ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

Blood

Volumn 118, Issue 14, 2011, Pages 3990-4002

  Huang, Royston Luke ^a   Teo, Ziqiang ^a   Chong, Han Chung ^a   Zhu, Pengcheng ^a   Tan, Ming Jie ^a   Tan, Chek Kun ^a   Lam, Chee Ren Ivan ^a   Sng, Ming Keat ^a   Leong, David Tai Wei ^b   Tan, Suet Mien ^a   Kersten, Sander ^c   Ding, Jeak Ling ^b   Li, Hoi Yeung ^a   Tan, Nguan Soon ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN; BETA CATENIN; C TERMINAL FIBRINOGEN LIKE DOMAIN OF ANGIOPOIETIN LIKE 4; CLAUDIN 5; INTEGRIN; P21 ACTIVATED KINASE 1; RAC PROTEIN; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VERY LATE ACTIVATION ANTIGEN 5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD VESSEL PERMEABILITY; CELL INTERACTION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENDOTHELIUM; FEMALE; HUMAN; HUMAN CELL; LUNG METASTASIS; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 80053637525     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-01-328716     Document Type: Article

References (38)

1. Yilmaz M, Christofori G, Lehembre F. Distinct mechanisms of tumor invasion and metastasis. Trends Mol Med. 2007;13(12):535-541. (Pubitemid 350123764)
2. Dejana E. Endothelial cell-cell junctions: happy together. Nat Rev Mol Cell Biol. 2004;5(4):261-270. (Pubitemid 38480607)
3. Komarova Y, Malik AB. Regulation of endothelial permeability via paracellular and transcellular transport pathways. Annu Rev Physiol. 2010;72:463-493.
4. Bazzoni G, Dejana E. Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev. 2004;84(3):869-901. (Pubitemid 38823769)
5. Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer. 2010;10(1):9-22.
6. Lampugnani MG, Resnati M, Dejana E, Marchisio PC. The role of integrins in the maintenance of endothelial monolayer integrity. J Cell Biol. 1991;112(3):479-490. (Pubitemid 21926002)
7. Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer. 2009;9(4):239-252.
8. Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol. 2004;5(10):816-826. (Pubitemid 39336275)
9. Thijssen VL, Barkan B, Shoji H, et al. Tumor cells secrete galectin-1 to enhance endothelial cell activity. Cancer Res. 2010;70(15):6216-6224.
10. Padua D, Zhang XHF, Wang Q, et al. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell. 2008;133(1):66-77. (Pubitemid 351442989)
11. Galaup A, Cazes A, Le JS, et al. Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness. Proc Natl Acad Sci U S A. 2006;103(49):18721-18726. (Pubitemid 44913477)
12. Ito Y, Oike Y, Yasunaga K, et al. Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4. Cancer Res. 2003;63(20):6651-6657. (Pubitemid 37322943)
13. Hu Z, Fan C, Livasy C, et al. A compact VEGF signature associated with distant metastases and poor outcomes. BMC Med. 2009;7:9.
14. Minn AJ, Gupta GP, Siegel PM, et al. Genes that mediate breast cancer metastasis to lung. Nature. 2005;436(7050):518-524. (Pubitemid 41112921)
15. Minn AJ, Gupta GP, Padua D, et al. Lung metastasis genes couple breast tumor size and metastatic spread. Proc Natl Acad Sci U S A. 2007;104(16):6740- 6745. (Pubitemid 47175571)
16. Zhu P, Tan MJ, Huang RL, et al. Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors. Cancer Cell. 2011;19(3):401-415.
17. Goh YY, Pal M, Chong HC, et al. Angiopoietin-Like 4 Interacts with Integrins {beta}1 and {beta}5 to Modulate Keratinocyte Migration. Am J Pathol. 2010;177(6):2791-2803.
