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Volumn 9, Issue 7, 2009, Pages 867-878

Nitric oxide synthase gene therapy: Progress and prospects

Author keywords

Cardiovascular disease; Gene therapy; Nitric oxide; Nitric oxide synthase

Indexed keywords

ADENOVIRUS VECTOR; ANGIOPOIETIN 1; BRADYKININ; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPLEX; LIPOSOME; MANGANESE SUPEROXIDE DISMUTASE; NEURONAL NITRIC OXIDE SYNTHASE; PLASMID DNA; SILDENAFIL; SUPEROXIDE DISMUTASE; TEMPOL; VASCULOTROPIN; VIRUS VECTOR;

EID: 67650391207     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712590903002047     Document Type: Review
Times cited : (40)

References (107)
  • 1
    • 0023505509 scopus 로고
    • Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
    • Ignarro LlJ, Buga GM, Wood KS, et al. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987;84(24):9265-9269
    • (1987) Proc Natl Acad Sci USA , vol.84 , Issue.24 , pp. 9265-9269
    • Llj, I.1    Buga, G.M.2    Wood, K.S.3
  • 2
    • 0023928184 scopus 로고
    • Endothelium-derived relaxing factor. Identification as nitric oxide and role in the control of vascular tone and platelet function
    • Moncada S, Radomski MW, Palmer RM. Endothelium-derived relaxing factor. Identification as nitric oxide and role in the control of vascular tone and platelet function. Biochem Pharmacol 1988;37(13):2495-2501
    • (1988) Biochem Pharmacol , vol.37 , Issue.13 , pp. 2495-2501
    • Moncada, S.1    Radomski, M.W.2    Palmer, R.M.3
  • 3
    • 33751104760 scopus 로고    scopus 로고
    • Nitric oxide and the endothelium: History and impact on cardiovascular disease
    • DOI 10.1016/j.vph.2006.08.002, PII S1537189106001674
    • Yetik-Anacak G, Catravas JD. Nitric oxide and the endothelium: history and impact on cardiovascular disease. Vascul Pharmacol 2006;45(5):268-276 (Pubitemid 44765289)
    • (2006) Vascular Pharmacology , vol.45 , Issue.5 , pp. 268-276
    • Yetik-Anacak, G.1    Catravas, J.D.2
  • 4
    • 0030711558 scopus 로고    scopus 로고
    • Nitric oxide synthases: Which, where, how, and why?
    • Michel T, Feron O. Nitric oxide synthases: which, where, how, and why? J Clin Invest 1997;100(9):2146-2152
    • (1997) J Clin Invest , vol.100 , Issue.9 , pp. 2146-2152
    • Michel, T.1    Feron, O.2
  • 6
    • 0026323665 scopus 로고
    • Purification of the inducible murine macrophage nitric oxide synthase: Identification as a flavoprotein
    • Hevel JM, White KA, Marletta MA. Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein. J Biol Chem 1991;266(34):22789-22791 (Pubitemid 21908718)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.34 , pp. 22789-22791
    • Hevel, J.M.1    White, K.A.2    Marletta, M.A.3
  • 9
    • 0033542414 scopus 로고    scopus 로고
    • Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    • • Shows a phosphorylated eNOS produces more NO and is less prone to superoxide production
    • Fulton D, Gratton JP, McCabe TJ, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999;399(6736):597- 601 • Shows a phosphorylated eNOS produces more NO and is less prone to superoxide production.
    • (1999) Nature , vol.399 , Issue.6736 , pp. 597-601
    • Fulton, D.1    Gratton, J.P.2    McCabe, T.J.3
  • 10
    • 3042730959 scopus 로고    scopus 로고
    • ENOS at a glance
    • Sessa WC. eNOS at a glance. J Cell Sci 2004;117(Pt 12):2427-2429
    • (2004) J Cell Sci , vol.117 , Issue.PART 12 , pp. 2427-2429
    • Sessa, W.C.1
  • 12
    • 41149105370 scopus 로고    scopus 로고
    • Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia
    • Cosentino F, Hürlimann D, Delli Gatti C, et al. Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia. Heart 2008;94(4):487-492
    • (2008) Heart , vol.94 , Issue.4 , pp. 487-492
    • Cosentino, F.1    Hürlimann, D.2    Delli Gatti, C.3
  • 13
    • 36249010869 scopus 로고    scopus 로고
    • Beneficial effect of a short-acting NO donor for the prevention of neointimal hyperplasia
    • Pearce CG, Najjar SF, Kapadia MR, et al. Beneficial effect of a short-acting NO donor for the prevention of neointimal hyperplasia. Free Radic Biol Med 2008;44(1):73-81
    • (2008) Free Radic Biol Med , vol.44 , Issue.1 , pp. 73-81
    • Pearce, C.G.1    Najjar, S.F.2    Kapadia, M.R.3
  • 16
    • 1942437436 scopus 로고    scopus 로고
    • A chimeric adenovirus vector encoding reovirus attachment protein sigma1 targets cells expressing junctional adhesion molecule 1
    • Mercier GT, Campbell JA, Chappell JD, et al. A chimeric adenovirus vector encoding reovirus attachment protein sigma1 targets cells expressing junctional adhesion molecule 1. Proc Natl Acad Sci USA 2004;101(16):6188-6193
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.16 , pp. 6188-6193
    • Mercier, G.T.1    Campbell, J.A.2    Chappell, J.D.3
