Characterization of dgat1 allelic effects in a sample of North American holstein cattle

Animal Biotechnology

Volumn 21, Issue 2, 2010, Pages 88-99

  Da Silva, Marcos Vinicius G Barbosa ^a,b   Sonstegard, Tad S ^a   Thallman, Richard M ^c   Connor, Erin E ^a   Schnabel, Robert D ^d   Van Tassell, Curt P ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b EMBRAPA CERRADOS   (Brazil)

^c U S MEAT ANIMAL RESEARCH CENTER   (United States)

^d UNIVERSITY OF MISSOURI   (United States)

Author keywords

Dairy cattle; Milk production; Quantitative trait loci; Substitution effect

Indexed keywords

ACYLTRANSFERASE; ALLELIC EFFECTS; DAIRY CATTLES; HOLSTEIN CATTLE; MILK PRODUCTION; PROTEIN COMPONENTS; QUANTITATIVE TRAIT LOCUS; SUBSTITUTION EFFECT;

AMINO ACIDS; GENE ENCODING; PLANTS (BOTANY); PROTEINS;

ECONOMIC AND SOCIAL EFFECTS;

DIACYLGLYCEROL ACYLTRANSFERASE;

ALLELE; ANIMAL; ARTICLE; BREEDING; CATTLE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; MALE; METABOLISM; MUTATION; NORTH AMERICA; PHYSIOLOGY; QUANTITATIVE TRAIT LOCUS; TIME;

ALLELES; ANIMALS; BREEDING; CATTLE; DIACYLGLYCEROL O-ACYLTRANSFERASE; FEMALE; GENE EXPRESSION REGULATION; GENOTYPE; MALE; MUTATION; NORTH AMERICA; QUANTITATIVE TRAIT LOCI; TIME FACTORS;

BOS;

EID: 77951082825     PISSN: 10495398     EISSN: 15322378     Source Type: Journal    
DOI: 10.1080/10495390903504625     Document Type: Article

References (21)

1. Ashwell MS, Van Tassell CP, Sonstegard TS. A genome scan to identify quantitative trait loci affecting economically important traits in a US Holstein population. J Dairy Sci. 2001;84:2535-2542.
2. Heyen DW, Weller JI, Ron M, Band M, Beever JE, Feldmesser E, Da Y, Wiggans GR, VanRaden PM, Lewin HA. A genome scan for QTL influencing milk production and health traits in dairy cattle. Physiol Genomics. 1999;1:165-175.
3. Grisart B, Coppieters W, Farnir F, Karim L, Ford C, Berzi P, Cambisano N, Mni M, Reid S, Simon P, Spelman R, Georges M, Snell R. Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome Res. 2002;12:222-231.
4. Winter A, Kramer W, Werner FA, Kollers S, Kata S, Durstewitz G, Buitkamp J, Womack JE, Thaller G, Fries R. Association of a lysine-232=alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content. Proc Natl Acad Sci USA. 2002;99:9300-9305.
5. Grisart B, Farnir F, Karim L, Cambisano N, Kim JJ, Kvasz A, Mni M, Simon P, Frere JM, Coppieters W, Georges M. Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition. Proc Natl Acad Sci USA. 2004;101:2398-2403.
6. Kühn C, Thaller G, Winter A, Bininda-Emonds OR, Kaupe B, Erhardt G, Bennewitz J, Schwerin M, Fries R. Evidence for multiple alleles at the DGAT1 locus better explains a quantitative trait locus with major effect on milk fat content in cattle. Genetics. 2004;167:1873-1881.
7. Thaller G, Kramer W, Winter A, Kaupe B, Erhardt G, Fries R. Effects of DGAT1 variants on milk production traits in German cattle breeds. J Anim Sci. 2003;81:1911-1918.
8. Da Y, Ron M, Yanai A, Band M, Everts RE, Heyen DW, Weller JI, Wiggans GR, Lewin, HA. The dairy bull DNA repository: A resource for mapping quantitative trait loci. In: Proceedings 5th World Congress on Genetics Applied to Livestock Produciton; Guelph, ON, Canada 1994; 18:229-232.
9. Ashwell MS, Van Tassell CP. The Cooperative Dairy DNA Repository: a new resource for quantitative trait loci detection and verification. In: Proceedings 8th Plant Animal Genome Conference; San Diego, CA 2000: 360.
10. VanRaden PM, Wiggans GR. Derivation, calculation, and use of national animal model information. J Dairy Sci. 1991;74:2737-2746.
11. Thallman RM, Bennett GL, Keele JW, Kappes SM. Efficient computation of genotype probabilities for loci with many alleles: I. Allelic peeling. J Anim Sci. 2001;79:26-33.
12. Thallman RM, Bennett GL, Keele JW, Kappes SM. Efficient computation of genotype probabilities for loci with many alleles: II. Iterative method for large, complex pedigrees. J Anim Sci. 2001;79:34-44.
13. Henderson CR. Application of Linear Models in Animal Breeding. Univ. Guelph, ON, Canada: Gulph Press. 1984.
14. Boldman KG, Kriese LA, Van Vleck LD, Van Tassell CP, Kachman SD. A Manual for Use of MTDFREML: A Set of Programs to Obtain Estimates of Variances and Covariances [DRAFT]. Clay Center, NE: US Dept. Agric., Agric. Res. Service; 1995.
15. Lynch M, Walsh B. Genetics and Analysis of Quantitative Traits. Sunderland, MA: Sinauer Associates, Inc. 1998.
16. Weller JI, Golik M, Seroussi E, Ezra E, Ron M. Population-wide analysis of a QTL affecting milk-fat production in the Israeli Holstein population. J Dairy Sci. 2003;86:2219-2227.
17. VanRaden PM Invited review: selection on net merit to improve lifetime profit. J Dairy Sci. 2004;87:3125-3131.
18. International Bull Evaluation Service. Appendix I: Estimated sire standard deviation and genetic correlations considered in the Interbull evaluation for dairy production traits of November 2004; 2004. http://www-interbull.slu.se/eval/appen1-044.html. Accessed Dec. 27, 2004
19. Spelman RJC, Ford A, McElhinney P, Gregory GC, Snell RG. Characterization of the DGAT1 gene in the New Zealand dairy population. J Dairy Sci. 2002;85:3514-3517.
20. Weigel KA, Rekaya R, Zwald NR, Fikse NW. International genetic evaluation of dairy sires using a multiple-trait model with individual animal performance records. J Dairy Sci. 2001;84:2789-2795.
21. Weigel KA. Controlling inbreeding in modern breeding programs. J Dairy Sci. 2001;84: E177-E184.