Glucocorticoid augmentation of macrophage capacity for phagocytosis of apoptotic cells is associated with reduced p130Cas expression, loss of paxillin/pyk2 phosphorylation, and high levels of active Rac

Journal of Immunology

Volumn 167, Issue 2, 2001, Pages 976-986

  Giles, K M ^a   Ross, K ^a   Rossi, A G ^a   Hotchin, N A ^a   Haslett, C ^a   Dransfield, I ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; PAXILLIN;

APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL ADHESION; CELL DEATH; CELL DIFFERENTIATION; HUMAN; HUMAN CELL; INFLAMMATORY CELL; MACROPHAGE ACTIVATION; MULTIGENE FAMILY; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION;

EID: 0035879302     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.2.976     Document Type: Article

References (54)

1. Mechanisms of disease: Tissue destruction by neutrophils
2. Phagocytosis of senescent neutrophils by human monocyte-derived macrophages and rabbit inflammatory macrophages
3. Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes
4. Macrophage phagocytosis of aging neutrophils in inflammation: Programmed cell death in the neutrophil leads to its recognition by macrophages
5. Impairment of function in ageing neutrophils is associated with apoptosis
6. Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2
7. 2, and PAF
8. Lethal effect of the anti-Fas antibody in mice
9. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis
10. Apoptosis in human autoimmune diseases
11. Macrophage recognition of cells undergoing programmed cell death (apoptosis)
12. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
13. Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis
14. A receptor for phosphatidylserine-specific clearance of apoptotic cells
15. Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro
16. Monoclonal antibodies against oxidized low density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: Evidence that oxidation-specific epitopes mediate macrophage recognition
17. Human CD14 mediates recognition and phagocytosis of apoptotic cells
18. 1 integrin-dependent mechanism of leukocyte adherence to apoptotic cells
19. The ATP binding cassette transporter, ABC1, is required for the engulfment of corpses generated by apoptotic cell death
20. Complement-dependent clearance of apoptotic cells by human macrophages
21. Homozygous Clq deficiency causes glomerulonephritis associated with multiple apoptotic bodies
22. An appetite for apoptotic cells? Controversies and challenges
23. Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosis
24. Regulation of macrophage phagocytosis of apoptotic cells by cAMP
25. CD44 regulates phagocytosis of apoptotic neutrophil granulocytes, but not apoptotic lymphocytes, by human macrophages
26. Regulation of macrophage phagocytosis of apoptotic cells by adhesion to fibronectin
27. C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
28. Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization
29. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
30. A novel signaling molecule, p130, forms stable complexes in viva with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner
31. Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G
32. Integrin signalling: A new Cas(t) of characters enters the stage
33. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane
34. Activation of Rac1 by a Crk SH3-binding protein, DOCK180
35. Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex
36. Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein
37. Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages
38. An overview of glucocorticoid anti-inflammatory actions
39. Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes
40. Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins
41. The functional role of CrkII in actin cytoskeleton organization and mitogenesis
42. Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas
43. Dexamethasone promotes phagocytosis and bacterial killing by human monocytes/macrophages in vitro
44. Dendritic cells acquire antigen from apoptotic cells and induce class-I-restricted CTLs
45. 5 integrin recruits the CrkII-Dock180-Rac1 complex for phagocytosis of apoptotic cells
46. The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells
47. Differential effects of corticosteroids during different stages of dendritic cell maturation
48. Corticosteroids inhibit the production of inflammatory mediators in immature monocyte-derived DC and induce the development of tolerogenic DC3
49. The polarization defect of Wiscott-Aldrich syndrome macrophages is linked to dislocalization of the Arp2/3 complex
50. Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts
51. Phenotypic characterization of γ interferon-induced human monocyte polykaryons
52. Molecular characterization of fusion regulatory protein-1 (FRP-1) that induces multinucleated giant cell formation of monocytes and HIV gp160-mediated cell fusion: FRP-1 and 4F2/CD98 are identical molecules
53. Fusion and activation of human alveolar macrophages induced by recombinant interferon-γ and their suppression by dexamethasone
54. Glucocorticoids induce apoptosis in human monocytes: Potential role of IL-1β