Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor α agonists

BMC Bioinformatics

Volumn 7, Issue SUPPL.2, 2006, Pages

  Guo, Lei ^a   Fang, Hong ^b   Collins, Jim ^c   Fan, Xiao Hui ^a   Dial, Stacey ^a   Wong, Alex ^c   Mehta, Kshama ^c   Blann, Ernice ^a   Shi, Leming ^a   Tong, Weida ^a   Dragan, Yvonne P ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b Z Tech Corporation   (United States)

^c AGILENT TECHNOLOGIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIFFERENTIAL GENE EXPRESSIONS; DIFFERENTIALLY EXPRESSED GENE; DOSE-DEPENDENT MANNER; FATTY ACID METABOLISM; GENE EXPRESSION PROFILES; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PLEIOTROPIC EFFECTS; REACTIVE OXYGEN SPECIES;

CELL PROLIFERATION; GENE EXPRESSION; MAMMALS;

CYTOLOGY;

BEZAFIBRATE; FENOFIBRATE; LUCIFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PIRINIXIC ACID; REACTIVE OXYGEN METABOLITE; PYRIMIDINE DERIVATIVE;

AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EXPOSURE; DRUG MECHANISM; ENZYME ASSAY; FATTY ACID METABOLISM; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; LIVER CARCINOGENESIS; LIVER CARCINOMA; LIVER CELL; LIVER DISEASE; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PEROXISOME; PLEIOTROPY; TRANSACTIVATION; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECT; DRUG POTENTIATION; GENE EXPRESSION REGULATION; METABOLISM;

RODENTIA;

ANIMALS; BEZAFIBRATE; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEPATOCYTES; MALE; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; PPAR ALPHA; PROCETOFEN; PYRIMIDINES;

EID: 33947308562     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-7-S2-S18     Document Type: Article

References (42)

