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Kersten S, Lichtenstein L, Steenbergen E et al. Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids. Arterioscler. Thromb. Vasc. Biol. 29(6), 969-974 (2009). An interesting human study from one of the major specialists in angiopoietin-like protein 4 (ANGPTL4) research, which demonstrates the role of ANGPTL4 in energy metabolism.
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ANGPTL4 upregulates cholesterol synthesis in liver via inhibition of ECM- And HL-dependent hepatic cholesterol uptake
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Fasting-induced adipose factor/ angiopoietin-like protein 4: A potential target for dyslipidemia?
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Zandbergen F, van Dijk S, Kersten S. Fasting-induced adipose factor/ angiopoietin-like protein 4: a potential target for dyslipidemia? Future Lipidol. 1(2), 227-236 (2006).
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Angiopoietin-like 4 (ANGPTL4/FIAF) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism
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Koliwad SK, Kuo T, Shipp LE et al. Angiopoietin-like 4 (ANGPTL4/FIAF) is a direct glucocorticoid receptor target and participates in glucocorticoid- regulated triglyceride metabolism. J. Biol. Chem. 284, 25593-25601 (2009).
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34
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Modulation of plasma TG lipolysis by angiopoietin-like proteins and GPIHBP1
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Interesting review in which the effect of ANGPTL4 on lipid metabolism is discussed extensively
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Lichtenstein L, Kersten S. Modulation of plasma TG lipolysis by angiopoietin-like proteins and GPIHBP1. Biochim. Biophys. Acta 1801(4), 415-420 (2010). Interesting review in which the effect of ANGPTL4 on lipid metabolism is discussed extensively.
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Lichtenstein, L.1
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Fleissner CK, Huebel N, Abd El-Bary MM, Loh G, Klaus S, Blaut M. Absence of intestinal microbiota does not protect mice from diet-induced obesity. Br. J. Nutr. 104, 919-929 (2010).
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Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample
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Robciuc MR, Tahvanainen E, Jauhiainen M, Ehnholm C. Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample. J. Lipid Res. 51(4), 824-831 (2010).
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38
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Koster A, Chao YB, Mosior M et al. Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology 146(11), 4943-4950 (2005).
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Koster, A.1
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39
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The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity
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Explores the different ANGPTL4 isoforms and target organs of several drugs with fasting-induced adipose factor-modulating capacities. Differences in ANGPTL4 isoforms between rodents and humans are demonstrated
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Mandard S, Zandbergen F, van Straten E et al. The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J. Biol. Chem. 281, 934-944 (2006). Explores the different ANGPTL4 isoforms and target organs of several drugs with fasting-induced adipose factor-modulating capacities. Differences in ANGPTL4 isoforms between rodents and humans are demonstrated.
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40
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Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages
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Interesting paper about the effect of ANGPTL4 on inflammation through extracellular matrix inhibition
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Lichtenstein L, Mattijssen F, de Wit NJ et al. Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages. Cell Metab. 12(6), 580-592 (2010). Interesting paper about the effect of ANGPTL4 on inflammation through extracellular matrix inhibition.
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Lichtenstein, L.1
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Desai U, Lee EC, Chung K et al. Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice. Proc. Natl Acad. Sci. USA 104(28), 11766-11771 (2007).
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Adachi H, Fujiwara Y, Kondo T et al. ANGPTL4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis. Biochem. Biophys. Res. Comm. 379(4), 806-811 (2009).
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