Ivermectin disrupts the function of the excretory- secretory apparatus in microfilariae of Brugia malayi

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 46, 2010, Pages 20120-20125

  Moreno, Yovany ^a   Nabhan, Joseph F ^a   Solomon, Jonathan ^a   MacKenzie, Charles D ^b   Geary, Timothy G ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Filarial nematode; Glutamate gated chloride channels; Macrocyclic lactone

Indexed keywords

CHLORIDE CHANNEL; GLUTAMATE GATED CHLORIDE CHANNEL; IVERMECTIN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; BRUGIA MALAYI; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; EXCRETORY SECRETORY APPARATUS; FILARIASIS; IMMUNOASSAY; IMMUNOLOCALIZATION; IN VITRO STUDY; IN VIVO STUDY; MACROFILARICIDAL ACTIVITY; MICROFILARIA (NEMATODE LARVA); MICROMORPHOLOGY; NEUROMUSCULAR FUNCTION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION;

BRUGIA MALAYI;

EID: 78650577794     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1011983107     Document Type: Article

References (39)

1. Ottesen EA, Hooper PJ, Bradley M, Biswas G (2008) The global programme to eliminate lymphatic filariasis: Health impact after 8 years. PLoS Negl Trop Dis 2:e317.
2. Molyneux DH, Bradley M, Hoerauf A, Kyelem D, Taylor MJ (2003) Mass drug treatment for lymphatic filariasis and onchocerciasis. Trends Parasitol 19:516-522.
3. Alleman MM, Twum-Danso NAY, Thylefors BI (2006) The Mectizan Donation Program-Highlights from 2005. Filaria J 5:11.
4. WHO (2009) Global programme to eliminate lymphatic filariasis. Wkly Epidemiol Rec 84:437-444.
5. Geary TG, et al. (2010) Unresolved issues in anthelmintic pharmacology for helminthiases of humans. Int J Parasitol 40:1-13.
6. Mak JW, Navaratnam V, Grewel JS, Mansor SM, Ambu S (1993) Treatment of subperiodic Brugia malayi infection with a single dose of ivermectin. Am J Trop Med Hyg 48:591-596.
7. Brown KR, Ricci FM, Ottesen EA (2000) Ivermectin: Effectiveness in lymphatic filariasis. Parasitology 121 (Suppl):S133-S146.
8. Basán̄ez M-G, et al. (2008) Effect of single-dose ivermectin on Onchocerca volvulus:A systematic review and meta-analysis. Lancet Infect Dis 8:310-322.
9. Bennett JL, Williams JF, Dave V (1988) Pharmacology of ivermectin. Parasitol Today 4: 226-228.
10. Geary TG, et al. (1993) Haemonchus contortus: Ivermectin-induced paralysis of the pharynx. Exp Parasitol 77:88-96.
11. Avery L, Horvitz HR (1990) Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans. J Exp Zool 253:263-270.
12. Kass IS, Wang CC, Walrond JP, Stretton AO (1980) Avermectin B1a, a paralyzing anthelmintic that affects interneurons and inhibitory motoneurons in Ascaris. Proc Natl Acad Sci USA 77:6211-6215.
13. Portillo V, Jagannathan S, Wolstenholme AJ (2003) Distribution of glutamate-gated chloride channel subunits in the parasitic nematode Haemonchus contortus. J Comp Neurol 462:213-222.
14. Wolstenholme AJ, Rogers AT (2005) Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. Parasitology 131(Suppl S1): S85-S95.
15. Ghedin E, et al. (2007) Draft genome of the filarial nematode parasite Brugia malayi. Science 317:1756-1760.
16. Williamson SM, Walsh TK, Wolstenholme AJ (2007) The cys-loop ligand-gated ion channel gene family of Brugia malayi and Trichinella spiralis: A comparison with Caenorhabditis elegans. Invert Neurosci 7:219-226.
17. Hoerauf A, Satoguina J, Saeftel M, Specht S (2005) Immunomodulation by filarial nematodes. Parasite Immunol 27:417-429.