  • 17
    • 2442660248 scopus 로고    scopus 로고
    • Enhanced gene transfer to mouse dendritic cells using adenoviral vectors coated with a novel adapter molecule
    • Pereboev AV, Nagle JM, Shakhmatov MA, et al. Enhanced gene transfer to mouse dendritic cells using adenoviral vectors coated with a novel adapter molecule. Mol Ther 2004;9(5):712-720
    • (2004) Mol Ther , vol.9 , Issue.5 , pp. 712-720
    • Pereboev, A.V.1    Nagle, J.M.2    Shakhmatov, M.A.3
  • 18
    • 33646861014 scopus 로고    scopus 로고
    • Comparison of adenovirus fiber, protein IX, and hexon capsomeres as scaffolds for vector purification and cell targeting
    • DOI 10.1016/j.virol.2006.01.032, PII S0042682206000420
    • Campos SK, Barry MA. Comparison of adenovirus fiber, protein IX, and hexon capsomeres as scaffolds for vector purification and cell targeting. Virology 2006;349(2):453-462 (Pubitemid 43782873)
    • (2006) Virology , vol.349 , Issue.2 , pp. 453-462
    • Campos, S.K.1    Barry, M.A.2
  • 20
    • 0042199037 scopus 로고    scopus 로고
    • Targeting adenoviral vectors using heterofunctional polyethylene glycol FGF2 conjugates
    • L lanciotti J, Song A, Doukas J, et al. Targeting adenoviral vectors using heterofunctional polyethylene glycol FGF2 conjugates. Mol Ther 2003;8(1):99-107
    • (2003) Mol Ther , vol.8 , Issue.1 , pp. 99-107
    • Lanciotti, J.1    Song, A.2    Doukas, J.3
  • 21
    • 0032170198 scopus 로고    scopus 로고
    • Development of novel cell surface CD34-targeted recombinant adenoassociated virus vectors for gene therapy
    • Yang Q, Mamounas M, Yu G, et al. Development of novel cell surface CD34-targeted recombinant adenoassociated virus vectors for gene therapy. Hum Gene Ther 1998;9(13):1929-1937
    • (1998) Hum Gene Ther , vol.9 , Issue.13 , pp. 1929-1937
    • Yang, Q.1    Mamounas, M.2    Yu, G.3
  • 22
    • 29244477182 scopus 로고    scopus 로고
    • An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery
    • Hedley SJ, Auf der Maur A, Hohn S, et al. An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery. Gene Ther 2006;13(1):88-94
    • (2006) Gene Ther , vol.13 , Issue.1 , pp. 88-94
    • Hedley, S.J.1    Auf Der Maur, A.2    Hohn, S.3
  • 25
    • 4544329958 scopus 로고    scopus 로고
    • Improved vascular gene transfer with a helper-dependent adenoviral vector
    • ••Helper-dependant adenovirus improved gene transfer to the vasculature
    • Wen S, Graf S, Massey PG, Dichek DA. Improved vascular gene transfer with a helper-dependent adenoviral vector. Circulation 2004;110(11):1484-1491 ••Helper-dependant adenovirus improved gene transfer to the vasculature.
    • (2004) Circulation , vol.110 , Issue.11 , pp. 1484-1491
    • Wen, S.1    Graf, S.2    Massey, P.G.3    Dichek, D.A.4
  • 27
    • 0344339191 scopus 로고    scopus 로고
    • Recombinant gene transfer of endothelial nitric oxide synthase augments coronary artery relaxations during hypoxia
    • Cable DG, Pompili VJ, O'Brien T, Schaff HV. Recombinant gene transfer of endothelial nitric oxide synthase augments coronary artery relaxations during hypoxia. Circulation 1999;100(19 Suppl):II335-9 (Pubitemid 29523556)
    • (1999) Circulation , vol.100 , Issue.19 SUPPL.
    • Cable, D.G.1    Pompili, V.J.2    O'Brien, T.3    Schaff, H.V.4
  • 28
    • 0037022843 scopus 로고    scopus 로고
    • Vascular gene transfer of phosphomimetic endothelial nitric oxide synthase (S1177D) using ultrasound-enhanced destruction of plasmid-loaded microbubbles improves vasoreactivity
    • Teupe C, Richter S, Fisslthaler B, et al. Vascular gene transfer of phosphomimetic endothelial nitric oxide synthase (S1177D) using ultrasound-enhanced destruction of plasmid-loaded microbubbles improves vasoreactivity. Circulation 2002;105(9):1104-1109
    • (2002) Circulation , vol.105 , Issue.9 , pp. 1104-1109
    • Teupe, C.1    Richter, S.2    Fisslthaler, B.3
  • 29
    • 0030729073 scopus 로고    scopus 로고
    • Expression and function of a recombinant endothelial nitric oxide synthase gene in porcine coronary arteries
    • Cable DG, O'Brien T, Kullo IJ, et al. Expression and function of a recombinant endothelial nitric oxide synthase gene in porcine coronary arteries. Cardiovasc Res 1997;35(3):553-559
    • (1997) Cardiovasc Res , vol.35 , Issue.3 , pp. 553-559
    • Cable, D.G.1    O'Brien, T.2    Kullo, I.J.3
  • 30
    • 5444269236 scopus 로고    scopus 로고
    • The role of gene therapy for intimal hyperplasia of bypass grafts
    • • Shows AdeNOS delivery to healthy vessels increases NO production and vascular tone
    • Cable DG, Caccitolo JA, Caplice N, et al. The role of gene therapy for intimal hyperplasia of bypass grafts. Circulation 1999;100(19 Suppl):II392-6• Shows AdeNOS delivery to healthy vessels increases NO production and vascular tone.
