Effect of polymorphisms in the leptin, leptin receptor and acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) genes and genetic polymorphism of milk proteins on bovine milk composition

Journal of Dairy Research

Volumn 79, Issue 1, 2012, Pages 110-118

  Glantz, Maria ^a   Lindmark Månsson, Helena ^a,b   Stålhammar, Hans ^c   Paulsson, Marie ^a  

^a LUND UNIVERSITY   (Sweden)

^b Swedish Dairy Association   (Sweden)

^c VikingGenetics   (Sweden)

Author keywords

acyl CoA:diacylglycerol acyltransferase 1 (DGAT1); Dairy cattle; leptin; leptin receptor; milk composition; milk protein polymorphism

Indexed keywords

DIACYLGLYCEROL ACYLTRANSFERASE; LEPTIN; LEPTIN RECEPTOR; MILK PROTEIN;

ALLELE; ANIMAL; ARTICLE; CATTLE; CHEMISTRY; FEMALE; GENETIC MARKER; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; METABOLISM; MILK;

ALLELES; ANIMALS; CATTLE; DIACYLGLYCEROL O-ACYLTRANSFERASE; FEMALE; GENETIC MARKERS; GENOTYPE; LEPTIN; MILK; MILK PROTEINS; POLYMORPHISM, GENETIC; RECEPTORS, LEPTIN;

BOS; BOVINAE;

EID: 84858781795     PISSN: 00220299     EISSN: 14697629     Source Type: Journal    
DOI: 10.1017/S0022029911000859     Document Type: Article

References (52)

