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Volumn 1, Issue 1, 2009, Pages 3-14

Is the adipose tissue the key road to inflammation?

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84859118923     PISSN: None     EISSN: 11786345     Source Type: Journal    
DOI: 10.4137/iii.s2145     Document Type: Review
Times cited : (9)

References (115)
  • 1
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 2
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-32.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3
  • 3
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: Mediators linking adipose tissue, inflammation and immunity
    • Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 2006;6:772-83.
    • (2006) Nat Rev Immunol , vol.6 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 4
    • 21844468939 scopus 로고    scopus 로고
    • Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells
    • Shen J, Sakaida I, Uchida K, et al. Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells. Life Sci. 2005;77:1502-15.
    • (2005) Life Sci , vol.77 , pp. 1502-1515
    • Shen, J.1    Sakaida, I.2    Uchida, K.3
  • 5
    • 0034058378 scopus 로고    scopus 로고
    • Leptin-deficient (ob/ob) mice are protected from T-cell-mediated hepatotoxicity: Role of tumor necrosis factor alpha and IL-18
    • Faggioni R, Jones-Carson J, Reed DA, et al. Leptin-deficient (ob/ob) mice are protected from T-cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18. Proc Natl Acad Sci U S A. 2000;97:2367-72.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 2367-2372
    • Faggioni, R.1    Jones-Carson, J.2    Reed, D.A.3
  • 6
    • 17544382289 scopus 로고    scopus 로고
    • AdipoQ is a novel adipose-specific gene dysregulated in obesity
    • Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem. 1996;271:10697-703.
    • (1996) J Biol Chem , vol.271 , pp. 10697-11703
    • Hu, E.1    Liang, P.2    Spiegelman, B.M.3
  • 7
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, et al. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest. 1995;95:2409-15.
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3
  • 8
    • 0035023128 scopus 로고    scopus 로고
    • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    • Kern PA, Ranganathan S, Li C, et al. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab. 2001;280:E745-51.
    • (2001) Am J Physiol Endocrinol Metab , vol.280
    • Kern, P.A.1    Ranganathan, S.2    Li, C.3
  • 9
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003; 112:1796-808.
    • (2003) J Clin Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3
  • 10
    • 0038039463 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha: A key regulator of adipose tissue mass
    • Warne JP. Tumour necrosis factor alpha: a key regulator of adipose tissue mass. J Endocrinol. 2003;177:351-5.
    • (2003) J Endocrinol , vol.177 , pp. 351-355
    • Warne, J.P.1
  • 11
    • 37349006913 scopus 로고    scopus 로고
    • TNF-alpha and adipocyte biology
    • Cawthorn WP, Sethi JK. TNF-alpha and adipocyte biology. FEBS Lett. 2008;582:117-31.
    • (2008) FEBS Lett , vol.582 , pp. 117-131
    • Cawthorn, W.P.1    Sethi, J.K.2
  • 12
    • 0031022434 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction
    • Stephens JM, Lee J, Pilch PF. Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J Biol Chem. 1997;272:971-6.
    • (1997) J Biol Chem , vol.272 , pp. 971-976
    • Stephens, J.M.1    Lee, J.2    Pilch, P.F.3
  • 13
    • 0036828912 scopus 로고    scopus 로고
    • Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factoralpha: Implications for insulin resistance
    • Ruan H, Miles PD, Ladd CM, et al. Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factoralpha: implications for insulin resistance. Diabetes. 2002b;51:3176-88.
    • (2002) Diabetes , vol.51 , pp. 3176-3188
    • Ruan, H.1    Miles, P.D.2    Ladd, C.M.3
  • 14
    • 0036313033 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: Nuclear factor-kappaB activation by TNF-alpha is obligatory
    • Ruan H, Hacohen N, Golub TR, et al. Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory. Diabetes. 2002a;51:1319-36.
    • (2002) Diabetes , vol.51 , pp. 1319-1336
    • Ruan, H.1    Hacohen, N.2    Golub, T.R.3
  • 15
    • 0023927767 scopus 로고
    • Recombinant human cachectin/ tumor necrosis factor but not interleukin-1 alpha downregulates lipoprotein lipase gene expression at the transcriptional level in mouse 3T3-L1 adipocytes
    • Zechner R, Newman TC, Sherry B, et al. Recombinant human cachectin/ tumor necrosis factor but not interleukin-1 alpha downregulates lipoprotein lipase gene expression at the transcriptional level in mouse 3T3-L1 adipocytes. Mol Cell Biol. 1988;8:2394-401.
    • (1988) Mol Cell Biol , vol.8 , pp. 2394-2401
    • Zechner, R.1    Newman, T.C.2    Sherry, B.3
  • 16
    • 0028302002 scopus 로고
    • Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase
    • Green A, Dobias SB, Walters DJ, et al. Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase. Endocrinology. 1994;134:2581-8.