    • (1999) Circulation , vol.100 , Issue.19 SUPPL.
    • Cable, D.G.1    Caccitolo, J.A.2    Caplice, N.3
  • 31
    • 0030824699 scopus 로고    scopus 로고
    • Adventitial gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries alters vascular reactivity
    • • Shows AdeNOS delivery to healthy vessels increases NO production and vascular tone
    • Kullo IJ, Mozes G, Schwartz RS, et al. Adventitial gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries alters vascular reactivity. Circulation 1997;96(7):2254-61• Shows AdeNOS delivery to healthy vessels increases NO production and vascular tone.
    • (1997) Circulation , vol.96 , Issue.7 , pp. 2254-2261
    • Kullo, I.J.1    Mozes, G.2    Schwartz, R.S.3
  • 32
    • 0030754269 scopus 로고    scopus 로고
    • Enhanced endothelium-dependent relaxations after gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries
    • Kullo IJ, Mozes G, Schwartz RS, et al. Enhanced endothelium-dependent relaxations after gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries. Hypertension 1997;30(3 Pt 1):314-320
    • (1997) Hypertension , vol.30 , Issue.3 PART 1 , pp. 314-320
    • Kullo, I.J.1    Mozes, G.2    Schwartz, R.S.3
  • 33
    • 0023859104 scopus 로고
    • Incidence of restenosis after successful coronary angioplasty: A time-related phenomenon. a quantitative angiographic study in 342 consecutive patients at 1, 2, 3, and 4 months
    • Serruys PW, Lluijten HE, Beatt KJ, et al. Incidence of restenosis after successful coronary angioplasty: a time-related phenomenon. A quantitative angiographic study in 342 consecutive patients at 1, 2, 3, and 4 months. Circulation 1988;77(2):361-371
    • (1988) Circulation , vol.77 , Issue.2 , pp. 361-371
    • Serruys, P.W.1    Lluijten, H.E.2    Beatt, K.J.3
  • 34
    • 0024393107 scopus 로고
    • Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia
    • liu MW, Roubin GS, King SB 3rd. Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia. Circulation 1989;79(6):1374-1387
    • (1989) Circulation , vol.79 , Issue.6 , pp. 1374-1387
    • Liu, M.W.1    Roubin, G.S.2    King III, S.B.3
  • 36
    • 49549125876 scopus 로고    scopus 로고
    • Inhibition of apoptotic signaling and neointimal hyperplasia by tempol and nitric oxide synthase following vascular injury
    • Jagadeesha DK, Miller FJ Jr, Bhalla RC. Inhibition of apoptotic signaling and neointimal hyperplasia by tempol and nitric oxide synthase following vascular injury. J Vasc Res 2008;46(2):109-118
    • (2008) J Vasc Res , vol.46 , Issue.2 , pp. 109-118
    • Jagadeesha, D.K.1    Miller Jr., F.J.2    Bhalla, R.C.3
  • 37
    • 0028798793 scopus 로고
    • Gene therapy inhibiting neointimal vascular lesion: In vivo transfer of endothelial cell nitric oxide synthase gene
    • von der leyen HE, Gibbons GH, Morishita R, et al. Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci USA 1995;92(4):1137-1141
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.4 , pp. 1137-1141
    • Von Der Leyen, H.E.1    Gibbons, G.H.2    Morishita, R.3
  • 40
    • 33847207524 scopus 로고    scopus 로고
    • Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury
    • DOI 10.1038/sj.gt.3302882, PII 3302882
    • Cooney R, Hynes SO, Sharif F, et al. Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury. Gene Ther 2007;14(5):396-404 (Pubitemid 46306540)
    • (2007) Gene Therapy , vol.14 , Issue.5 , pp. 396-404
    • Cooney, R.1    Hynes, S.O.2    Sharif, F.3    Howard, L.4    O'Brien, T.5
  • 45
    • 54749144683 scopus 로고    scopus 로고
    • Gene-eluting stents: Adenovirus-mediated delivery of eNOS to the blood vessel wall accelerates re-endothelialization and inhibits restenosis
    • •• Gene transfer of eNOS found to promote re-endothelisation in damaged vessel
    • Sharif F, Hynes SO, Cooney R, et al. Gene-eluting stents: adenovirus-mediated delivery of eNOS to the blood vessel wall accelerates re-endothelialization and inhibits restenosis. Mol Ther 2008;16(10):1674-1680 •• Gene transfer of eNOS found to promote re-endothelisation in damaged vessel.
