Role of the ferroportin iron-responsive element in iron and nitric oxide dependent gene regulation

Blood cells, molecules & diseases

Volumn 29, Issue 3, 2002, Pages 315-326

  Liu, Xiao Bing ^a   Hill, Ping ^a   Haile, David J ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATION TRANSPORT PROTEIN; IRON; MESSENGER RNA; METAL TRANSPORTING PROTEIN 1; NITRIC OXIDE;

5' UNTRANSLATED REGION; ANIMAL; ARTICLE; CELL STRAIN COS1; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; REPORTER GENE; TRANSCRIPTION INITIATION SITE;

5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CATION TRANSPORT PROTEINS; COS CELLS; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; IRON; MOLECULAR SEQUENCE DATA; NITRIC OXIDE; RNA, MESSENGER; TRANSCRIPTION INITIATION SITE;

EID: 0344974223     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1006/bcmd.2002.0572     Document Type: Article

References (45)

1. S.I. Patruta W.H. Horl Iron and infection Kidney Int. Suppl. 69 1999 S125 S130
2. R.L. Jurado Iron, infections, and anemia of inflammation Clin. Infect. Dis. 25 1997 888 895
3. G. Weiss Iron and anemia of chronic disease Kidney Int. Suppl. 69 1999 S12 S17
4. E.D. Weinberg Modulation of intramacrophage iron metabolism during microbial cell invasion Microbes Infect. 2 2000 85 89
5. S. Gruenheid P. Gros Genetic susceptibility to intracellular infections: Nramp1, macrophage function and divalent cations transport Curr. Opin. Microbiol. 3 2000 43 48
6. R.T. Means Jr. Advances in the anemia of chronic disease Int. J. Hematol. 70 1999 7 12
7. M.T. Bertero F. Caligaris-Cappio Anemia of chronic disorders in systemic autoimmune diseases Haematologica 82 1997 375 381
8. W. Zhong W.P. Lafuse B.S. Zwilling Infection with Mycobacterium avium differentially regulates the expression of iron transport protein mRNA in murine peritoneal macrophages Infect. Immun. 69 2001 6618 6624
9. S. Gruenheid E. Pinner M. Desjardins P. Gros Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome J. Exp. Med. 185 1997 717 730
10. V. Picard G. Govoni N. Jabado Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool J. Biol. Chem. 275 2000 35738 35745
11. R.A. Feelders G. Vreugdenhil A.M. Eggermont P.A. Kuiper-Kramer H.G. van Eijk A.J. Swaak Regulation of iron metabolism in the acute-phase response: interferon gamma and tumour necrosis factor alpha induce hypoferraemia, ferritin production and a decrease in circulating transferrin receptors in cancer patients Eur. J. Clin. Invest. 28 1998 520 527
12. L.L. Moldawer M.A. Marano H. Wei Y. Fong M.L. Silen G. Kuo K.R. Manogue H. Vlassara H. Cohen A. Cerami S.F. Lowry Cachectin/tumor necrosis factor-alpha alters red blood cell kinetics and induces anemia in vivo FASEB J. 3 1989 1637 1643
13. T. Uchida A. Yamagiwa K. Nakamura The effect of interleukin-1 on iron metabolism in rats Eur. J. Haematol. 46 1991 1 5
14. R.F. Kampschmidt M. Mesecher Interleukin-1 from P388D1: effects upon neutrophils, plasma iron, and fibrinogen in rats, mice, and rabbits Proc. Soc. Exp. Biol. Med. 179 1985 197 200
15. J. Nieken N.H. Mulder J. Buter E. Vellenga P.C. Limburg D.A. Piers E.G. de Vries Recombinant human interleukin-6 induces a rapid and reversible anemia in cancer patients Blood 86 1995 900 905
16. M. Kobune Y. Kohgo J. Kato E. Miyazaki Y. Niitsu Interleukin-6 enhances hepatic transferrin uptake and ferritin expression in rats Hepatology 19 1994 1468 1475
17. V. Mulero J.H. Brock Regulation of iron metabolism in murine J774 macrophages: role of nitric oxide-dependent and –independent pathways following activation with gamma interferon and lipopolysaccharide Blood 94 1999 2383 2389
18. S. Kim P. Ponka Control of transferrin receptor expression via nitric oxide-mediated modulation of iron-regulatory protein 2 J. Biol. Chem. 274 1999 33035 33042
19. S. Kim P. Ponka Effects of interferon-gamma and lipopolysaccharide on macrophage iron metabolism are mediated by nitric oxide-induced degradation of iron regulatory protein 2 J. Biol. Chem. 275 2000 6220 6226
20. S. Kim P. Ponka Nitrogen monoxide-mediated control of ferritin synthesis: Implications for macrophage iron homeostasis Proc. Natl. Acad. Sci. USA 99 2002 12214 12219
21. V. Mulero X.Q. Wei F.Y. Liew J.H. Brock Regulation of phagosomal iron release from murine macrophages by nitric oxide Biochem. J. 365 2002 127 132
22. J.D. Phillips D.V. Kinikini Y. Yu B. Guo E.A. Leibold Differential regulation of IRP1 and IRP2 by nitric oxide in rat hepatoma cells Blood 87 1996 2983 2992