1. Schoonjans K, Staels B, Auwerx J: Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 1996, 37(5):907-925.
2. Schoonjans K, Staels B, Auwerx I: The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1996, 1302(2):93-109.
3. Corton JC, Anderson SP, Stauber A: Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators. Annu Rev Pharmacol Toxicol 2000, 40:491-518.
4. Tugwood JD, Issemann I, Anderson RG, Bundell KR, McPheat WL, Green S: The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. Embo J 1992, 11(2):433-439.
5. Dreyer C, Krey G, Keller H, Givel F, Helftenbein G, Wahli W: Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 1992, 68(5):879-887.
6. Muerhoff AS, Griffin KJ, Johnson EF: The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P45O fatty acid omega-hydroxylase, by clofibric acid. J Biol Chem 1992, 267(27):19051-19053.
7. Vanden Heuvel JP, Sterchele PF, Nesbit DJ, Peterson RE: Coordinate induction of acyl-CoA binding protein, fatty acid binding protein and peroxisomal beta-oxidation by peroxisome proliferators. Biochim Biophys Acta 1993, 1177(2):183-190.
8. Klaunig JE, Babich MA, Baetcke KP, Cook JC, Corton JC, David RM, DeLuca JG, Lai DY, McKee RH, Peters JM, et al.: PPARalpha agonist-induced rodent tumors: Modes of action and human relevance. Crit Rev Toxicol 2003, 33(6):655-780.
9. Yeldandi AV, Rao MS, Reddy JK: Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis. Mutat Res 2000, 448(2):159-177.
10. Schena M, Shalon D, Davis RW, Brown PO: Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 1995, 270(5235):467-470.
11. Lipshutz RJ, Fodor SP, Gingeras TP, Lockhart DJ: High density synthetic oligonucleotide arrays. Nat Genet 1999, 21 (1 Suppl):20-24.
12. Burczynski ME, McMillian M, Ciervo J, Li L, Parker JB, Dunn RT 2nd, Hicken S, Farr S, Johnson MD: Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells. Toxicol Sci 2000, 58(2):399-415.
13. Waring JF, Ciurlionis R, Jolly RA, Heindel M, Ulrich RG: Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity. Toxicol Lett 2001, 120(1-3):359-368.
14. Issemann I, Green S: Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990, 347(6294):645-650.
15. Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ: Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 1995, 15(6):3012-3022.
16. Peters JM, Aoyama T, Cattley RC, Nobumitsu U, Hashimoto T, Gonzalez FJ: Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver. Carcinogenesis 1998, 19(11):1989-1994.
17. Vanden Heuvel JP, Kreder D, Belda B, Hannon DB, Nugent CA, Burns KA, Taylor MJ: Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643. Toxicol Appl Pharmacol 2003, 188(3):185-198.
18. Bardot O, Aldridge TC, Latruffe N, Green S: PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene. Biochem Biophys Res Commun 1993, 192(1):37-45.
19. Schoonjans K, Watanabe M, Suzuki H, Mahfoudi A, Krey G, Wahli W, Grimaldi P, Staels B, Yamamoto T, Auwerxj: Induction of the acylcoenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J Biol Chem 1995, 270(33):19269-19276.
20. Cornwell PD, De Souza AT, Ulrich RG: Profiling of hepatic gene expression in rats treated with fibric acid analogs. Mutat Res 2004, 549(1-2):131-145.
21. Klaunig JE, Xu Y, Isenberg JS, Bachowski S, Kolaia KL, Jiang J, Stevenson DE, Walborg EF Jr: The role of oxidative stress in chemical carcinogenesis. Environ Health Perspect 1998, 106(Suppl 1):289-295.
22. Cho S, Park EM, Febbraio M, Annather J, Park L, Racchumi G, Silverstein RL, Iadecola C: The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. J Neurosci 2005, 25(10):2504-2512.
23. Li X, Gould SJ: The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11. J Biol Chem 2003, 278(19):17012-17020.
24. Khan SH, Sorof S: Liver fattS acid-binding protein: specific mediator of the mitogenesis induced by two classes of carcinogenic peroxisome proliferators. Proc Natl Acad Sci USA 1994, 91(3):848-852.
25. Roberts RA, James NH, Hasmall SC, Holden PR, Lambe K, Macdonald N, West D, Woodyatt NJ, Whitcome D: Apoptosis and proliferation in nongenotoxic carcinogenesis: Species differences and role of PPARalpha. Toxicol Lett 2000, 112-113:49-57.
26. Stepan H, Leo C, Purz S, Hockel M, Horn LC: Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome. Eur J Obstet Gynecol Reprod Biol 2005, 122(2):172-176.
27. Petrescu AD, Payne HP, Boedecker A, Chao H, Hertz R, Bar-Tana J, Schroeder F, Kier AB: Physical and functional interaction of Acyl-CoA-binding protein with hepatocyte nuclear factor-4 alpha. J Biol Chem 2003, 278(51):51813-51824.
28. Venturini I, Zeneroli ML, Corsi L, Baraldi C, Ferrarese C, Pecora N, Frigo M, Alho H, Farina F, Baraldi M: Diazepam binding inhibitor and total cholesterol plasma levels in cirrhosis and hepatocellular carcinoma. Regul Pept 1998, 74(1):31-34.
29. Venturini I, Alho H, Podkletnova I, Corsi L, Rybnikova E, Pellicci R, Baraldi M, Pelto-Huikko M, Helen P, Zeneroli ML Increased expression of peripheral benzodiazepine receptors and diazepam binding inhibitor in human tumors sited in the liver. Life Sci 1999, 65(21):2223-2231.
30. Suzuki T, Watanabe K, Ono T: Immunohistochemical demonstration of liver fatty acid-binding protein in human hepatocellular malignancies. J Pathol 1990, 161(1):79-83.
31. Evert M, Schneider-Stock R, Dombrowski F: Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat. Lob Invest 2005, 85(1):99-108.
32. Huang GW, Yang LY, Lu WQ: Expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor in hepatocellular carcinoma: Impact on neovascularization and survival. World J Gastroenterol 2005, 11(11):1705-1708.
33. Hsu DK, Dowling CA, Jeng KC, Chen JT, Yang RY, Liu FT: Galectin-3 expression is induced in cirrhotic liver and hepatocellular carcinoma. Int J Cancer 1999, 81(4):519-526.
34. Itoh T, Hayashi Y, Kanamaru T, Morita Y, Suzuki S, Wang W, Zhou L, Rui JA, Yamamoto M, Kuroda Y, et al.: Clinical significance of urokinase-type plasminogen activator activity in hepatocellular carcinoma. J Gastroenterol Hepatol 2000, 15(4):422-430.
35. Zheng Q, Tang ZY, Xue Q, Shi DR, Song HY, Tang HB: Invasion and metastasis of hepatocellular carcinoma in relation to urokinase-type plasminogen activator, its receptor and inhibitor. J Cancer Res Clin Oncol 2000, 126(11):641-646.
36. Kreamer BL, Staecker JL, Sawada N, Sattler GL, Hsia MT, Pitot HC: Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations. In Vitro Cell Dev Biol 1986, 22(4):201-211.
37. Seglen PO: Preparation of isolated rat liver cells. Methods Cell Biol 1976, 13:29-83.
38. Zhang B, Marcus SL, Miyata KS, Subramani S, Capone JP, Rachubinski RA: Characterization of protein-DNA interactions within the peroxisome proliferator-responsive element of the rat hydratase-dehydrogenase gene. J Biol Chem 1993, 268(17):12939-12945.
39. Tong W, Harris S, Cao X, Fang H, Shi L, Sun H, Fuscoe J, Harris A, Hong H, Xie Q, et al.: Development of public toxicogenomics software for microarray data management and analysis. Mutat Res 2004, 549(1-2):241-253.
40. Tong W, Cao X, Harris S, Sun H, Fang H, Fuscoe J, Harris A, Hong H, Xie Q, Perkins P. et ol.: ArrayTrack-supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research. Environ Health Perspect 2003, 111(15):1819-1826.
41. Kanehisa M, Goto S, Kawashima S, Nakaya A: The KEGG data-bases at GenomeNet. Nucleic Acids Res 2002, 30(1):42-46.
42. Zeeberg BR, FengW, Wang G, Wang MID, Fojo AT, Sunshine M, Narasimhan S, Kane DW, Reinhold WC, Lababidi S, et al.: GoMiner. a resource for biological interpretation of genomic and proteomic data. Genome Biol 2003, 4(4):R28.