Kinome sirna screen identifies SMG-1 as a negative regulator hypoxia-inducible factor-1α in hypoxia

Journal of Biological Chemistry

Volumn 284, Issue 25, 2009, Pages 16752-16758

  Chen, Run Qiang ^a   Yang, Qing Kai ^a   Chen, Yan Ling ^a   Oliveira, Vasco A ^b   Dalton, William S ^b   Fearns, Colleen ^a   Lee, Jiing Dwan ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; ANGIOGENIC FACTOR; CARBONIC ANHYDRASE; EPIDERMAL GROWTH FACTORS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIC CELLS; HYPOXIC CONDITION; KINASE ACTIVITY; KINASE FAMILY; LOW OXYGEN; LUCIFERASE REPORTER ASSAYS; NEGATIVE REGULATORS; PHOSPHOINOSITIDE 3-KINASE; RESPONSE ELEMENTS; SMALL INTERFERENCE RNA; SURVIVAL FACTOR; TUMOR PROGRESSIONS;

CELL MEMBRANES; ENZYME INHIBITION; GENES; NUCLEIC ACIDS; OXYGEN; PATHOLOGY; RNA; SONOCHEMISTRY;

DIFFRACTION GRATINGS;

ANGIOGENIC FACTOR; ATM PROTEIN; ATR PROTEIN; CARBONATE DEHYDRATASE IX; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE SMG 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CANCER CELL; CELL HYPOXIA; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME REPRESSION; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN SECRETION; TRANSCRIPTION REGULATION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, NEOPLASM; CARBONIC ANHYDRASES; CELL HYPOXIA; CELL LINE, TUMOR; CELL MOVEMENT; GENE LIBRARY; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MAP KINASE SIGNALING SYSTEM; PROTEIN ARRAY ANALYSIS; PROTEOME; RNA, SMALL INTERFERING; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 67650541863     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.014316     Document Type: Article

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