Granulocytes in helminth infection-Who is calling the shots?

Current Medicinal Chemistry

Volumn 19, Issue 10, 2012, Pages 1567-1586

  Makepeacel, B L ^a   Martin, C ^b   Turner, J D ^c   Specht, S ^d  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^d UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Basophil; Filariasis; Helminths Eosinophil; Neutrophil; Nitricoxide; Reactive nitrogen species; Reactive oxygen species; T H2 response

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G4; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 22; INTERLEUKIN 25; INTERLEUKIN 3; INTERLEUKIN 33; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9; MACROPHAGE ELASTASE; THYMIC STROMAL LYMPHOPOIETIN; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR;

ANTIBODY PRODUCTION; BASOPHIL; CESTODE; CYTOKINE PRODUCTION; ECHINOCOCCUS GRANULOSUS; EFFECTOR CELL; EOSINOPHIL; FILARIASIS; GRANULOCYTE; GRANULOCYTE FUNCTION; HELMINTHIASIS; HOST PARASITE INTERACTION; HOST RESISTANCE; HUMAN; IMMUNE SYSTEM; IMMUNOPATHOLOGY; NEMATODE; NEUTROPHIL; NONHUMAN; PARASITE CLEARANCE; PROTEIN EXPRESSION; REVIEW; SCHISTOSOMA; TH2 CELL; TREMATODE; TRICHINELLA;

ANIMALS; GRANULOCYTES; HELMINTHIASIS; HELMINTHS; HOST-PARASITE INTERACTIONS; HUMANS; INTESTINAL DISEASES, PARASITIC;

EID: 84858779359     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712799828337     Document Type: Review

References (299)

1. Kondo, M. Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors. Immunol. Rev., 2010, 238, 37-46.
2. Doulatov, S.; Notta, F.; Eppert, K.; Nguyen, L. T.; Ohashi, P. S.; Dick, J. E. Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development. Nat. Immunol., 2010, 11, 585-593.
3. Himmelweit, E. The Collected Papers of Paul Ehrlich Vol. 1-Histology, Biochemistry and Pathology. Pergmon Press: London and New York, 1956; Vol. 1, 653 pp.
4. Sorci, G.; Faivre, B. Inflammation and oxidative stress in vertebrate hostparasite systems. Philos. Trans. R. Soc. Lond. B. Biol. Sci., 2009, 364, 71-83.
5. Shamri, R.; Xenakis, J. J.; Spencer, L. A., Eosinophils in innate immunity: an evolving story. Cell Tissue Res., 2011, 343 (1), 57-83.
6. Heneberg, P.; Draberova, L.; Bambouskova, M.; Pompach, P.; Draber, P. Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts. J. Biol. Chem., 2010, 285, 12787-12802.
7. Voehringer, D., Basophils in immune responses against helminths. Microbes Infect., 2011, 13, 881-887.
8. Katona, I. M.; Urban, J. F., Jr.; Finkelman, F. D., The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis. J. Immunol., 1988, 140, 3206-3211.
9. Al-Qaoud, K. M.; Taubert, A.; Zahner, H.; Fleischer, B.; Hoerauf, A. Infection of BALB/c mice with the filarial nematode Litomosoides sigmodontis : role of CD4+ T cells in controlling larval development. Infect. Immun., 1997, 65, 2457-2461. (Pubitemid 27237337)
10. Allen, J. E.; Maizels, R. M. Diversity and dialogue in immunity to helminths. Nat. Rev. Immunol., 2011, 11, 375-388.
11. Cervi, L.; MacDonald, A. S.; Kane, C.; Dzierszinski, F.; Pearce, E. J. Cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartments, and concurrently induce microbe-specific Th1 and helminthspecific Th2 responses. J. Immunol., 2004, 172, 2016-2020. (Pubitemid 38182346)
12. Saenz, S. A.; Taylor, B. C.; Artis, D. Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites. Immunol. Rev., 2008, 226, 172-190.
13. Ballantyne, S. J.; Barlow, J. L.; Jolin, H. E.; Nath, P.; Williams, A. S.; Chung, K. F.; Sturton, G.; Wong, S. H.; McKenzie, A. N. Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. J. Allergy Clin. Immunol., 2007, 120, 1324-1331. (Pubitemid 350216590)
14. Fort, M. M.; Cheung, J.; Yen, D.; Li, J.; Zurawski, S. M.; Lo, S.; Menon, S.; Clifford, T.; Hunte, B.; Lesley, R.; Muchamuel, T.; Hurst, S. D.; Zurawski, G.; Leach, M. W.; Gorman, D. M.; Rennick, D. M. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity, 2001, 15, 985-995. (Pubitemid 34075378)
15. Schmitz, J.; Owyang, A.; Oldham, E.; Song, Y.; Murphy, E.; McClanahan, T. K.; Zurawski, G.; Moshrefi, M.; Qin, J.; Li, X.; Gorman, D. M.; Bazan, J. F.; Kastelein, R. A. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity, 2005, 23, 479-490. (Pubitemid 41587888)
16. Ziegler, S. F.; Artis, D. Sensing the outside world: TSLP regulates barrier immunity. Nat. Immunol., 2010, 11, 289-293.
17. Neill, D. R.; McKenzie, A. N. Nuocytes and beyond: new insights into helminth expulsion. Trends Parasitol., 2011, 27, 214-221.
18. Hasnain, S. Z.; Evans, C. M.; Roy, M.; Gallagher, A. L.; Kindrachuk, K. N.; Barron, L.; Dickey, B. F.; Wilson, M. S.; Wynn, T. A.; Grencis, R. K.; Thornton, D. J. Muc5ac: a critical component mediating the rejection of enteric nematodes. J. Exp. Med., 2011, 208, 893-900.
19. Perrigoue, J. G.; Saenz, S. A.; Siracusa, M. C.; Allenspach, E. J.; Taylor, B. C.; Giacomin, P. R.; Nair, M. G.; Du, Y.; Zaph, C.; van Rooijen, N.; Comeau, M. R.; Pearce, E. J.; Laufer, T. M.; Artis, D. MHC class IIdependent basophil-CD4+ T cell interactions promote T(H)2 cytokinedependent immunity. Nat. Immunol., 2009, 10, 697-705.
20. Allen, J. E.; Wynn, T. A. Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens. PLoS Pathog., 2011, 7, e1002003.
21. Hogan, S. P.; Rosenberg, H. F.; Moqbel, R.; Phipps, S.; Foster, P. S.; Lacy, P.; Kay, A. B.; Rothenberg, M. E. Eosinophils: biological properties and role in health and disease. Clin. Exp. Allergy, 2008, 38, 709-750. (Pubitemid 351550670)
22. Melo, R. C.; Weller, P. F. Piecemeal degranulation in human eosinophils: a distinct secretion mechanism underlying inflammatory responses. Histol. Histopathol., 2010, 25, 1341-1354.
23. Swartz, J. M.; Dyer, K. D.; Cheever, A. W.; Ramalingam, T.; Pesnicak, L.; Domachowske, J. B.; Lee, J. J.; Lee, N. A.; Foster, P. S.; Wynn, T. A.; Rosenberg, H. F. Schistosoma mansoni infection in eosinophil lineageablated mice. Blood, 2006, 108, 2420-2427. (Pubitemid 44497528)
24. Rothenberg, M. E.; MacLean, J. A.; Pearlman, E.; Luster, A. D.; Leder, P. Targeted disruption of the chemokine eotaxin partially reduces antigeninduced tissue eosinophilia. J. Exp. Med., 1997, 185, 785-790. (Pubitemid 27098162)
25. Denzler, K. L.; Farmer, S. C.; Crosby, J. R.; Borchers, M.; Cieslewicz, G.; Larson, K. A.; Cormier-Regard, S.; Lee, N. A.; Lee, J. J. Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma. J. Immunol., 2000, 165, 5509-5517.
26. Denzler, K. L.; Borchers, M. T.; Crosby, J. R.; Cieslewicz, G.; Hines, E. M.; Justice, J. P.; Cormier, S. A.; Lindenberger, K. A.; Song, W.; Wu, W.; Hazen, S. L.; Gleich, G. J.; Lee, J. J.; Lee, N. A. Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation. J. Immunol., 2001, 167, 1672-1682. (Pubitemid 32703170)
27. Kitamura, D.; Roes, J.; Kuhn, R.; Rajewsky, K. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature, 1991, 350, 423-426. (Pubitemid 21912244)
28. Summers, C.; Rankin, S. M.; Condliffe, A. M.; Singh, N.; Peters, A. M.; Chilvers, E. R. Neutrophil kinetics in health and disease. Trends Immunol., 2010, 31, 318-324.
29. Mantovani, A.; Cassatella, M. A.; Costantini, C.; Jaillon, S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat. Rev. Immunol., 2011, 11, 519-531.
30. Balabanian, K.; Lagane, B.; Pablos, J. L.; Laurent, L.; Planchenault, T.; Verola, O.; Lebbe, C.; Kerob, D.; Dupuy, A.; Hermine, O.; Nicolas, J. F.; Latger-Cannard, V.; Bensoussan, D.; Bordigoni, P.; Baleux, F.; Le Deist, F.; Virelizier, J. L.; Arenzana-Seisdedos, F.; Bachelerie, F. WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12. Blood, 2005, 105, 2449-2457. (Pubitemid 40387045)
31. Etzioni, A. Loss of endothelial surface expression of E-selectin-a third LAD syndrome. Blood, 1999, 94, 3956.
32. Mollinedo, F.; Borregaard, N.; Boxer, L. A., Novel trends in neutrophil structure, function and development. Immunol. Today, 1999, 20, 535-537.
33. Cassatella, M. A.; Gasperini, S.; Russo, M. P. Cytokine expression and release by neutrophils. Ann. N. Y. Acad. Sci., 1997, 832, 233-242. (Pubitemid 28045318)
34. Fialkow, L.; Wang, Y.; Downey, G. P. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic. Biol. Med., 2007, 42, 153-164. (Pubitemid 46001554)
35. Cua, D. J.; Tato, C. M. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev. Immunol., 2010, 10, 479-489.
36. Chollet-Martin, S.; Jourdain, B.; Gibert, C.; Elbim, C.; Chastre, J.; Gougerot-Pocidalo, M. A. Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS. Am. J. Respir. Crit. Care Med., 1996, 154, 594-601. (Pubitemid 26327278)
37. Williams, T. J.; Jose, P. J. Neutrophils in chronic obstructive pulmonary disease. Novartis Found Symp., 2001, 234, 136-141.