    • (1994) Endocrinology , vol.134 , pp. 2581-2588
    • Green, A.1    Dobias, S.B.2    Walters, D.J.3
  • 17
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesityinduced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, et al. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesityinduced insulin resistance. Science. 1996;271:665-8.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3
  • 18
    • 0034153883 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha stimulates cell proliferation in adipose tissue-derived stromal-vascular cell culture: Promotion of adipose tissue expansion by paracrine growth factors
    • Kras KM, Hausman DB, Martin RJ. Tumor necrosis factor-alpha stimulates cell proliferation in adipose tissue-derived stromal-vascular cell culture: promotion of adipose tissue expansion by paracrine growth factors. Obes Res. 2000;8:186-93.
    • (2000) Obes Res , vol.8 , pp. 186-193
    • Kras, K.M.1    Hausman, D.B.2    Martin, R.J.3
  • 19
    • 2042480671 scopus 로고    scopus 로고
    • Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans
    • Fain JN, Madan AK, Hiler ML, et al. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology. 2004;145:2273-82.
    • (2004) Endocrinology , vol.145 , pp. 2273-2282
    • Fain, J.N.1    Madan, A.K.2    Hiler, M.L.3
  • 20
    • 0031762908 scopus 로고    scopus 로고
    • Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid
    • Fried SK, Bunkin DA, Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab. 1998;83:847-50.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 847-850
    • Fried, S.K.1    Bunkin, D.A.2    Greenberg, A.S.3
  • 21
    • 0026032419 scopus 로고
    • The metabolic effects of tumor necrosis factor and other cytokines
    • Grunfeld C, Feingold KR. The metabolic effects of tumor necrosis factor and other cytokines. Biotherapy. 1991;3:143-58.
    • (1991) Biotherapy , vol.3 , pp. 143-158
    • Grunfeld, C.1    Feingold, K.R.2
  • 22
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • Kanda H, Tateya S, Tamori Y, et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest. 2006;116:1494-505.
    • (2006) J Clin Invest , vol.116 , pp. 1494-1505
    • Kanda, H.1    Tateya, S.2    Tamori, Y.3
  • 23
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman JM and Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395:763-70.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 24
    • 0033515761 scopus 로고    scopus 로고
    • Paradoxical decrease of an adiposespecific protein, adiponectin, in obesity
    • Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adiposespecific protein, adiponectin, in obesity. Biochem Biophys Res Commun. 1999;257:79-83.
    • (1999) Biochem Biophys Res Commun , vol.257 , pp. 79-83
    • Arita, Y.1    Kihara, S.2    Ouchi, N.3
  • 25
    • 2442618838 scopus 로고    scopus 로고
    • The weight of leptin in immunity
    • La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol. 2004;4:371-9.
    • (2004) Nat Rev Immunol , vol.4 , pp. 371-379
    • la Cava, A.1    Matarese, G.2
  • 27
    • 11844253254 scopus 로고    scopus 로고
    • Leptin, from fat to inflammation: Old questions and new insights
    • Otero M, Lago R, Lago F, et al. Leptin, from fat to inflammation: old questions and new insights. FEBS Lett. 2005;579:295-301.
    • (2005) FEBS Lett , vol.579 , pp. 295-301
    • Otero, M.1    Lago, R.2    Lago, F.3
  • 28
    • 0032917633 scopus 로고    scopus 로고
    • Leptin deficiency enhances sensitivity to endotoxin-induced lethality
    • Faggioni R, Fantuzzi G, Gabay C, et al. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol. 1999;276: R136-42.
    • (1999) Am J Physiol , vol.276
    • Faggioni, R.1    Fantuzzi, G.2    Gabay, C.3
  • 29
    • 33744946045 scopus 로고    scopus 로고
    • Leptin receptor expression and signaling in lymphocytes: Kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice
    • Papathanassoglou E, El-Haschimi K, Li XC, et al. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol. 2006;176:7745-52.
    • (2006) J Immunol , vol.176 , pp. 7745-7752
    • Papathanassoglou, E.1    El-Haschimi, K.2    Li, X.C.3
  • 30
    • 33750311697 scopus 로고    scopus 로고
    • Impairment of dendritic cell functionality and steady-state number in obese mice
    • Macia L, Delacre M, Abboud G, et al. Impairment of dendritic cell functionality and steady-state number in obese mice. J Immunol. 2006;177:5997-6006.
    • (2006) J Immunol , vol.177 , pp. 5997-6006
    • Macia, L.1    Delacre, M.2    Abboud, G.3
  • 31
    • 33749560678 scopus 로고    scopus 로고
    • Influence of high-fat feeding on both naïve and antigen-experienced T-cell immune response in DO 10.11 mice
    • Verwaerde C, Delanoye A, Macia L, et al. Influence of high-fat feeding on both naïve and antigen-experienced T-cell immune response in DO 10.11 mice. Scand J Immunol. 2006;64:457-66.
