Detection of KRAS gene mutations in endoscopic ultrasound-guided fine-needle aspiration biopsy for improving pancreatic cancer diagnosis

American Journal of Gastroenterology

Volumn 106, Issue 12, 2011, Pages 2104-2111

  Wang, Xiaowei ^a   Gao, Jun ^a   Ren, Yan ^a   Gu, Junjun ^a   Du, Yiqi ^a   Chen, Jie ^a   Jin, Zhendong ^a   Zhan, Xianbao ^a   Li, Zhaoshen ^a   Huang, Haojie ^a   Lv, Shunli ^a   Gong, Yanfang ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CA 19-9 ANTIGEN; CARBOHYDRATE ANTIGEN; PEPTIDE NUCLEIC ACID;

ADULT; ARTICLE; ASPIRATION BIOPSY; CANCER DIAGNOSIS; CODON; CYTOPATHOLOGY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DNA SEQUENCE; ENDOSCOPIC ECHOGRAPHY; FEMALE; GASTROINTESTINAL ENDOSCOPY; GENE MUTATION; GENETIC ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KIRSTEN SARCOMA ONCOVIRUS; KRISTEN RAT SARCOMA 2 VIRUS; MAJOR CLINICAL STUDY; MALE; PANCREAS CANCER; POLYMERASE CHAIN REACTION; PRECANCER; PRIORITY JOURNAL; TUMOR BIOPSY; VIRUS GENE;

BIOPSY, FINE-NEEDLE; CA-19-9 ANTIGEN; CARCINOMA, PANCREATIC DUCTAL; DNA PRIMERS; ENDOSONOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; PANCREATIC NEOPLASMS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS, DNA;

EID: 82955187335     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2011.281     Document Type: Article

References (44)

