Tumour necrosis factor α: A key regulator of adipose tissue mass

Journal of Endocrinology

Volumn 177, Issue 3, 2003, Pages 351-355

  Warne, James P ^a  

^a Faculty of Medicine   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOSE TISSUE; APOPTOSIS; ARTICLE; BODY FAT; CACHEXIA; CELL FUNCTION; CELL SECRETION; HUMAN; INSULIN RESISTANCE; LIPID METABOLISM; LIPOGENESIS; LIPOLYSIS; METABOLIC DISORDER; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM;

ADIPOCYTES; ANIMALS; APOPTOSIS; CACHEXIA; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; OBESITY; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0038039463     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1770351     Document Type: Article

References (26)

1. Argiles JM, Lopez-Soriano J, Busquets S & Lopez-Soriano FJ 1997 Journey from cachexia to obesity by TNF. FASEB Journal 11 743-751.
2. Bastard JP, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, Vidal H & Hainque B 2000 Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. Journal of Clinical Endocrinology and Metabolism 85 3338-3342.
3. Bost F, Carion L, Marchetti I, Dani C, Le Marchand-Brustel Y & Binétruy B 2002 Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage. Biochemical Journal 361 621-627.
4. Eurlings PM, Van Der Kallen CJ, Geurts JM, Kouwenberg P, Boeckx WD & De Bruin TW 2002 Identification of differentially expressed genes in subcutaneous adipose tissue from subjects with familial combined hyperlipidemia. Journal of Lipid Research 43 930-935.
5. Fruhbeck G, Gomez-Ambrosi J, Muruzabal FJ & Burrell MA 2001 The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. American Journal of Physiology 280 E827-E847.
6. Hauner H, Petruschke T, Russ M, Rohrig K & Eckel J 1995 Effects of tumour necrosis factor alpha (TNF alpha) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture. Diabetologia 38 764-771.
7. Hotamisligil GS, Shargill NS & Spiegelman BM 1993 Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 87-91.
8. Hotamisligil GS, Arner P, Caro JF, Atkinson RL & Spiegelman BM 1995 Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. Journal of Clinical Investigation 95 2409-2415.
9. Hotamisligil GS, Arner P, Atkinson RL & Spiegelman BM 1997 Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes 46 451-455.
10. Hu E, Kim JB, Sarraf P & Spiegelman BM 1996 Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma. Science 274 2100-2103.
11. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R & Simsolo RB 1995 The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. Journal of Clinical Investigation 95 2111-2119.
12. Kern PA, Ranganathan S, Li C, Wood L & Ranganathan G 2001 Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. American Journal of Physiology 280 E745-E751.
13. Koistinen HA, Bastard JP, Dusserre E, Ebeling P, Zegari N, Andreelli F, Jardel C, Donner M, Meyer L, Moulin P, Hainque B, Riou JP, Laville M, Koivisto VA & Vidal H 2000 Subcutaneous adipose tissue expression of tumour necrosis factor-alpha is not associated with whole body insulin resistance in obese nondiabetic or in type-2 diabetic subjects. European Journal of Clinical Investigation 30 302-310.
14. MacDougald OA & Mandrup S 2002 Adipogenesis: forces that tip the scales. Trends in Endocrinology and Metabolism 13 5-11.
15. Memon RA, Feingold KR, Moser AH, Fuller J & Grunfeld C 1998a Regulation of fatty acid transport protein and fatty acid translocase mRNA levels by endotoxin and cytokines. American Journal of Physiology 274 E210-E217.
16. Memon RA, Fuller J, Moser AH, Smith PJ, Feingold KR & Grunfeld C 1998b In vivo regulation of acyl-CoA synthetase mRNA and activity by endotoxin and cytokines. American Journal of Physiology 275 E64-E72.
17. Moller DE 2000 Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends in Endocrinology and Metabolism 11 212-217.
18. Prins JB, Niesler CU, Winterford CM, Bright NA, Siddle K, O'Rahilly S, Walker NI & Cameron DP 1997 Tumor necrosis factor-alpha induces apoptosis of human adipose cells. Diabetes 46 1939-1944.
19. Prusty D, Park BH, Davis KE & Farmer SR 2002 Activation of MEK/ERK signalling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor γ (PPARγ) and C/EBPα gene expression during differentiation of 3T3-L1 preadipocytes. Journal of Biological Chemistry 277 46226-46232.
20. Qian H, Hausman DB, Compton MM, Martin RJ, Della-Fera MA, Hartzell DL & Baile CA 2001 TNFalpha induces and insulin inhibits caspase 3-dependent adipocyte, apoptosis. Biochemical and Biophysical Research Communications 284 1176-1183.
21. Ramsay TG 1996 Fat cells. Endocrinology and Metabolism Clinics of North America 25 847-870.
22. Sethi JK & Hotamisligil GS 1999 The role of TNF alpha in adipocyte metabolism. Seminars in Cell and Developmental Biology 10 19-29.
23. Tisdale MJ 2002 Cachexia in cancer patients. Nature Reviews Cancer 2 862-871.
24. Xu H, Sethi JK & Hotamisligil GS 1999 Transmembrane tumor necrosis factor (TNF)-alpha inhibits adipocyte, differentiation by selectively activating TNF receptor 1. Journal of Biological Chemistry 274 26287-26295.
25. Zhang HH, Kumar S, Barnett AH & Eggo MC 2001 Dexamethasone inhibits tumor necrosis factor-alpha-induced apoptosis and interleukin-1 beta release in human subcutaneous adipocytes and preadipocytes. Journal of Clinical Endocrinology and Metabolism 86 2817-2825.
26. Zhang HH, Halbleib M, Ahmad F, Manganiello VC & Greenberg AS 2002 Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP. Diabetes 51 2029-2935.