    • (2006) Scand J Immunol , vol.64 , pp. 457-466
    • Verwaerde, C.1    Delanoye, A.2    Macia, L.3
  • 32
    • 34347383552 scopus 로고    scopus 로고
    • An assessment of serum leptin levels in patients with chronic viral hepatitis: A prospective study
    • Manolakopoulos S, Bethanis S, Liapi C, et al. An assessment of serum leptin levels in patients with chronic viral hepatitis: a prospective study. BMC Gastroenterol. 2007;7:17.
    • (2007) BMC Gastroenterol , vol.7 , pp. 17
    • Manolakopoulos, S.1    Bethanis, S.2    Liapi, C.3
  • 33
    • 23244450956 scopus 로고    scopus 로고
    • Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes
    • Ajuwon KM, Spurlock ME. Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes. J Nutr. 2005;135:1841-6.
    • (2005) J Nutr , vol.135 , pp. 1841-1846
    • Ajuwon, K.M.1    Spurlock, M.E.2
  • 34
    • 0033613545 scopus 로고    scopus 로고
    • Novel modulator for endothelial adhesion molecules:Adipocyte-derived plasma protein adiponectin
    • Ouchi N, Kihara S, Arita Y, et al. Novel modulator for endothelial adhesion molecules:adipocyte-derived plasma protein adiponectin. Circulation. 1999;100:2473-6.
    • (1999) Circulation , vol.100 , pp. 2473-2476
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3
  • 35
    • 1442275317 scopus 로고    scopus 로고
    • Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes
    • Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004;27:813-23.
    • (2004) Diabetes Care , vol.27 , pp. 813-823
    • Pickup, J.C.1
  • 38
    • 0037380645 scopus 로고    scopus 로고
    • Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs
    • Andonegui G, Bonder CS, Green F, et al. Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J Clin Invest. 2003;111:1011-20.
    • (2003) J Clin Invest , vol.111 , pp. 1011-1020
    • Andonegui, G.1    Bonder, C.S.2    Green, F.3
  • 39
    • 33846243725 scopus 로고    scopus 로고
    • Proximal effects of Toll-like receptor activation in dendritic cells
    • Watts C, Zaru R, Prescott AR, et al. Proximal effects of Toll-like receptor activation in dendritic cells. Curr Opin Immunol. 2007;19:73-8.
    • (2007) Curr Opin Immunol , vol.19 , pp. 73-78
    • Watts, C.1    Zaru, R.2    Prescott, A.R.3
  • 40
    • 0034637439 scopus 로고    scopus 로고
    • The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes
    • Lin Y, Lee H, Berg AH, et al. The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem. 2000;275:24255-63.
    • (2000) J Biol Chem , vol.275 , pp. 24255-24263
    • Lin, Y.1    Lee, H.2    Berg, A.H.3
  • 41
    • 33846465070 scopus 로고    scopus 로고
    • Presence of functional TLR2 and TLR4 on human adipocytes
    • Bes-Houtmann S, Roche R, Hoareau L, et al. Presence of functional TLR2 and TLR4 on human adipocytes. Histochem Cell Biol. 2007;127:131-7.
    • (2007) Histochem Cell Biol , vol.127 , pp. 131-137
    • Bes-Houtmann, S.1    Roche, R.2    Hoareau, L.3
  • 42
    • 34247573389 scopus 로고    scopus 로고
    • Differentiation-dependent expression of interferon gamma and toll-like receptor 9 in 3T3-F442A adipocytes
    • Khazen W, M'Bika JP, Collinet M, et al. Differentiation-dependent expression of interferon gamma and toll-like receptor 9 in 3T3-F442A adipocytes. Biochimie. 2007;89:669-75.
    • (2007) Biochimie , vol.89 , pp. 669-675
    • Khazen, W.1    M'Bika, J.P.2    Collinet, M.3
  • 43
    • 34447302602 scopus 로고    scopus 로고
    • Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes
    • Batra A, Pietsch J, Fedke I, et al. Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes. Am J Pathol. 2007;170:1931-41.
    • (2007) Am J Pathol , vol.170 , pp. 1931-1941
    • Batra, A.1    Pietsch, J.2    Fedke, I.3
  • 44
    • 33947637709 scopus 로고    scopus 로고
    • Preadipocyte response and impairment of differentiation in an inflammatory environment
    • Poulain-Godefroy O, Froguel P. Preadipocyte response and impairment of differentiation in an inflammatory environment. Biochem Biophys Res Commun. 2007;356:662-7.
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 662-667
    • Poulain-Godefroy, O.1    Froguel, P.2
  • 45
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi H, Kokoeva MV, Inouye K, et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006;116: 3015-25.
    • (2006) J Clin Invest , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3
  • 46
    • 33745187112 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
    • Song MJ, Kim KH, Yoon JM, et al. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun. 2006;346:739-45.
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 739-745
    • Song, M.J.1    Kim, K.H.2    Yoon, J.M.3
  • 47
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56:1761-72.