1. Aleandri R, Buttazzoni LG, Schneider JC, Caroli A & Davoli R 1990 The effects of milk protein polymorphisms in milk components and cheese-producing ability. Journal of Dairy Science 73 241-255
2. Amenu B & Deeth HC 2007 The impact of milk composition on cheedar cheese manufacture. Australian Journal of Dairy Technology 62 171-184 (Pubitemid 350255458)
3. Auldist MJ, Walsh BJ & Thomson NA 1998 Seasonal and lactational influences on bovine milk composition in New Zealand. Journal of Dairy Research 65 401-411 (Pubitemid 28367560)
4. Banos G, Woolliams JA, Woodward BW, Forbes AB & Coffey MP 2008 Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows. Journal of Dairy Science 91 3190-3200
5. Berry DP, Howard D, O'Boyle PO, Waters S, Kearney JF & McCabeM2010 Associations between K232A polymorphism in the diacylglycerol-Otransferase 1 (DGAT1) gene and performance in Irish Holstein-Friesian dairy cattle. Irish Journal of Agricultural and Food Research 49 1-9
6. Bobe G, Beitz DC, Freeman AE & Lindberg GL 1999 Effect of milk protein genotypes on milk protein composition and its genetic parameter estimates. Journal of Dairy Science 82 2797-2804 (Pubitemid 129545930)
7. Bovenhuis H, van Arendonk JAM & Korver S 1992 Associations between milk protein polymorphisms and milk production traits. Journal of Dairy Science 75 2549-2559
8. Buchanan FC, Van Kessel AG, Waldner C & Christensen DA 2003 An association between a leptin single nucleotide polymorphism and milk and protein yield. Journal of Dairy Science 86 3164-3166 (Pubitemid 38995020)
9. Buchberger J & Dovc P 2000 Lactoprotein genetic variants in cattle and cheese making ability. Food Technology and Biotechnology 38 91-98
10. Cases S, Smith S, Zheng Y, Myers H, Lear S, Sande E, Novak S, Collins C, Welch C, Lusis A, Erickson S & Farese RJ 1998 Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proceedings of the National Academy of Sciences of the United States of America 95 13018-13023 (Pubitemid 28509516)
11. Chebel RC, Susca F & Santos JEP 2008 Leptin genotype is associated with lactation perfomance and health of Holstein cows. Journal of Dairy Science 91 2893-2900 (Pubitemid 351976611)
12. Conte G, Mele M, Chessa S, Castiglioni B, Serra A, Pagnacco G & Secchiari P 2010 Diacylglycerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1 gene polymorphisms and milk fatty acid composition in Italian Brown cattle. Journal of Dairy Science 93 753-763
13. da Silva MVGB, Sonstegard TS, Thallman RM, Connor EE, Schnabel RD & Van Tassell CP 2010 Characterization of DGAT1 allelic effects in asample of North American Holstein cattle. Animal Biotechnology 21 88-99
14. Fruhbeck G, Jebb SA & Prentice AM 1998 Leptin: Physiology and pathophysiology. Clinical Physiology 18 399-419 (Pubitemid 28451466)
15. Glantz M, Devold TG, Vegarud GE, Lindmark Månsson H, Stålhammar H & Paulsson M 2010 Importance of casein micelle size and milk composition for milk gelation. Journal of Dairy Science 93 1444-1451
16. Glantz M, Lindmark Månsson H, Stålhammar H, Bårström L-O, Fröjelin M, Knutsson A, Teluk C & Paulsson M 2009 Effects of animal selection on milk composition and processability. Journal of Dairy Science 92 4589-4603
17. Glantz M, Lindmark Månsson H, StålhammarH & PaulssonM2011 Effect of polymorphisms in the leptin, leptin receptor, and acyl-coenzyme A: Diacylglycerol acyltransferase 1 (DGAT1) genes and genetic polymorphism of milk proteins on cheese characteristics. Journal of Dairy Science 94 3295-3304
18. Grisart B, Coppieters W, Farnir F, Karim L, Ford C, Berzi P, Cambisano N, Mni M, Reid S, Simon P, Spelman R, GeorgesM& Snell R 2002 Positional candidate cloning of a QTL in dairy cattle: Identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome Research 12 222-231 (Pubitemid 34162989)
19. Hallén E, Allmere T, Näslund J, Andrén A & Lundén A 2007 Effect of genetic polymorphism of milk proteins on rheology of chymosin-induced milk gels. International Dairy Journal 17 791-799 (Pubitemid 46498728)
20. Hallén E, Wedholm A, Andrén A & Lundén A 2008 Effect of beta-casein, kappa-casein and beta-lactoglobulin genotypes on concentration of milk protein variants. Journal of Animal Breeding and Genetics 125 119-129 (Pubitemid 351445625)
21. Heck JLM, Schennink A, van Valenberg HJF, Bovenhuis H, Visker MHPW, van Arendonk JAM & van Hooijdonk ACM 2009 Effects on milk protein variants on the protein composition of bovine milk. Journal of Dairy Science 92 1192-1202
22. Ikonen T, Ahlfors K, Kempe R, Ojala M & Ruottinen O 1999a Genetic parameters for the milk coagulation properties and prevalence of noncoagulating milk in Finnish dairy cows. Journal of Dairy Science 82 205-214 (Pubitemid 129552334)
23. Ikonen T, Ojala M & Ruottinen O 1999b Associations between milk protein polymorphism and first lactation milk production traits in Finnish Ayrshire cows. Journal of Dairy Science 82 1026-1033 (Pubitemid 129601767)
24. Ikonen T, Ojala M & Syväoja EL 1997 Effects of composite casein and betalactoglobulin genotypes on renneting properties and composition of bovine milk by assuming an animal model. Agricultural and Food Science Finland 6 283-294 (Pubitemid 127364594)
25. Kaminski S, Brym P, Rusc A, Wójcik E, Ahman A & Mägi R 2006 Associations between milk performance traits in Holstein cows and 16 candidate SNPs identified by arrayed primer extension (apex) microarray. Animal Biotechnology 17 1-11
26. Kaupe B, Brandt H, Prinzenberg E-M & Erhardt G 2007 Joint analysis of the influence of CYP11B1 and DGAT1 genetic variation on milk production, somatic cell score, conformation, reproduction, and productive lifespan in German Holstein cattle. Journal of Animal Science 85 11-21 (Pubitemid 46648213)
