메뉴 건너뛰기




Volumn 18, Issue 12, 2012, Pages 1286-1294

Mouse models of pancreatic cancer

Author keywords

K Ras; Mouse models; Pancreatic cancer; Transgenic; Xenografts

Indexed keywords

BRCA2 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; K RAS PROTEIN; MIST1 PROTEIN; PANCREAS TRANSCRIPTION FACTOR 1; PROTEIN P48; SMAD4 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDX 1; TRP53 PROTEIN; UNCLASSIFIED DRUG;

EID: 84859081186     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v18.i12.1286     Document Type: Article
Times cited : (131)

References (70)
  • 2
    • 0030015038 scopus 로고    scopus 로고
    • Chemotherapy for pancreatic carcinoma
    • Ahlgren JD. Chemotherapy for pancreatic carcinoma. Cancer 1996; 78: 654-663
    • (1996) Cancer , vol.78 , pp. 654-663
    • Ahlgren, J.D.1
  • 4
    • 64049089987 scopus 로고    scopus 로고
    • Molecular classification of neoplasms of the pancreas
    • Hruban RH, Adsay NV. Molecular classification of neoplasms of the pancreas. Hum Pathol 2009; 40: 612-623
    • (2009) Hum Pathol , vol.40 , pp. 612-623
    • Hruban, R.H.1    Adsay, N.V.2
  • 6
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo M. Pancreatic cancer. N Engl J Med 2010; 362: 1605-1617
    • (2010) N Engl J Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 7
    • 77950215863 scopus 로고    scopus 로고
    • Modeling pancreatic cancer in vivo: From xenograft and carcinogen-induced systems to genetically engineered mice
    • Ding Y, Cravero JD, Adrian K, Grippo P. Modeling pancreatic cancer in vivo: from xenograft and carcinogen-induced systems to genetically engineered mice. Pancreas 2010; 39: 283-292
    • (2010) Pancreas , vol.39 , pp. 283-292
    • Ding, Y.1    Cravero, J.D.2    Adrian, K.3    Grippo, P.4
  • 8
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 12
    • 0038405066 scopus 로고    scopus 로고
    • Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice
    • Grippo PJ, Nowlin PS, Demeure MJ, Longnecker DS, Sandgren EP. Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice. Cancer Res 2003; 63: 2016-2019
    • (2003) Cancer Res , vol.63 , pp. 2016-2019
    • Grippo, P.J.1    Nowlin, P.S.2    Demeure, M.J.3    Longnecker, D.S.4    Sandgren, E.P.5
  • 15
    • 0346731132 scopus 로고    scopus 로고
    • The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer
    • Lewis BC, Klimstra DS, Varmus HE. The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. Genes Dev 2003; 17: 3127-3138
    • (2003) Genes Dev , vol.17 , pp. 3127-3138
    • Lewis, B.C.1    Klimstra, D.S.2    Varmus, H.E.3
  • 19
  • 20
    • 0032818440 scopus 로고    scopus 로고
    • Molecular genetic basis of pancreatic adenocarcinoma
    • Hilgers W, Kern SE. Molecular genetic basis of pancreatic adenocarcinoma. Genes Chromosomes Cancer 1999; 26: 1-12
    • (1999) Genes Chromosomes Cancer , vol.26 , pp. 1-12
    • Hilgers, W.1    Kern, S.E.2
  • 21
    • 82955187335 scopus 로고    scopus 로고
    • Detection of KRAS gene mutations in endoscopic ultrasound-guided fine-needle aspiration biopsy for improving pancreatic cancer diagnosis
    • Wang X, Gao J, Ren Y, Gu J, Du Y, Chen J, Jin Z, Zhan X, Li Z, Huang H, Lv S, Gong Y. Detection of KRAS gene mutations in endoscopic ultrasound-guided fine-needle aspiration biopsy for improving pancreatic cancer diagnosis. Am J Gastroenterol 2011; 106: 2104-2111
    • (2011) Am J Gastroenterol , vol.106 , pp. 2104-2111
    • Wang, X.1    Gao, J.2    Ren, Y.3    Gu, J.4    Du, Y.5    Chen, J.6    Jin, Z.7    Zhan, X.8    Li, Z.9    Huang, H.10    Lv, S.11    Gong, Y.12
  • 27
    • 33751247898 scopus 로고    scopus 로고
    • Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression
    • Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S, Wright CV, Moses HL. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev 2006; 20: 3147-3160
    • (2006) Genes Dev , vol.20 , pp. 3147-3160
    • Ijichi, H.1    Chytil, A.2    Gorska, A.E.3    Aakre, M.E.4    Fujitani, Y.5    Fujitani, S.6    Wright, C.V.7    Moses, H.L.8
  • 30
    • 34248372925 scopus 로고    scopus 로고