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1    Amar, J.2    Iglesias, M.A.3
  • 48
    • 9444223848 scopus 로고    scopus 로고
    • A genetic basis for the "Adonis" phenotype of low adiposity and strong bones
    • Johnson GB, Riggs BL, Platt JL. A genetic basis for the "Adonis" phenotype of low adiposity and strong bones. Faseb J. 2004;18: 1282-4.
    • (2004) Faseb J , vol.18 , pp. 1282-1284
    • Johnson, G.B.1    Riggs, B.L.2    Platt, J.L.3
  • 49
    • 34247884376 scopus 로고    scopus 로고
    • C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet
    • Poggi M, Bastelica D, Gual P, et al. C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Diabetologia. 2007;50:1267-76.
    • (2007) Diabetologia , vol.50 , pp. 1267-1276
    • Poggi, M.1    Bastelica, D.2    Gual, P.3
  • 50
    • 33846302361 scopus 로고    scopus 로고
    • Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation
    • Suganami T, Mieda T, Itoh M, et al. Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation. Biochem Biophys Res Commun. 2007;354:45-9.
    • (2007) Biochem Biophys Res Commun , vol.354 , pp. 45-49
    • Suganami, T.1    Mieda, T.2    Itoh, M.3
  • 51
    • 34250169823 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
    • Kim F, Pham M, Luttrell I, et al. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res. 2007a;100:1589-96.
    • (2007) Circ Res , vol.100 , pp. 1589-1596
    • Kim, F.1    Pham, M.2    Luttrell, I.3
  • 52
    • 34547602916 scopus 로고    scopus 로고
    • Lossof- function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    • Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, et al. Lossof- function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes. 2007;56:1986-98.
    • (2007) Diabetes , vol.56 , pp. 1986-1998
    • Tsukumo, D.M.1    Carvalho-Filho, M.A.2    Carvalheira, J.B.3
  • 53
    • 1642633752 scopus 로고    scopus 로고
    • Inflamed about obesity
    • Lehrke M, Lazar MA. Inflamed about obesity. Nat Med. 2004;10:126-7.
    • (2004) Nat Med , vol.10 , pp. 126-127
    • Lehrke, M.1    Lazar, M.A.2
  • 54
    • 0038660699 scopus 로고    scopus 로고
    • Preadipocyte conversion to macrophage. Evidence of plasticity
    • Charriere G, Cousin B, Arnaud E, et al. Preadipocyte conversion to macrophage. Evidence of plasticity. J Biol Chem. 2003;278:9850-5.
    • (2003) J Biol Chem , vol.278 , pp. 9850-9855
    • Charriere, G.1    Cousin, B.2    Arnaud, E.3
  • 55
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat Rev Immunol. 2003;3:23-35.
    • (2003) Nat Rev Immunol , vol.3 , pp. 23-35
    • Gordon, S.1
  • 56
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • Mantovani A, Sica A, Sozzani S, et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004;25:677-86.
    • (2004) Trends Immunol , vol.25 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3
  • 57
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986;136:2348-57.
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3
  • 58
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112:1821-30.
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 59
    • 33644826101 scopus 로고    scopus 로고
    • Macrophages in human visceral adipose tissue: Increased accumulation in obesity and a source of resistin and visfatin
    • Curat CA, Wegner V, Sengenes C, et al. Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin. Diabetologia. 2006;49:744-7.
    • (2006) Diabetologia , vol.49 , pp. 744-747
    • Curat, C.A.1    Wegner, V.2    Sengenes, C.3
  • 60
    • 23644450775 scopus 로고    scopus 로고
    • Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss
    • Cancello R, Henegar C, Viguerie N, et al. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes. 2005;54:2277-86.
    • (2005) Diabetes , vol.54 , pp. 2277-2286
    • Cancello, R.1    Henegar, C.2    Viguerie, N.3
  • 61
    • 33646397556 scopus 로고    scopus 로고
    • Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects
    • Bruun JM, Helge JW, Richelsen B, et al. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab. 2006;290:E961-7.
    • (2006) Am J Physiol Endocrinol Metab , vol.290
    • Bruun, J.M.1    Helge, J.W.2    Richelsen, B.3
  • 62
    • 2342537773 scopus 로고    scopus 로고
    • From blood monocytes to adipose tissue-resident macrophages: Induction of diapedesis by human mature adipocytes
    • Curat CA, Miranville A, Sengenes C, et al. From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes. 2004;53:1285-92.
    • (2004) Diabetes , vol.53 , pp. 1285-1292
    • Curat, C.A.1    Miranville, A.2    Sengenes, C.3
  • 63
    • 31044456529 scopus 로고    scopus 로고
    • CCR2 modulates inflammatory and metabolic effects of high-fat feeding
    • Weisberg SP, Hunter D, Huber R, et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest. 2006; 116:115-24.
    • (2006) J Clin Invest , vol.116 , pp. 115-124
    • Weisberg, S.P.1    Hunter, D.2    Huber, R.3
  • 64
    • 34548434020 scopus 로고    scopus 로고
    • Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue
    • Inouye KE, Shi H, Howard JK, et al. Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes. 2007;56:2242-50.