    • (2008) Mol Ther , vol.16 , Issue.10 , pp. 1674-1680
    • Sharif, F.1    Hynes, S.O.2    Cooney, R.3
  • 46
    • 42449136279 scopus 로고    scopus 로고
    • Local delivery of gene vectors from bare-metal stents by use of a biodegradable synthetic complex inhibits in-stent restenosis in rat carotid arteries
    • DOI 10.1161/CIRCULATIONAHA.107.746412
    • Fishbein I, Alferiev I, Bakay M, et al. local delivery of gene vectors from bare-metal stents by use of a biodegradable synthetic complex inhibits in-stent restenosis in rat carotid arteries. Circulation 2008;117(16):2096-2103 (Pubitemid 351572181)
    • (2008) Circulation , vol.117 , Issue.16 , pp. 2096-2103
    • Fishbein, I.1    Alferiev, I.2    Bakay, M.3    Stachelek, S.J.4    Sobolewski, P.5    Lai, M.6    Choi, H.7    Chen, I.-W.8    Levy, R.J.9
  • 47
    • 0034711508 scopus 로고    scopus 로고
    • The late phase of preconditioning
    • Bolli R. The late phase of preconditioning. Circ Res 2000;87(11):972-983
    • (2000) Circ Res , vol.87 , Issue.11 , pp. 972-983
    • Bolli, R.1
  • 48
    • 0034735906 scopus 로고    scopus 로고
    • Pivotal role of nitric oxide in delayed pharmacological preconditioning against myocardial infarction
    • Xi l, Kukreja RC. Pivotal role of nitric oxide in delayed pharmacological preconditioning against myocardial infarction. Toxicology 2000;155(1-3):37-44
    • (2000) Toxicology , vol.155 , Issue.1-3 , pp. 37-44
    • Xi, L.1    Kukreja, R.C.2
  • 49
    • 0034926683 scopus 로고    scopus 로고
    • Delayed preconditioning myocardium: Current perspectives
    • DOI 10.1007/s003950170041
    • Baxter GF, Ferdinandy P. Delayed preconditioning of myocardium: current perspectives. Basic Res Cardiol 2001;96(4):329-344 (Pubitemid 32700570)
    • (2001) Basic Research in Cardiology , vol.96 , Issue.4 , pp. 329-344
    • Baxter, G.F.1    Ferdinandy, P.2
  • 50
    • 34848834223 scopus 로고    scopus 로고
    • Cardioprotection afforded by inducible nitric oxide synthase gene therapy is mediated by cyclooxygenase-2 via a nuclear factor-êB dependent pathway
    • Li Q, Guo Y, Tan W, et al. Cardioprotection afforded by inducible nitric oxide synthase gene therapy is mediated by cyclooxygenase-2 via a nuclear factor-êB dependent pathway. Circulation 2007;116(14):1577-1584
    • (2007) Circulation , vol.116 , Issue.14 , pp. 1577-1584
    • Li, Q.1    Guo, Y.2    Tan, W.3
  • 51
    • 33644871719 scopus 로고    scopus 로고
    • Gene therapy with iNOS provides long-term protection against myocardial infarction without adverse functional consequences
    • Li Q, Guo Y, Tan W, et al. Gene therapy with iNOS provides long-term protection against myocardial infarction without adverse functional consequences. Am J Physiol Heart Circ Physiol 2006;290(2):H584-9
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , Issue.2
    • Li, Q.1    Guo, Y.2    Tan, W.3
  • 52
    • 54049117690 scopus 로고    scopus 로고
    • Cardiac cholinergic NO-cGMP signaling following acute myocardial infarction and nNOS gene transfer
    • Dawson TA, Li D, Woodward T, et al. Cardiac cholinergic NO-cGMP signaling following acute myocardial infarction and nNOS gene transfer. Am J Physiol Heart Circ Physiol 2008;295(3):H990-8
    • (2008) Am J Physiol Heart Circ Physiol , vol.295 , Issue.3
    • Dawson, T.A.1    Li, D.2    Woodward, T.3
  • 53
    • 14844309367 scopus 로고    scopus 로고
    • Human endothelial nitric oxide synthase gene delivery protects against cardiac remodeling and reduces oxidative stress after myocardial infarction
    • Smith RS Jr, Agata J, Xia CF, et al. Human endothelial nitric oxide synthase gene delivery protects against cardiac remodeling and reduces oxidative stress after myocardial infarction. Life Sci 2005;76(21):2457-2471
    • (2005) Life Sci , vol.76 , Issue.21 , pp. 2457-2471
    • Smith Jr., R.S.1    Agata, J.2    Xia, C.F.3
  • 55
    • 38349147337 scopus 로고    scopus 로고
    • Expansive remodeling in venous bypass grafts: Novel implications for vein graft disease
    • Wong AP, Nili N, Jackson ZS, et al. Expansive remodeling in venous bypass grafts: novel implications for vein graft disease. Atherosclerosis 2008;196(2):580-589
    • (2008) Atherosclerosis , vol.196 , Issue.2 , pp. 580-589
    • Wong, A.P.1    Nili, N.2    Jackson, Z.S.3
  • 56