1. DeVita VT Jr, Hellman S, Rosenberg SA. Cancer: Principles and Practice of Oncology. Lippincott-Raven Publishers: Philadelphia and New York, 1997. pp 1054-81.
2. Li D, Xie K, Wolff R et al. Pancreatic cancer. Lancet 2004; 363: 1049-57. (Pubitemid 38410779)
3. Yamao K, Mizuno N, Takagi T et al. How I do it and when I use (and do not use) EUS-FNA. Gastrointest Endosc 2009; 69: S134-7.
4. Jenssen C, Dietrich CF. Endoscopic ultrasound-guided fi ne-needle aspiration biopsy and trucut biopsy in gastroenterology-an overview. Best Pract Res Clin Gastroenterol 2009; 23: 743-59.
5. Harewood GC, Wiersema MJ. Endosonography-guided fi ne needle aspiration biopsy in the evaluation of pancreatic masses. Am J Gastroenterol 2002; 97: 1386-91. (Pubitemid 34664782)
6. Ylagan LR, Edmundowicz S, Kasal IK et al. Endoscopic ultrasound guided fi ne-needle aspiration cytology of pancreatic carcinoma: a 3-year experience and review of the literature. Cancer 2002; 96: 362-9. (Pubitemid 37356011)
7. Bhutani MS, Hawes RH, Baron PL et al. Endoscopic ultrasound guided fi ne needle aspiration of malignant pancreatic lesions. Endoscopy 1997; 29: 854-8. (Pubitemid 28043602)
8. Gao J, Li Z, Chen Z et al. Antisense Smo under the control of the PTCH1 promoter delivered by an adenoviral vector inhibits the growth of human pancreatic cancer. Gene Th er 2006; 13: 1587-94. (Pubitemid 44688459)
9. Shao J, Zhang L, Gao J et al. Aberrant expression of PTCH (patched gene) and Smo (smoothened gene) in human pancreatic cancerous tissues and its association with hyperglycemia. Pancreas 2006; 33: 38-44. (Pubitemid 43995338)
10. Scarpa A, Capelli P, Mukai K et al. Pancreatic adenocarcinomas frequently show p53 gene mutations. Am J Pathol 1993; 142: 1534-43. (Pubitemid 24058140)
11. Pellegata NS, Sessa F, Renault B et al. K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through diff erent genetic lesions. Cancer Res 1994; 54: 1556-60. (Pubitemid 24106422)
12. Bournet B, Souque A, Senesse P et al. Endoscopic ultrasound-guided fi neneedle aspiration biopsy coupled with KRAS mutation assay to distinguish pancreatic cancer from pseudotumoral chronic pancreatitis. Endoscopy 2009; 41: 552-7.
13. Maluf-Filho F, Kumar A, Gerhardt R et al. Kras mutation analysis of fi ne needle aspirate under EUS guidance facilitates risk stratifi cation of patients with pancreatic mass. J Clin Gastroenterol 2007; 41: 906-10. (Pubitemid 350307077)
14. Pellise M, Castells A, Gines A et al. Clinical usefulness of KRAS mutational analysis in the diagnosis of pancreatic adenocarcinoma by means of endosonography-guided fi ne-needle aspiration biopsy. Aliment Pharmacol Th er 2003; 17: 1299-307. (Pubitemid 36693731)
15. Tada M, Komatsu Y, Kawabe T et al. Quantitative analysis of K-ras gene mutation in pancreatic tissue obtained by endoscopic ultrasonographyguided fi ne needle aspiration: clinical utility for diagnosis of pancreatic tumor. Am J Gastroenterol 2002; 97: 2263-70.
16. Takahashi K, Yamao K, Okubo K et al. Diff erential diagnosis of pancreatic cancer and focal pancreatitis by using EUS-guided FNA. Gastrointest Endosc 2005; 61: 76-9. (Pubitemid 40169815)
17. Almoguera C, Shibata D, Forrester K et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988; 53: 549-54.
18. Klimstra DS, Longnecker DS. K-ras mutations in pancreatic ductal proliferative lesions. Am J Pathol 1994; 145: 1547-50. (Pubitemid 24378508)
19. Hruban RH, Wilentz RE, Kern SE. Genetic progression in the pancreatic ducts. Am J Pathol 2000; 156: 1821-5. (Pubitemid 30641750)
20. Wang Y, Gao J, Li Z et al. Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profi le in endoscopic ultrasound-guided fi ne-needle aspiration specimens of the pancreas. Int J Cancer 2007; 121: 2716-22. (Pubitemid 350136417)
21. Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 2010; 17: 1471-4.
22. Th iede C, Bayerdorff er E, Blasczyk R et al. Simple and sensitive detection of mutations in the ras proto-oncogenes using PNA-mediated PCR clamping. Nucleic Acids Res 1996; 24: 983-4. (Pubitemid 26076209)
23. Taback B, Bilchik AJ, Saha S et al. Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes. Int J Cancer 2004; 111: 409-14. (Pubitemid 38998822)
24. Wei S, Liang Z, Gao J et al. Patterns of K-ras codon 12 and 13 mutations found in pancreatic adenocarcinoma of 30 Chinese patients by microdissection, PCR and direct sequencing. J Gastroenterol Hepatol 2005; 20: 67-72. (Pubitemid 40143636)
25. Krypuy M, Newnham GM, Thomas DM et al. High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer. BMC Cancer 2006; 6: 295.
26. Simi L, Pratesi N, Vignoli M et al. High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer. Am J Clin Pathol 2008; 130: 247-53.
27. Andre T, Balosso J, Louvet C et al. [Adenocarcinoma of the pancreas. General characteristics]. Presse Med 1998; 27: 533-6.
28. Moller K, Papanikolaou IS, Toermer T et al. EUS-guided FNA of solid pancreatic masses: high yield of 2 passes with combined histologic-cytologic analysis. Gastrointest Endosc 2009; 70: 60-9.
29. Klapman JB, Logrono R, Dye CE et al. Clinical impact of on-site cytopathology interpretation on endoscopic ultrasound-guided fi ne needle aspiration. Am J Gastroenterol 2003; 98: 1289-94. (Pubitemid 36741524)
30. Kimura W, Zhao B, Futakawa N et al. Signifi cance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas. Hepatogastroenterology 1999; 46: 532-9. (Pubitemid 29154812)
31. Mizumoto K, Tanaka M. Genetic diagnosis of pancreatic cancer. J Hepatobiliary Pancreat Surg 2002; 9: 39-44. (Pubitemid 34477369)
32. Crous-Bou M, Porta M, Lopez T et al. Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma. Environ Mol Mutagen 2009; 50: 421-30.
33. Fryzek JP, Garabrant DH, Schenk M et al. The association between selected risk factors for pancreatic cancer and the expression of p53 and K-ras codon 12 mutations. Int J Gastrointest Cancer 2006; 37: 139-45. (Pubitemid 351642217)
34. Lohr M, Kloppel G, Maisonneuve P et al. Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis. Neoplasia 2005; 7: 17-23. (Pubitemid 40209467)
35. Luttges J, Vogel I, Menke M et al. Clear cell carcinoma of the pancreas: an adenocarcinoma with ductal phenotype. Histopathology 1998; 32: 444-8. (Pubitemid 28231378)
36. Raimondi S, Maisonneuve P, Lowenfels AB. Epidemiology of pancreatic cancer: an overview. Nat Rev Gastroenterol Hepatol 2009; 6: 699-708.
37. Talamini G, Bassi C, Falconi M et al. Early detection of pancreatic cancer following the diagnosis of chronic pancreatitis. Digestion 1999; 60: 554-61. (Pubitemid 29495665)
38. Hruban RH, Maitra A, Kern SE et al. Precursors to pancreatic cancer. Gastroenterol Clin North Am 2007; 36: 831-49, vi. (Pubitemid 350051704)
39. Kamisawa T, Tsuruta K, Okamoto A et al. Frequent and signifi cant K-ras mutation in the pancreas, the bile duct, and the gallbladder in autoimmune pancreatitis. Pancreas 2009; 38: 890-5.
40. Schoedel KE, Finkelstein SD, Ohori NP. K-Ras and microsatellite marker analysis of fi ne-needle aspirates from intraductal papillary mucinous neoplasms of the pancreas. Diagn Cytopathol 2006; 34: 605-8. (Pubitemid 44298560)
41. Siveke JT, Einwachter H, Sipos B et al. Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN. Cancer Cell 2007; 12: 266-79. (Pubitemid 47333415)
42. Jang JY, Park YC, Song YS et al. Increased K-ras mutation and expression of S100A4 and MUC2 protein in the malignant intraductal papillary mucinous tumor of the pancreas. J Hepatobiliary Pancreat Surg 2009; 16: 668-74.
43. Bazan V, Migliavacca M, Zanna I et al. Specifi c codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype. Ann Oncol 2002; 13: 1438-46.
44. Capella G, Cronauer-Mitra S, Pienado MA et al. Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors. Environ Health Perspect 1991; 93: 125-31.