38. Sur, S.; Crotty, T. B.; Kephart, G. M.; Hyma, B. A.; Colby, T. V.; Reed, C. E.; Hunt, L. W.; Gleich, G. J. Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? Am. Rev. Respir. Dis., 1993, 148, 713-719. (Pubitemid 23263785)
39. Tkalcevic, J.; Novelli, M.; Phylactides, M.; Iredale, J. P.; Segal, A. W.; Roes, J. Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity, 2000, 12, 201-210. (Pubitemid 30398634)
40. Heneberg, P.; Draber, P. Regulation of cys-based protein tyrosine phosphatases via reactive oxygen and nitrogen species in mast cells and basophils. Curr. Med. Chem., 2005, 12, 1859-1871. (Pubitemid 41015183)
41. Lantz, C. S.; Boesiger, J.; Song, C. H.; Mach, N.; Kobayashi, T.; Mulligan, R. C.; Nawa, Y.; Dranoff, G.; Galli, S. J. Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature, 1998, 392, 90-93. (Pubitemid 28150595)
42. Siracusa, M. C.; Saenz, S. A.; Hill, D. A.; Kim, B. S.; Headley, M. B.; Doering, T. A.; Wherry, E. J.; Jessup, H. K.; Siegel, L. A.; Kambayashi, T.; Dudek, E. C.; Kubo, M.; Cianferoni, A.; Spergel, J. M.; Ziegler, S. F.; Comeau, M. R.; Artis, D. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature, 2011, 477, 229-233.
43. Stone, K. D.; Prussin, C.; Metcalfe, D. D. IgE, mast cells, basophils, and eosinophils. J Allergy Clin. Immunol., 2010, 125, S73-S80.
44. Sullivan, B. M.; Locksley, R. M. Basophils: a nonredundant contributor to host immunity. Immunity, 2009, 30, 12-20.
45. Fallon, P. G.; Richardson, E. J.; McKenzie, G. J.; McKenzie, A. N. Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent. J. Immunol., 2000, 164, 2585-2591. (Pubitemid 30115489)
46. Mukai, K.; Matsuoka, K.; Taya, C.; Suzuki, H.; Yokozeki, H.; Nishioka, K.; Hirokawa, K.; Etori, M.; Yamashita, M.; Kubota, T.; Minegishi, Y.; Yonekawa, H.; Karasuyama, H. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity, 2005, 23, 191-202. (Pubitemid 41169288)
47. Tsujimura, Y.; Obata, K.; Mukai, K.; Shindou, H.; Yoshida, M.; Nishikado, H.; Kawano, Y.; Minegishi, Y.; Shimizu, T.; Karasuyama, H. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-Emediated systemic anaphylaxis. Immunity, 2008, 28, 581-589.
48. Obata, K.; Mukai, K.; Tsujimura, Y.; Ishiwata, K.; Kawano, Y.; Minegishi, Y.; Watanabe, N.; Karasuyama, H. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood, 2007, 110, 913-920. (Pubitemid 47267429)
49. Karasuyama, H.; Mukai, K.; Tsujimura, Y.; Obata, K. Newly discovered roles for basophils: a neglected minority gains new respect. Nat. Rev. Immunol., 2009, 9, 9-13.
50. Wada, T.; Ishiwata, K.; Koseki, H.; Ishikura, T.; Ugajin, T.; Ohnuma, N.; Obata, K.; Ishikawa, R.; Yoshikawa, S.; Mukai, K.; Kawano, Y.; Minegishi, Y.; Yokozeki, H.; Watanabe, N.; Karasuyama, H. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J. Clin. Invest., 2010, 120, 2867-2875.
51. Lilla, J. N.; Chen, C. C.; Mukai, K.; Benbarak, M. J.; Franco, C. B.; Kalesnikoff, J.; Yu, M.; Tsai, M.; Piliponsky, A. M.; Galli, S. J. Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice. Blood, 2011, 118, 6930-6938.
52. Mohrs, K.; Wakil, A. E.; Killeen, N.; Locksley, R. M.; Mohrs, M. A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity, 2005, 23, 419-429. (Pubitemid 41443443)
53. Sullivan, B. M.; Liang, H. E.; Bando, J. K.; Wu, D.; Cheng, L. E.; McKerrow, J. K.; Allen, C. D.; Locksley, R. M. Genetic analysis of basophil function in vivo. Nat. Immunol., 2011, 12, 527-535.
54. Magalhaes, K. G.; Almeida, P. E.; Atella, G. C.; Maya-Monteiro, C. M.; Castro-Faria-Neto, H. C.; Pelajo-Machado, M.; Lenzi, H. L.; Bozza, M. T.; Bozza, P. T. Schistosomal-derived lysophosphatidylcholine are involved in eosinophil activation and recruitment through Toll-like receptor-2-dependent mechanisms. J. Infect. Dis., 2010, 202, 1369-1379.
55. Thomas, P. G.; Carter, M. R.; Atochina, O.; Da'Dara, A. A.; Piskorska, D.; McGuire, E.; Harn, D. A. Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism. J. Immunol., 2003, 171, 5837-5841. (Pubitemid 37467200)
56. van der Kleij, D.; Latz, E.; Brouwers, J. F.; Kruize, Y. C.; Schmitz, M.; Kurt-Jones, E. A.; Espevik, T.; de Jong, E. C.; Kapsenberg, M. L.; Golenbock, D. T.; Tielens, A. G.; Yazdanbakhsh, M. A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. J. Biol. Chem., 2002, 277, 48122-48129. (Pubitemid 35470760)
57. Parker, L. C.; Prestwich, E. C.; Ward, J. R.; Smythe, E.; Berry, A.; Triantafilou, M.; Triantafilou, K.; Sabroe, I. A phosphatidylserine species inhibits a range of TLR-but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains. J. Immunol., 2008, 181, 5606-5617.
58. Goodridge, H. S.; Marshall, F. A.; Else, K. J.; Houston, K. M.; Egan, C.; Al-Riyami, L.; Liew, F. Y.; Harnett, W.; Harnett, M. M. Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. J. Immunol., 2005, 174, 284-293. (Pubitemid 40007415)
59. Brattig, N. W.; Bazzocchi, C.; Kirschning, C. J.; Reiling, N.; Büttner, D. W.; Ceciliani, F.; Geisinger, F.; Hochrein, H.; Ernst, M.; Wagner, H.; Bandi, C.; Hoerauf, A. The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4. J. Immunol., 2004, 173, 437-445. (Pubitemid 38797370)
60. Turner, J. D.; Langley, R. S.; Johnston, K. L.; Gentil, K.; Ford, L.; Wu, B.; Graham, M.; Sharpley, F.; Slatko, B.; Pearlman, E.; Taylor, M. J. Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis. J. Biol. Chem., 2009, 284, 22364-22378.
61. Perrigoue, J. G.; Marshall, F. A.; Artis, D. On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites. Cell Microbiol., 2008, 10, 1757-1764.
62. Venugopal, P. G.; Nutman, T. B.; Semnani, R. T. Activation and regulation of toll-like receptors (TLRs) by helminth parasites. Immunol. Res., 2009, 43, 252-263.
63. Akuthota, P.; Wang, H.; Weller, P. F. Eosinophils as antigen-presenting cells in allergic upper airway disease. Curr. Opin. Allergy Clin. Immunol., 2010, 10, 14-19.
64. Wright, H. L.; Moots, R. J.; Bucknall, R. C.; Edwards, S. W. Neutrophil function in inflammation and inflammatory diseases. Rheumatology (Oxford), 2010, 49, 1618-1631.
65. Nakanishi, K. Basophils as APC in Th2 response in allergic inflammation and parasite infection. Curr. Opin. Immunol., 2010, 22, 814-820.
66. Mawhorter, S. D.; Pearlman, E.; Kazura, J. W.; Boom, W. H. Class II major histocompatibility complex molecule expression on murine eosinophils activated in vivo by Brugia malayi. Infect. Immun., 1993, 61, 5410-5412. (Pubitemid 23353930)
67. Mawhorter, S. D.; Kazura, J. W.; Boom, W. H. Human eosinophils as antigen-presenting cells: relative efficiency for superantigen-and antigeninduced CD4+ T-cell proliferation. Immunology, 1994, 81, 584-591. (Pubitemid 24246508)
68. Padigel, U. M.; Lee, J. J.; Nolan, T. J.; Schad, G. A.; Abraham, D. Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis. Infect. Immun., 2006, 74, 3232-3238. (Pubitemid 43794511)
69. Padigel, U. M.; Hess, J. A.; Lee, J. J.; Lok, J. B.; Nolan, T. J.; Schad, G. A.; Abraham, D. Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice. J. Infect. Dis., 2007, 196, 1844-1851. (Pubitemid 351411946)
70. Shinkai, K.; Mohrs, M.; Locksley, R. M. Helper T cells regulate type-2 innate immunity in vivo. Nature, 2002, 420, 825-829. (Pubitemid 36019631)
71. Ohnmacht, C.; Voehringer, D. Basophil effector function and homeostasis during helminth infection. Blood, 2009, 113, 2816-2825.
72. Schramm, G.; Mohrs, K.; Wodrich, M.; Doenhoff, M. J.; Pearce, E. J.; Haas, H.; Mohrs, M. Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo. J. Immunol., 2007, 178, 6023-6027. (Pubitemid 46717379)
73. Falcone, F. H.; Dahinden, C. A.; Gibbs, B. F.; Noll, T.; Amon, U.; Hebestreit, H.; Abrahamsen, O.; Klaucke, J.; Schlaak, M.; Haas, H. Human basophils release interleukin-4 after stimulation with Schistosoma mansoni egg antigen. Eur. J. Immunol., 1996, 26, 1147-1155. (Pubitemid 26158515)
74. Schramm, G.; Falcone, F. H.; Gronow, A.; Haisch, K.; Mamat, U.; Doenhoff, M. J.; Oliveira, G.; Galle, J.; Dahinden, C. A.; Haas, H. Molecular characterization of an interleukin-4-inducing factor from Schistosoma mansoni eggs. J. Biol. Chem., 2003, 278, 18384-18392. (Pubitemid 36799460)
75. Ohnmacht, C.; Voehringer, D. Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells. J. Immunol., 2010, 184, 344-350.
76. Torrero, M. N.; Hubner, M. P.; Larson, D.; Karasuyama, H.; Mitre, E. Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode Litomosoides sigmodontis. J. Immunol., 2010, 185, 7426-7434.
