Phosphorylation regulates assembly of the caspase-6 substrate-binding groove

Structure

Volumn 20, Issue 4, 2012, Pages 742-751

  Velázquez Delgado, Elih M ^a   Hardy, Jeanne A ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 6; PROLINE; SERINE;

ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; CRYSTALLOGRAPHY; ENZYME BINDING; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MASS SPECTROMETRY; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

APOPTOSIS; BINDING SITES; CASPASE 6; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HUMANS; MODELS, MOLECULAR; MOLECULAR MIMICRY; NEURODEGENERATIVE DISEASES; PHOSPHORYLATION; PROLINE; PROTEIN BINDING; PROTEIN KINASES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; SERINE; SIGNAL TRANSDUCTION;

EID: 84859416412     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2012.02.003     Document Type: Article

References (39)

1. D. Barford, S.H. Hu, and L.N. Johnson Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP J. Mol. Biol. 218 1991 233 260
2. R. Baumgartner, G. Meder, C. Briand, A. Decock, A. D'arcy, U. Hassiepen, R. Morse, and M. Renatus The crystal structure of caspase-6, a selective effector of axonal degeneration Biochem. J. 423 2009 429 439
3. M.H. Cardone, N. Roy, H.R. Stennicke, G.S. Salvesen, T.F. Franke, E. Stanbridge, S. Frisch, and J.C. Reed Regulation of cell death protease caspase-9 by phosphorylation Science 282 1998 1318 1321
4. J. Chai, E. Shiozaki, S.M. Srinivasula, Q. Wu, P. Datta, E.S. Alnemri, and Y. Shi Structural basis of caspase-7 inhibition by XIAP Cell 104 2001 769 780
5. V. Cowling, and J. Downward Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain Cell Death Differ. 9 2002 1046 1056
6. M.S. Dennis, M. Roberge, C. Quan, and R.A. Lazarus Selection and characterization of a new class of peptide exosite inhibitors of coagulation factor VIIa Biochemistry 40 2001 9513 9521
7. Q.L. Deveraux, R. Takahashi, G.S. Salvesen, and J.C. Reed X-linked IAP is a direct inhibitor of cell-death proteases Nature 388 1997 300 304
8. J.S. Duncan, J.P. Turowec, K.E. Duncan, G. Vilk, C. Wu, B. Lüscher, S.S. Li, G.B. Gloor, and D.W. Litchfield A peptide-based target screen implicates the protein kinase CK2 in the global regulation of caspase signaling Sci. Signal. 4 2011 ra30
9. P. Fuentes-Prior, and G.S. Salvesen The protein structures that shape caspase activity, specificity, activation and inhibition Biochem. J. 384 2004 201 232
10. V. Galvan, O.F. Gorostiza, S. Banwait, M. Ataie, A.V. Logvinova, S. Sitaraman, E. Carlson, S.A. Sagi, N. Chevallier, and K. Jin Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664 Proc. Natl. Acad. Sci. USA 103 2006 7130 7135
11. R.K. Graham, Y. Deng, E.J. Slow, B. Haigh, N. Bissada, G. Lu, J. Pearson, J. Shehadeh, L. Bertram, and Z. Murphy Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin Cell 125 2006 1179 1191
12. H. Guo, D. Pétrin, Y. Zhang, C. Bergeron, C.G. Goodyer, and A.C. LeBlanc Caspase-1 activation of caspase-6 in human apoptotic neurons Cell Death Differ. 13 2006 285 292
13. S.K. Hansen, M.T. Cancilla, T.P. Shiau, J. Kung, T. Chen, and D.A. Erlanson Allosteric inhibition of PTP1B activity by selective modification of a non-active site cysteine residue Biochemistry 44 2005 7704 7712
14. J.A. Hardy, J. Lam, J.T. Nguyen, T. O'Brien, and J.A. Wells Discovery of an allosteric site in the caspases Proc. Natl. Acad. Sci. USA 101 2004 12461 12466
15. J.A. Hardy, and J.A. Wells Dissecting an allosteric switch in caspase-7 using chemical and mutational probes J. Biol. Chem. 284 2009 26063 26069
16. J.H. Hurley, A.M. Dean, J.L. Sohl, D.E. Koshland Jr., and R.M. Stroud Regulation of an enzyme by phosphorylation at the active site Science 249 1990 1012 1016
17. S.H. Jia, J. Parodo, A. Kapus, O.D. Rotstein, and J.C. Marshall Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8 J. Biol. Chem. 283 2008 5402 5413
