Mast cells, eosinophils and antibody-mediated cellular cytotoxicity are not critical in resistance to Trichuris muris

Parasite Immunology

Volumn 21, Issue 1, 1999, Pages 45-52

  Betts, Catherine J ^a   Else, Kathryn J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

ADCC; Effector mechanisms; Eosinophils; Mast cells; Trichuris muris

Indexed keywords

INTERLEUKIN 5; STEM CELL FACTOR RECEPTOR;

ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CELL MEDIATED CYTOTOXICITY; EOSINOPHIL; HOST PARASITE INTERACTION; IMMUNE RESPONSE; IMMUNITY; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRICHURIASIS; TRICHURIS;

ANIMALS; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; EOSINOPHILS; IMMUNITY, NATURAL; INTERLEUKIN-5; MAST CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTORS, IGG; TRICHURIASIS; TRICHURIS;

EID: 0033047649     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1999.00200.x     Document Type: Article

References (27)

1. Chan M.S. (1997) The global burden of intestinal nematode infections - fifty years on. Parasitology Today 13, 438-443
2. Clynes R. & Ravetch J.V. (1995) Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity 3, 21-26
3. Coffman R.L., Seymour B.W.P., Hudak S., Jackson J. & Rennick D. (1989) Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice. Science 245, 308-310
4. Cooper E.S. & Bundy D.A.P. (1988) Trichuris is not trivial. Parasitology Today 4, 301-306
5. v anaemic mice. Infection and Immunity 33, 54-58
6. Donaldson L.E., Schmitt E., Huntley J.F., Newlands G.F.J. & Grencis R.K. (1996) A critical role for stem cell factor and c-kit in host protective immunity to an intestinal helminth. International Immunol 8, 559-567
7. Else K.J. & Wakelin D. (1988) The effects of H-2 and non H-2 genes on the expulsion of the nematode Trichuris muris from inbred and congenic mice. Parasitology 96, 543-550
8. Else K.J. & Grencis R.K. (1991) Cellular immune responses to the nematode parasite Trichuris muris. I. Differential cytokine production during acute or chronic infection. Immunology 72, 508-513
9. Else K.J. & Grencis R.K. (1996) Antibody-independent effector mechanisms in resistance to the intestinal nematode parasite Trichuris muris. Infection and Immunity 64, 2950-2954
10. Else K.J., Wakelin D., Wassom D.L. & Hauda K.M. (1990a) MHC-restricted antibody responses to Trichuris muris excretory/secretory (E/S) antigen. Parasite Immunology 12, 509-517
11. Else K.J., Wakelin D., Wassom D.L. & Hauda K.M. (1990b) The influence of genes mapping within the major histocompatibility complex on resistance to Trichuris muris infections in mice. Parasitology 101, 61-67
12. Else K.J., Finkelman F.D., Maliszewski C.R. & Grencis R.K. (1994) Cytokine mediated regulation of chronic intestinal helminth infection. Journal of Experimental Medicine 179, 347-351
13. Else K.J., Entwistle G.M. & Grencis R.K. (1993) Correlations between worm burdens and markers of Th1 and Th2 cell subset activation in an inbred strain of mouse infected with Trichuris muris. Parasite Immunology 15, 595-600
14. Else K.J., Hultner L. & Grencis R.K. (1992) Cellular immune response to nematode parasite Trichuris muris II. Differential induction of Th cell subsets in resistant versus susceptible mice. Immunology 75, 232-237
15. Enerback L. (1966) Mast cells in rat gastrointestinal mucosa. I effect of fixation. Acta Pathologica Microbiologica Scandinavica 66, 289-295
16. Faulkner H., Humphries N., Renauld J-C., Van Snick J. & Grencis R.K. (1997) Interleukin-9 is involved in host protective immunity to intestinal nematode infection. European Journal of Immunology 27, 2536-2540
17. Finkelman F.D., Pearce E.J., Urban Jr J.F. & Sher A. (1991) Regulation and biological function of helminth-induced cytokine responses. In: Immunoparasitology Today, Ash C. & Gallagher R.B., eds, A62-A66. Elsevier Trends Journals, Cambridge
18. Grencis R.K., Else K.J., Huntly J.F. & Nishikawa S.I. (1993) The in vivo role of stem cell factor (c-kit ligand) on mastocytosis and host protective immunity to the intestinal nematode Trichinella spiralis in mice. Parasite Immunology 15, 55-59
19. Herndon F.J. & Kayes S.G. (1992) Depletion of eosinophils by anti-IL-5 monoclonal antibody treatment of mice infected with Trichinella spiralis does not alter parasite burden or immunologic resistance to reinfection. Journal of Immunology 149, 3642-3647
20. Huntley J.F., Gooden C., Newlands G.F.J. et al. (1990) Distribution of intestinal mast cell protease in blood and tissues of normal and Trichinella-infected mice. Parasite Immunology 12, 85-95
21. Koyama K., Tamanchi H. & Ito Y. (1995) The role of CD4+ and CD8+ T cells in protective immunity to the murine parasite Trichuris muris. Parasite Immunology 17, 161-165
22. Madden K.B., Urban Jr J.F., Ziltener H.J. et al. (1991) Antibodies to IL-3 and IL-4 suppress helminth induced intestinal mastocytosis. Journal of Immunology 147, 1387-1391
23. Ogawa M., Matsuzaki Y., Nishikawa S. et al. (1991) Expression and function of c-kit in haemopoeitic progenitor cells. Journal of Experimental Medicine 174, 63-71
24. Sher A., Coffman R.L., Hieny S., Scott P. & Cheever A.W. (1990) Interleukin-5 is required for blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni. Proceedings of the National Academy of Sciences, USA 87, 61-65
25. Takai T., Li M., Sylvestre D., Clynes R. & Ravetch J.V. (1994) FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell 76, 519-529
26. Tsai M., Shih L.S., Newlands G.F.J. et al. (1991) The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. Analysis by anatomical distribution, histochemistry and protease phenotype. Journal of Experimental Medicine 174, 125-131
27. Urban J.F., Katona I.M., Paul W.E. & Finkelman F.D. (1991) Interleukin-4 is important in protective immunity to gastrointestinal nematode infection in mice. Proceedings of the National Academy of Sciences, USA 88, 5513-5517