-
1
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham R.T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15:2001;2177-2196
-
(2001)
Genes Dev.
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
2
-
-
0037415691
-
SMG-5, required for C. elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A
-
Anders K.R., Grimson A., Anderson P. SMG-5, required for C. elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. EMBO J. 22:2003;641-650
-
(2003)
EMBO J.
, vol.22
, pp. 641-650
-
-
Anders, K.R.1
Grimson, A.2
Anderson, P.3
-
3
-
-
0032508504
-
Enhanced phosphorylation of p53 by ATM in response to DNA damage
-
Banin S., Moyal L., Shieh S., Taya Y., Anderson C.W., Chessa L., Smorodinsky N.I., Prives C., Reiss Y., Shiloh Y., et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science. 281:1998;1674-1677
-
(1998)
Science
, vol.281
, pp. 1674-1677
-
-
Banin, S.1
Moyal, L.2
Shieh, S.3
Taya, Y.4
Anderson, C.W.5
Chessa, L.6
Smorodinsky, N.I.7
Prives, C.8
Reiss, Y.9
Shiloh, Y.10
-
4
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
Bartek J., Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell. 3:2003;421-429
-
(2003)
Cancer Cell
, vol.3
, pp. 421-429
-
-
Bartek, J.1
Lukas, J.2
-
5
-
-
0035834693
-
ATM phosphorylates histone H2AX in response to DNA double-strand breaks
-
Burma S., Chen B.P., Murphy M., Kurimasa A., Chen D.J. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem. 276:2001;42462-42467
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42462-42467
-
-
Burma, S.1
Chen, B.P.2
Murphy, M.3
Kurimasa, A.4
Chen, D.J.5
-
6
-
-
0031766755
-
MRNA surveillance mitigates genetic dominance in Caenorhabditis elegans
-
Cali B.M., Anderson P. mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans. Mol. Gen. Genet. 260:1998;176-184
-
(1998)
Mol. Gen. Genet.
, vol.260
, pp. 176-184
-
-
Cali, B.M.1
Anderson, P.2
-
7
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
Canman C.E., Lim D.S., Cimprich K.A., Taya Y., Tamai K., Sakaguchi K., Appella E., Kastan M.B., Siliciano J.D. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science. 281:1998;1677-1679
-
(1998)
Science
, vol.281
, pp. 1677-1679
-
-
Canman, C.E.1
Lim, D.S.2
Cimprich, K.A.3
Taya, Y.4
Tamai, K.5
Sakaguchi, K.6
Appella, E.7
Kastan, M.B.8
Siliciano, J.D.9
-
8
-
-
0037279012
-
Characterization of human Smg5/7a: A protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1
-
Chiu S.Y., Serin G., Ohara O., Maquat L.E. Characterization of human Smg5/7a. a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1 RNA. 9:2003;77-87
-
(2003)
RNA
, vol.9
, pp. 77-87
-
-
Chiu, S.Y.1
Serin, G.2
Ohara, O.3
Maquat, L.E.4
-
9
-
-
0032472330
-
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
-
Cliby W.A., Roberts C.J., Cimprich K.A., Stringer C.M., Lamb J.R., Schreiber S.L., Friend S.H. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17:1998;159-169
-
(1998)
EMBO J.
, vol.17
, pp. 159-169
-
-
Cliby, W.A.1
Roberts, C.J.2
Cimprich, K.A.3
Stringer, C.M.4
Lamb, J.R.5
Schreiber, S.L.6
Friend, S.H.7
-
10
-
-
0033082394
-
RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer
-
Culbertson M.R. RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer. Trends Genet. 15:1999;74-80
-
(1999)
Trends Genet.