77. Kim, S.; Prout, M.; Ramshaw, H.; Lopez, A. F.; LeGros, G.; Min, B. Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3. J. Immunol., 2010, 184, 1143-1147.
78. Castro, G. A. Helminths: Structure, Classification, Growth, and Development. Medical Microbiology. The University of Texas Medical Branch at Galveston. 1996.
79. Andrade, Z. A. Pathology of human schistosomiasis. Mem. Inst. Oswaldo Cruz, 1987, 82(Suppl 4), 17-23.
80. Gryseels, B.; Polman, K.; Clerinx, J.; Kestens, L. Human schistosomiasis. Lancet, 2006, 368, 1106-1118. (Pubitemid 44402679)
81. Ramalho-Pinto, F. J.; McLaren, D. J.; Smithers, S. R. Complement-mediated killing of schistosomula of Schistosoma mansoni by rat eosinophils in vitro. J. Exp. Med., 1978, 147, 147-156. (Pubitemid 8250814)
82. Capron, M.; Capron, A.; Torpier, G.; Bazin, H.; Bout, D.; Joseph, M. Eosinophil-dependent cytotoxicity in rat schistosomiasis. Involvement of IgG2a antibody and role of mast cells. Eur. J. Immunol., 1978, 8, 127-133. (Pubitemid 8327028)
83. Butterworth, A. E.; Sturrock, R. F.; Houba, V.; Mahmoud, A. A.; Sher, A.; Rees, P. H. Eosinophils as mediators of antibody-dependent damage to schistosomula. Nature, 1975, 256, 727-729.
84. Vadas, M. A.; David, J. R.; Butterworth, A. E.; Houba, V.; Sturrock, R. F.; David, L.; Herson, R.; Siongok, T. A.; Kimani, R. Functional studies on purified eosinophils and neutrophils from patients with Schistosoma mansoni infections. Clin. Exp. Immunol., 1980, 39, 683-694. (Pubitemid 10135952)
85. Dessein, A.; Butterworth, A. E.; Vadas, M. A.; David, J. R. Maturation in vivo of Schistosoma mansoni schistosomula after culture in vitro with granulocytes and antibody. Infect. Immun., 1983, 39, 225-232. (Pubitemid 13212520)
86. Serradell, M. C.; Guasconi, L.; Masih, D. T. Involvement of a mitochondrial pathway and key role of hydrogen peroxide during eosinophil apoptosis induced by excretory-secretory products from Fasciola hepatica. Mol. Biochem. Parasitol., 2009, 163, 95-106.
87. Freudenstein-Dan, A.; Gold, D.; Fishelson, Z. Killing of schistosomes by elastase and hydrogen peroxide: implications for leukocyte-mediated schistosome killing. J. Parasitol., 2003, 89, 1129-1135. (Pubitemid 38049798)
88. Jenkins, S. J.; Hewitson, J. P.; Jenkins, G. R.; Mountford, A. P. Modulation of the host's immune response by schistosome larvae. Parasite Immunol., 2005, 27, 385-393. (Pubitemid 41413486)
89. Incani, R. N.; McLaren, D. J. Histopathological and ultrastructural studies of cutaneous reactions elicited in naive and chronically infected mice by invading schistosomula of Schistosoma mansoni. Int. J. Parasitol., 1984, 14, 259-276.
90. Paveley, R. A.; Aynsley, S. A.; Cook, P. C.; Turner, J. D.; Mountford, A. P. Fluorescent imaging of antigen released by a skin-invading helminth reveals differential uptake and activation profiles by antigen presenting cells. PLoS Negl. Trop. Dis., 2009, 3, e528.
91. Hogg, K. G.; Kumkate, S.; Anderson, S.; Mountford, A. P. Interleukin-12 p40 secretion by cutaneous CD11c+ and F4/80+ cells is a major feature of the innate immune response in mice that develop Th1-mediated protective immunity to Schistosoma mansoni. Infect. Immun., 2003, 71, 3563-3571. (Pubitemid 36637585)
92. Jenkins, S. J.; Mountford, A. P. Dendritic cells activated with products released by schistosome larvae drive Th2-type immune responses, which can be inhibited by manipulation of CD40 costimulation. Infect. Immun., 2005, 73, 395-402. (Pubitemid 40041132)
93. Cook, P. C.; Aynsley, S. A.; Turner, J. D.; Jenkins, G. R.; Van Rooijen, N.; Leeto, M.; Brombacher, F.; Mountford, A. P. Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells. PLoS Pathog., 2011, 7, e1001323.
94. Pearce, E. J.; Caspar, P.; Grzych, J. M.; Lewis, F. A.; Sher, A. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med., 1991, 173, 159-166.
95. Wilson, M. S.; Mentink-Kane, M. M.; Pesce, J. T.; Ramalingam, T. R.; Thompson, R.; Wynn, T. A. Immunopathology of schistosomiasis. Immunol. Cell Biol., 2007, 85, 148-154. (Pubitemid 46398720)
96. Pearce, E. J.; MacDonald, A. S. The immunobiology of schistosomiasis. Nat. Rev. Immunol., 2002, 2, 499-511. (Pubitemid 37328741)
97. Anthony, R. M.; Rutitzky, L. I.; Urban, J. F., Jr.; Stadecker, M. J.; Gause, W. C. Protective immune mechanisms in helminth infection. Nat. Rev. Immunol., 2007, 7, 975-987. (Pubitemid 350166058)
98. Cutts, L.; Wilson, R. A. Elimination of a primary schistosome infection from rats coincides with elevated IgE titres and mast cell degranulation. Parasite Immunol., 1997, 19, 91-102. (Pubitemid 27110317)
99. Capron, M.; Capron, A. Immunoglobulin E and effector cells in schistosomiasis. Science, 1994, 264, 1876-1877. (Pubitemid 24245625)
100. Lee, J. J.; Lee, N. A. Eosinophil degranulation: an evolutionary vestige or a universally destructive effector function? Clin. Exp. Allergy, 2005, 35, 986-994. (Pubitemid 41603131)
101. Clark, K.; Simson, L.; Newcombe, N.; Koskinen, A. M.; Mattes, J.; Lee, N. A.; Lee, J. J.; Dent, L. A.; Matthaei, K. I.; Foster, P. S. Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen. J. Leukoc. Biol., 2004, 75, 1001-1009. (Pubitemid 38720640)
102. Capron, M.; Jouault, T.; Prin, L.; Joseph, M.; Ameisen, J. C.; Butterworth, A. E.; Papin, J. P.; Kusnierz, J. P.; Capron, A. Functional study of a monoclonal antibody to IgE Fc receptor (Fc epsilon R2) of eosinophils, platelets, and macrophages. J. Exp. Med., 1986, 164, 72-89. (Pubitemid 16069223)
103. Dombrowicz, D.; Quatannens, B.; Papin, J. P.; Capron, A.; Capron, M. Expression of a functional Fc epsilon RI on rat eosinophils and macrophages. J. Immunol., 2000, 165, 1266-1271. (Pubitemid 30604553)
104. Kayaba, H.; Dombrowicz, D.; Woerly, G.; Papin, J. P.; Loiseau, S.; Capron, M. Human eosinophils and human high affinity IgE receptor transgenic mouse eosinophils express low levels of high affinity IgE receptor, but release IL-10 upon receptor activation. J. Immunol., 2001, 167, 995-1003. (Pubitemid 32660857)
105. Hewitson, J. P.; Hamblin, P. A.; Mountford, A. P. Immunity induced by the radiation-attenuated schistosome vaccine. Parasite Immunol., 2005, 27, 271-280. (Pubitemid 41344619)
106. Mastin, A. J.; Bickle, Q. D.; Wilson, R. A. Schistosoma mansoni: migration and attrition of irradiated and challenge schistosomula in the mouse. Parasitology, 1983, 87, 87-102.
107. Mountford, A. P.; Coulson, P. S.; Saunders, N.; Wilson, R. A. Characteristics of protective immunity in mice induced by drug-attenuated larvae of Schistosoma mansoni. Antigen localization and antibody responses. J. Immunol., 1989, 143, 989-995. (Pubitemid 19203830)
108. Coulson, P. S. The radiation-attenuated vaccine against schistosomes in animal models: paradigm for a human vaccine? Adv. Parasitol., 1997, 39, 271-336. (Pubitemid 27334272)
109. Wynn, T. A.; Oswald, I. P.; Eltoum, I. A.; Caspar, P.; Lowenstein, C. J.; Lewis, F. A.; James, S. L.; Sher, A. Elevated expression of Th1 cytokines and nitric oxide synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni. J. Immunol., 1994, 153, 5200-5209. (Pubitemid 24356152)
110. Street, M.; Coulson, P. S.; Sadler, C.; Warnock, L. J.; McLaughlin, D.; Bluethmann, H.; Wilson, R. A. TNF is essential for the cell-mediated protective immunity induced by the radiation-attenuated schistosome vaccine. J. Immunol., 1999, 163, 4489-4494. (Pubitemid 29474518)
111. Mountford, A. P.; Hogg, K. G.; Coulson, P. S.; Brombacher, F. Signaling via interleukin-4 receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice. Infect. Immun., 2001, 69, 228-236. (Pubitemid 32038319)
112. Sher, A.; Coffman, R. L.; Hieny, S.; Cheever, A. W. Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. J. Immunol., 1990, 145, 3911-3916.
113. Ashton, P. D.; Harrop, R.; Shah, B.; Wilson, R. A. The schistosome egg: development and secretions. Parasitology, 2001, 122, 329-338. (Pubitemid 32234876)
114. Chiaramonte, M. G.; Schopf, L. R.; Neben, T. Y.; Cheever, A. W.; Donaldson, D. D.; Wynn, T. A. IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs. J. Immunol., 1999, 162, 920-930. (Pubitemid 29035417)
115. Souza, P. R.; Souza, A. L.; Negrao-Correa, D.; Teixeira, A. L.; Teixeira, M. M. The role of chemokines in controlling granulomatous inflammation in Schistosoma mansoni infection. Acta Trop., 2008, 108, 135-138.
116. Everts, B.; Perona-Wright, G.; Smits, H. H.; Hokke, C. H.; van der Ham, A. J.; Fitzsimmons, C. M.; Doenhoff, M. J.; van der Bosch, J.; Mohrs, K.; Haas, H.; Mohrs, M.; Yazdanbakhsh, M.; Schramm, G. Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses. J. Exp. Med., 2009, 206, 1673-1680.
