Helper T cells regulate type-2 innate immunity in vivo

Nature

Volumn 420, Issue 6917, 2002, Pages 825-829

  Shinkai, Kanade ^a   Mohrs, Markus ^a,b   Locksley, Richard M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TRUDEAU INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGIES; ANTIGENS; TISSUE;

INFLAMMATION;

CELLS;

CYTOKINE; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9;

MEDICINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; EOSINOPHIL; IMMUNE RESPONSE; IMMUNITY; MOUSE; NIPPOSTRONGYLUS BRASILIENSIS; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE;

ANIMALS; CELL DEGRANULATION; EOSINOPHILS; FEMALE; FLOW CYTOMETRY; GENE DELETION; GENES, RAG-1; IMMUNITY, NATURAL; INTERFERON TYPE II; INTERLEUKIN-4; LUNG; MICE; MICE, INBRED BALB C; NIPPOSTRONGYLUS; T-LYMPHOCYTES, HELPER-INDUCER;

ANIMALIA; ARTHROPODA; NEMATODA; NIPPOSTRONGYLUS BRASILIENSIS; VERMES;

EID: 0037180805     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01202     Document Type: Article

References (30)

1. Wills-Karp, M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17, 255-281 (1999).
2. Finkelman, E. D. et al. Cytokine regulation of host defense against parasitic gastrointestinal nematodes: Lessons from studies with rodent models. Annu. Rev. Immunol. 15, 505-533 (1997).
3. Akira, S. Toll-Iike receptors and innate immunity. Adv. Immunol. 78, 1-56 (2001).
4. Schnare, M. et al. Toll-like receptors control activation of adaptive immune responses. Nature. Immunol. 29, 47-50 (2001).
5. Chin, A. I. et al. Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 416, 190-194 (2002).
6. Kobayashi, K. et al. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416, 194-199 (2002).
7. Suzuki, N. et al. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 416, 750-754 (2002).
8. Mohrs, M., Shinkai, K., Mohrs, K. & Locksley, R. M. Analysis of type 2 immunity in vivo with a biscistronic reporter. Immunity 15, 303-311 (2001).
9. Dvorak, A. & Weller, P. F. Ultrastructural analysis of human eosinophils. Chem. Immunol. 76, 1-28 (2000).
10. McKenzie, G. J., Fallon, P. G., Emson, C. L., Grencis, R. K. & McKenzie, A. N. J. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J. Exp. Med. 189, 1565-1572 (1999).
11. Urban, J. F. Jr et al. IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasilieasis. Immunity 8, 255-264 (1998).
12. Walsh, G. M. Eosinophil granule proteins and their role in disease. Curr. Opin. Hematol. 8, 28-33 (2001).
13. Rumbley, C. A. et al. Activated eosinophils are the major source of Th2-associated cytokines in the schistosome granuloma. J. Immunol. 162, 1003-1009 (1999).
14. Justice, J. P. et al. Ragweed-induced expression of GATA-3, IL-4, and IL-5 by eosinophils in the lungs of allergic C57BL/6J mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 282, L302-L309 (2002).
15. Foster, P. S. et al. Elemental signals regulating eosinophil accumulation in the lung. Immunol. Rev. 179, 173-181 (2001).
16. Mould, A. W. et al. The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity. J. Immunol. 164, 2142-2150 (2000).
17. Denzler, K. L. et al. Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflamation. J. Immunol. 167, 1672-1682 (2001).
18. Erjefalt, J. S. & Persson, C. G. A. New aspects of degranulation and fates of airway mucosal eosinophils. Am. J. Respir. Crit. Care Med. 161, 2074-2085 (2000).
19. Karawaiczyk, M. et al. Piecemeal degranulation of peripheral blood eosinophils. A study of allergic subjects during and out of pollen season. Am. J. Respir. Cell Mol. Biol. 23, 521-529 (2000).
20. Sabin, E. A., Kopf, M. A. & Pearce, E. J. Schistosoma mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophds. J. Exp. Med. 184, 1871-1878 (1996).
21. Dent, L. A., Strath, M., Mellor, A. L. & Sanderson, C. J. Eosinophilia in transgenic mice expressing interleukin 5. J. Exp. Med. 172, 1425-1431 (1990).
22. Lee, N. A. et al. Expression of IL-5 in thymocytes/T cells leads to the development of a massive eosinophilia, extramedullary eosinophilopoiesis, and unique histopathologies. J. Immunol. 158, 1332-1344 (1997).
23. Conrad, D. H., Ben-Sasson, S. Z., Le Gros, G., Finkelman, F. D. & Paul, W. E. Infection with Nippostrongylus brasiliensis or injection with anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells. J. Exp. Med. 171, 1497-1508 (1990).
24. Dvorak, A. M. Cell biology of the basophil. Int. Rev. Cytol. 180, 87-236 (1998).
25. Leckie, M. J. et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356, 2144-2148 (2000).
26. Foster, P. S. et al. Interleukin-5 and eosinophils as therapeutic targets for asthma. Trends Mol. Med. 8, 162-167 (2002).
27. Milgrom, H. et al. Treatment of allergic asthma with monoclonal anti-IgE antibody. rhuMAb-E25 study group. N. Engl. J. Med. 341, 1966-1973 (1999).
28. 1o thymocytes in vivo. Science 250, 1720-1722 (1990).
29. Fowell, D. J., Magram, J., Turck, C. W., Killeen, N. & Locksley, R. M. Impaired Th2 subset development in the absence of CD4. Immunity 6, 559-569 (1997).
30. Brown, D. R. et al. Beta-2-microglobulin-dependent NK1.1 + T cells are not essential for T helper cell 2 immune responses. J. Exp. Med. 184, 1295-1304 (1996).