A missense mutation in the bovine leptin receptor gene is associated with leptin concentrations during late pregnancy

Animal Genetics

Volumn 35, Issue 2, 2004, Pages 138-141

  Liefers, S C ^a   Veerkamp, R F ^a   Te Pas, M F W ^a   Delavaud, C ^b   Chilliard, Y ^b   Van Der Lende, T ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b UMR1213 HERBIVORES   (France)

Author keywords

Lactation; Leptin concentrations; Leptin receptor; Mutation; Pregnancy

Indexed keywords

CELL SURFACE RECEPTOR; LEPTIN; LEPTIN RECEPTOR; PRIMER DNA;

ANIMAL; ARTICLE; BREEDING; CATTLE; COMPARATIVE STUDY; DNA SEQUENCE; EXON; FEMALE; GENE FREQUENCY; GENETICS; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PREGNANCY; RADIOIMMUNOASSAY;

ANIMALS; BASE SEQUENCE; CATTLE; DNA PRIMERS; EXONS; FEMALE; GENE FREQUENCY; LEPTIN; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PREGNANCY; PREGNANCY, ANIMAL; RADIOIMMUNOASSAY; RECEPTORS, CELL SURFACE; SEQUENCE ANALYSIS, DNA;

ANIMALIA; BOS TAURUS; BOVINAE; MAMMALIA;

EID: 1842715690     PISSN: 02689146     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2052.2004.01115.x     Document Type: Article

References (19)

1. Chehab F.F., Lim M.E. & Lu R. (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genetics 12, 318-20.
2. Chen H., Charlat O., Tartaglia L.A. et al. (1996) Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84, 491-5.
3. Chua S.C. Jr, White D.W., Wu-Peng X.S. et al. (1996) Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (LEPR). Diabetes 45, 1141-3.
4. Cioffi J.A., Shafer A.W., Zupancic T.J., Smith-Gbur J., Mikhail A., Platika D. & Snodgrass H.R. (1996) Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nature Medicine 2, 585-9.
5. Clement K., Vaisse C., Lahlou N. et al. (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398-401.
6. Delavaud C., Bocquier F., Chilliard Y., Keisler D.H., Gertler A. & Kann G. (2000) Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentration assessed by a specific RIA in sheep. Journal of Endocrinology 165, 519-26.
7. Fong T.M., Huang R.R., Tota M.R., Mao C., Smith T., Varnerin J., Karpitskiy V.V., Krause J.E. & Van der Ploeg L.H. (1998) Localization of leptin binding domain in the leptin receptor. Molecular Pharmacology 53, 234-40.
8. Garcia M.D., Casanueva F.F., Dieguez C. & Senaris R.M. (2000) Gestational profile of leptin messenger ribonucleic acid (mRNA) content in the placenta and adipose tissue in the rat, and regulation of the mRNA levels of the leptin receptor subtypes in the hypothalamus during pregnancy and lactation. Biology of Reproduction 62, 698-703.
9. Gavrilova O., Barr V., Marcus-Samuels B. & Reitman M. (1997) Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor. Journal of Biological Chemistry 272, 30546-51.
10. Gilmour A.R., Cullis B.R., Welham S.J. & Thompson R. (2001) ASREML. Reference Manual. NSW Agriculture. Orange, Australia.
11. Liefers S.C., te Pas M.F.W., Veerkamp R.F., Delavaud C., Chilliard Y. & van der Lende T. (2003a) Association of leptin gene polymorphisms with serum leptin concentration in dairy cows. Mammalian Genome 14, 657-63.
12. Liefers S.C., Veerkamp R.F., te Pas M.F.W., Delavaud C., Chilliard Y. & van der Lende T. (2003b) Leptin concentrations in relation to energy balance, milk yield, intake, live weight, and estrus in dairy cows. Journal of Dairy Science 86, 799-807.
13. Montague C.T., Farooqi I.S., Whitehead J.P. et al. (1997) Congenital leptin deficiency is associated with severe early onset obesity in humans. Nature 387, 903-8.
14. Pfister-Genskow M., Hayes H., Eggen A. & Bishop M.D. (1997) The leptin receptor (LEPR) gene maps to bovine chromosome 3q33. Mammalian Genome 8, 227.
15. Tartaglia L.A. (1997) The leptin receptor. Journal of Biological Chemistry 272, 6093-6.
16. Tartaglia L.A., Dembski M., Weng X. et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263-71.
17. Vaisse C., Halaas J.L., Horvath C.M., Darnell J.E. Jr. Stoffel M. & Friedman J.M. (1996) Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nature Genetics 14, 95-7.
18. White D.W., Kuropatwinski K.K., Devos R., Baumann H. & Tartaglia L.A. (1997) Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. Journal of Biological Chemistry 272, 4065-71.
19. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L. & Friedman J.M. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-32.