi ^a   Witte, David P ^a   Jiroušková, Markéta ^b   Soloviev, Dmitry A ^c   Busuttil, Steven J ^c   Plow, Edward F ^c   Degen, Jay L ^a,d  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; FIBRIN; FIBRINOGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL PERITONITIS; BLOOD CLOTTING; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INFLAMMATION; LEUKOCYTE ADHERENCE; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE AGGREGATION; ANIMAL; GENETICS; LEUKOCYTE; METABOLISM; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS; THROMBOCYTE;

ANIMALS; BLOOD COAGULATION; BLOOD PLATELETS; FIBRIN; FIBRINOGEN; INFLAMMATION; LEUKOCYTES; MACROPHAGE-1 ANTIGEN; MICE; MUTAGENESIS, SITE-DIRECTED;

EID: 85047691114     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI20741     Document Type: Article

References (52)

1. Springer, T.A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multi-step paradigm. Cell. 76:301-314.
2. Anderson, D.C., Kishimoto, T.K., and Smith, C.W. 1995. Leukocyte adhesion deficiency and other disorders of leukocyte adherence and motility. In The metabolic and molecular bases of inherited disease. W.S. Sly, C.R. Scriver, A.L. Beaudet, and D. Valle, editors. McGraw-Hill. New York, New York, USA. 3955-3994.
3. Larson, R.S., and Springer, T.A. 1990. Structure and function of leukocyte integrins. Immunol. Rev. 114:181-217.
4. Van der Vieren, M., et al. 1995. A novel leukointegrin, αdβ2, binds preferentially to ICAM-3. Immunity. 3:683-690.
5. Coxon, A., et al. 1996. A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 5:653-666.
6. Mizgerd, J.P., et al. 1997. Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice J. Exp. Med. 186:1357-1364.
7. Lu, H., et al. 1997. LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice. J. Clin. Invest. 99:1340-1350.
8. Ding, Z.M., et al. 1999. Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J. Immunol. 163:5029-5038.
9. Walzog, B., Jeblonski, F., Zakrzewicz, A., and Gaehtgens, P. 1997. β2 integrins (CD11/CD18) promote apoptosis of human neutrophils. FASEB J. 11:1177-1186.
10. Dunne, J.L., Ballantyne, C.M., Beaudet, A.L., and Ley, K. 2002. Control of leukocyte rolling velocity in TNF-alpha-induced inflammation by LFA-1 and Mac-1. Blood. 99:336-341.
11. Henderson, R.B., et al. 2001. The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and α4 integrin in the inflammatory response of neutrophils. J. Exp. Med. 194:219-226.
12. Plow, E.F., Haas, T.A., Zhang, L., Loftus, J., and Smith, J.W. 2000. Ligand binding to integrins. J. Biol. Chem. 275:21785-21788.
13. Forsyth, C.B., Solovjov, D.A., Ugarova, T.P., and Plow, E.F. 2001. Integrin αMβ2-mediated cell migration to fibrinogen and its recognition peptides. J. Exp. Med. 193:1123-1133.
14. Languino, L.R., et al. 1993. Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway. Cell. 73:1423-1434.
15. Shi, C., Zhang, X., Chen, Z., Robinson, M.K., and Simon, D.I. 2001. Leukocyte integrin Mac-1 recruits toll/interleukin-1 receptor superfamily signaling intermediates to modulate NF-κB activity. Circ. Res. 89:859-865.
16. Rubel, C., et al. 2001. Fibrinogen promotes neutrophil activation and delays apoptosis. J. Immunol. 166:2002-2010.
17. Rubel, C., et al. 2002. Soluble fibrinogen modulates neutrophil functionality through the activation of an extracellular signal-regulated kinase-dependent pathway. J. Immunol. 168:3527-3535.
18. Smiley, S.T., King, J.A., and Hancock, W.W. 2001. Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J. Immunol. 167:2887-2894.
19. Loike, J.D., et al. 1992. The role of protected extracellular compartments in interactions between leukocytes, and platelets, and fibrin/fibrinogen matrices. Ann. N. Y. Acad. Sci. 667:163-172.
20. Lishko, V.K., Kudryk, B., Yakubenko, V.P., Yee, V.C., and Ugarova, T.P. 2002. Regulated unmasking of the cryptic binding site for integrin αMβ2 in the γ C-domain of fibrinogen. Biochemistry. 41:12942-12951.
21. Ugarova, T.P., et al. 1998. Identification of a novel recognition sequence for integrin αMβ2 within the γ-chain of fibrinogen. J. Biol. Chem. 273:22519-22527.
22. Ugarova, T.P., et al. 2003. Sequence γ 377-395(P2), but not γ 190-202(P1), is the binding site for the αM I-domain of integrin αMβ2 in the γ C-domain of fibrinogen. Biochemistry. 42:9365-9373.
23. Holmback, K., Danton, M.J., Suh, T.T., Daugherty, C.C., and Degen, J.L. 1996. Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin αIIbβ3. EMBO J. 15:5760-5771.
24. Hooper, M., Hardy, K., Handyside, A., Hunter, S., and Monk, M. 1987. HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells: Nature. 326:292-295.