, vol.15
, pp. 74-80
-
-
Culbertson, M.R.1
-
11
-
-
0035933889
-
Cloning of a novel phosphatidylinositol kinase-related kinase: Characterization of the human SMG-1 RNA surveillance protein
-
Denning G., Jamieson L., Maquat L.E., Thompson E.A., Fields A.P. Cloning of a novel phosphatidylinositol kinase-related kinase. characterization of the human SMG-1 RNA surveillance protein J. Biol. Chem. 276:2001;22709-22714
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 22709-22714
-
-
Denning, G.1
Jamieson, L.2
Maquat, L.E.3
Thompson, E.A.4
Fields, A.P.5
-
12
-
-
0029655983
-
Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo
-
Diaz-Meco M.T., Municio M.M., Sanchez P., Lozano J., Moscat J. Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo. Mol. Cell. Biol. 16:1996;105-114
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 105-114
-
-
Diaz-Meco, M.T.1
Municio, M.M.2
Sanchez, P.3
Lozano, J.4
Moscat, J.5
-
13
-
-
0032837376
-
Nonsense-mediated mRNA decay in health and disease
-
Frischmeyer P.A., Dietz H.C. Nonsense-mediated mRNA decay in health and disease. Hum. Mol. Genet. 8:1999;1893-1900
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 1893-1900
-
-
Frischmeyer, P.A.1
Dietz, H.C.2
-
14
-
-
0026456536
-
DNA damage-induced gene expression: Signal transduction and relation to growth factor signaling
-
Herrlich P., Ponta H., Rahmsdorf H.J. DNA damage-induced gene expression. signal transduction and relation to growth factor signaling Rev. Physiol. Biochem. Pharmacol. 119:1992;187-223
-
(1992)
Rev. Physiol. Biochem. Pharmacol.
, vol.119
, pp. 187-223
-
-
Herrlich, P.1
Ponta, H.2
Rahmsdorf, H.J.3
-
15
-
-
0030669170
-
Nuclear and non-nuclear targets of genotoxic agents in the induction of gene expression. Shared principles in yeast, rodents, man and plants
-
Herrlich P., Blattner C., Knebel A., Bender K., Rahmsdorf H.J. Nuclear and non-nuclear targets of genotoxic agents in the induction of gene expression. Shared principles in yeast, rodents, man and plants. Biol. Chem. 378:1997;1217-1229
-
(1997)
Biol. Chem.
, vol.378
, pp. 1217-1229
-
-
Herrlich, P.1
Blattner, C.2
Knebel, A.3
Bender, K.4
Rahmsdorf, H.J.5
-
16
-
-
0024444026
-
A new kind of informational suppression in the nematode Caenorhabditis elegans
-
Hodgkin J., Papp A., Pulak R., Ambros V., Anderson P. A new kind of informational suppression in the nematode Caenorhabditis elegans. Genetics. 123:1989;301-313
-
(1989)
Genetics
, vol.123
, pp. 301-313
-
-
Hodgkin, J.1
Papp, A.2
Pulak, R.3
Ambros, V.4
Anderson, P.5
-
17
-
-
0028856331
-
When is a lipid kinase not a lipid kinase? When it is a protein kinase
-
Hunter T. When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell. 83:1995;1-4
-
(1995)
Cell
, vol.83
, pp. 1-4
-
-
Hunter, T.1
-
18
-
-
0035823036
-
Evidence for a pioneer round of mRNA translation: MRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20
-
Ishigaki Y., Li X.J., Serin G., Maquat L.E. Evidence for a pioneer round of mRNA translation. mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20 Cell. 106:2001;607-617
-
(2001)
Cell
, vol.106
, pp. 607-617
-
-
Ishigaki, Y.1
Li, X.J.2
Serin, G.3
Maquat, L.E.4
-
19
-
-
0037341599
-
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
-
Lukas C., Falck J., Bartkova J., Bartek J., Lukas J. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat. Cell Biol. 5:2003;255-260
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 255-260
-
-
Lukas, C.1
Falck, J.2
Bartkova, J.3
Bartek, J.4
Lukas, J.5
-
20
-
-
1842693361
-
Nonsense-mediated mRNA decay in mammalian cells: From pre-mRNA splicing to mRNA translation and degradation
-
J. Lapointe, & L. Brakier-Gingras. Austin, TX: Landes Biosciences
-
Maquat L.E. Nonsense-mediated mRNA decay in mammalian cells. from pre-mRNA splicing to mRNA translation and degradation Lapointe J., Brakier-Gingras L. Translation Mechanisms. 2003;213-222 Landes Biosciences, Austin, TX
-
(2003)
Translation Mechanisms
, pp. 213-222
-
-
Maquat, L.E.1
-
21
-
-
0035951432
-
Quality control of mRNA function
-
Maquat L.E., Carmichael G.G. Quality control of mRNA function. Cell. 104:2001;173-176
-
(2001)
Cell
, vol.104
, pp. 173-176
-
-
Maquat, L.E.1
Carmichael, G.G.2
-
22
-
-
0035339357
-
ATM-dependent phosphorylation of Mdm2 on serine 395: Role in p53 activation by DNA damage
-
Maya R., Balass M., Kim S.T., Shkedy D., Leal J.F.M., Shifman O., Moas M., Buschmann T., Ronai Z., Shiloh Y., et al. ATM-dependent phosphorylation of Mdm2 on serine 395. role in p53 activation by DNA damage Genes Dev. 15:2001;1067-1077
-
(2001)
Genes Dev.