18. Hewitson JP, Grainger JR, Maizels RM (2009) Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity. Mol Biochem Parasitol 167: 1-11.
19. Beech RN, Wolstenholme AJ, Neveu C, Dent JA (2010) Nematode parasite genes: What's in a name? Trends Parasitol 26:334-340.
20. Raymond V, Sattelle DB (2002) Novel animal-health drug targets from ligand-gated chloride channels. Nat Rev Drug Discov 1:427-436.
21. Yates DM, Wolstenholme AJ (2004) An ivermectin-sensitive glutamate-gated chloride channel subunit from Dirofilaria immitis. Int J Parasitol 34:1075-1081.
22. Tongu Y (1974) Ultrastructural studies on the microfilaria of Brugia malayi. Acta Med Okayama 28:219-242.
23. Osei-Atweneboana MY, Eng JK, Boakye DA, Gyapong JO, Prichard RK (2007) Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: A two-phase epidemiological study. Lancet 369: 2021-2029.
24. Schwab AE, Boakye DA, Kyelem D, Prichard RK (2005) Detection of benzimidazole resistance-associated mutations in the filarial nematode Wuchereria bancrofti and evidence for selection by albendazole and ivermectin combination treatment. Am J Trop Med Hyg 73:234-238.
25. Geary TG (2005) Ivermectin 20 years on: Maturation of a wonder drug. Trends Parasitol 21:530-532.
26. Dent JA, Smith MM, Vassilatis DK, Avery L (2000) The genetics of ivermectin resistance in Caenorhabditis elegans. Proc Natl Acad Sci USA 97:2674-2679.
27. Martin RJ (1996) An electrophysiological preparation of Ascaris suum pharyngeal muscle reveals a glutamate-gated chloride channel sensitive to the avermectin analogue, milbemycin D. Parasitology 112:247-252.
28. Cully DF, et al. (1994) Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature 371:707-711.
29. Tompkins JB, Stitt LE, Ardelli BF (2010) Brugia malayi: In vitro effects of ivermectin and moxidectin on adults and microfilariae. Exp Parasitol 124:394-402.
30. Feng X-P, Hayashi J, Beech RN, Prichard RK (2002) Study of the nematode putative GABA type-Areceptor subunits: Evidence for modulation by ivermectin. J Neurochem 83:870-878.
31. Hewitson JP, et al. (2008) The secretome of the filarial parasite, Brugia malayi: Proteomic profile of adult excretory-secretory products. Mol Biochem Parasitol 160: 8-21.
32. Moreno Y, Geary TG (2008) Stage-and gender-specific proteomic analysis of Brugia malayi excretory-secretory products. PLoS Negl Trop Dis 2:e326.
33. Bennuru S, et al. (2009) Brugia malayi excreted/secreted proteins at the host/parasite interface: Stage- and gender-specific proteomic profiling. PLoS Negl Trop Dis 3:e410.
34. Cooper PJ, et al. (1996) RANTES in onchocerciasis: Changes with ivermectin treatment. Clin Exp Immunol 106:462-467.
35. Zahner H, Schmidtchen D (1994) Ivermectin-induced cell-dependent lethal effects on litomosoides carinii microfilariae in vitro. Trop Med Parasitol 45:336-340.
36. Rao UR, Chandrashekar R, Subrahmanyam D (1987) Effect of ivermectin on serum dependent cellular interactions to Dipetalonema viteae microfilariae. Trop Med Parasitol 38:123-127.
37. Gonzalez Canga A, et al. (2008) The pharmacokinetics and interactions of ivermectin in humans - A mini-review. AAPS J 10:42-46.
38. Ali MMM, et al. (2002) Immunocompetence may be important in the effectiveness of Mectizan (ivermectin) in the treatment of human onchocerciasis. Acta Trop 84:49-53.
39. Duerr JS (2006) Immunohistochemistry. in WormBook, ed The C. elegans Research Community (WormBook), 10.1895/wormbook.1.105.1. Available athttp://www.wormbook.org.