    • 0034124263 scopus 로고    scopus 로고
    • Role of endothelial cell denudation and smooth muscle cell dedifferentiation in neointimal formation of human vein grafts after coronary artery bypass grafting: Therapeutic implications
    • Sasaki Y, Suehiro S, Becker AE, et al. Role of endothelial cell denudation and smooth muscle cell dedifferentiation in neointimal formation of human vein grafts after coronary artery bypass grafting: therapeutic implications. Heart 2000;83(1):69-75 (Pubitemid 30307643)
    • (2000) Heart , vol.83 , Issue.1 , pp. 69-75
    • Sasaki, Y.1    Suehiro, S.2    Becker, A.E.3    Kinoshita, H.4    Ueda, M.5
  • 57
    • 0035949605 scopus 로고    scopus 로고
    • Nitric oxide synthase (nNOS) gene transfer modifies venous bypass graft remodeling: Effects on vascular smooth muscle cell differentiation and superoxide production
    • West NE, Qian H, Guzik TJ, et al. Nitric oxide synthase (nNOS) gene transfer modifies venous bypass graft remodeling: effects on vascular smooth muscle cell differentiation and superoxide production. Circulation 2001;104(13):1526-1532 (Pubitemid 32917346)
    • (2001) Circulation , vol.104 , Issue.13 , pp. 1526-1532
    • West, N.E.J.1    Qian, H.2    Guzik, T.J.3    Black, E.4    Cai, S.5    George, S.E.6    Channon, K.M.7
  • 58
    • 0036088832 scopus 로고    scopus 로고
    • Intraluminal gene transfer of endothelial cell-nitric oxide synthase suppresses intimai hyperplasia of vein grafts in cholesterol-fed rabbit: A limited biological effect as a result of the loss of medial smooth muscle cells
    • DOI 10.1067/msy.2002.124878
    • Ohta S, Komori K, Yonemitsu Y, et al. Intraluminal gene transfer of endothelial cell-nitric oxide synthase suppresses intimal hyperplasia of vein grafts in cholesterol-fed rabbit: a limited biological effect as a result of the loss of medial smooth muscle cells. Surgery 2002;131(6):644-653 (Pubitemid 34666766)
    • (2002) Surgery , vol.131 , Issue.6 , pp. 644-653
    • Ohta, S.1    Komori, K.2    Yonemitsu, Y.3    Onohara, T.4    Matsumoto, T.5    Sugimachi, K.6
  • 59
    • 33646147801 scopus 로고    scopus 로고
    • Lipoplex gene transfer of inducible nitric oxide synthase inhibits the reactive intimal hyperplasia after expanded polytetrafluoroethylene bypass grafting
    • Pfeiffer T, Wallich M, Sandmann W, et al. lipoplex gene transfer of inducible nitric oxide synthase inhibits the reactive intimal hyperplasia after expanded polytetrafluoroethylene bypass grafting. J Vasc Surg 2006;43(5):1021-1027
    • (2006) J Vasc Surg , vol.43 , Issue.5 , pp. 1021-1027
    • Pfeiffer, T.1    Wallich, M.2    Sandmann, W.3
  • 60
    • 18844417604 scopus 로고    scopus 로고
    • Gene therapy for ischemic cardiovascular diseases: Some lessons learned from the first clinical trials
    • DOI 10.1016/j.tcm.2004.09.001, PII S1050173804001410
    • Yla-Herttuala S, Markkanen JE, Rissanen TT. Gene therapy for ischemic cardiovascular diseases: some lessons learned from the first clinical trials. Trends Cardiovasc Med 2004;14(8):295-300 (Pubitemid 41110607)
    • (2004) Trends in Cardiovascular Medicine , vol.14 , Issue.8 , pp. 295-300
    • Yla-Herttuala, S.1    Markkanen, J.E.2    Rissanen, T.T.3
  • 61
    • 0036341231 scopus 로고    scopus 로고
    • Human endothelial nitric oxide synthase gene delivery promotes angiogenesis in a rat model of hindlimb ischemia
    • Smith RS Jr, Lin KF, Agata J, et al. Human endothelial nitric oxide synthase gene delivery promotes angiogenesis in a rat model of hindlimb ischemia. Arterioscler Thromb Vasc Biol 2002;22(8):1279-1285
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , Issue.8 , pp. 1279-1285
    • Smith Jr., R.S.1    Lin, K.F.2    Agata, J.3
  • 62
    • 0242361643 scopus 로고    scopus 로고
    • Angiogenesis Induced by Endothelial Nitric Oxide Synthase Gene Through Vascular Endothelial Growth Factor Expression in a Rat Hindlimb Ischemia Model
    • DOI 10.1161/01.CIR.0000093190.53478.78
    • Namba T, Koike H, Murakami K, et al. Angiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model. Circulation 2003;108(18):2250-2257 (Pubitemid 37363043)
    • (2003) Circulation , vol.108 , Issue.18 , pp. 2250-2257
    • Namba, T.1    Koike, H.2    Murakami, K.3    Aoki, M.4    Makino, H.5    Hashiya, N.6    Ogihara, T.7    Kaneda, Y.8    Kohno, M.9    Morishita, R.10
