Inactivation of NADP+-dependent isocitrate dehydrogenase by peroxynitrite: Implications for cytotoxicity and alcohol-induced liver injury

Journal of Biological Chemistry

Volumn 278, Issue 51, 2003, Pages 51360-51371

  Lee, Jin Hyup ^a   Yang, Eun Sun ^a   Park, Jeen Woo ^a  

^a Kyungpook National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; ANTIOXIDANTS; BIOLOGICAL ORGANS; CELLS; MASS SPECTROMETRY; ORGANIC ACIDS;

OXIDATIVE DAMAGE; REDOX BALANCE;

ENZYMES;

8 ANILINO 1 NAPHTHALENESULFONIC ACID; ANTIOXIDANT; CYSTEINE; DITHIOTHREITOL; ISOCITRATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PEROXYNITRITE; S NITROSOTHIOL; TYROSINE;

ALCOHOL LIVER DISEASE; ARTICLE; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INACTIVATION; ENZYME PURIFICATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IMMUNOPRECIPITATION; LIVER INJURY; LIVER MITOCHONDRION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; TARGET CELL;

ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ETHANOL; HUMANS; ISOCITRATE DEHYDROGENASE; KINETICS; MALE; MITOCHONDRIA, LIVER; MITOCHONDRIAL PROTEINS; PEROXIDES; PEROXYNITROUS ACID; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL COMPOUNDS; SWINE; TYROSINE;

EID: 0347695994     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302332200     Document Type: Article

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