    • (2007) Diabetes , vol.56 , pp. 2242-2250
    • Inouye, K.E.1    Shi, H.2    Howard, J.K.3
  • 65
    • 48449102722 scopus 로고    scopus 로고
    • Macrophage chemoattractant protein-1 deficiency fails to restrain macrophage infiltration into adipose tissue
    • Kirk EA, Sagawa ZK, McDonald TO, et al. Macrophage chemoattractant protein-1 deficiency fails to restrain macrophage infiltration into adipose tissue. Diabetes. 2008;57:1254-61.
    • (2008) Diabetes , vol.57 , pp. 1254-1261
    • Kirk, E.A.1    Sagawa, Z.K.2    McDonald, T.O.3
  • 66
    • 34948813665 scopus 로고    scopus 로고
    • Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice
    • Nomiyama T, Perez-Tilve D, Ogawa D, et al. Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest. 2007;117:2877-88.
    • (2007) J Clin Invest , vol.117 , pp. 2877-2888
    • Nomiyama, T.1    Perez-Tilve, D.2    Ogawa, D.3
  • 68
    • 36148989537 scopus 로고    scopus 로고
    • Obesity-associated mouse adipose stem cell secretion of monocyte chemotactic protein-1
    • Zhou HR, Kim EK, Kim H, et al. Obesity-associated mouse adipose stem cell secretion of monocyte chemotactic protein-1. Am J Physiol Endocrinol Metab. 2007;293:E11153-8.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Zhou, H.R.1    Kim, E.K.2    Kim, H.3
  • 69
    • 34848872799 scopus 로고    scopus 로고
    • Obesity-associated improvements in metabolic profile through expansion of adipose tissue
    • Kim JY, van de Wall E, Laplante M, et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest. 2007b;117:2621-37.
    • (2007) J Clin Invest , vol.117 , pp. 2621-2637
    • Kim, J.Y.1    van de Wall, E.2    Laplante, M.3
  • 70
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti S, Mitchell G, Barbatelli G, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res. 2005;46:2347-55.
    • (2005) J Lipid Res , vol.46 , pp. 2347-2355
    • Cinti, S.1    Mitchell, G.2    Barbatelli, G.3
  • 71
    • 36849012057 scopus 로고    scopus 로고
    • Adipocyte death, adipose tissue remodeling, and obesity complications
    • Strissel KJ, Stancheva Z, Miyoshi H, et al. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes. 2007;56:2910-8.
    • (2007) Diabetes , vol.56 , pp. 2910-2918
    • Strissel, K.J.1    Stancheva, Z.2    Miyoshi, H.3
  • 72
    • 33845975254 scopus 로고    scopus 로고
    • Macrophage heterogeneity and tissue lipids
    • Gordon S. Macrophage heterogeneity and tissue lipids. J Clin Invest. 2007;117:89-93.
    • (2007) J Clin Invest , vol.117 , pp. 89-93
    • Gordon, S.1
  • 73
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    • Lumeng CN, Deyoung SM, Bodzin JL, et al. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 2007b;56:16-23.
    • (2007) Diabetes , vol.56 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3
  • 74
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007a;117:175-84.
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 75
    • 44349112305 scopus 로고    scopus 로고
    • Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    • Kang K, Reilly SM, Karabacak V, et al. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008;7:485-95.
    • (2008) Cell Metab , vol.7 , pp. 485-495
    • Kang, K.1    Reilly, S.M.2    Karabacak, V.3
  • 76
    • 33745428666 scopus 로고    scopus 로고
    • Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
    • Vats D, Mukundan L, Odegaard JI, et al. Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab. 2006;4:13-24.
    • (2006) Cell Metab , vol.4 , pp. 13-24
    • Vats, D.1    Mukundan, L.2    Odegaard, J.I.3
  • 77
    • 0030842027 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma and the control of adipogenesis
    • Brun RP, Kim JB, Hu E, et al. Peroxisome proliferator-activated receptor gamma and the control of adipogenesis. Curr Opin Lipidol. 1997;8:212-8.
    • (1997) Curr Opin Lipidol , vol.8 , pp. 212-218
    • Brun, R.P.1    Kim, J.B.2    Hu, E.3
  • 78
    • 0842263981 scopus 로고    scopus 로고
    • The biology of peroxisome proliferator-activated receptors: Relationship with lipid metabolism and insulin sensitivity
    • Ferre P. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes. 2004;53:S43-50.
    • (2004) Diabetes , vol.53
    • Ferre, P.1
  • 79
    • 50649097541 scopus 로고    scopus 로고
    • Fat and beyond: The diverse biology of PPARgamma
    • Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem. 2008;77:289-312.
    • (2008) Annu Rev Biochem , vol.77 , pp. 289-312
    • Tontonoz, P.1    Spiegelman, B.M.2
  • 80
    • 34347354309 scopus 로고    scopus 로고
    • Macrophagespecific PPARgamma controls alternative activation and improves insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, et al. Macrophagespecific PPARgamma controls alternative activation and improves insulin resistance. Nature. 2007;447:1116-20.