, vol.15
, pp. 1067-1077
-
-
Maya, R.1
Balass, M.2
Kim, S.T.3
Shkedy, D.4
Leal, J.F.M.5
Shifman, O.6
Moas, M.7
Buschmann, T.8
Ronai, Z.9
Shiloh, Y.10
-
23
-
-
0037064145
-
Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts
-
Mendell J.T., Rhys C., Dietz H.C. Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts. Science. 298:2002;419-422
-
(2002)
Science
, vol.298
, pp. 419-422
-
-
Mendell, J.T.1
Rhys, C.2
Dietz, H.C.3
-
24
-
-
0034112360
-
P53 and cell-cycle control: A finger in every pie
-
North S., Hainaut P. p53 and cell-cycle control. a finger in every pie Pathol. Biol. 48:2000;255-270
-
(2000)
Pathol. Biol.
, vol.48
, pp. 255-270
-
-
North, S.1
Hainaut, P.2
-
25
-
-
10744232514
-
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7
-
Ohnishi T., Yamashita A., Kashima I., Schell T., Anders K.R., Grimson A., Hachiya T., Hentze M.W., Anderson P., Ohno S. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Mol. Cell. 12:2003;1187-1200
-
(2003)
Mol. Cell
, vol.12
, pp. 1187-1200
-
-
Ohnishi, T.1
Yamashita, A.2
Kashima, I.3
Schell, T.4
Anders, K.R.5
Grimson, A.6
Hachiya, T.7
Hentze, M.W.8
Anderson, P.9
Ohno, S.10
-
26
-
-
0034725592
-
Utilization of oriented peptide libraries to identify substrate motifs selected by ATM
-
O'Neill T., Dwyer A.J., Ziv Y., Chan D.W., Lees-Miller S.P., Abraham R.H., Lai J.H., Hill D., Shiloh Y., Cantley L.C., et al. Utilization of oriented peptide libraries to identify substrate motifs selected by ATM. J. Biol. Chem. 275:2000;22719-22727
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 22719-22727
-
-
O'Neill, T.1
Dwyer, A.J.2
Ziv, Y.3
Chan, D.W.4
Lees-Miller, S.P.5
Abraham, R.H.6
Lai, J.H.7
Hill, D.8
Shiloh, Y.9
Cantley, L.C.10
-
27
-
-
0032771414
-
SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast
-
Page M.F., Carr B., Anders K.R., Grimson A., Anderson P. SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Mol. Cell. Biol. 19:1999;5943-5951
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 5943-5951
-
-
Page, M.F.1
Carr, B.2
Anders, K.R.3
Grimson, A.4
Anderson, P.5
-
28
-
-
0035038083
-
Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway
-
Pal M., Ishigaki Y., Nagy E., Maquat L.E. Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway. RNA. 7:2001;5-15
-
(2001)
RNA
, vol.7
, pp. 5-15
-
-
Pal, M.1
Ishigaki, Y.2
Nagy, E.3
Maquat, L.E.4
-
29
-
-
0028936626
-
Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay
-
Powell S.N., DeFrank J.S., Connell P., Eogan M., Preffer F., Dombkowski D., Tang W., Friend S. Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay. Cancer Res. 55:1995;1643-1648
-
(1995)
Cancer Res.
, vol.55
, pp. 1643-1648
-
-
Powell, S.N.1
Defrank, J.S.2
Connell, P.3
Eogan, M.4
Preffer, F.5
Dombkowski, D.6
Tang, W.7
Friend, S.8
-
30
-
-
0027382460
-
MRNA surveillance by the Caenorhabditis elegans smg genes
-
Pulak R., Anderson P. mRNA surveillance by the Caenorhabditis elegans smg genes. Genes Dev. 7:1993;1885-1897
-
(1993)
Genes Dev.
, vol.7
, pp. 1885-1897
-
-
Pulak, R.1
Anderson, P.2
-
31
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273:1998;5858-5868
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
32
-
-
0032861343
-
Megabase chromatin domains involved in DNA double-strand breaks in vivo
-
Rogakou E.P., Boon C., Redon C., Bonner W.M. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 146:1999;905-916
-
(1999)
J. Cell Biol.
, vol.146
, pp. 905-916
-
-
Rogakou, E.P.1
Boon, C.2
Redon, C.3
Bonner, W.M.4
-
33
-
-
0032189483
-
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
-
Sarkaria J.N., Tibbetts R.S., Busby E.C., Kennedy A.P., Hill D.E., Abraham R.T. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res. 58:1998;4375-4382
-
(1998)
Cancer Res.
