Interleukin-5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections

Parasite Immunology

Volumn 22, Issue 10, 2000, Pages 487-492

  Vallance, B A ^a   Matthaei, K I ^b   Sanovic, S ^a   Young, I G ^b   Collins, S M ^a,c  

^a MCMASTER UNIVERSITY   (Canada)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

Eosinophils; Expulsion; Intestine; Nematode

Indexed keywords

INTERLEUKIN 5;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; EOSINOPHIL; EOSINOPHILIA; HOST RESISTANCE; IMMUNE DEFICIENCY; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRICHINELLA SPIRALIS;

ANIMALS; DISEASE MODELS, ANIMAL; EOSINOPHILS; INTERLEUKIN-5; LEUKOCYTE COUNT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TRICHINELLA SPIRALIS; TRICHINOSIS;

ANIMALIA; NEMATODA; TRICHINELLA SPIRALIS;

EID: 0033775828     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.2000.00328.x     Document Type: Article

References (31)

1. Intestinal IgA plasma cells of the B- 1 lineage are IL-5 dependent
2. Trichinella spiralis: Evidence that mice do not express rapid expulsion
3. Rapid expulsion of Trichinella spiralis in adult rats mediated by monoclonal antibodies of distinct IgG isotypes
4. Isolation, structure and expression of cDNA and genomic clones for murine eosinophil differentiation factor. Comparison with other eosinophilopoietic lymphokines and identity with interleukin-5
5. Carbohydrates and lipids in Trichinella spiralis larvae and their utilization
6. Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice
7. The biology of the eosinophilic leukocyte
8. Lymphocyte proliferation and cytokine production in mice infected with different geographical isolates of Trichinella spiralis
9. Comparative toxicity of purified human eosinophil granule proteins for newborn larvae of Trichinella spiralis
10. Trichinosis in a herd of swine: Cannibalism as a major mode of transmission
11. Depletion of eosinophils by anti-IL-5 monoclonal antibody treatment of mice infected with Trichinella spiralis does not alter parasite burden or immunological resistance to reinfection
12. Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II
13. IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses
14. Genetic influences upon eosinophilia and resistance in mice infected with Trichinella spiralis
15. Helminthotoxic responses of intestinal eosinophils to Trichinella spiralis newborn larvae
16. Regulation of primary infections with Strongyloides ratti infections in mice: A role for interleukin-5
17. Physiological characterization of a biphasic immune response to Trichinella spiralis in the rat
18. Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse
19. Inhibition of programmed eosinophil death: A key pathogenic event for eosinophilia?
20. Apoptosis in human eosinophils. Programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5
21. A primary intestinal helminthic infection rapidly induces a gut-associated elevation of Th2-associated cytokines and IL-3
22. The importance of TH2 cytokines in protective immunity to nematodes
23. IL-5 contributes to, but is not critical for muscle hyper-contractility and worm expulsion in a primary T. spiralis infection
24. Helminth infections
25. Allergic inflammation as a hypothesis for the expulsion of worms from tissues
26. Eosinophils: Structure and functions
27. Interleukin-5 expressed by an attenuated strain of salmonella serotype Dublin enhances specific mucosal IgA response in vivo
28. Immunity and immunoregulation in helminth infections
29. Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival: IL-5 as an eosinophil chemotactic factor
30. Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony-stimulating factor activities: Relationship to interleukin 5
31. Differential expression of interleukin-5 mRNA+ cells and eosinophils in Nippostrongylus brasiliensis infection in resistant and susceptible strains of mice