  • 63
    • 33748328242 scopus 로고    scopus 로고
    • Effective treatment of vascular endothelial growth factor refractory hindlimb ischemia by a mutant endothelial nitric oxide synthase gene
    • Qian HS, Liu P, Huw LY, et al. Effective treatment of vascular endothelial growth factor refractory hindlimb ischemia by a mutant endothelial nitric oxide synthase gene. Gene Ther 2006;13(18):1342-1350
    • (2006) Gene Ther , vol.13 , Issue.18 , pp. 1342-1350
    • Qian, H.S.1    Liu, P.2    Huw, L.Y.3
  • 64
    • 52449092179 scopus 로고    scopus 로고
    • Arteriolar genesis and angiogenesis induced by endothelial nitric oxide synthase overexpression results in a mature vasculature
    • Benest AV, Stone OA, Miller WH, et al. Arteriolar genesis and angiogenesis induced by endothelial nitric oxide synthase overexpression results in a mature vasculature. Arterioscler Thromb Vasc Biol 2008;28(8):1462-1468
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.8 , pp. 1462-1468
    • Benest, A.V.1    Stone, O.A.2    Miller, W.H.3
  • 65
    • 0035234518 scopus 로고    scopus 로고
    • Gene transfer for cerebrovascular disease
    • Khurana VG, Katusic ZS. Gene transfer for cerebrovascular disease. Curr Cardiol Rep 2001;3(1):10-16
    • (2001) Curr Cardiol Rep , vol.3 , Issue.1 , pp. 10-16
    • Khurana, V.G.1    Katusic, Z.S.2
  • 68
    • 0031692410 scopus 로고    scopus 로고
    • Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery after experimental subarachnoid hemorrhage
    • discussion 1965-1966
    • Onoue H, Tsutsui M, Smith l, et al. Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery after experimental subarachnoid hemorrhage. Stroke 1998;29(9):1959-65; discussion 1965-1966
    • (1998) Stroke , vol.29 , Issue.9 , pp. 1959-1965
    • Onoue, H.1    Tsutsui, M.2    Smith, L.3
  • 70
    • 0036218374 scopus 로고    scopus 로고
    • Expression and function of recombinant S1179D endothelial nitric oxide synthase in canine cerebral arteries
    • DOI 10.1161/hs0402.105553
    • Akiyama M, Eguchi D, Weiler D, et al. Expression and function of recombinant S1179D endothelial nitric oxide synthase in canine cerebral arteries. Stroke 2002;33(4):1071-1076 (Pubitemid 34293594)
    • (2002) Stroke , vol.33 , Issue.4 , pp. 1071-1076
    • Akiyama, M.1    Eguchi, D.2    Weiler, D.3    O'Brien, T.4    Kovesdi, I.5    Scotland, R.S.6    Sessa, W.C.7    Katusic, Z.S.8
  • 71
    • 0033839404 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer to human cerebral arteries
    • Khurana VG, Smith lA, Weiler DA, et al. Adenovirus-mediated gene transfer to human cerebral arteries. J Cereb Blood Flow Metab 2000;20(9):1360-1371
    • (2000) J Cereb Blood Flow Metab , vol.20 , Issue.9 , pp. 1360-1371
    • Khurana, V.G.1    La, S.2    Weiler, D.A.3
  • 72
    • 0032127042 scopus 로고    scopus 로고
    • Transfer and expression of recombinant nitric oxide synthase genes in the cardiovascular system
    • DOI 10.1016/S0165-6147(98)01190-0
    • Chen AF, O'Brien T, Katusic ZS. Transfer and expression of recombinant nitric oxide synthase genes in the cardiovascular system. Trends Pharmacol Sci 1998;19(7):276-286 (Pubitemid 28358087)
    • (1998) Trends in Pharmacological Sciences , vol.19 , Issue.7 , pp. 276-286
    • Chen, A.F.Y.1    O'Brien, T.2    Katusic, Z.S.3
  • 73
    • 0036196152 scopus 로고    scopus 로고
    • Protective vasomotor effects of in vivo recombinant endothelial nitric oxide synthase gene expression in a canine model of cerebral vasospasm
    • Khurana VG, Smith lA, Baker TA, et al. Protective vasomotor effects of in vivo recombinant endothelial nitric oxide synthase gene expression in a canine model of cerebral vasospasm. Stroke 2002;33(3):782-789
    • (2002) Stroke , vol.33 , Issue.3 , pp. 782-789
    • Khurana, V.G.1    La, S.2    Baker, T.A.3
  • 74
    • 0019819316 scopus 로고
    • The effect of chronic hypoxia on pulmonary arteries in young rats
    • Meyrick B, Reid l. The effect of chronic hypoxia on pulmonary arteries in young rats. Exp lung Res 1981;2(4):257-271
    • (1981) Exp Lung Res , vol.2 , Issue.4 , pp. 257-271
    • Meyrick, B.1    Reid, L.2
  • 75
    • 0021339465 scopus 로고
    • Lung growth in health and disease
    • DOI 10.1016/S0007-0971(84)80092-3
    • Reid lM. lung growth in health and disease. Br J Dis Chest 1984;78(2):113-134 (Pubitemid 14167833)