117. Steinfelder, S.; Andersen, J. F.; Cannons, J. L.; Feng, C. G.; Joshi, M.; Dwyer, D.; Caspar, P.; Schwartzberg, P. L.; Sher, A.; Jankovic, D. The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1). J. Ex. Med., 2009, 206, 1681-1690.
118. McLaren, M. L.; Lillywhite, J. E.; Dunne, D. W.; Doenhoff, M. J. Serodiagnosis of human Schistosoma mansoni infections: enhanced sensitivity and specificity in ELISA using a fraction containing S. mansoni egg antigens omega 1 and alpha 1. Trans. R. Soc. Trop. Med. Hyg., 1981, 75, 72-79.
119. Wynn, T. A.; Cheever, A. W. Cytokine regulation of granuloma formation in schistosomiasis. Curr. Opin. Immunol., 1995, 7, 505-511.
120. Fallon, P. G.; Dunne, D. W. Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection. J. Immunol., 1999, 162, 4122-4132. (Pubitemid 29314797)
121. Herbert, D. R.; Holscher, C.; Mohrs, M.; Arendse, B.; Schwegmann, A.; Radwanska, M.; Leeto, M.; Kirsch, R.; Hall, P.; Mossmann, H.; Claussen, B.; Forster, I.; Brombacher, F. Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity, 2004, 20, 623-635. (Pubitemid 38659504)
122. Hoffmann, K. F.; Cheever, A. W.; Wynn, T. A. IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J. Immunol., 2000, 164, 6406-6416. (Pubitemid 30408823)
123. Reiman, R. M.; Thompson, R. W.; Feng, C. G.; Hari, D.; Knight, R.; Cheever, A. W.; Rosenberg, H. F.; Wynn, T. A. Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity. Infect. Immun., 2006, 74, 1471-1479. (Pubitemid 43346779)
124. El-Sokkary, G. H.; Omar, H. M.; Hassanein, A. F.; Cuzzocrea, S.; Reiter, R. J. Melatonin reduces oxidative damage and increases survival of mice infected with Schistosoma mansoni. Free Radic. Biol. Med., 2002, 32, 319-332. (Pubitemid 34159086)
125. Weinstock, J. V.; Boros, D. L. Organ-dependent differences in composition and function observed in hepatic and intestinal granulomas isolated from mice with Schistosoma mansoni. J. Immunol., 1983, 130, 418-422. (Pubitemid 13172691)
126. Londono, B.; Carmona, J.; Blair, S. Comparison between OptiMAL and the thick smear tests for malaria diagnosis in an endemic area during a nonepidemic period. Biomedica, 2002, 22, 466-475.
127. Cardona, A. E.; Restrepo, B. I.; Jaramillo, J. M.; Teale, J. M. Development of an animal model for neurocysticercosis: immune response in the central nervous system is characterized by a predominance of gamma delta T cells. J. Immunol., 1999, 162, 995-1002. (Pubitemid 29035426)
128. Camp, C. J.; Leid, R. W. Chemokinetic factors obtained from the larval stage of the cestode, Taenia taeniaeformis. Parasite Immunol., 1982, 4, 373-381. (Pubitemid 13255997)
129. Chaible, L. M.; Alba-Loureiro, T. C.; Maia, A. A.; Pugine, S. M.; Valle, C. R.; Pithon-Curi, T. C.; Curi, R.; De Melo, M. P. Effect of Cysticercus cellulosae on neutrophil function and death. Vet. Parasitol., 2005, 127, 121-129. (Pubitemid 41373303)
130. Aldridge, J. R.; Johnson, E. C.; Kuhn, R. E. CpG stimulates protective immunity in Balb/cJ mice infected with larval Taenia crassiceps. J. Parasitol., 2010, 96, 920-928.
131. Aceti, A.; Celestino, D.; Teggi, A.; Caferro, M. Spontaneous in vitro generation of histamine releasing factor from mononuclear cells of patients with hydatidosis. Int. Arch. Allergy Immunol., 1992, 98, 247-251.
132. Aumuller, E.; Schramm, G.; Gronow, A.; Brehm, K.; Gibbs, B. F.; Doenhoff, M. J.; Haas, H. Echinococcus multilocularis metacestode extract triggers human basophils to release interleukin-4. Parasite Immunol., 2004, 26, 387-395. (Pubitemid 40364834)
133. Bresson-Hadni, S.; Beurton, I.; Bartholomot, B.; Vuitton, D. A.; Kern, P.; Mantion, G.; Miguet, J. P. Alveolar echinococcosis. Hepatology, 1998, 27, 1453-1456.
134. Strath, M.; Sanderson, C. J. Detection of eosinophil differentiation factor and its relationship to eosinophilia in Mesocestoides corti-infected mice. Exp. Hematol., 1986, 14, 16-20. (Pubitemid 16168462)
135. Ansari, A.; Williams, J. F. The eosinophilic response of the rat to infection with Taenia taeniaeformis. J. Parasitol., 1976, 62, 728-736.
136. Leid, R. W. Immunity to the metacestode of Taenia taeniaeformis in the laboratory rat. Am. J. Trop. Med. Hyg., 1977, 26, 54-60. (Pubitemid 8265259)
137. Potter, K. A.; Leid, R. W., Isolation and partial characterization of an eosinophil chemotacticfactor from metacestodes of Taenia taeniaeformis (ECF-Tt). J. Immunol., 1986, 136, 1712-1717. (Pubitemid 16119580)
138. Niwa, A.; Miyazato, T. Reactive oxygen intermediates from eosinophils in mice infected with Hymenolepis nana. Parasite Immunol., 1996, 18, 285-295. (Pubitemid 26227977)
139. Slais, J.; Vanek, M. Tissue reaction to spherical and lobular hydatid cysts of Echinococcus granulosus (Batsch, 1786). Folia Parasitol. (Praha), 1980, 27, 135-143.
140. de Aluja, A.; Vargas, G., The histopathology of porcine cysticercosis. Vet. Parasitol., 1988, 28, 65-77.
141. Bortoletti, G.; Conchedda, M.; Ferretti, G. Damage and early destruction of Taenia taeniaeformis larvae in resistant hosts, and anomalous development in susceptible hosts: a light microscopic and ultrastructural study. Int. J. Parasitol., 1985, 15, 377-384. (Pubitemid 15019154)
142. Letonja, T.; Hammerberg, C. Taenia taeniaeformis: early inflammatory response around developing metacestodes in the liver of resistant and susceptible mice I. Identification of leukocyte response with monoclonal antibodies. J. Parasitol., 1987, 73, 962-970.
143. Bortoletti, G.; Gabriele, F.; Palmas, C. Kinetics of mast cells, eosinophils and phospholipase B activity in the spontaneous-cure response of two strains of mice (rapid and slow responder) to the cestode Hymenolepis nana. Parasitol. Res., 1989, 75, 465-469. (Pubitemid 19142653)
144. Lammas, D. A.; Mitchell, L. A.; Wakelin, D. Genetic influences upon eosinophilia and resistance in mice infected with Mesocestoides corti. Parasitology, 1990, 101, 291-299. (Pubitemid 20379388)
145. Hindsbo, O.; Andreassen, J.; Ruitenberg, J. Immunological and histopathological reactions of the rat against the tapeworm Hymenolepis diminuta and the effects of anti-thymocyte serum. Parasite Immunol., 1982, 4, 59-76. (Pubitemid 12108021)
146. Ishiwata, K.; Oku, Y.; Ito, M.; Kamiya, M. Responses to larval Taenia taeniaeformis in mice with severe combined immunodeficiency (scid). Parasitology, 1992, 104, 363-369.
147. Ferreira, A. M.; Breijo, M.; Sim, R. B.; Nieto, A. Contribution of C5-mediated mechanisms to host defence against Echinococcus granulosus hydatid infection. Parasite Immunol., 2000, 22, 445-453. (Pubitemid 30636385)
148. Willms, K.; Merchant, M. T. The inflammatory reaction surrounding Taenia solium larvae in pig muscle: ultrastructural and light microscopic observations. Parasite Immunol., 1980, 2, 261-275. (Pubitemid 11159257)
149. Londono, D. P.; Alvarez, J. I.; Trujillo, J.; Jaramillo, M. M.; Restrepo, B. I. The inflammatory cell infiltrates in porcine cysticercosis: immunohistochemical analysis during various stages of infection. Vet. Parasitol., 2002, 109, 249-259. (Pubitemid 35356256)
150. Sakamoto, T.; Cabrera, P. A. Immunohistochemical observations on cellular response in unilocular hydatid lesions and lymph nodes of cattle. Acta Trop., 2003, 85, 271-279. (Pubitemid 36246649)
151. Engelkirk, P. G.; Williams, J. F. Taenia taeniaeformis (Cestoda) in the rat: ultrastructure of the host-parasite interface on days 8 to 22 postinfection. J. Parasitol., 1983, 69, 828-837. (Pubitemid 14150028)
152. Ovington, K. S.; Behm, C. A. The enigmatic eosinophil: investigation of the biological role of eosinophils in parasitic helminth infection. Mem. Inst. Oswaldo Cruz, 1997, 92, 93-104.
153. Rawat, J.; Dixon, J. B.; Macintyre, A. R.; McGarry, H. F.; Taylor, M. J. IL-4 dependent resistance to the tapeworm Mesocestoides corti (Cestoda) in mice. Parasite Immunol., 2003, 25, 553-557. (Pubitemid 38445398)
154. Meeusen, E.; Gorrell, M. D.; Rickard, M. D.; Brandon, M. R. Lymphocyte subpopulations of sheep in protective immunity to Taenia hydatigena. Parasite Immunol., 1989, 11, 169-181. (Pubitemid 19105827)
155. Meeusen, E.; Barcham, G. J.; Gorrell, M. D.; Rickard, M. D.; Brandon, M. R. Cysticercosis: cellular immune responses during primary and secondary infection. Parasite Immunol., 1990, 12, 403-418. (Pubitemid 20237259)
156. Molinari, J. L.; Meza, R.; Tato, P. Taenia solium: cell reactions to the larva (Cysticercus cellulosae) in naturally parasitized, immunized hogs. Exp. Parasitol., 1983, 56, 327-338. (Pubitemid 14181406)
157. Molinari, J. L.; Soto, R.; Tato, P.; Rodriguez, D.; Retana, A.; Sepulveda, J.; Palet, A. Immunization against porcine cysticercosis in an endemic area in Mexico: a field and laboratory study. Am. J. Trop. Med. Hyg., 1993, 49, 502-512. (Pubitemid 23320087)
158. Cortes, I.; Molinari, J. L.; Solano, S.; Hernandez-Mendoza, L.; Ramirez, A.; Tato, P. Taenia solium metacestode antigens which are protective for pigs induce Th1/Th2 mixed responses in mice. Parasitol. Res., 2003, 90, 273-279. (Pubitemid 36930327)
159. Ito, A.; Onitake, K.; Sasaki, J.; Takami, T. Hymenolepis nana: immunity against oncosphere challenge in mice previously given viable or non-viable oncospheres of H. nana, H. diminuta, H. microstoma and Taenia taeniaeformis. Int. J. Parasitol., 1991, 21, 241-245.