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Goforth, M.H.3
  • 81
    • 39549122799 scopus 로고    scopus 로고
    • Remodeling phenotype of human subcutaneous adipose tissue macrophages
    • Epub 2008; Jan 28
    • Bourlier V, Zakaroff-Girard A, Miranville A, et al. Remodeling phenotype of human subcutaneous adipose tissue macrophages. Circulation. 2008;117:806-15.Epub 2008; Jan 28.
    • (2008) Circulation , vol.117 , pp. 806-815
    • Bourlier, V.1    Zakaroff-Girard, A.2    Miranville, A.3
  • 82
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    • Nguyen MT, Favelyukis S, Nguyen AK, et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem. 2007;282:35279-92.
    • (2007) J Biol Chem , vol.282 , pp. 35279-35292
    • Nguyen, M.T.1    Favelyukis, S.2    Nguyen, A.K.3
  • 83
    • 52749092267 scopus 로고    scopus 로고
    • Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
    • Patsouris D, Li PP, Thapar D, et al. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab. 2008;8:301-9.
    • (2008) Cell Metab , vol.8 , pp. 301-309
    • Patsouris, D.1    Li, P.P.2    Thapar, D.3
  • 84
    • 21244474452 scopus 로고    scopus 로고
    • Adipose tissues as an ancestral immune organ: Site-specific change in obesity
    • Caspar-Bauguil S, Cousin B, Galinier A, et al. Adipose tissues as an ancestral immune organ: site-specific change in obesity. FEBS Lett. 2005;579:3487-92.
    • (2005) FEBS Lett , vol.579 , pp. 3487-3492
    • Caspar-Bauguil, S.1    Cousin, B.2    Galinier, A.3
  • 85
    • 33847280286 scopus 로고    scopus 로고
    • T-cell accumulation and regulated on activation, normal T-cell expressed and secreted upregulation in adipose tissue in obesity
    • Wu H, Ghosh S, Perrard XD, et al. T-cell accumulation and regulated on activation, normal T-cell expressed and secreted upregulation in adipose tissue in obesity. Circulation. 2007;115:1029-38.
    • (2007) Circulation , vol.115 , pp. 1029-1038
    • Wu, H.1    Ghosh, S.2    Perrard, X.D.3
  • 86
    • 46249117032 scopus 로고    scopus 로고
    • T-lymphocyte infiltration in visceral adipose tissue: A primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler
    • Kintscher U, Hartge M, Hess K, et al. T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vase Biol. 2008;28:1304-10.
    • (2008) Thromb Vase Biol , vol.28 , pp. 1304-1310
    • Kintscher, U.1    Hartge, M.2    Hess, K.3
  • 87
    • 84872754367 scopus 로고    scopus 로고
    • Interferon-{gamma}, a Th1 Cytokine, Regulates Fat Inflammation. A Role for Adaptive Immunity in Obesity
    • Rocha VZ, Folco EJ, Sukhova G, et al. Interferon-{gamma}, a Th1 Cytokine, Regulates Fat Inflammation. A Role for Adaptive Immunity in Obesity. Circ Res. 2008;24:24.
    • (2008) Circ Res , vol.24 , pp. 24
    • Rocha, V.Z.1    Folco, E.J.2    Sukhova, G.3
  • 88
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    • Lord GM, Matarese G, Howard JK, et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998;394:897-901.
    • (1998) Nature , vol.394 , pp. 897-901
    • Lord, G.M.1    Matarese, G.2    Howard, J.K.3
  • 89
    • 2342427536 scopus 로고    scopus 로고
    • Glucocorticoids and 11betahydroxysteroid dehydrogenase in adipose tissue
    • Seckl JR, Morton NM, Chapman KE, et al. Glucocorticoids and 11betahydroxysteroid dehydrogenase in adipose tissue. Recent Prog Horm Res. 2004;59:359-93.
    • (2004) Recent Prog Horm Res , vol.59 , pp. 359-393
    • Seckl, J.R.1    Morton, N.M.2    Chapman, K.E.3
  • 90
    • 33750620067 scopus 로고    scopus 로고
    • Mechanisms of disease: Regulation of glucocorticoid and receptor levels-impact on the metabolic syndrome
    • Witchel SF, DeFranco DB. Mechanisms of disease: regulation of glucocorticoid and receptor levels-impact on the metabolic syndrome. Nat Clin Pract Endocrinol Metab. 2006;2:621-31.
    • (2006) Nat Clin Pract Endocrinol Metab , vol.2 , pp. 621-631
    • Witchel, S.F.1    Defranco, D.B.2
  • 91
    • 34250791225 scopus 로고    scopus 로고
    • Readjusting the glucocorticoid balance: An opportunity for modulators of 11beta-hydroxysteroid dehydrogenase type 1 activity?
