Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome

Nature Medicine

Volumn 17, Issue 1, 2011, Pages 117-122

  Clement, Lionel C ^a   Avila Casado, Carmen ^b   MacÉ, Camille ^a   Soria, Elizabeth ^b   Bakker, Winston W ^c   Kersten, Sander ^d   Chugh, Sumant S ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; ANGIOPOIETIN LIKE 4 PROTEIN; GLUCOCORTICOID; GLYCOPROTEIN; LIPOPOLYSACCHARIDE; N ACETYL DEXTRO MANNOSAMINE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; GENE OVEREXPRESSION; GLOMERULUS BASEMENT MEMBRANE; MINIMAL CHANGE GLOMERULONEPHRITIS; MOUSE; NEPHROTIC SYNDROME; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEINURIA; RAT; SIALYLATION; TRANSGENE; UPREGULATION;

ALBUMINURIA; ANGIOPOIETINS; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, KNOCKOUT; NEPHROTIC SYNDROME; PROTEINURIA; RATS; RATS, TRANSGENIC;

MUS; RATTUS;

EID: 78651252297     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2261     Document Type: Article

References (23)

1. Nachman, P.H., Jennette, J.C. & Falk, R. Primary glomerular disease. in The Kidney 8th edn. (ed. Brenner, B.M.) 987-1066 (Elsevier, Philadelphia, 2008).
2. Chugh, S. et al. Aminopeptidase A: a nephritogenic target antigen of nephrotoxic serum. Kidney Int. 59, 601-613 (2001).
3. Liu, G., Clement, L., Kanwar, Y.S., Avila-Casado, C. & Chugh, S.S. ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. J. Biol. Chem. 281, 39681-39692 (2006).
4. Yoshida, K., Shimizugawa, T., Ono, M. & Furukawa, H. Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase. J. Lipid Res. 43, 1770-1772 (2002).
5. Padua, D. et al. TGF-primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133, 66-77 (2008).
6. Kersten, S. et al. Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J. Biol. Chem. 275, 28488-28493 (2000).
7. Yoon, J.C. et al. Peroxisome proliferator-activated receptor target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol. Cell. Biol. 20, 5343-5349 (2000).
8. Kim, I. et al. Hepatic expression, synthesis and secretion of a novel fibrinogen/ angiopoietin-related protein that prevents endothelial-cell apoptosis. Biochem. J. 346, 603-610 (2000).
9. Ge, H. et al. Oligomerization and regulated proteolytic processing of angiopoietinlike protein 4. J. Biol. Chem. 279, 2038-2045 (2004).
10. Ge, H., Yang, G., Yu, X., Pourbahrami, T. & Li, C. Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4. J. Lipid Res. 45, 2071-2079 (2004). (Pubitemid 40990901)
11. Romeo, S. et al. Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat. Genet. 39, 513-516 (2007).
12. Romeo, S. et al. Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. J. Clin. Invest. 119, 70-79 (2009).
13. Mandard, S. et al. The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J. Biol. Chem. 281, 934-944 (2006).
14. Avila-Casado, C. et al. Proteinuria in rats induced by serum from patients with collapsing glomerulopathy. Kidney Int. 66, 133-143 (2004).
15. Clement, L. et al. Early changes in gene expression that influence the course of primary glomerular disease. Kidney Int. 72, 337-347 (2007).
16. Boute, N. et al. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat. Genet. 24, 349-354 (2000).
17. Eremina, V. et al. VEGF inhibition and renal thrombotic microangiopathy. N. Engl. J. Med. 358, 1129-1136 (2008).
18. Davis, B. et al. Podocyte-specific expression of angiopoietin-2 causes proteinuria and apoptosis of glomerular endothelia. J. Am. Soc. Nephrol. 18, 2320-2329 (2007).
19. Cazes, A. et al. Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton. Circ. Res. 99, 1207-1215 (2006).
20. Malicdan, M.C., Noguchi, S., Hayashi, Y.K., Nonaka, I. & Nishino, I. Prophylactic treatment with sialic acid metabolites precludes the development of the myopathic phenotype in the DMRV-hIBM mouse model. Nat. Med. 15, 690-695 (2009).
21. Galeano, B. et al. Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine. J. Clin. Invest. 117, 1585-1594 (2007).
22. Koliwad, S.K. et al. Angiopoietin-like 4 (ANGPTL4/FIAF) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism. J. Biol. Chem. 284, 25593-25601 (2009).
23. Graves, R.A., Tontonoz, P., Platt, K.A., Ross, S.R. & Spiegelman, B.M. Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression. J. Cell. Biochem. 49, 219-224 (1992).