160. Hernandez-Pomi, A.; Borras-Salvador, R.; Mir-Gisbert, A. Analysis of cytokine and specific antibody profiles in hydatid patients with primary infection and relapse of disease. Parasite Immunol., 1997, 19, 553-561. (Pubitemid 28022533)
161. Chavarria, A.; Fleury, A.; Garcia, E.; Marquez, C.; Fragoso, G.; Sciutto, E. Relationship between the clinical heterogeneity of neurocysticercosis and the immune-inflammatory profiles. Clin. Immunol., 2005, 116, 271-278. (Pubitemid 41112731)
162. Jenne, L.; Kilwinski, J.; Scheffold, W.; Kern, P., IL-5 expressed by CD4+ lymphocytes from Echinococcus multilocularis-infected patients. Clin. Exp. Immunol., 1997, 109, 90-97. (Pubitemid 27293889)
163. Siracusano, A.; Margutti, P.; Delunardo, F.; Profumo, E.; Rigano, R.; Buttari, B.; Teggi, A.; Ortona, E. Molecular cross-talk in host-parasite relationships: the intriguing immunomodulatory role of Echinococcus antigen B in cystic echinococcosis. Int. J. Parasitol., 2008, 38, 1371-1376.
164. Virginio, V. G.; Taroco, L.; Ramos, A. L.; Ferreira, A. M.; Zaha, A.; Ferreira, H. B.; Hernandez, A. Effects of protoscoleces and AgB from Echinococcus granulosus on human neutrophils: possible implications on the parasite's immune evasion mechanisms. Parasitol. Res., 2007, 100, 935-942. (Pubitemid 46354861)
165. Rigano, R.; Profumo, E.; Bruschi, F.; Carulli, G.; Azzara, A.; Ioppolo, S.; Buttari, B.; Ortona, E.; Margutti, P.; Teggi, A.; Siracusano, A. Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses. Infect. Immun., 2001, 69, 288-296. (Pubitemid 32038325)
166. Ortona, E.; Margutti, P.; Delunardo, F.; Nobili, V.; Profumo, E.; Rigano, R.; Buttari, B.; Carulli, G.; Azzara, A.; Teggi, A.; Bruschi, F.; Siracusano, A. Screening of an Echinococcus granulosus cDNA library with IgG4 from patients with cystic echinococcosis identifies a new tegumental protein involved in the immune escape. Clin. Exp. Immunol., 2005, 142, 528-538. (Pubitemid 41719850)
167. Alkarmi, T.; Behbehani, K. Echinococcus multilocularis: inhibition of murine neutrophil and macrophage chemotaxis. Exp. Parasitol., 1989, 69, 16-22. (Pubitemid 19187895)
168. Mejri, N.; Gottstein, B. Echinococcus multilocularis metacestode metabolites contain a cysteine protease that digests eotaxin, a CC pro-inflammatory chemokine. Parasitol Res., 2009, 105, 1253-1260.
169. Tato, P.; White, A. C., Jr.; Willms, K.; Rodriguez, D.; Solano, S.; Sepulveda, J.; Molinari, J. L. Immunosuppression and inhibition of inflammation in mice induced by a small Taenia solium RNA-peptide to implanted T. solium metacestodes. Parasitol. Res., 1996, 82, 590-597. (Pubitemid 26265854)
170. Yan, H. L.; Xue, G.; Mei, Q.; Ding, F. X.; Wang, Y. Z.; Sun, S. H. Calciumdependent proapoptotic effect of Taenia solium metacestodes annexin B1 on human eosinophils: a novel strategy to prevent host immune response. Int. J. Biochem. Cell Biol., 2008, 40, 2151-2163.
171. Zepeda, N.; Solano, S.; Copitin, N.; Fernandez, A. M.; Hernandez, L.; Tato, P.; Molinari, J. L. Decrease of peritoneal inflammatory CD4+, CD8+, CD19+ lymphocytes and apoptosis of eosinophils in a murine Taenia crassiceps infection. Parasitol. Res., 2010, 107, 1129-1135.
172. Ramos, A. L.; Discipio, R. G.; Ferreira, A. M. Eosinophil cationic protein damages protoscoleces in vitro and is present in the hydatid cyst. Parasite Immunol., 2006, 28, 347-355. (Pubitemid 44099951)
173. Anderson, R. C., Nematode Parasites of Vertebrates. Their Development and Transmission. CABI Publishing: Oxon, UK, 2000; 650 pp.
174. Hotez, P. J.; Brindley, P. J.; Bethony, J. M.; King, C. H.; Pearce, E. J.; Jacobson, J. Helminth infections: the great neglected tropical diseases. J. Clin. Invest., 2008, 118, 1311-1321. (Pubitemid 351500423)
175. Jenkins, S. J.; Allen, J. E. Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes. J. Biomed. Biotechnol., 2010, 2010, 262609.
176. Anthony, R. M.; Urban, J. F., Jr.; Alem, F.; Hamed, H. A.; Rozo, C. T.; Boucher, J. L.; Van Rooijen, N.; Gause, W. C. Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat. Med., 2006, 12, 955-960. (Pubitemid 44175149)
177. Liu, S. K.; Cypess, R. H.; van Zandt, P. Gastritis caused by multiple Nematospiroides dubius infections. J. Parasitol., 1974, 60, 790-793.
178. Penttila, I. A.; Ey, P. L.; Jenkin, C. R. Reduced infectivity of Nematospiroides dubius larvae after incubation in vitro with neutrophils or eosinophils from infected mice and a lack of effect by neutrophils from normal mice. Parasite Immunol., 1984, 6, 295-308.
179. Morimoto, M.; Whitmire, J.; Xiao, S.; Anthony, R. M.; Mirakami, H.; Star, R. A.; Urban, J. F., Jr.; Gause, W. C. Peripheral CD4 T cells rapidly accumulate at the host: parasite interface during an inflammatory Th2 memory response. J. Immunol., 2004, 172, 2424-2430. (Pubitemid 38182391)
180. Urban, J. F., Jr.; Katona, I. M.; Paul, W. E.; Finkelman, F. D. Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc. Natl. Acad. Sci. USA, 1991, 88, 5513-5517. (Pubitemid 21914775)
181. Madden, K. B.; Yeung, K. A.; Zhao, A.; Gause, W. C.; Finkelman, F. D.; Katona, I. M.; Urban, J. F., Jr.; Shea-Donohue, T. Enteric nematodes induce stereotypic STAT6-dependent alterations in intestinal epithelial cell function. J. Immunol., 2004, 172, 5616-5621. (Pubitemid 38542064)
182. Tilney, L. G.; Connelly, P. S.; Guild, G. M.; Vranich, K. A.; Artis, D. Adaptation of a nematode parasite to living within the mammalian epithelium. J. Exp. Zool. A Comp. Exp. Biol., 2005, 303, 927-945. (Pubitemid 43093579)
183. Betts, C. J.; Else, K. J. Mast cells, eosinophils and antibody-mediated cellular cytotoxicity are not critical in resistance to Trichuris muris. Parasite Immunol., 1999, 21, 45-52. (Pubitemid 29050399)
184. Svensson, M.; Bell, L.; Little, M. C.; DeSchoolmeester, M.; Locksley, R. M.; Else, K. J. Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection. Parasite Immunol., 2011, 33, 1-11.
185. Kaur, G.; Raj, S. M.; Naing, N. N., Trichuriasis: localized inflammatory responses in the colon. Southeast Asian J. Trop. Med. Public Health, 2002, 33, 224-228.
186. Ohnmacht, C.; Pullner, A.; van Rooijen, N.; Voehringer, D. Analysis of eosinophil turnover in vivo reveals their active recruitment to and prolonged survival in the peritoneal cavity. J. Immunol., 2007, 179, 4766-4774.
187. Giacomin, P. R.; Wang, H.; Gordon, D. L.; Botto, M.; Dent, L. A. Loss of complement activation and leukocyte adherence as Nippostrongylus brasiliensis develops within the murine host. Infect. Immun., 2005, 73, 7442-7449. (Pubitemid 41587648)
188. Yates, J. A.; Higashi, G. I.; Lowichik, A.; Orihel, T. C.; Lowrie, R. C., Jr.; Eberhard, M. L. Activation of the alternative complement pathway in normal human serum by Loa loa and Brugia malayi infective stage larvae. Acta Trop., 1985, 42, 157-163. (Pubitemid 15064107)
189. Gruden-Movsesijan, A.; Petrovic, M.; Sofronic-Milosavljevic, L. Interaction of mannan-binding lectin with Trichinella spiralis glycoproteins, a possible innate immune mechanism. Parasite Immunol., 2003, 25, 545-552. (Pubitemid 38445397)
190. Giacomin, P. R.; Gordon, D. L.; Botto, M.; Daha, M. R.; Sanderson, S. D.; Taylor, S. M.; Dent, L. A. The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensis. Mol. Immunol., 2008, 45, 446-455. (Pubitemid 47337123)
191. Knott, M. L.; Matthaei, K. I.; Giacomin, P. R.; Wang, H.; Foster, P. S.; Dent, L. A. Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis. Int. J. Parasitol., 2007, 37, 1367-1378. (Pubitemid 47285107)
192. Knott, M. L.; Matthaei, K. I.; Foster, P. S.; Dent, L. A. The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri. Mol. Immunol., 2009, 46, 2714-2722.
193. Mearns, H.; Horsnell, W. G.; Hoving, J. C.; Dewals, B.; Cutler, A. J.; Kirstein, F.; Myburgh, E.; Arendse, B.; Brombacher, F. Interleukin-4-promoted T helper 2 responses enhance Nippostrongylus brasiliensisinduced pulmonary pathology. Infect. Immun., 2008, 76, 5535-5542.