    • Atanasov AG, Odermatt A. Readjusting the glucocorticoid balance: an opportunity for modulators of 11beta-hydroxysteroid dehydrogenase type 1 activity? Endocr Metab Immune Disord Drug Targets. 2007;7:125-40.
    • (2007) Endocr Metab Immune Disord Drug Targets , vol.7 , pp. 125-140
    • Atanasov, A.G.1    Odermatt, A.2
  • 92
    • 36749001617 scopus 로고    scopus 로고
    • Estrogens and glucocorticoid hormones in adipose tissue metabolism
    • Mattsson C, Olsson T. Estrogens and glucocorticoid hormones in adipose tissue metabolism. Curr Med Chem. 2007;14:2918-24.
    • (2007) Curr Med Chem , vol.14 , pp. 2918-2924
    • Mattsson, C.1    Olsson, T.2
  • 93
    • 36549073576 scopus 로고    scopus 로고
    • Modulation of glucocorticoid action and the treatment of type-2 diabetes
    • Tomlinson JW, Stewart PM. Modulation of glucocorticoid action and the treatment of type-2 diabetes. Best Pract Res Clin Endocrinol Metab. 2007;21:607-19.
    • (2007) Best Pract Res Clin Endocrinol Metab , vol.21 , pp. 607-619
    • Tomlinson, J.W.1    Stewart, P.M.2
  • 94
    • 0035879302 scopus 로고    scopus 로고
    • Glucocorticoid augmentation of macrophage capacity for phagocytosis of apoptotic cells is associated with reduced p130Cas expression, loss of paxillin/pyk2 phosphorylation, and high levels of active Rac
    • Giles KM, Ross K, Rossi AG, et al. Glucocorticoid augmentation of macrophage capacity for phagocytosis of apoptotic cells is associated with reduced p130Cas expression, loss of paxillin/pyk2 phosphorylation, and high levels of active Rac. J Immunol. 2001;167:976-86.
    • (2001) J Immunol , vol.167 , pp. 976-986
    • Giles, K.M.1    Ross, K.2    Rossi, A.G.3
  • 95
    • 33846889318 scopus 로고    scopus 로고
    • Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes
    • Ehrchen J, Steinmuller L, Barczyk K, et al. Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes. Blood. 2007;109:1265-74.
    • (2007) Blood , vol.109 , pp. 1265-1274
    • Ehrchen, J.1    Steinmuller, L.2    Barczyk, K.3
  • 96
    • 50849139609 scopus 로고    scopus 로고
    • Glucocorticoids induce an activated, anti-inflammatory monocyte subset in mice that resembles myeloid-derived suppressor cells
    • Varga G, Ehrchen J, Tsianakas A, et al. Glucocorticoids induce an activated, anti-inflammatory monocyte subset in mice that resembles myeloid-derived suppressor cells. J Leukoc Biol. 2008;84:644-50.
    • (2008) J Leukoc Biol , vol.84 , pp. 644-650
    • Varga, G.1    Ehrchen, J.2    Tsianakas, A.3
  • 97
    • 0035824440 scopus 로고    scopus 로고
    • A transgenic model of visceral obesity and the metabolic syndrome
    • Masuzaki H, Paterson J, Shinyama H, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science. 2001;294:2166-70.
    • (2001) Science , vol.294 , pp. 2166-2170
    • Masuzaki, H.1    Paterson, J.2    Shinyama, H.3
  • 98
    • 33846888049 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients
    • Desbriere R, Vuaroqueaux V, Achard V, et al. 11beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients. Obesity (Silver Spring). 2006;14:794-8.
    • (2006) Obesity (Silver Spring) , vol.14 , pp. 794-798
    • Desbriere, R.1    Vuaroqueaux, V.2    Achard, V.3
  • 99
    • 34548621405 scopus 로고    scopus 로고
    • 11Beta-HSD type 1 expression in human adipose tissue: Impact of gender, obesity, and fat localization
    • Paulsen SK, Pedersen SB, Fisker S, et al. 11Beta-HSD type 1 expression in human adipose tissue: impact of gender, obesity, and fat localization. Obesity (Silver Spring). 2007;15:1954-60.
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 1954-1960
    • Paulsen, S.K.1    Pedersen, S.B.2    Fisker, S.3
  • 100
    • 33750813483 scopus 로고    scopus 로고
    • Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: New molecules and patterns of gene expression
    • Martinez FO, Gordon S, Locati M, et al. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol. 2006;177:7303-11.
    • (2006) J Immunol , vol.177 , pp. 7303-7311
    • Martinez, F.O.1    Gordon, S.2    Locati, M.3
  • 101
    • 24744446455 scopus 로고    scopus 로고
    • Expression of 11betahydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells
    • Freeman L, Hewison M, Hughes SV, et al. Expression of 11betahydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells. Blood. 2005;106:2042-9.