23. G. Weiss B. Goossen W. Doppler D. Fuchs K. Pantopoulos G. Werner-Felmayer H. Wachter M.W. Hentze Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway EMBO J. 12 1993 3651 3657
24. S.L. Wardrop C. Wells T. Ravasi D.A. Hume D.R. Richardson Induction of Nramp2 in activated mouse macrophages is dissociated from regulation of the Nramp1, classical inflammatory genes, and genes involved in iron metabolism J. Leukoc. Biol. 71 2002 99 106
25. P.G. Atkinson J.M. Blackwell C.H. Barton Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages Biochem. J. 325 1997 779 786
26. G. Govoni S. Gauthier F. Billia N.N. Iscove P. Gros Cell-specific and inducible Nramp1 gene expression in mouse macrophages in vitro and in vivo J. Leukoc. Biol. 62 1997 277 286
27. G. Zhang H. Wu C.R. Ross J.E. Minton F. Blecha Cloning of porcine NRAMP1 and its induction by lipopolysaccharide, tumor necrosis factor alpha, and interleukin-1beta: role of CD14 and mitogen-activated protein kinases Infect. Immun. 68 2000 1086 1093
28. S.L. Wardrop D.R. Richardson Interferon-gamma and lipopolysaccharide regulate the expression of Nramp2 and increase the uptake of iron from low relative molecular mass complexes by macrophages Eur. J. Biochem. 267 2000 6586 6593
29. R.S. Eisenstein Iron regulatory proteins and the molecular control of mammalian iron metabolism Annu. Rev. Nutr. 20 2000 627 662
30. A.T. McKie P. Marciani A. Rolfs K. Brennan K. Wehr D. Barrow S. Miret A. Bomford T.J. Peters F. Farzaneh M.A. Hediger M.W. Hentze R.J. Simpson A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation Mol. Cell. 5 2000 299 309
31. A. Donovan A. Brownlie Y. Zhou J. Shepard S.J. Pratt J. Moynihan B.H. Paw A. Drejer B. Barut A. Zapata T.C. Law C. Brugnara S.E. Lux G.S. Pinkus J.L. Pinkus P.D. Kingsley J. Palis M.D. Fleming N.C. Andrews L.I. Zon Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter Nature 403 2000 776 781
32. S. Abboud D.J. Haile A novel mammalian iron-regulated protein involved in intracellular iron metabolism J. Biol. Chem. 275 2000 19906 19912
33. F. Yang X.B. Liu M. Quinones P.C. Melby A. Ghio D.J. Haile Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation J. Biol. Chem. 2002
34. D.J. Haile T.A. Rouault C.K. Tang J. Chin J.B. Harford R.D. Klausner Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster Proc. Natl. Acad. Sci. USA 89 1992 7536 7540
35. B. Goossen M.W. Hentze Position is the critical determinant for function of iron-responsive elements as translational regulators Mol. Cell. Biol. 12 1992 1959 1966
36. K.L. Schalinske K.P. Blemings D.W. Steffen O.S. Chen R.S. Eisenstein Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line Proc. Natl. Acad. Sci. USA 94 1997 10681 10686
37. A.M. Konijn C. Hershko Ferritin synthesis in inflammation. I. Pathogenesis of impaired iron release Br. J. Haematol. 37 1977 7 16
38. S. Recalcati D. Taramelli D. Conte G. Cairo Nitric oxide-mediated induction of ferritin synthesis in J774 macrophages by inflammatory cytokines: role of selective iron regulatory protein-2 downregulation Blood 91 1998 1059 1066
39. S. Recalcati R. Pometta S. Levi D. Conte G. Cairo Response of monocyte iron regulatory protein activity to inflammation: abnormal behavior in genetic hemochromatosis Blood 91 1998 2565 2572
40. G. Nicolas M. Bennoun A. Porteu S. Mativet C. Beaumont B. Grandchamp M. Sirito M. Sawadogo A. Kahn S. Vaulont Severe iron deficiency anemia in transgenic mice expressing liver hepcidin Proc. Natl. Acad. Sci. USA 99 2002 4596 4601
41. C. Pigeon G. Ilyin B. Courselaud P. Leroyer B. Turlin P. Brissot O. Loreal A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload J. Biol. Chem. 16;276 2001 7811 7819
42. J.C. Drapier H. Hirling J. Wietzerbin P. Kaldy L.C. Kuhn Reciprocal modulation of aconitase activity and RNA-binding activity of iron regulatory factor by nitric oxide Adv. Exp. Med. Biol. 356 1994 141 148
43. C. Bouton L. Oliveira J.C. Drapier Converse modulation of IRP1 and IRP2 by immunological stimuli in murine RAW 264.7 macrophages J. Biol. Chem. 273 1998 9403 9408
44. L. Oliveira J.C. Drapier Down-regulation of iron regulatory protein 1 gene expression by nitric oxide Proc. Natl. Acad. Sci. USA 97 2000 6550 6555
45. S.L. Wardrop R.N. Watts D.R. Richardson Nitrogen monoxide activates iron regulatory protein 1 RNA-binding activity by two possible mechanisms: effect on the [4Fe-4S] cluster and iron mobilization from cells Biochemistry 39 2000 2748 2758