, vol.58
, pp. 4375-4382
-
-
Sarkaria, J.N.1
Tibbetts, R.S.2
Busby, E.C.3
Kennedy, A.P.4
Hill, D.E.5
Abraham, R.T.6
-
34
-
-
0027417482
-
Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events
-
Secrist J.P., Burns L.A., Karnitz L., Koretzky G.A., Abraham R.T. Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J. Biol. Chem. 268:1993;5886-5893
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 5886-5893
-
-
Secrist, J.P.1
Burns, L.A.2
Karnitz, L.3
Koretzky, G.A.4
Abraham, R.T.5
-
35
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh Y. ATM and related protein kinases. safeguarding genome integrity Nat. Rev. Cancer. 3:2003;155-168
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
36
-
-
0032544062
-
A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells
-
Sun X., Perlick H.A., Dietz H.C., Maquat L.E. A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells. Proc. Natl. Acad. Sci. USA. 95:1998;10009-10014
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 10009-10014
-
-
Sun, X.1
Perlick, H.A.2
Dietz, H.C.3
Maquat, L.E.4
-
38
-
-
0033555260
-
A role for ATR in the DNA damage-induced phosphorylation of p53
-
Tibbetts R.S., Brumbaugh K.M., Williams J.M., Sarkaria J.N., Cliby W.A., Shieh S.Y., Taya Y., Prives C., Abraham R.T. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13:1999;152-157
-
(1999)
Genes Dev.
, vol.13
, pp. 152-157
-
-
Tibbetts, R.S.1
Brumbaugh, K.M.2
Williams, J.M.3
Sarkaria, J.N.4
Cliby, W.A.5
Shieh, S.Y.6
Taya, Y.7
Prives, C.8
Abraham, R.T.9
-
39
-
-
0028849274
-
P21 is necessary for the p53-mediated G1 arrest in human cancer cells
-
Waldman T., Kinzler K.W., Vogelstein B. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res. 55:1995;5187-5190
-
(1995)
Cancer Res.
, vol.55
, pp. 5187-5190
-
-
Waldman, T.1
Kinzler, K.W.2
Vogelstein, B.3
-
40
-
-
0036809882
-
Nonsense-associated altered splicing: A frame-dependent response distinct from nonsense-mediated decay
-
Wang J., Chang Y.F., Hamilton J.I., Wilkinson M.F. Nonsense-associated altered splicing. a frame-dependent response distinct from nonsense-mediated decay Mol. Cell. 10:2002;951-957
-
(2002)
Mol. Cell
, vol.10
, pp. 951-957
-
-
Wang, J.1
Chang, Y.F.2
Hamilton, J.I.3
Wilkinson, M.F.4
-
41
-
-
0035930537
-
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
-
Ward I.M., Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 276:2001;47759-47762
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47759-47762
-
-
Ward, I.M.1
Chen, J.2
-
42
-
-
0037102275
-
Phosphorylation of serine 1387 in brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation
-
Xu B., O'Donnell H., Kim S.T., Kastan M.B. Phosphorylation of serine 1387 in brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. Cancer Res. 62:2002;4588-4591
-
(2002)
Cancer Res.
, vol.62
, pp. 4588-4591
-
-
Xu, B.1
O'Donnell, H.2
Kim, S.T.3
Kastan, M.B.4
-
43
-
-
0035449691
-
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
-
Yamashita A., Ohnishi T., Kashima I., Taya Y., Ohno S. Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev. 15:2001;2215-2228
-
(2001)
Genes Dev.
, vol.15
, pp. 2215-2228
-
-
Yamashita, A.1
Ohnishi, T.2
Kashima, I.3
Taya, Y.4
Ohno, S.5
-
44
-
-
16044371194
-
Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase
-
Yao S.L., Akhtar A.J., McKenna K.A., Bedi G.C., Sidransky D., Mabry M., Ravi R., Collector M.I., Jones R.J., Sharkis S.J., et al. Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase. Nat. Med. 2:1996;1140-1143
-
(1996)
Nat. Med.
, vol.2
, pp. 1140-1143
-
-
Yao, S.L.1
Akhtar, A.J.2
McKenna, K.A.3
Bedi, G.C.4
Sidransky, D.5
Mabry, M.6
Ravi, R.7
Collector, M.I.8
Jones, R.J.9
Sharkis, S.J.10
|