18. Goh YY, Pal M, Chong HC, et al. Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing. J Biol Chem. 2010;285(43):32999-33009.
19. Ito Y, Oike Y, Yasunaga K, et al. Inhibition of angiogenesis and vascular leakiness by angiopoietin- related protein 4. Cancer Res. 2003;63(20):6651- 6657. (Pubitemid 37322943)
20. Allalou A, Wählby C. BlobFinder, a tool for fluorescence microscopy image cytometry. Comput Methods Programs Biomed. 2009;94(1):58-65.
21. Wen H, Watry DD, Marcondes MCG, Fox HS. Selective decrease in paracellular conductance of tight junctions: role of the first extracellular domain of claudin-5. Mol Cell Biol. 2004;24(19):8408-8417. (Pubitemid 39245063)
22. Taveau JC, Dubois M, Le Bihan O, et al. Structure of artificial and natural VE-cadherin-based adherens junctions. Biochem Soc Trans. 2008;36(Pt 2):189-193. (Pubitemid 351570589)
23. Taddei A, Giampietro C, Conti A, et al. Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5. Nat Cell Biol. 2008;10(8):923-934.
24. Stockton RA, Schaefer E, Schwartz MA. p21-activated kinase regulates endothelial permeability through modulation of contractility. J Biol Chem. 2004;279(45):46621-46630. (Pubitemid 39518307)
25. Galan Moya EM, Le Guelte A, Gavard J. PAKing up to the endothelium. Cell Signal. 2009;21(12):1727-1737.
26. Gimond C, Van Der Flier A, Van Delft S, et al. Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function. J Cell Biol. 1999;147(6):1325-1340. (Pubitemid 30012816)
27. Beckers CML, García-Vallejo JJ, Van Hinsbergh VWM, Van Nieuw Amerongen GP. Nuclear targeting of beta-catenin and p120ctn during thrombin-induced endothelial barrier dysfunction. Cardiovasc Res. 2008;79(4):679-688.
28. Conacci-Sorrell M, Zhurinsky J, Ben-Ze'ev A. The cadherin-catenin adhesion system in signaling and cancer. J Clin Invest. 2002;109(8):987-991. (Pubitemid 34408571)
29. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57-70. (Pubitemid 30046295)
30. Miyamoto Y, Reddig P, Juliano RL. Regulation of signal transduction by integrins. Handb Exp Pharmacol. 2004;165:197-216.
31. Hoang MV, Nagy JA, Senger DR. Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1. Blood. 2011;117(5):1751-1760.
32. Sumpio BE, Riley JT, Dardik A. Cells in focus: endothelial cell. Int J Biochem Cell Biol. 2002;34(12):1508-1512.
33. Harris ES, Nelson WJ. VE-cadherin: at the front, center, and sides of endothelial cell organization and function. Curr Opin Cell Biol. 2010;22(5):651-658.
34. Skurk C, Maatz H, Rocnik E, Bialik A, Force T, Walsh K. Glycogen-synthase kinase3beta/betacatenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells. Circ Res. 2005;96(3):308-318. (Pubitemid 40279905)
35. Conacci-Sorrell M, Zhurinsky J, Ben-Ze'ev A. The cadherin-catenin adhesion system in signaling and cancer. J Clin Invest. 2002;109(8):987-991. (Pubitemid 34408571)
36. Beckers CML, García-Vallejo JJ, Van Hinsbergh VWM, Van Nieuw Amerongen GP. Nuclear targeting of beta-catenin and p120ctn during thrombin-induced endothelial barrier dysfunction. Cardiovasc Res. 2008;79(4):679-688.
37. Le Jan S, Amy C, Cazes A, et al. Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma. Am J Pathol. 2003;162(5):1521-1528. (Pubitemid 36512834)
38. Fukumura D, Duda DG, Munn LL, Jain RK. Tumor microvasculature and microenvironment: novel insights through intravital imaging in preclinical models. Microcirculation. 2010;17(3):206-225.