25. Suh, T.T., et al. 1995. Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Genes Dev. 9:2020-2033.
26. Farrell, D.H., and Thiagarajan, P. 1994. Binding of recombinant fibrinogen mutants to platelets. J. Biol. Chem. 269:226-231.
27. Jirousková, M., Chereshnev, I., Väänänen, H., Degen, J.L., and Coller, B.S. 2004. Antibody blockade or mutation of the fibrinogen γ chain C-terminus are more effective in inhibiting murine arterial thrombus formation than complete absence of fibrinogen. Blood. 103:1995-2002.
28. Zhang, L., and Plow, E.F. 1996. Overlapping, but not identical, sites are involved in the recognition of C3bi, neutrophil inhibitory factor, and adhesive ligands by the αMβ2 integrin. J. Biol. Chem. 271:18211-18216.
29. Kumagai, K., Itoh, K., Hinuma, S., and Tada, M. 1979. Pretreatment of plastic Petri dishes with fetal calf serum. A simple method for macrophage isolation. J. Immunol. Methods. 29:17-25.
30. Adams, D.O., Edelson, P.J., and Koren, H.S. 1981. Methods for studying mononuclear phagocytes. Academic Press. New York, New York, USA. xxiv, 1023 pp.
31. Doolittle, R.F., Yang, Z., and Mochalkin, I. 2001. Crystal structure studies on fibrinogen and fibrin. Ann. N. Y. Acad. Sci. 936:31-43.
32. Wright, S.D., et al. 1988. Complement receptor type three (CD11b/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen. Proc. Natl. Acad. Sci. U. S. A. 85:7734-7738.
33. Altieri, D.C., Plescia, J., and Plow, E.F. 1993. The structural motif glycine 190-valine 202 of the fibrinogen γ chain interacts with CD11b/CD18 integrin (alpha;Mβ2, Mac-1) and promotes leukocyte adhesion. J. Biol. Chem. 268:1847-1853.
34. Zhang, L., and Plow, E.F. 1997. Identification and reconstruction of the binding site within αMβ2 for a specific and high affinity ligand, NIF. J. Biol. Chem. 272:17558-17564.
35. Diamond, M.S., et al. 1990. ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). J. Cell Biol. 111:3129-3139.
36. Yakubenko, V.P., Lishko, V.K., Lam, S.C., and Ugarova, T.P. 2002. A molecular basis for integrin alpha;M;β2 ligand binding promiscuity. J. Biol. Chem. 277:48635-48642.
37. Gregory, S.H., et al. 2002. Complementary adhesion molecules promote neutrophil-Kupffer cell interaction and the elimination of bacteria taken up by the liver. J. Immunol. 168:308-315.
38. Miyamoto, M., et al. 2003. Neutrophilia in LFA-1-deficient mice confers resistance to listeriosis: possible contribution of granulocyte-colony- stimulating factor and IL-17. J. Immunol 170:5228-5234.
39. Prince, J.E., et al. 2001. The differential roles of LFA-1 and Mac-1 in host defense against systemic infection with Streptococcus pneumoniae. J. Immunol. 166:7362-7369.
40. Sitrin, R.G., Pan, P.M., Srikanth, S., and Todd, R.F., 3rd. 1998. Fibrinogen activates NF-κ transcription factors in mononuclear phagocytes. J. Immunol. 161:1462-1470.
41. Szaba, F.M., and Smiley, S.T. 2002. Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo. Blood. 99:1053-1059.
42. Takami, M., Terry, V., and Petruzzelli, L. 2002. Signaling pathways involved in IL-8-dependent activation of adhesion through Mac-1. J. Immunol. 168:4559-4566.
43. Lishko, V.K., Yakubenko, V.P., Hertzberg, K.M., Grieninger, G., and Ugarova, T.P. 2001. The alternatively spliced αE C domain of human fibrinogen-420 is a novel ligand for leukocyte integrins alpha;Mβ2 and αXβ2. Blood. 98:2448-2455.
44. Gordon, D.L., Rice, J., Finlay-Jones, J.J., McDonald, P.J., and Hostetter, M.K. 1988. Analysis of C3 deposition and degradation on bacterial surfaces after opsonization. J. Infect. Dis. 157:697-704.
45. Scharffetter-Kochanek, K., et al. 1998. Spontaneous skin ulceration and defective T cell function in CD18 null mice. J. Exp. Med. 188:119-131.
46. Simon, D.I., et al. 2000. Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty. J. Clin. Invest. 105:293-300.
47. Diacovo, T.G., Roth, S.J., Buccola, J.M., Bainton, D.F., and Springer, T.A. 1996. Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the β2-integrin CD11b/CD18. Blood. 88:146-157.
48. Lei, B., et al. 2001. Evasion of human innate and acquired immunity by a bacterial homolog of CD11b that inhibits opsonophagocytosis. Nat. Med. 7:1298-1305.
49. Moreillon, P., et al. 1995. Role of Staphylacoccus aureus coagulase and clumping factor in pathogenesis of experimental endocarditis. Infect. Immun. 63:4738-4743.
50. McDevitt, D., et al. 1997. Characterization of the interaction between the Staphylococcus aureus clumping factor (ClfA) and fibrinogen. Eur. J. Biochem. 247:416-424.
51. Esmon, C.T. 2002. Protein C pathway in sepsis. Ann. Med. 34:598-605.
52. Busso, N., et al. 1998. Exacerbation of antigen-induced arthritis in urokinase-deficient mice. J. Clin. Invest. 102:41-50.