    • (1984) British Journal of Diseases of the Chest , vol.78 , Issue.2 , pp. 113-134
    • Reid, L.M.1
  • 76
  • 77
    • 0030017320 scopus 로고    scopus 로고
    • Adenoviral-mediated transfer of the human endothelial nitric oxide synthase gene reduces acute hypoxic pulmonary vasoconstriction in rats
    • Janssens SP, Bloch KD, Nong Z, et al. Adenoviral-mediated transfer of the human endothelial nitric oxide synthase gene reduces acute hypoxic pulmonary vasoconstriction in rats. J Clin Invest 1996;98(2):317-324 (Pubitemid 26255729)
    • (1996) Journal of Clinical Investigation , vol.98 , Issue.2 , pp. 317-324
    • Janssens, S.P.1    Bloch, K.D.2    Nong, Z.3    Gerard, R.D.4    Zoldhelyi, P.5    Collen, D.6
  • 79
    • 33745873708 scopus 로고    scopus 로고
    • Effect of adenovirus-mediated gene transfer of nitric oxide synthase on vascular reactivity of rat isolated pulmonary arteries
    • Jiang l, Quarck R, Janssens S, et al. Effect of adenovirus-mediated gene transfer of nitric oxide synthase on vascular reactivity of rat isolated pulmonary arteries. Pflugers Arch 2006;452(2):213-221
    • (2006) Pflugers Arch , vol.452 , Issue.2 , pp. 213-221
    • Jiang, L.1    Quarck, R.2    Janssens, S.3
  • 80
    • 14844360656 scopus 로고    scopus 로고
    • Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: Efficacy of combined cell and eNOS gene therapy in established disease
    • DOI 10.1161/01.RES.0000157672.70560.7b
    • Zhao YD, Courtman DW, Deng Y, et al. Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease. Circ Res 2005;96(4):442-450 (Pubitemid 40354538)
    • (2005) Circulation Research , vol.96 , Issue.4 , pp. 442-450
    • Zhao, Y.D.1    Courtman, D.W.2    Deng, Y.3    Kugathasan, L.4    Zhang, Q.5    Stewart, D.J.6
  • 81
    • 39049083233 scopus 로고    scopus 로고
    • NCT00469027 US National Institute for Health. Available from: [last updated 8 January 2009] [last accessed 5 May 2009]
    • Pulmonary Hypertension: Assessment of Cell Therapy (PHACeT). NCT00469027 US National Institute for Health. Available from: http://www.clinicaltrials.gov/ ct2/ show/NCT00469027?term = nct00469027&rank = 1 [last updated 8 January 2009] [last accessed 5 May 2009]
    • Pulmonary Hypertension: Assessment of Cell Therapy (PHACeT)
  • 82
    • 33747186449 scopus 로고    scopus 로고
    • Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension
    • DOI 10.1161/CIRCULATIONAHA.105.001487, PII 0000301720060704100030
    • Kanki-Horimoto S, Horimoto H, Mieno S, et al. Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension. Circulation 2006;114(Suppl 1):I181-5 (Pubitemid 44297148)
    • (2006) Circulation , vol.114 , Issue.SUPPL. 1
    • Kanki-Horimoto, S.1    Horimoto, H.2    Mieno, S.3    Kishida, K.4    Watanabe, F.5    Furuya, E.6    Katsumata, T.7
  • 83
    • 38349096471 scopus 로고    scopus 로고
    • Gene transfer of endothelial nitric oxide synthase attenuates flow-induced pulmonary hypertension in rabbits
    • Zhang F, Wu S, Lu X, et al. Gene transfer of endothelial nitric oxide synthase attenuates flow-induced pulmonary hypertension in rabbits. Ann Thorac Surg 2008;85(2):581-585
    • (2008) Ann Thorac Surg , vol.85 , Issue.2 , pp. 581-585
    • Zhang, F.1    Wu, S.2    Lu, X.3
  • 84
    • 0036185991 scopus 로고    scopus 로고
    • Nitric oxide drives skin repair: Novel functions of an established mediator
    • DOI 10.1046/j.1523-1755.2002.00237.x
    • Frank S, Kämpfer H, Wetzler C, Pfeilschifter J. Nitric oxide drives skin repair: novel functions of an established mediator. Kidney Int 2002;61(3):882-888 (Pubitemid 34175456)
    • (2002) Kidney International , vol.61 , Issue.3 , pp. 882-888
    • Frank, S.1    Kampfer, H.2    Wetzler, C.3    Pfeilschifter, J.4
  • 85
    • 0036227477 scopus 로고    scopus 로고
    • Role of nitric oxide in wound repair
    • DOI 10.1016/S0002-9610(02)00815-2, PII S0002961002008152
    • Witte MB, Barbul A. Role of nitric oxide in wound repair. Am J Surg 2002;183(4):406-412 (Pubitemid 34442505)
    • (2002) American Journal of Surgery , vol.183 , Issue.4 , pp. 406-412
    • Witte, M.B.1    Barbul, A.2
  • 87
    • 2642597076 scopus 로고    scopus 로고
    • Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells
    • Papapetropoulos A, García-Cardeña G, Madri JA, Sessa WC. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest 1997;100(12):3131-3139 (Pubitemid 28022851)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.12 , pp. 3131-3139
    • Papapetropoulos, A.1    Garcia-Cardena, G.2    Madri, J.A.3    Sessa, W.C.4
  • 88
    • 0032721941 scopus 로고    scopus 로고
    • Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair
    • Frank S, Stallmeyer B, Kämpfer H, et al. Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair. FASEB J 1999;13(14):2002-14
    • (1999) FASEB J , vol.13 , Issue.14 , pp. 2002-2014
    • Frank, S.1    Stallmeyer, B.2    Kämpfer, H.3
  • 91
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • DOI 10.1038/414813a
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001;414(6865):813-820 (Pubitemid 34000785)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 813-820
    • Brownlee, M.1
  • 93
    • 0037046214 scopus 로고    scopus 로고
    • Mechanisms of increased vascular superoxide production in human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase
    • DOI 10.1161/01.CIR.0000012748.58444.08
    • Guzik TJ, Mussa S, Gastaldi D, et al. Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 2002;105(14):1656-1662 (Pubitemid 34298608)
    • (2002) Circulation , vol.105 , Issue.14 , pp. 1656-1662
    • Guzik, T.J.1    Mussa, S.2    Gastaldi, D.3    Sadowski, J.4    Ratnatunga, C.5    Pillai, R.6    Channon, K.M.7
  • 94
    • 6444226659 scopus 로고    scopus 로고
    • Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice
    • Luo JD, Wang YY, Fu Wl, et al. Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice. Circulation 2004;110(16):2484-2493
    • (2004) Circulation , vol.110 , Issue.16 , pp. 2484-2493
    • Luo, J.D.1    Wang, Y.Y.2    Fu, W.3
  • 96
    • 66249093482 scopus 로고    scopus 로고
    • Fibrin scaffold promotes adenoviral gene transfer and controlled vector delivery
    • Breen A, Dockery P, O'Brien T, Pandit A. Fibrin scaffold promotes adenoviral gene transfer and controlled vector delivery. J Biomed Mater Res A 2009;89A:876-884
    • (2009) J Biomed Mater Res A , vol.89 A , pp. 876-884
    • Breen, A.1    Dockery, P.2    O'Brien, T.3    Pandit, A.4
  • 98
    • 33845332378 scopus 로고    scopus 로고
    • Pathophysiology and treatment of diabetic erectile dysfunction
    • DOI 10.1111/j.1745-7262.2006.00223.x
    • Moore CR, Wang R. Pathophysiology and treatment of diabetic erectile dysfunction. Asian J Androl 2006;8(6):675-684 (Pubitemid 44869615)
    • (2006) Asian Journal of Andrology , vol.8 , Issue.6 , pp. 675-684
    • Moore, C.R.1    Wang, R.2
  • 99
    • 9644299891 scopus 로고    scopus 로고
    • Molecular pathophysiology and gene therapy of aging-related erectile dysfunction
    • DOI 10.1016/j.exger.2004.06.022, PII S0531556504002852
    • Gonzalez-Cadavid NF, Rajfer J. Molecular pathophysiology and gene therapy of aging-related erectile dysfunction. Exp Gerontol 2004;39(11-12):1705-1712 (Pubitemid 39576140)
    • (2004) Experimental Gerontology , vol.39 , Issue.11-12 SPEC. ISS , pp. 1705-1712
    • Gonzalez-Cadavid, N.F.1    Rajfer, J.2
  • 100
    • 4243094095 scopus 로고    scopus 로고
    • Therapy of erectile dysfunction: Potential future treatments
    • DOI 10.1385/ENDO:23:2-3:167
    • Gonzalez-Cadavid NF, Rajfer J. Therapy of erectile dysfunction: potential future treatments. Endocrine 2004;23(2-3):167-176 (Pubitemid 39140230)
    • (2004) Endocrine , vol.23 , Issue.2-3 , pp. 167-176
    • Gonzalez-Cadavid, N.F.1    Rajfer, J.2
  • 106
    • 33746234766 scopus 로고    scopus 로고
    • ENOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: A role for eNOS uncoupling
    • Elrod JW, Duranski MR, Langston W, et al. eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling. Circ Res 2006;99(1):78-85
    • (2006) Circ Res , vol.99 , Issue.1 , pp. 78-85
    • Elrod, J.W.1    Duranski, M.R.2    Langston, W.3
  • 107
    • 13844251902 scopus 로고    scopus 로고
    • Helper-dependent adenoviral vectors for gene therapy
    • DOI 10.1089/hum.2005.16.1
    • Palmer DJ, Ng P. Helper-dependent adenoviral vectors for gene therapy. Hum Gene Ther 2005;16(1):1-16 (Pubitemid 40250327)
    • (2005) Human Gene Therapy , vol.16 , Issue.1 , pp. 1-16
    • Palmer, D.J.1    Ng, P.2


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