Inactivation of Brca2 promotes Trp53-associated but inhibits KrasG12D-dependent pancreatic cancer development in mice

Gastroenterology

Volumn 140, Issue 4, 2011, Pages 1303-1313.e3

  Rowley, Matthew ^a   Ohashi, Akihiro ^a   Mondal, Gourish ^a   Mills, Lisa ^a   Yang, Lin ^a   Zhang, Lizhi ^a   Sundsbak, Rhianna ^b   Shapiro, Virginia ^b   Muders, Michael H ^a   Smyrk, Thomas ^a   Couch, Fergus J ^a  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

Cancer Genetics; Neoplasia; Oncogene; Pancreas

Indexed keywords

BRCA2 PROTEIN; K RAS PROTEIN; TRYPTOPHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; FEMALE; GENE DELETION; GENE INACTIVATION; GENE MUTATION; HISTOPATHOLOGY; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; WILD TYPE;

EID: 79953181635     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.12.039     Document Type: Article

References (32)

1. M.E. Moynahan, A.J. Pierce, and M. Jasin BRCA2 is required for homology-directed repair of chromosomal breaks Mol Cell 7 2001 263 272 (Pubitemid 32206494)
2. A. Tutt, D. Bertwistle, and J. Valentine In Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences EMBO J 20 2001 4704 4716 (Pubitemid 32848624)
3. Consortium TBCL Cancer risks in BRCA2 mutation carriers J Natl Cancer Inst 91 1999 1310 1316
4. F.J. Couch, M.R. Johnson, and K. Rabe Germ line Fanconi anemia complementation group C mutations and pancreatic cancer Cancer Res 65 2005 383 386
5. K.M. Murphy, K.A. Brune, and C. Griffin Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17% Cancer Res 62 2002 3789 3793 (Pubitemid 34728862)
6. M. Goggins, M. Schutte, and J. Lu Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas Cancer Res 56 1996 5360 5364 (Pubitemid 27011364)
7. H. Ozcelik, B. Schmocker, and N. Di Nicola Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients Nat Genet 16 1997 17 18
8. S. Jones, R.H. Hruban, and M. Kamiyama Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene Science 324 2009 217
9. R.H. Hruban, R.E. Wilentz, and S.E. Kern Genetic progression in the pancreatic ducts Am J Pathol 156 2000 1821 1825 (Pubitemid 30641750)
10. C. Almoguera, D. Shibata, and K. Forrester Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes Cell 53 1988 549 554
11. M.S. Redston, C. Caldas, and A.B. Seymour p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions Cancer Res 54 1994 3025 3033 (Pubitemid 24187791)
12. A. Maitra, N.V. Adsay, and P. Argani Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray Mod Pathol 16 2003 902 912 (Pubitemid 37152020)
13. S.R. Hingorani, E.F. Petricoin, and A. Maitra Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse Cancer Cell 4 2003 437 450 (Pubitemid 38050041)
14. J. Jonkers, R. Meuwissen, and H. van der Gulden Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer Nat Genet 29 2001 418 425 (Pubitemid 34326692)
15. T. Crook, L.A. Brooks, and S. Crossland p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours Oncogene 17 1998 1681 1689 (Pubitemid 28482645)
16. F. Skoulidis, L.D. Cassidy, and V. Pisupati Germline Brca2 heterozygosity promotes Kras(G12D)-driven carcinogenesis in a murine model of familial pancreatic cancer Cancer Cell 18 2010 499 509
17. H.E. Bryant, N. Schultz, and H.D. Thomas Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase Nature 434 2005 913 917 (Pubitemid 40559005)
18. H. Farmer, N. McCabe, and C.J. Lord Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature 434 2005 917 921 (Pubitemid 40559006)
19. S.S. Yuan, S.Y. Lee, and G. Chen BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo Cancer Res 59 1999 3547 3551 (Pubitemid 29381849)
20. M.J. Daniels, Y. Wang, and M. Lee Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2 Science 306 2004 876 879 (Pubitemid 39446997)
21. A. Tutt, A. Gabriel, and D. Bertwistle Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification Curr Biol 9 1999 1107 1110 (Pubitemid 29504480)
22. L. Zhu, G. Shi, and C.M. Schmidt Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia Am J Pathol 171 2007 263 273 (Pubitemid 47339243)
23. S.P. Thayer, M.P. di Magliano, and P.W. Heiser Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis Nature 425 2003 851 856 (Pubitemid 37355945)
24. J.P. Morris 4th, D.A. Cano, and S. Sekine Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice J Clin Invest 120 2010 508 520
25. E. Rozenblum, M. Schutte, and M. Goggins Tumor-suppressive pathways in pancreatic carcinoma Cancer Res 57 1997 1731 1734 (Pubitemid 27199667)
26. M. Goggins, R.H. Hruban, and S.E. Kern BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications Am J Pathol 156 2000 1767 1771 (Pubitemid 30646713)
27. A.J. Aguirre, N. Bardeesy, and M. Sinha Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma Genes Dev 17 2003 3112 3126 (Pubitemid 38040774)
28. N. Bardeesy, K.H. Cheng, and J.H. Berger Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer Genes Dev 20 2006 3130 3146 (Pubitemid 44790628)
29. B.C. Lewis, D.S. Klimstra, and H.E. Varmus The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer Genes Dev 17 2003 3127 3138 (Pubitemid 38040775)
30. S.Y. Gidekel Friedlander, G.C. Chu, and E.L. Snyder Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras Cancer Cell 16 2009 379 389
31. P.C. Fong, D.S. Boss, and T.A. Yap Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers N Engl J Med 361 2009 123 134
32. A. Tutt, M. Robson, and J.E. Garber Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial Lancet 376 2010 235 244