Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis

Biochemical and Biophysical Research Communications

Volumn 379, Issue 4, 2009, Pages 806-811

  Adachi, Hironori ^a   Fujiwara, Yukio ^a   Kondo, Tatsuya ^a   Nishikawa, Takeshi ^a   Ogawa, Rei ^b   Matsumura, Takeshi ^a   Ishii, Norio ^a   Nagai, Ryoji ^a   Miyata, Keishi ^a   Tabata, Mitsuhisa ^a   Motoshima, Hiroyuki ^a   Furukawa, Noboru ^a   Tsuruzoe, Kaku ^a   Kawashima, Junji ^a   Takeya, Motohiro ^a   Yamashita, Shizuya ^c   Koh, Gou Young ^d   Nagy, Andras ^e   Suda, Toshio ^f   Oike, Yuichi ^a   Araki, Eiichi ^a   more..

^a KUMAMOTO UNIVERSITY   (Japan)

^b PREFECTURAL UNIVERSITY OF KUMAMOTO   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^e UNIVERSITY OF TORONTO   (Canada)

^f Institute for Advanced Medical Research   (Japan)

Author keywords

Angptl 4; Apolipoprotein E; Atherosclerosis; Foam cell formation; Foam cells; Knockout mice; Lipid metabolism; Lipoprotein lipase; Macrophage; Oxidized low density lipoprotein; Postprandial hypertriglyceridemia

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN LIKE PROTEIN 4; CHOLESTEROL ESTER; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CELL PROTECTION; CHOLESTEROL BLOOD LEVEL; DISEASE COURSE; ENZYME DEFICIENCY; ENZYME REGULATION; FOAM CELL; GENE REPRESSION; IN VITRO STUDY; KNOCKOUT GENE; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANGIOPOIETINS; ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CHOLESTEROL; FOAM CELLS; LIPID METABOLISM; LIPOPROTEINS; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; TRIGLYCERIDES;

MUS;

EID: 58949083661     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.12.018     Document Type: Article

References (22)