18. L.N. Johnson Glycogen phosphorylase: control by phosphorylation and allosteric effectors FASEB J. 6 1992 2274 2282
19. L.N. Johnson, and D. Barford Electrostatic effects in the control of glycogen phosphorylase by phosphorylation Protein Sci. 3 1994 1726 1730
20. M. Kato, R.M. Wynn, J.L. Chuang, S.C. Tso, M. Machius, J. Li, and D.T. Chuang Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops Structure 16 2008 1849 1859
21. G. Klaiman, N. Champagne, and A.C. LeBlanc Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells Biochim. Biophys. Acta 1793 2009 592 601
22. M. Kurokawa, and S. Kornbluth Caspases and kinases in a death grip Cell 138 2009 838 854
23. X. Li, W. Wen, K. Liu, F. Zhu, M. Malakhova, C. Peng, T. Li, H.G. Kim, W. Ma, and Y.Y. Cho Phosphorylation of caspase-7 by p21-activated protein kinase (PAK)2 inhibits chemotherapeutic drugs-induced apoptosis of breast cancer cell lines J. Biol. Chem. 286 2011 22291 22299
24. C. López-Otín, and T. Hunter The regulatory crosstalk between kinases and proteases in cancer Nat. Rev. Cancer 10 2010 278 292
25. M. Podobnik, R. Kuhelj, V. Turk, and D. Turk Crystal structure of the wild-type human procathepsin B at 2.5 A resolution reveals the native active site of a papain-like cysteine protease zymogen J. Mol. Biol. 271 1997 774 788
26. M. Roberge, L. Santell, M.S. Dennis, C. Eigenbrot, M.A. Dwyer, and R.A. Lazarus A novel exosite on coagulation factor VIIa and its molecular interactions with a new class of peptide inhibitors Biochemistry 40 2001 9522 9531
27. J.M. Scheer, M.J. Romanowski, and J.A. Wells A common allosteric site and mechanism in caspases Proc. Natl. Acad. Sci. USA 103 2006 7595 7600
28. F.L. Scott, J.B. Denault, S.J. Riedl, H. Shin, M. Renatus, and G.S. Salvesen XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs EMBO J. 24 2005 645 655
29. E.N. Shiozaki, J. Chai, D.J. Rigotti, S.J. Riedl, P. Li, S.M. Srinivasula, E.S. Alnemri, R. Fairman, and Y. Shi Mechanism of XIAP-mediated inhibition of caspase-9 Mol. Cell 11 2003 519 527
30. S.M. Srinivasula, T. Fernandes-Alnemri, J. Zangrilli, N. Robertson, R.C. Armstrong, L. Wang, J.A. Trapani, K.J. Tomaselli, G. Litwack, and E.S. Alnemri The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32 J. Biol. Chem. 271 1996 27099 27106
31. H.R. Stennicke, C.A. Ryan, and G.S. Salvesen Reprieval from execution: the molecular basis of caspase inhibition Trends Biochem. Sci. 27 2002 94 101
32. A. Suzuki, G. Kusakai, A. Kishimoto, Y. Shimojo, S. Miyamoto, T. Ogura, A. Ochiai, and H. Esumi Regulation of caspase-6 and FLIP by the AMPK family member ARK5 Oncogene 23 2004 7067 7075
33. S. Vaidya, and J.A. Hardy Caspase-6 latent state stability relies on helical propensity Biochemistry 50 2011 3282 3287
34. S. Vaidya, E.M. Velázquez-Delgado, G. Abbruzzese, and J.A. Hardy Substrate-induced conformational changes occur in all cleaved forms of caspase-6 J. Mol. Biol. 406 2011 75 91
35. X.J. Wang, Q. Cao, X. Liu, K.T. Wang, W. Mi, Y. Zhang, L.F. Li, A.C. LeBlanc, and X.D. Su Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation EMBO Rep. 11 2010 841 847
36. W.A. Witkowski, and J.A. Hardy L2′ loop is critical for caspase-7 active site formation Protein Sci. 18 2009 1459 1468
37. W.A. Witkowski, and J.A. Hardy A designed redox-controlled caspase Protein Sci. 20 2011 1421 1431
38. R.M. Wynn, M. Kato, M. Machius, J.L. Chuang, J. Li, D.R. Tomchick, and D.T. Chuang Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation Structure 12 2004 2185 2196
39. S.E. Zographos, N.G. Oikonomakos, K.E. Tsitsanou, D.D. Leonidas, E.D. Chrysina, V.T. Skamnaki, H. Bischoff, S. Goldmann, K.A. Watson, and L.N. Johnson The structure of glycogen phosphorylase b with an alkyldihydropyridine- dicarboxylic acid compound, a novel and potent inhibitor Structure 5 1997 1413 1425