27. Kay JK, Weber WJ, Moore CE, Bauman DE, Hansen LB, Chester-Jones H, Crooker BA & Baumgard LH 2005 Effects of week of lactation and genetic selection for milk yield on milk fatty acid composition in Holstein cows. Journal of Dairy Science 88 3886-3893 (Pubitemid 41577603)
28. Kgwatalala PM, Ibeagha-Awemu EM, Mustafa AF & Zhao X 2009 Stearoyl-CoA desaturase 1 genotype and stage of lactation influences milk fatty acid composition of Canadian Holstein cows. Animal Genetics 40 609-615
29. Komisarek J 2010 Impact of LEP and LEPR gene polymorphisms on functional traits in Polish Holstein-Friesian cattle. Animal Science Papers and Reports 28 133-141
30. Komisarek J & Dorynek Z 2006 The relationship between the T945M single nucleotide polymorphism in the leptin receptor gene (LEPR) and milk production traits in Jersey cows. Animal Science Papers and Reports 24 271-277
31. Komisarek J, Szyda J, Michalak A & Dorynek Z 2005 Impact of leptin gene polymorphisms on breeding value for milk production traits in cattle. Journal of Animal and Feed Sciences 14 491-500 (Pubitemid 41425976)
32. Kulig H, Kmiec M, Kowalewska-Luczak I & Andziak G 2009 Effect of leptin gene polymorphisms on milk production traits of Jersey cows. Turkish Journal of Veterinary and Animal Sciences 33 143-146
33. Kulig H, Kmiec M & Wojdak-Maksymiec K 2010 Associations between leptin gene polymorphisms and somatic cell count in milk of Jersey cows. Acta Veterinaria Brno 79 237-242
34. Liefers SC, te Pas MFW, Veerkamp RF & van der Lende T 2002 Associations between leptin gene polymorphisms and production, live weight, energy balance, feed intake, and fertility in Holstein heifers. Journal of Dairy Science 85 1633-1638 (Pubitemid 38572225)
35. Liefers SC, Veerkamp RF, te Pas MFW, Delavaud C, Chilliard Y & van der Lende T 2004 A missense mutation in the bovine leptin receptor gene is associated with leptin concentrations during late pregnancy. Animal Genetics 35 138-141 (Pubitemid 38458991)
36. Liefers SC, Veerkamp RF, Te Pas MFW, Delavaud C, Chilliard Y, Platje M & van der Lende T 2005 Leptin promoter mutations affect leptin levels and performance traits in dairy cows. Animal Genetics 36 111-118 (Pubitemid 40518693)
37. Lien S, Kantanen J, Olsaker I, Holm L-E, Eytorsdottir E, Sandberg K, Dalsgard B & Adalsteinsson S 1999 Comparison of milk protein allele frequencies in Nordic cattle breeds. Animal Genetics 30 85-91 (Pubitemid 29273000)
38. Lundén A, Nilsson M & Janson L 1997 Marked effect of beta-lactoglobulin polymorphism on the ratio of casein to total protein in milk. Journal of Dairy Science 80 2996-3005 (Pubitemid 127450977)
39. Näslund J, Fikse WF, Pielberg GR & Lundén A 2008 Frequency and effect of the bovine acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) K232A polymorphism in Swedish dairy cattle. Journal of Dairy Science 91 2127-2134 (Pubitemid 351730917)
40. Ng-Kwai-Hang KF 1998 Genetic polymorphism of milk proteins: Relationships with production traits, milk composition and technological properties. Canadian Journal of Animal Science 78 131-147 (Pubitemid 128451098)
41. Nordic Cattle Genetic Evaluation 2011 Routine evaluation-milk traits. http://www.nordicebv.info/Routine+evaluation/Milk+traits/Milk+Traits. htm. Accessed Feb. 21, 2011
42. Schennink A, Heck JML, Bovenhuis H, Visker MHPW, van Valenberg HJF & van Arendonk JAM 2008 Milk fatty acid unsaturation: Genetic parameters and effects of stearoyl-CoA desaturase (SCD1) and acyl CoA: Diacylglycerol acyltransferase 1 (DGAT1). Journal of Dairy Science 91 2135-2143 (Pubitemid 351730918)
43. Schennink A, Stoop WM, Visker MHPW, Heck JML, Bovenhuis H, van der Poel JJ, van Valenberg HJF & van Arendonk JAM 2007 DGAT1 underlies large genetic variation in milk-fat composition of dairy cows. Animal Genetics 38 467-473 (Pubitemid 47480946)
44. Signorelli F, Orrù L, Napolitano F, De Matteis G, Scatà MC, Catillo G, Marchitelli C & Moioli B 2009 Exploring polymorphisms and effects on milk traits of the DGAT1, SCD1 and GHR genes in four cattle breeds. Livestock Science 125 74-79
45. Spelman RJ, Ford CA, McElhinney P, Gregory GC & Snell RG 2002 Characterization of the DGAT1 gene in the New Zealand dairy population. Journal of Dairy Science 85 3514-3517 (Pubitemid 38587565)
46. Sun D, Jia J, Ma Y, Zhang Y, Wang Y, Yu Y & Zhang Y 2009 Effects of DGAT1 and GHR on milk yield and milk composition in the Chinese dairy population. Animal Genetics 40 997-1000
47. Swedish Dairy Association 2009 Dairy Statistics. Stockholm, Sweden: Swedish Dairy Association
48. Tellam RL 2007 Capturing benefits from the bovine genome sequence. Australian Journal of Experimental Agriculture 47 1039-1050 (Pubitemid 47221966)
49. Thaller G, KrämerW, Winter A, Kaupe B, ErhardtG& Fries R 2003 Effects of DGAT1 variants on milk production traits in German cattle breeds. Journal of Animal Science 81 1911-1918 (Pubitemid 38571705)
50. Walstra P & Jenness R 1984 Dairy Chemistry and Physics. Hoboken, NJ: US John Wiley & Sons Inc.
51. Wedholm A, Hallén E, Larsen LB, Lindmark Månsson H, Karlsson AH & Allmere T 2006a Comparison of milk protein composition in a Swedish and a Danish dairy herd using reversed phase HPLC. Acta Agriculturae Scandinavica Section A 56 8-15 (Pubitemid 44186977)
52. Wedholm A, Larsen LB, Lindmark Månsson H, Karlsson AH & Andrén A 2006b Effect of protein composition and the cheese-making properties of milk from individual dairy cows. Journal of Dairy Science 89 3296-3305 (Pubitemid 44305972)