    • (2005) Blood , vol.106 , pp. 2042-2049
    • Freeman, L.1    Hewison, M.2    Hughes, S.V.3
  • 102
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: Principles of pathogenesis and therapy
    • Stumvoll M, Goldstein BJ, van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. Lancet. 2005;365:1333-46.
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    van Haeften, T.W.3
  • 103
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444:840-6.
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 104
    • 13344280346 scopus 로고    scopus 로고
    • Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
    • Schwartz MW, Baskin DG, Bukowski TR, et al. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes. 1996;45:531-5.
    • (1996) Diabetes , vol.45 , pp. 531-535
    • Schwartz, M.W.1    Baskin, D.G.2    Bukowski, T.R.3
  • 105
    • 0036063777 scopus 로고    scopus 로고
    • Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
    • Maeda N, Shimomura I, Kishida K, et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med. 2002;8:731-7.
    • (2002) Nat Med , vol.8 , pp. 731-737
    • Maeda, N.1    Shimomura, I.2    Kishida, K.3
  • 106
    • 2542443652 scopus 로고    scopus 로고
    • Lipodystrophies: Rare disorders causing metabolic syndrome
    • Garg A, Misra A. Lipodystrophies: rare disorders causing metabolic syndrome. Endocrinol Metab Clin North Am. 2004;33:305-31.
    • (2004) Endocrinol Metab Clin North Am , vol.33 , pp. 305-331
    • Garg, A.1    Misra, A.2
  • 107
    • 33750310241 scopus 로고    scopus 로고
    • Genetic disorders of adipose tissue development, differentiation, and death
    • Agarwal AK, Garg A. Genetic disorders of adipose tissue development, differentiation, and death. Annu Rev Genomics Hum Genet. 2006;7:175-99.
    • (2006) Annu Rev Genomics Hum Genet , vol.7 , pp. 175-199
    • Agarwal, A.K.1    Garg, A.2
  • 108
    • 2942657651 scopus 로고    scopus 로고
    • Metabolic and body composition factors in subgroups of obesity: What do we know
    • Karelis AD, St-Pierre DH, Conus F, et al. Metabolic and body composition factors in subgroups of obesity: what do we know? J Clin Endocrinol Metab. 2004;89:2569-75.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2569-2575
    • Karelis, A.D.1    St-Pierre, D.H.2    Conus, F.3
  • 109
    • 0035052940 scopus 로고    scopus 로고
    • What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women?
    • Brochu M, Tchernof A, Dionne IT, et al. What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? J Clin Endocrinol Metab. 2001;86:1020-5.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1020-1025
    • Brochu, M.1    Tchernof, A.2    Dionne, I.T.3
  • 110
    • 33749126980 scopus 로고    scopus 로고
    • Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: Low inflammation and LDL oxidation in MHO women
    • Shin MJ, Hyun YJ, Kim OY, et al. Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women. Int J Obes (Lond). 2006;30:1529-34.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 1529-1534
    • Shin, M.J.1    Hyun, Y.J.2    Kim, O.Y.3
  • 111
    • 23044454515 scopus 로고    scopus 로고
    • The metabolically healthy but obese individual presents a favorable inflammation profile
    • Karelis AD, Faraj M, Bastard JP, et al. The metabolically healthy but obese individual presents a favorable inflammation profile. J Clin Endocrinol Metab. 2005;90:4145-50.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4145-4150
    • Karelis, A.D.1    Faraj, M.2    Bastard, J.P.3
  • 112
    • 38149142633 scopus 로고    scopus 로고
    • Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration
    • Rausch ME, Weisberg S, Vardhana P, et al. Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond). 2008;32:451-63.
    • (2008) Int J Obes (Lond) , vol.32 , pp. 451-463
    • Rausch, M.E.1    Weisberg, S.2    Vardhana, P.3
  • 113
    • 0242552753 scopus 로고    scopus 로고
    • Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: Roles of the receptor complex
    • Fujihara M, Muroi M, Tanamoto K, et al. Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol Ther. 2003;100:171-94.
    • (2003) Pharmacol Ther , vol.100 , pp. 171-194
    • Fujihara, M.1    Muroi, M.2    Tanamoto, K.3
  • 114
    • 34250221497 scopus 로고    scopus 로고
    • Innate immune pathway links obesity to insulin resistance
    • Shah PK. Innate immune pathway links obesity to insulin resistance. Circ Res. 2007;100:1531-3.
    • (2007) Circ Res , vol.100 , pp. 1531-1533
    • Shah, P.K.1
  • 115
    • 33751523577 scopus 로고    scopus 로고
    • Adipose tissue of human omentum is a major source of dendritic cells, which lose MHC Class II and stimulatory function in Crohn's disease
    • Bedford PA, Todorovic V, Westcott ED, et al. Adipose tissue of human omentum is a major source of dendritic cells, which lose MHC Class II and stimulatory function in Crohn's disease. J Leukoc Biol. 2006;80:546-54.
    • (2006) J Leukoc Biol , vol.80 , pp. 546-554
    • Bedford, P.A.1    Todorovic, V.2    Westcott, E.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.