194. Price, A. E.; Liang, H. E.; Sullivan, B. M.; Reinhardt, R. L.; Eisley, C. J.; Erle, D. J.; Locksley, R. M. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc. Natl. Acad. Sci. USA, 2010, 107, 11489-11494.
195. Chitkara, R. K.; Krishna, G. Parasitic pulmonary eosinophilia. Semin. Respir. Crit. Care Med., 2006, 27, 171-184.
196. Chitkara, R. K.; Sarinas, P. S. Dirofilaria, visceral larva migrans, and tropical pulmonary eosinophilia. Semin. Respir. Infect., 1997, 12, 138-148. (Pubitemid 27259960)
197. Weller, P. F. Eosinophils: structure and functions. Curr. Opin. Immunol., 1994, 6, 85-90. (Pubitemid 24050710)
198. Horii, Y.; Owhashi, M.; Fujita, K.; Nakanishi, H.; Ishii, A. A comparative study on eosinophil and neutrophil chemotactic activities of various helminth parasites. Parasitol. Res., 1988, 75, 76-78.
199. Falcone, F. H.; Rossi, A. G.; Sharkey, R.; Brown, A. P.; Pritchard, D. I.; Maizels, R. M. Ascaris suum-derived products induce human neutrophil activation via a G protein-coupled receptor that interacts with the interleukin-8 receptor pathway. Infect. Immun., 2001, 69, 4007-4018. (Pubitemid 32493323)
200. Owhashi, M.; Kirai, N.; Horii, Y. Eosinophil chemotactic factor release from neutrophils induced by stimulation with Schistosoma japonicum eggs. Parasitol. Res., 1997, 83, 42-46. (Pubitemid 26396348)
201. Herbert, D. R.; Lee, J. J.; Lee, N. A.; Nolan, T. J.; Schad, G. A.; Abraham, D. Role of IL-5 in innate and adaptive immunity to larval Strongyloides stercoralis in mice. J. Immunol., 2000, 165, 4544-4551.
202. Galioto, A. M.; Hess, J. A.; Nolan, T. J.; Schad, G. A.; Lee, J. J.; Abraham, D. Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval strongyloides stercoralis in mice. Infect. Immun., 2006, 74, 5730-5738. (Pubitemid 44484558)
203. O'Connell, A. E.; Hess, J. A.; Santiago, G. A.; Nolan, T. J.; Lok, J. B.; Lee, J. J.; Abraham, D. Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice. Infect. Immun., 2011, 79, 2770-2778.
204. Alban, L.; Pozio, E.; Boes, J.; Boireau, P.; Boue, F.; Claes, M.; Cook, A. J.; Dorny, P.; Enemark, H. L.; van der Giessen, J.; Hunt, K. R.; Howell, M.; Kirjusina, M.; Nockler, K.; Rossi, P.; Smith, G. C.; Snow, L.; Taylor, M. A.; Theodoropoulos, G.; Vallee, I.; Viera-Pinto, M. M.; Zimmer, I. A. Towards a standardised surveillance for Trichinella in the European Union. Prev. Vet. Med., 2011, 99, 148-160.
205. Capo, V.; Despommier, D. D. Clinical aspects of infection with Trichinella spp. Clin. Microbiol. Rev., 1996, 9, 47-54. (Pubitemid 26035538)
206. Li, C. K.; Seth, R.; Gray, T.; Bayston, R.; Mahida, Y. R.; Wakelin, D. Production of proinflammatory cytokines and inflammatory mediators in human intestinal epithelial cells after invasion by Trichinella spiralis. Infect. Immun., 1998, 66, 2200-2206. (Pubitemid 28194121)
207. Bruschi, F.; Korenaga, M.; Watanabe, N. Eosinophils and Trichinella infection: toxic for the parasite and the host? Trends Parasitol., 2008, 24, 462-467.
208. Kazura, J. W.; Aikawa, M. Host defense mechanisms against Trichinella spiralis infection in the mouse: eosinophil-mediated destruction of newborn larvae in vitro. J. Immunol., 1980, 124, 355-361. (Pubitemid 10130754)
209. Ogilvie, B. M.; Askenase, P. W.; Rose, M. E. Basophils and eosinophils in three strains of rats and in athymic (nude) rats following infection with the nematodes Nippostrongylus brasiliensis or Trichinella spiralis. Immunology, 1980, 39, 385-389. (Pubitemid 10120784)
210. Vallance, B. A.; Matthaei, K. I.; Sanovic, S.; Young, I. G.; Collins, S. M. Interleukin-5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections. Parasite Immunol., 2000, 22, 487-492.
211. Gurish, M. F.; Humbles, A.; Tao, H.; Finkelstein, S.; Boyce, J. A.; Gerard, C.; Friend, D. S.; Austen, K. F. CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis. J. Immunol., 2002, 168, 5730-5736. (Pubitemid 34556157)
212. Fabre, M. V.; Beiting, D. P.; Bliss, S. K.; Appleton, J. A. Immunity to Trichinella spiralis muscle infection. Vet. Parasitol., 2009, 159, 245-248.
213. Perez, O.; Capron, M.; Lastre, M.; Venge, P.; Khalife, J.; Capron, A. Angiostrongylus cantonensis: role of eosinophils in the neurotoxic syndrome (Gordon-like phenomenon). Exp. Parasitol., 1989, 68, 403-413. (Pubitemid 19160268)
214. Yoshimura, K.; Uchida, K.; Sato, K.; Oya, H. Ultrastructural evidence for eosinophil-mediated destruction of Angiostrongylus cantonensis transferred into the pulmonary artery of non-permissive hosts. Parasite Immunol., 1984, 6, 105-118. (Pubitemid 14145365)
215. Lan, K. P.; Lai, S. C. Differences of proteolytic enzymes and pathological changes in permissive and nonpermissive animal hosts for Angiostrongylus cantonensis infection. Vet. Parasitol., 2009, 165, 265-272.
216. Lee, H. H.; Chou, H. L.; Chen, K. M.; Lai, S. C. Association of matrix metalloproteinase-9 in eosinophilic meningitis of BALB/c mice caused by Angiostrongylus cantonensis. Parasitol. Res., 2004, 94, 321-328. (Pubitemid 40022299)
217. Tseng, Y. K.; Tu, W. C.; Lee, H. H.; Chen, K. M.; Chou, H. L.; Lai, S. C. Ultrastructural localization of matrix metalloproteinase-9 in eosinophils from the cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. Ann. Trop. Med. Parasitol., 2004, 98, 831-841. (Pubitemid 40013189)
218. Chen, K. M.; Lee, H. H.; Chou, H. L.; Liu, J. Y.; Tsai, B. C.; Lai, S. C. Upregulation of MMP-9/TIMP-1 enzymatic system in eosinophilic meningitis caused by Angiostrongylus cantonensis. Int. J. Exp. Pathol., 2005, 86, 81-89.
219. Sugaya, H.; Aoki, M.; Yoshida, T.; Takatsu, K.; Yoshimura, K. Eosinophilia and intracranial worm recovery in interleukin-5 transgenic and interleukin-5 receptor alpha chain-knockout mice infected with Angiostrongylus cantonensis. Parasitol. Res., 1997, 83, 583-590. (Pubitemid 27272523)
220. Chang, E. E.; Yen, C. M. Eosinophil chemoattracted by eotaxin from cerebrospinal fluid of mice infected with Angiostrongylus cantonensis assayed in a microchamber. Kaohsiung J. Med. Sci., 2004, 20, 209-215. (Pubitemid 38856509)
221. Intapan, P. M.; Niwattayakul, K.; Sawanyawisuth, K.; Chotmongkol, V.; Maleewong, W. Cerebrospinal fluid eotaxin and eotaxin-2 levels in human eosinophilic meningitis associated with angiostrongyliasis. Cytokine, 2007, 39, 138-141. (Pubitemid 47513837)
222. Intapan, P. M.; Kittimongkolma, S.; Niwattayakul, K.; Sawanyawisuth, K.; Maleewong, W. Cerebrospinal fluid cytokine responses in human eosinophilic meningitis associated with angiostrongyliasis. J. Neurol. Sci., 2008, 267, 17-21. (Pubitemid 351249897)
223. Chuang, C. C.; Su, K. E.; Chen, C. W.; Fan, C. K.; Lin, F. K.; Chen, Y. S.; Du, W. Y., Anti-CCR3 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected ICR mice. Acta Trop., 2010, 113, 209-213.
224. Ishida, K.; Yoshimura, K. Characterization of monoclonal antibodies against eosinophil chemotactic factors from young adult worms of Angiostrongylus cantonensis. Parasite Immunol., 1992, 14, 633-644.
225. Sugaya, H.; Ishida, K.; Yoshimura, K. Induction of cerebrospinal fluid eosinophilia in rats by the intraventricular injection of Angiostrongylus cantonensis antigen. Int. J. Parasitol., 1997, 27, 113-117. (Pubitemid 27128378)
226. Du, W. Y.; Liao, J. W.; Fan, C. K.; Su, K. E., Combined treatment with interleukin-12 and mebendazole lessens the severity of experimental eosinophilic meningitis caused by Angiostrongylus cantonensis in ICR mice. Infect. Immun., 2003, 71, 3947-3953.
227. Sugaya, H.; Abe, T.; Yoshimura, K. Eosinophils in the cerebrospinal fluid of mice infected with Angiostrongylus cantonensis are resistant to apoptosis. Int. J. Parasitol., 2001, 31, 1649-1658. (Pubitemid 33152820)
228. Audicana, M. T.; Kennedy, M. W. Anisakis simplex: from obscure infectious worm to inducer of immune hypersensitivity. Clin. Microbiol. Rev., 2008, 21, 360-379. (Pubitemid 351555512)
229. Tanaka, J.; Torisu, M. Anisakis and eosinophil. I. Detection of a soluble factor selectively chemotactic for eosinophils in the extract from Anisakis larvae. J. Immunol., 1978, 120, 745-749. (Pubitemid 8305530)
230. Iwasaki, K.; Torisu, M. Anisakis and eosinophil. II. Eosinophilic phlegmon experimentally induced in normal rabbits by parasite-derived eosinophil chemotactic factor (ECF-P). Clin. Immunol. Immunopathol., 1982, 23, 593-605. (Pubitemid 12090072)
231. Jones, R. E.; Deardorff, T. L.; Kayes, S. G. Anisakis simplex: histopathological changes in experimentally infected CBA/J mice. Exp. Parasitol., 1990, 70, 305-313. (Pubitemid 20230654)
232. Deardorff, T. L.; Kayes, S. G.; Fukumura, T. Human anisakiasis transmitted by marine food products. Hawaii Med. J., 1991, 50, 9-16.