1. Rosenson R.S. Hypertriglyceridemia and coronary heart disease risk. Cardiol. Rev. 7 (1999) 342-348
2. Taskinen M.R. Diabetic dyslipidaemia: from basic research to clinical practice. Diabetologia 46 (2003) 733-749
3. Yagyu H., Ishibashi S., Chen Z., Osuga J., Okazaki M., Perrey S., Kitamine T., Shimada M., Ohashi K., Harada K., Shionoiri F., Yahagi N., Gotoda T., Yazaki Y., and Yamada N. Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice. J. Lipid Res. 40 (1999) 1677-1685
4. Shimada M., Ishibashi S., Inaba T., Yagyu H., Harada K., Osuga J.I., Ohashi K., Yazaki Y., and Yamada N. Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc. Natl. Acad. Sci. USA 93 (1996) 7242-7246
5. Chiba T., Miura S., Sawamura F., Uetsuka R., Tomita I., Inoue Y., Tsutsumi K., and Tomita T. Antiatherogenic effects of a novel lipoprotein lipase-enhancing agent in cholesterol-fed New Zealand white rabbits. Arterioscler. Thromb. Vasc. Biol. 17 (1997) 2601-2608
6. Oike Y., Akao M., Yasunaga K., Yamauchi T., Morisada T., Ito Y., Urano T., Kimura Y., Kubota Y., Maekawa H., Miyamoto T., Miyata K., Matsumoto S., Sakai J., Nakagata N., Takeya M., Koseki H., Ogawa Y., Kadowaki T., and Suda T. Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat. Med. 11 (2005) 400-408
7. Ge H., Yang G., Huang L., Motola D.L., Pourbahrami T., and Li C. Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4. J. Biol. Chem. 279 (2004) 2038-2045
8. Backhed F., Ding H., Wang T., Hooper L.V., Koh G.Y., Nagy A., Semenkovich C.F., and Gordon J.I. The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl. Acad. Sci. USA 101 (2004) 15718-15723
9. Desai U., Lee E.C., Chung K., Gao C., Gay J., Key B., Hansen G., Machajewski D., Platt K.A., Sands A.T., Schneider M., Van Sligtenhorst I., Suwanichkul A., Vogel P., Wilganowski N., Wingert J., Zambrowicz B.P., Landes G., and Powell D.R. Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice. Proc. Natl. Acad. Sci. USA 104 (2007) 11766-11771
10. Koster A., Chao Y.B., Mosior M., Ford A., Gonzalez-DeWhitt P.A., Hale J.E., Li D., Qiu Y., Fraser C.C., Yang D.D., Heuer J.G., Jaskunas S.R., and Eacho P. Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology 146 (2005) 4943-4950
11. Sukonina V., Lookene A., Olivecrona T., and Olivecrona G. Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Proc. Natl. Acad. Sci. USA 103 (2006) 17450-17455
12. Aalto-Setala K., Fisher E.A., Chen X., Chajek-Shaul T., Hayek T., Zechner R., Walsh A., Ramakrishnan R., Ginsberg H.N., and Breslow J.L. Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles. J. Clin. Invest. 90 (1992) 1889-1900
13. Fujiwara Y., Kiyota N., Hori M., Matsushita S., Iijima Y., Aoki K., Shibata D., Takeya M., Ikeda T., Nohara T., and Nagai R. Esculeogenin A, a new tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in ApoE-deficient mice by inhibiting ACAT. Arterioscler. Thromb. Vasc. Biol. 27 (2007) 2400-2406
14. Taketa K., Matsumura T., Yano M., Ishii N., Senokuchi T., Motoshima H., Murata Y., Kim-Mitsuyama S., Kawada T., Itabe H., Takeya M., Nishikawa T., Tsuruzoe K., and Araki E. Oxidized low density lipoprotein activates peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARgamma through MAPK-dependent COX-2 expression in macrophages. J. Biol. Chem. 283 (2008) 9852-9862
15. Miyazaki A., Sakai M., Suginohara Y., Hakamata H., Sakamoto Y., Morikawa W., and Horiuchi S. Acetylated low density lipoprotein reduces its ligand activity for the scavenger receptor after interaction with reconstituted high density lipoprotein. J. Biol. Chem. 269 (1994) 5264-5269
16. Karpe F., Tornvall P., Olivecrona T., Steiner G., Carlson L.A., and Hamsten A. Composition of human low density lipoprotein: effects of postprandial triglyceride-rich lipoproteins, lipoprotein lipase, hepatic lipase and cholesteryl ester transfer protein. Atherosclerosis 98 (1993) 33-49
17. Ichikawa T., Kitajima S., Liang J., Koike T., Wang X., Sun H., Okazaki M., Morimoto M., Shikama H., Watanabe T., Yamada N., and Fan J. Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis. Lab. Invest. 84 (2004) 715-726
18. Still W.J., and Marriott P.R. Comparative morphology of the early atherosclerotic lesion in man and cholesterol-atherosclerosis in the rabbit an electron microscopic study. J. Atheroscler. Res. 4 (1964) 373-386
19. Tushuizen M.E., Diamant M., and Heine R.J. Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes. Postgrad. Med. J. 81 (2005) 1-6
20. Babaev V.R., Fazio S., Gleaves L.A., Carter K.J., Semenkovich C.F., and Linton M.F. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo. J. Clin. Invest. 103 (1999) 1697-1705
21. Romeo S., Pennacchio L.A., Fu Y., Boerwinkle E., Tybjaerg-Hansen A., Hobbs H.H., and Cohen J.C. Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat. Genet. 39 (2007) 513-516
22. Shimamura M., Matsuda M., Yasumo H., Okazaki M., Fujimoto K., Kono K., Shimizugawa T., Ando Y., Koishi R., Kohama T., Sakai N., Kotani K., Komuro R., Ishida T., Hirata K., Yamashita S., Furukawa H., and Shimomura I. Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. Arterioscler. Thromb. Vasc. Biol. 27 (2007) 366-372