    • The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia
    • Carrière C, Seeley ES, Goetze T, Longnecker DS, Korc M. The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia. Proc Natl Acad Sci USA 2007; 104: 4437-4442
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4437-4442
    • Carrière, C.1    Seeley, E.S.2    Goetze, T.3    Longnecker, D.S.4    Korc, M.5
  • 33
    • 0036777339 scopus 로고    scopus 로고
    • Signaling and transcriptional control of pancreatic organogenesis
    • Kim SK, MacDonald RJ. Signaling and transcriptional control of pancreatic organogenesis. Curr Opin Genet Dev 2002; 12: 540-547
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 540-547
    • Kim, S.K.1    Macdonald, R.J.2
  • 35
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    • Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 2002; 32: 128-134
    • (2002) Nat Genet , vol.32 , pp. 128-134
    • Kawaguchi, Y.1    Cooper, B.2    Gannon, M.3    Ray, M.4    Macdonald, R.J.5    Wright, C.V.6
  • 36
    • 0024411240 scopus 로고
    • Identification of a cell-specific DNA-binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas
    • Cockell M, Stevenson BJ, Strubin M, Hagenbüchle O, Wellauer PK. Identification of a cell-specific DNA-binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas. Mol Cell Biol 1989; 9: 2464-2476
    • (1989) Mol Cell Biol , vol.9 , pp. 2464-2476
    • Cockell, M.1    Stevenson, B.J.2    Strubin, M.3    Hagenbüchle, O.4    Wellauer, P.K.5
  • 43
    • 0032473502 scopus 로고    scopus 로고
    • The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of myoD
    • Lemercier C, To RQ, Carrasco RA, Konieczny SF. The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of myoD. EMBO J 1998; 17: 1412-1422
    • (1998) EMBO J , vol.17 , pp. 1412-1422
    • Lemercier, C.1    To, R.Q.2    Carrasco, R.A.3    Konieczny, S.F.4
  • 46
    • 84924133024 scopus 로고    scopus 로고
    • The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity
    • Pin CL, Rukstalis JM, Johnson C, Konieczny SF. The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J Cell Biol 2001; 155: 519-530
    • (2001) J Cell Biol , vol.155 , pp. 519-530
    • Pin, C.L.1    Rukstalis, J.M.2    Johnson, C.3    Konieczny, S.F.4
  • 47
    • 0031080922 scopus 로고    scopus 로고
    • Mist1: A novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern
    • Lemercier C, To RQ, Swanson BJ, Lyons GE, Konieczny SF. Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern. Dev Biol 1997; 182: 101-113
    • (1997) Dev Biol , vol.182 , pp. 101-113
    • Lemercier, C.1    To, R.Q.2    Swanson, B.J.3    Lyons, G.E.4    Konieczny, S.F.5
  • 48
    • 0034214035 scopus 로고    scopus 로고
    • Mist1 expression is a common link among serous exocrine cells exhibiting regulated exocytosis
    • Pin CL, Bonvissuto AC, Konieczny SF. Mist1 expression is a common link among serous exocrine cells exhibiting regulated exocytosis. Anat Rec 2000; 259: 157-167
    • (2000) Anat Rec , vol.259 , pp. 157-167
    • Pin, C.L.1    Bonvissuto, A.C.2    Konieczny, S.F.3
  • 49
    • 1442299170 scopus 로고    scopus 로고
    • Mist1 is necessary for the establishment of granule organization in serous exocrine cells of the gastrointestinal tract
    • Johnson CL, Kowalik AS, Rajakumar N, Pin CL. Mist1 is necessary for the establishment of granule organization in serous exocrine cells of the gastrointestinal tract. Mech Dev 2004; 121: 261-272
    • (2004) Mech Dev , vol.121 , pp. 261-272
    • Johnson, C.L.1    Kowalik, A.S.2    Rajakumar, N.3    Pin, C.L.4
  • 51
    • 0029102927 scopus 로고
    • Brief report: A familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene
    • Whelan AJ, Bartsch D, Goodfellow PJ. Brief report: a familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene. N Engl J Med 1995; 333: 975-977
    • (1995) N Engl J Med , vol.333 , pp. 975-977
    • Whelan, A.J.1    Bartsch, D.2    Goodfellow, P.J.3
  • 56
    • 0032404111 scopus 로고    scopus 로고
    • Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas
    • Goggins M, Shekher M, Turnacioglu K, Yeo CJ, Hruban RH, Kern SE. Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res 1998; 58: 5329-5332
    • (1998) Cancer Res , vol.58 , pp. 5329-5332
    • Goggins, M.1    Shekher, M.2    Turnacioglu, K.3    Yeo, C.J.4    Hruban, R.H.5    Kern, S.E.6
  • 58
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001; 29: 117-129
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 59
    • 0036199441 scopus 로고    scopus 로고
    • Conditional inactivation of the TGF-beta type II receptor using Cre: Lox
    • Chytil A, Magnuson MA, Wright CV, Moses HL. Conditional inactivation of the TGF-beta type II receptor using Cre: Lox. Genesis 2002; 32: 73-75
    • (2002) Genesis , vol.32 , pp. 73-75
    • Chytil, A.1    Magnuson, M.A.2    Wright, C.V.3    Moses, H.L.4
  • 60
    • 33645736793 scopus 로고    scopus 로고
    • Genetically engineered models have advantages over xenografts for preclinical studies
    • discussion 3358-3359
    • Becher OJ, Holland EC. Genetically engineered models have advantages over xenografts for preclinical studies. Cancer Res 2006; 66: 3355-3358, discussion 3358-3359
    • (2006) Cancer Res , vol.66 , pp. 3355-3358
    • Becher, O.J.1    Holland, E.C.2
  • 61
    • 79957600437 scopus 로고    scopus 로고
    • Development of an orthotopic human pancreatic cancer xenograft model using ultrasound guided injection of cells
    • Huynh AS, Abrahams DF, Torres MS, Baldwin MK, Gillies RJ, Morse DL. Development of an orthotopic human pancreatic cancer xenograft model using ultrasound guided injection of cells. PLoS One 2011; 6: e20330
    • (2011) PLoS One , vol.6
    • Huynh, A.S.1    Abrahams, D.F.2    Torres, M.S.3    Baldwin, M.K.4    Gillies, R.J.5    Morse, D.L.6
  • 62
    • 33749337828 scopus 로고    scopus 로고
    • The use of targeted mouse models for preclinical testing of novel cancer therapeutics
    • Olive KP, Tuveson DA. The use of targeted mouse models for preclinical testing of novel cancer therapeutics. Clin Cancer Res 2006; 12: 5277-5287
    • (2006) Clin Cancer Res , vol.12 , pp. 5277-5287
    • Olive, K.P.1    Tuveson, D.A.2
  • 63
    • 34347254640 scopus 로고    scopus 로고
    • Establishment of human tumor xenografts in immunodeficient mice
    • Morton CL, Houghton PJ. Establishment of human tumor xenografts in immunodeficient mice. Nat Protoc 2007; 2: 247-250
    • (2007) Nat Protoc , vol.2 , pp. 247-250
    • Morton, C.L.1    Houghton, P.J.2
  • 64
    • 20544468218 scopus 로고    scopus 로고
    • Assessing growth and response to therapy in murine tumor models
    • Reynolds CP, Sun BC, DeClerck YA, Moats RA. Assessing growth and response to therapy in murine tumor models. Methods Mol Med 2005; 111: 335-350
    • (2005) Methods Mol Med , vol.111 , pp. 335-350
    • Reynolds, C.P.1    Sun, B.C.2    Declerck, Y.A.3    Moats, R.A.4
  • 68
    • 0032410157 scopus 로고    scopus 로고
    • Orthotopic models are necessary to predict therapy of transplantable tumors in mice
    • Killion JJ, Radinsky R, Fidler IJ. Orthotopic models are necessary to predict therapy of transplantable tumors in mice. Cancer Metastasis Rev 1998-1999; 17: 279-284
    • (1998) Cancer Metastasis Rev , vol.17 , pp. 279-284
    • Killion, J.J.1    Radinsky, R.2    Fidler, I.J.3
  • 69
    • 0033500248 scopus 로고    scopus 로고
    • Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: A bridge to the clinic
    • Hoffman RM. Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Invest New Drugs 1999; 17: 343-359
    • (1999) Invest New Drugs , vol.17 , pp. 343-359
    • Hoffman, R.M.1
  • 70
    • 80053198686 scopus 로고    scopus 로고
    • Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo
    • Wang ZH, Chen H, Guo HC, Tong HF, Liu JX, Wei WT, Tan W, Ni ZL, Liu HB, Lin SZ. Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo. Int J Oncol 2011; 39: 1123-1131
    • (2011) Int J Oncol , vol.39 , pp. 1123-1131
    • Wang, Z.H.1    Chen, H.2    Guo, H.C.3    Tong, H.F.4    Liu, J.X.5    Wei, W.T.6    Tan, W.7    Ni, Z.L.8    Liu, H.B.9    Lin, S.Z.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.