233. del Pozo, V.; Arrieta, I.; Tunon, T.; Cortegano, I.; Gomez, B.; Cardaba, B.; Gallardo, S.; Rojo, M.; Renedo, G.; Palomino, P.; Tabar, A. I.; Lahoz, C. Immunopathogenesis of human gastrointestinal infection by Anisakis simplex. J. Allergy Clin. Immunol., 1999, 104, 637-643. (Pubitemid 29451656)
234. Anadon, A. M.; Rodriguez, E.; Garate, M. T.; Cuellar, C.; Romaris, F.; Chivato, T.; Rodero, M.; Gonzalez-Diaz, H.; Ubeira, F. M. Diagnosing human anisakiasis: recombinant Ani s 1 and Ani s 7 allergens versus the UniCAP 100 fluorescence enzyme immunoassay. Clin. Vaccine Immunol., 2010, 17, 496-502.
235. Cho, M. K.; Ahn, S. C.; Kim, D. H.; Yu, H. S. Parasite excretory-secretory proteins elicit TRIF dependent CXCL1 and IL-6 mediated allergic inflammation. Parasite Immunol., 2010, 32, 354-360.
236. Rodriguez-Mahillo, A. I.; Gonzalez-Munoz, M.; Gomez-Aguado, F.; Rodriguez-Perez, R.; Corcuera, M. T.; Caballero, M. L.; Moneo, I. Cloning and characterisation of the Anisakis simplex allergen Ani s 4 as a cysteineprotease inhibitor. Int. J. Parasitol., 2007, 37, 907-917. (Pubitemid 46879751)
237. Rodriguez-Mahillo, A. I.; Gonzalez-Munoz, M.; de las Heras, C.; Tejada, M.; Moneo, I. Quantification of Anisakis simplex allergens in fresh, longterm frozen, and cooked fish muscle. Foodborne Pathog. Dis., 2010, 7, 967-973.
238. Petit, G.; Diagne, M.; Marechal, P.; Owen, D.; Taylor, D.; Bain, O. Maturation of the filaria Litomosoides sigmodontis in BALB/c mice; comparative susceptibility of nine other inbred strains. Ann. Parasitol. Hum. Comp., 1992, 67, 144-150.
239. Martin, C.; Saeftel, M.; Vuong, P. N.; Babayan, S.; Fischer, K.; Bain, O.; Hoerauf, A. B-cell deficiency suppresses vaccine-induced protection against murine filariasis but does not increase the recovery rate for primary infection. Infect. Immun., 2001, 69, 7067-7073. (Pubitemid 32995467)
240. Lange, A. M.; Yutanawiboonchai, W.; Scott, P.; Abraham, D. IL-4 and IL-5-dependent protective immunity to Onchocerca volvulus infective larvae in BALB/cBYJ mice. J. Immunol., 1994, 153, 205-211. (Pubitemid 24186533)
241. Le Goff, L.; Loke, P.; Ali, H. F.; Taylor, D. W.; Allen, J. E. Interleukin-5 is essential for vaccine-mediated immunity but not innate resistance to a filarial parasite. Infect. Immun., 2000, 68, 2513-2517. (Pubitemid 30253820)
242. Bleiss, W.; Oberlander, U.; Hartmann, S.; Adam, R.; Marko, A.; Schonemeyer, A.; Lucius, R. Protective immunity induced by irradiated third-stage larvae of the filaria Acanthocheilonema viteae is directed against challenge third-stage larvae before molting. J. Parasitol., 2002, 88, 264-270. (Pubitemid 34493391)
243. Abraham, D.; Leon, O.; Schnyder-Candrian, S.; Wang, C. C.; Galioto, A. M.; Kerepesi, L. A.; Lee, J. J.; Lustigman, S. Immunoglobulin E and eosinophildependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae. Infect. Immun., 2004, 72, 810-817. (Pubitemid 38166659)
244. Martin, C.; Le Goff, L.; Ungeheuer, M. N.; Vuong, P. N.; Bain, O. Drastic reduction of a filarial infection in eosinophilic interleukin-5 transgenic mice. Infect. Immun., 2000, 68, 3651-3656. (Pubitemid 30340470)
245. Specht, S.; Saeftel, M.; Arndt, M.; Endl, E.; Dubben, B.; Lee, N. A.; Lee, J. J.; Hoerauf, A. Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection. Infect. Immun., 2006, 74, 5236-5243. (Pubitemid 44300442)
246. Al-Qaoud, K. M.; Pearlman, E.; Hartung, T.; Klukowski, J.; Fleischer, B.; Hoerauf, A. A new mechanism for IL-5-dependent helminth control: neutrophil accumulation and neutrophil-mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5. Int. Immunol., 2000, 12, 899-908. (Pubitemid 30410462)
247. Saeftel, M.; Volkmann, L.; Korten, S.; Brattig, N.; Al-Qaoud, K.; Fleischer, B.; Hoerauf, A. Lack of interferon-gamma confers impaired neutrophil granulocyte function and imparts prolonged survival of adult filarial worms in murine filariasis. Microbes Infect., 2001, 3, 203-213. (Pubitemid 32453148)
248. Saeftel, M.; Arndt, M.; Specht, S.; Volkmann, L.; Hoerauf, A. Synergism of gamma interferon and interleukin-5 in the control of murine filariasis. Infect. Immun., 2003, 71, 6978-6985. (Pubitemid 37475329)
249. Hall, L. R.; Pearlman, E. Pathogenesis of onchocercal keratitis (River blindness). Clin. Microbiol. Rev., 1999, 12, 445-453. (Pubitemid 29330139)
250. St. André, A.; Blackwell, N. M.; Hall, L. R.; Hoerauf, A.; Brattig, N.; Taylor, M.; Ford L.; Hise, A.; Volkmann, L.; Lass, J. H.; Diaconu, E.; Pearlman, E. A critical role for endosymbiotic Wolbachia bacteria and TLR4 signaling in the pathogenesis of river blindness. Science, 2002, 295, 1892-1895. (Pubitemid 34214126)
251. Slatko, B. E.; Taylor, M. J.; Foster, J. M., The Wolbachia endosymbiont as an anti-filarial nematode target. Symbiosis, 2010, 51, 55-65.
252. Kaifi, J. T.; Hall, L. R.; Diaz, C.; Sypek, J.; Diaconu, E.; Lass, J. H.; Pearlman, E. Impaired eosinophil recruitment to the cornea in P-selectindeficient mice in Onchocerca volvulus keratitis (River blindness). Invest. Ophthalmol. Vis. Sci., 2000, 41, 3856-3861.
253. Hall, L. R.; Diaconu, E.; Patel, R.; Pearlman, E. CXC chemokine receptor 2 but not C-C chemokine receptor 1 expression is essential for neutrophil recruitment to the cornea in helminth-mediated keratitis (river blindness). J. Immunol., 2001, 166, 4035-4041. (Pubitemid 32224933)
254. Hall, L. R.; Diaconu, E.; Pearlman, E. A dominant role for Fc gamma receptors in antibody-dependent corneal inflammation. J. Immunol., 2001, 167, 919-925. (Pubitemid 32660848)
255. Hall, L. R.; Kaifi, J. T.; Diaconu, E.; Pearlman, E. CD4(+) depletion selectively inhibits eosinophil recruitment to the cornea and abrogates Onchocerca volvulus keratitis (River blindness). Infect. Immun., 2000, 68, 5459-5461.
256. Mpagi, J. L.; Rickert, R.; Steinhart, H.; Brattig, N. W. Hyperreactive onchocerciasis exhibits reduced arachidonate and linoleate levels in serum triglycerides. Am. J. Trop. Med. Hyg., 2000, 62, 705-710. (Pubitemid 32281490)
257. Korten, S.; Wildenburg, G.; Darge, K.; Buttner, D. W. Mast cells in onchocercomas from patients with hyperreactive onchocerciasis (sowda). Acta Trop., 1998, 70, 217-231. (Pubitemid 28310751)
258. Tischendorf, F. W.; Brattig, N. W.; Buttner, D. W.; Pieper, A.; Lintzel, M. Serum levels of eosinophil cationic protein, eosinophil-derived neurotoxin and myeloperoxidase in infections with filariae and schistosomes. Acta Trop., 1996, 62, 171-182. (Pubitemid 27072571)
259. Hoerauf, A.; Kruse, S.; Brattig, N. W.; Heinzmann, A.; Mueller-Myhsok, B.; Deichmann, K. A. The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda). Microbes Infect., 2002, 4, 37-42. (Pubitemid 34127989)
260. Rubio de Krömer, M. T.; Krömer, M.; Luersen, K.; Brattig, N. W. Detection of a chemotactic factor for neutrophils in extracts of female Onchocerca volvulus. Acta Trop., 1998, 71, 45-56. (Pubitemid 28398921)
261. Vijayan, V. K. Tropical pulmonary eosinophilia: pathogenesis, diagnosis and management. Curr. Opin. Pulm. Med., 2007, 13, 428-433. (Pubitemid 47472306)
262. Lobos, E.; Nutman, T. B.; Hothersall, J. S.; Moncada, S. Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity. Infect. Immun., 2003, 71, 747-753. (Pubitemid 36150768)
263. Queto, T.; Xavier-Elsas, P.; Gardel, M. A.; de Luca, B.; Barradas, M.; Masid, D.; PM, E. S.; Peixoto, C. A.; Vasconcelos, Z. M.; Dias, E. P.; Gaspar-Elsas, M. I. Inducible nitric oxide synthase/CD95L-dependent suppression of pulmonary and bone marrow eosinophilia by diethylcarbamazine. Am. J. Respir. Crit. Care Med., 2010, 181, 429-437.
264. Peixoto, C. A.; Rocha, A.; Aguiar-Santos, A.; Florencio, M. S. The effects of diethylcarbamazine on the ultrastructure of microfilariae of Wuchereria bancrofti in vivo and in vitro. Parasitol. Res., 2004, 92, 513-517. (Pubitemid 38658349)
265. Moreno, Y.; Nabhan, J. F.; Solomon, J.; Mackenzie, C. D.; Geary, T. G. Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi. Proc. Natl. Acad. Sci. USA, 2010, 107, 20120-20125.
