Developmental biology: SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells

Science

Volumn 310, Issue 5752, 2005, Pages 1327-1330

  Reddien, Peter W ^a,b   Oviedo, Néstor J ^a,c   Jennings, Joya R ^a   Jenkin, James C ^a   Sánchez Alvarado, Alejandro ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c FORSYTH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRRADIATION; PLANT CELL CULTURE; RNA;

ADULT STEM CELLS; GENES: SMEDWI-1; HOMEOSTASIS; HOMOLOGY;

PROTEINS;

HELMINTH PROTEIN; PIWI LIKE PROTEIN; SMEDWI 2 PROTEIN; UNCLASSIFIED DRUG; CYCLIN B;

BIOLOGY;

ARABIDOPSIS; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; DROSOPHILA; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE; GENE EXPRESSION; HOMEOSTASIS; IRRADIATION; NEOBLAST; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROGENY; PROTEIN FAMILY; REGENERATION; RNA INTERFERENCE; SCHMIDTERA MEDITERRANEA; SEQUENCE HOMOLOGY; SMEDWI 1 GENE; SMEDWI 2 GENE; STEM CELL; TURBELLARIA; AMINO ACID SEQUENCE; ANIMAL; CELL COUNT; CELL DIFFERENTIATION; CELL DIVISION; CELL MOTION; CELL SEPARATION; CELL SHAPE; CHEMISTRY; CYTOLOGY; GENETICS; MITOSIS; MOLECULAR GENETICS; PHENOTYPE; PHYSIOLOGY;

ARABIDOPSIS; PLANARIA; SCHMIDTEA MEDITERRANEA; TURBELLARIA; VERMES;

AMINO ACID SEQUENCE; ANIMALS; CELL COUNT; CELL DIFFERENTIATION; CELL DIVISION; CELL MOVEMENT; CELL SEPARATION; CELL SHAPE; CYCLIN B; FLOW CYTOMETRY; GENE EXPRESSION; GENES, HELMINTH; HELMINTH PROTEINS; HOMEOSTASIS; MITOSIS; MOLECULAR SEQUENCE DATA; PHENOTYPE; PLANARIANS; REGENERATION; RNA INTERFERENCE; STEM CELLS;

EID: 28144464878     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1116110     Document Type: Article

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20. We thank K. Agata for FACS protocols, N. H. Oh for FACS assistance, P. Newmark and F. Cebriá for discussions, B. Pearson for comments, and all Sánchez lab members for support. P.W.R. is a Helen Hay Whitney Foundation fellow. A.S.A. is a Howard Hughes Medical Institute Investigator. Supported by National Institute of General Medical Sciences grant RO-1 GM57260 (A.S.A.).