Endothelium-derived toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs

Journal of Clinical Investigation

Volumn 111, Issue 7, 2003, Pages 1011-1020

  Andonegui, Graciela ^a   Bonder, Claudine S ^a   Green, Francis ^a   Mullaly, Sarah C ^a   Zbytnuik, Lori ^a   Raharjo, Eko ^a   Kubes, Paul ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ARTICLE; BONE MARROW TRANSPLANTATION; CELL INTERACTION; CHIMERA; CONTROLLED STUDY; CREMASTER MUSCLE; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVITY; HISTOLOGY; LEUKOCYTE ACTIVATION; LUNG SEQUESTRATION; MACROPHAGE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0037380645     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI16510     Document Type: Article

References (37)

1. Bone, R.C. 1991. The pathogenesis of sepsis. Ann. Intern. Med. 115:457-469.
2. 1993. Mortality pattern: United States 1990. Centers for Disease Control and Prevention. National Center for Health Statistics. Mon. Vital Stat. Rep. 41:5.
3. Welbourn, C.R., and Young, Y. 1992. Endotoxin, septic shock and acute lung injury: neutrophils, macrophages and inflammatory mediators. Br. J. Surg. 79:998-1003.
4. Sheridan, B.C., et al. 1997. Neutrophils mediate pulmonary vasomotor dysfunction in endotoxin-induced acute lung injury. J. Trauma. 42:391-396.
5. Poltorak, A., et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 282:2085-2088.
6. Takeuchi, O., et al. 1999. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 11:443-451.
7. Andonegui, G., Goyert, S.M., and Kubes, P. 2002. Lipopolysaccharideinduced leukocyte-endothelial cell interactions: a role for CD14 versus toll-like receptor 4 within microvessels. J. Immunol. 169:2111-2119.
8. Carvalho-Tavares, J., et al. 2000. A role for platelets and endothelial selectins in tumor necrosis factor-alpha-induced leukocyte recruitment in the brain microvasculature. Circ. Res. 87:1141-1148.
9. Hickey, M.J., et al. 2002. Inducible nitric oxide synthase (iNOS) in endotoxemia: chimeric mice reveal different cellular sources in various tissues. FASEB J. 16:1141-1143.
10. Hickey, M.J., et al. 1997. Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia. FASEB J. 11:955-964.
11. Krawisz, J.E., Sharon, P., and Stenson, W.F. 1984. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology. 87:1344-1350.
12. Johnston, B., Burns, A.R., and Kubes, P. 1998. A role for mast cells in the development of adjuvant-induced vasculitis and arthritis. Am. J. Pathol. 152:555-563.
13. Eppihimer, M.J., Wolitzky, B., Anderson, D.C., Labow, M.A., and Granger, D.N. 1996. Heterogeneity of expression of E- and P-selectins in vivo. Circ. Res. 79:560-569.
14. Hickey, M.J., et al. 1999. Varying roles of E-selectin and P-selectin in different microvascular beds in response to antigen. J. Immunol. 162:1137-1143.
15. Haziot, A., et al. 1996. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity. 4:407-414.
16. Hafezi-Moghadam, A., Thomas, K.L., Prorock, A.J., Huo, Y., and Ley, K. 2001. L-selectin shedding regulates leukocyte recruitment. J. Exp. Med. 193:863-872.
17. Kubo, H., et al. 1999. L- and P-selectin and CD11/CD18 in intracapillary neutrophil sequestration in rabbit lungs. Am. J. Respir. Crit. Care Med. 159:267-274.
18. Wong, J., et al. 1997. A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature. J. Clin. Invest. 99:2782-2790.
19. Mizgerd, J.P., et al. 1997. Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice. J. Exp. Med. 186:1357-1364.
20. van Furth, R. 1992. Development and distribution of mononuclear phagocytes. In Inflammation: basic principles and clinical correlates. J.I. Gallin, I.M. Goldstein, and R. Snyderman, editors. Lippincott Williams and Wilkins. Philadelphia, Pennsylvania, USA. 325-339.
21. Haslett, C., et al. 1987. The pulmonary vascular sequestration of neutrophils in endotoxemia is initiated by an effect of endotoxin on the neutrophil in the rabbit. Am. Rev. Respir. Dis. 136:9-18.
22. Erzurum, S.C., et al. 1992. Mechanisms of lipopolysaccharide-induced neutrophil retention. Relative contributions of adhesive and cellular mechanical properties. J. Immunol. 149:154-162.
23. Yipp, B.G., et al. 2002. Profound differences in leukocyte-endothelial cell responses to lipopolysaccharide versus lipoteichoic acid. J. Immunol. 168:4650-4658.
24. Tanaka, H., Nishino, M., and Dahms, T.E. 2002. Physiologic responses to small emboli and hemodynamic effects of changes in deformability of polymorphonuclear leukocytes in isolated rabbit lung. Microvasc. Res. 63:81-90.
25. Chow, J.C., Young, D.W., Golenbock, D.T., Christ, W.J., and Gusovsky, F. 1999. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J. Biol. Chem. 274:10689-10692.
26. Yang, H., Young, D.W., Gusovsky, F., and Chow, J.C. 2000. Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1. J. Biol. Chem. 275:20861-20866.
27. Yang, R.B., et al. 1998. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature. 395:284-288.
28. Yang, R.B., Mark, M.R., Gurney, A.L., and Godowski, P.J. 1999. Signaling events induced by lipopolysaccharide-activated toll-like receptor 2. J. Immunol. 163:639-643.
29. Kirschning, C.J., Wesche, H., Merrill, A.T., and Rothe, M. 1998. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J. Exp. Med. 188:2091-2097.
30. Brightbill, H.D., et al. 1999. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science. 285:732-736.
31. Hoshino, K., et al. 1999. Cutting edge. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162:3749-3752.
32. Hirschfeld, M., Ma, Y., Weis, J.H., Vogel, S.N., and Weis, J.J. 2000. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J. Immunol. 165:618-622.
33. Zhang, F.X., et al. 1999. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J. Biol. Chem. 274:7611-7614.
34. Faure, E., et al. 2000. Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells. J. Biol. Chem. 275:11058-11063.
35. Faure, E., et al. 2001. Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation. J. Immunol. 166:2018-2024.
36. Zhao, B., Bowden, R.A., Stavchansky, S.A., and Bowman, P.D. 2001. Human endothelial cell response to gram-negative lipopolysaccharide assessed with cDNA microarrays. Am. J. Physiol. Cell Physiol. 281:C1587-C1595.
37. Mahalingam, S., and Karupiah, G. 1999. Chemokines and chemokine receptors in infectious diseases. Immunol. Cell Biol. 77:469-475.