266. Soboslay, P. T.; Dreweck, C. M.; Hoffmann, W. H.; Lüder, C. G.; Heuschkel, C.; Gorgen, H.; Banla, M.; Schulz-Key, H. Ivermectin-facilitated immunity in onchocerciasis. Reversal of lymphocytopenia, cellular anergy and deficient cytokine production after single treatment. Clin. Exp. Immunol., 1992, 89, 407-413.
267. Mukhopadhyay, S.; Ravindran, B., Antibodies to diethylcarbamazine potentiate the antifilarial activity of the drug. Parasite Immunol., 1997, 19, 191-195. (Pubitemid 27183498)
268. Tischendorf, F. W.; Brattig, N. W.; Hoyer, A.; Medina-De la Garza, C. E.; Geisinger, F. Modulatory effects of antifilarial drugs ivermectin, CGP 6140 and CGP 20376 on the oxidative burst of eosinophilic granulocytes. Acta Trop., 1993, 53, 27-37. (Pubitemid 23113695)
269. Callahan, H. L.; Crouch, R. K.; James, E. R. Hydrogen peroxide is the most toxic oxygen species for Onchocerca cervicalis microfilariae. Parasitology, 1990, 100, 407-415. (Pubitemid 20327808)
270. Racz, P.; Tenner-Racz, K.; Luther, B.; Büttner, D. W.; Albiez, E. J. Immunopathologic aspects in human onchocercal lymphadenitis. Bull. Soc. Pathol. Exot., 1983, 76, 676-680. (Pubitemid 14153476)
271. Wildenburg, G.; Darge, K.; Knab, J.; Tischendorf, F. W.; Bonow, I.; Buttner, D. W. Lymph nodes of onchocerciasis patients after treatment with ivermectin: reaction of eosinophil granulocytes and their cationic granule proteins. Trop. Med. Parasitol., 1994, 45, 87-96.
272. Ackerman, S. J.; Kephart, G. M.; Francis, H.; Awadzi, K.; Gleich, G. J.; Ottesen, E. A. Eosinophil degranulation. An immunologic determinant in the pathogenesis of the Mazzotti reaction in human onchocerciasis. J. Immunol., 1990, 144, 3961-3969. (Pubitemid 20171211)
273. Gutierrez-Pena, E. J.; Knab, J.; Büttner, D. W. Neutrophil granule proteins: evidence for the participation in the host reaction to skin microfilariae of Onchocerca volvulus after diethylcarbamazine administration. Parasitology, 1996, 113, 403-414. (Pubitemid 26333625)
274. Keiser, P. B.; Reynolds, S. M.; Awadzi, K.; Ottesen, E. A.; Taylor, M. J.; Nutman, T. B., Bacterial endosymbionts of Onchocerca volvulus in the pathogenesis of posttreatment reactions. J. Infect. Dis., 2002, 185, 805-811. (Pubitemid 34226208)
275. Supali, T.; Djuardi, Y.; Pfarr, K. M.; Wibowo, H.; Taylor, M. J.; Hoerauf, A.; Houwing-Duistermaat, J. J.; Yazdanbakhsh, M.; Sartono, E. Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment. Clin. Infect. Dis., 2008, 46, 1385-1393. (Pubitemid 351589938)
276. Hoerauf, A.; Nissen-Pähle, K.; Schmetz, C.; Henkle-Dührsen, K.; Blaxter, M. L.; Büttner, D. W.; Gallin, M. Y.; Al-Qaoud, K. M.; Lucius, R.; Fleischer, B. Tetracycline therapy targets intracellular bacteria in the filarial nematode Litomosoides sigmodontis and results in filarial infertility. J. Clin. Invest., 1999, 103, 11-18. (Pubitemid 29031158)
277. Langworthy, S.; Renz, A.; Mackenstedt, U.; Henkle-Dührsen, K.; Bronsvoort, M.; Tanya, V.; Donnelly, M.; Trees, A. Macrofilaricidal activity of tetracycline against the filarial nematode, Onchocerca ochengi: elimination of Wolbachia preceeds worm death and suggests a dependent relationship. Proc. Royal Soc. London Ser. B, 2000, 267, 1063-1069. (Pubitemid 30389017)
278. Hoerauf, A.; Specht, S.; Buttner, M.; Pfarr, K.; Mand, S.; Fimmers, R.; Marfo-Debrekyei, Y.; Konadu, P.; Debrah, A. Y.; Bandi, C.; Brattig, N.; Albers, A.; Larbi, J.; Batsa, L.; Taylor, M. J.; Adjei, O.; Buttner, D. W. Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study. Med. Microbiol. Immunol., 2008, 197, 295-311.
279. Brattig, N. W.; Buttner, D. W.; Hoerauf, A. Neutrophil accumulation around Onchocerca worms and chemotaxis of neutrophils are dependent on Wolbachia
280. Nfon, C. K.; Makepeace, B. L.; Njongmeta, L. M.; Tanya, V. N.; Bain, O.; Trees, A. J. Eosinophils contribute to killing of adult Onchocerca ochengi within onchocercomata following elimination of Wolbachia. Microbes Infect., 2006, 8, 2698-2705. (Pubitemid 44692545)
281. Hansen, R. D.; Trees, A. J.; Bah, G. S.; Hetzel, U.; Martin, C.; Bain, O.; Tanya, V. N.; Makepeace, B. L. A worm's best friend: recruitment of neutrophils by Wolbachia confounds eosinophil degranulation against the filarial nematode Onchocerca ochengi. Proc. Biol. Sci., 2011, 278, 2293-2302.
282. Hausdorf, B. Early evolution of the bilateria. Syst. Biol., 2000, 49, 130-142.
283. de Andres, B.; Rakasz, E.; Hagen, M.; McCormik, M. L.; Mueller, A. L.; Elliot, D.; Metwali, A.; Sandor, M.; Britigan, B. E.; Weinstock, J. V.; Lynch, R. G. Lack of Fc-epsilon receptors on murine eosinophils: implications for the functional significance of elevated IgE and eosinophils in parasitic infections. Blood, 1997, 89, 3826-3836. (Pubitemid 27227108)
284. Meeusen, E. N.; Balic, A. Do eosinophils have a role in the killing of helminth parasites? Parasitol. Today, 2000, 16, 95-101. (Pubitemid 30116822)
285. Klion, A. D.; Nutman, T. B. The role of eosinophils in host defense against helminth parasites. J. Allergy Clin. Immunol., 2004, 113, 30-37. (Pubitemid 38096158)
286. Babayan, S. A.; Read, A. F.; Lawrence, R. A.; Bain, O.; Allen, J. E. Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy. PLoS Biol., 2010, 8, e1000525.
287. Fabre, V.; Beiting, D. P.; Bliss, S. K.; Gebreselassie, N. G.; Gagliardo, L. F.; Lee, N. A.; Lee, J. J.; Appleton, J. A. Eosinophil deficiency compromises parasite survival in chronic nematode infection. J. Immunol., 2009, 182, 1577-1583.
288. Brattig, N.W.; Tenner-Racz, K.; Korten, S.; Hoerauf, A.; Büttner, D. W.; Lee. Immunohisology of ectopic secondary lymph follicels in subcutaneous nodules from patients with hyperreactive onchocerciasis (sowda). Parasitol. Res. 2010, 107 (3), 657-66.
289. O'Mahony, D. S.; Pham, U., Iyer, R.; Hawn, T. R.; Liles, W. C. Differential constitutive and cytokine-modulated expression of human Toll-like receptors in promary neutrophils, monocytes, and macrophages. Int. J. Med. Sci. 2008, 5(1), 1-8.
290. Kogiso, M., Nishiyama, A., Shinohara, T., Nakamura, M., Mizoguchi, E., Misawa, Y., Guinet, E., Nouri-Shirazi, M., Dorey, C. K., Henriksen, R. A.; Shibata Y. Chitin particles induce size-dependent but carbohydrateindependent innate eosinophilia. J. Leukoc. Biol. 2011, 90 (1), 167-176.
291. Nagase, H.; Okugawa, S.; Ota, Y.; Yamaguchi, M.; Tomizawa, H.; Matsushima, K.; Ohta, K.; Yamamoto, K.; Hirai, K. Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand. J. Immunol. 2003, 1718(8), 3977-3982. (Pubitemid 37238671)
292. Kurt-Jones, E. A.; Mandell, L.; Whitney, C.; Padgett, A.; Gosselin, K.; Newburger, P. E.; Finberg, R. W. Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils. Blood 2002, 100(5), 1860-1868. (Pubitemid 34925167)
293. Komiya, A.; Nagase, H.; Okugawa, S.; Ota, Y.; Suzukawa, M.; Kawakami, A.; Sekiya, T.; Matsushima, K.; Ohta, K.; Hirai, K.; Yamamoto, K.; Yamaguchi, M. Expression and function of toll-like receptors in human basophils. Int. Arch. Allergy Immunol. 2006, 140 Suppl 1, 23-27. (Pubitemid 43882381)
294. Da Silva, C. A.; Hartl, D.; Liu, W.; Lee, C. G.; Elias, J. A. TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation. J. Immunol. 2008, 181(6), 4279-4286.
295. Mansson, A.; Fransson, M.; Adner, M.; Benson, M.; Uddman, R.; Bjornsson, S.; Cardell, L. O. TLR3 in human eosinophils: functional effects and decreased expression during allergic rhinitis. Int. Arch. Allergy Immunol. 2010, 151(2), 118-128.
296. Wong, C. K.; Cheung, P. F. Y.; Ip, W. K.; Lam, C. W. K. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am. J. Respir. Cell Mol. Biol. 2007, 37(1), 85-96. (Pubitemid 46999540)
297. Nakao, Y.; Funami, K.; Kikkawa, S.; Taniguchi, M.; Nishiguchi, M.; Fukumori, Y.; Seya, T.; Matsumoto, M. Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. J. Immunol. 2005, 174(3), 1566-1573.
298. Phipps, S.; Lam, C. E.; Mahalingam, S.; Newhouse, M.; Ramirez, R.; Rosenberg, H. F.; Foster, P. S.; Matthaei, K. I. Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus. Blood 2007, 110(5), 1578-1586. (Pubitemid 47443974)
299. Yanagisawa, S.; Koarai, A.; Sugiura, H.; Ichikawa, T.; Kanda, M.; Tanaka, R.; Akamatsu, K.; Hirano, T.; Matsunaga, K.; Minakata, Y.; Ichinose, M. Oxidative stress augments toll-like receptor 8 mediated neutrophilic responses in healthy subjects. Respir. Res. 2009, 10, 50.