Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: A randomized placebo-controlled study (Medical Microbiology and Immunology DOI: 10.1007/s00430-007-0062-1);Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: A randomized placebo-controlled study

Medical Microbiology and Immunology

Volumn 197, Issue 3, 2008, Pages 295-311

  Hoerauf, Achim ^a   Specht, Sabine ^a   Büttner, Marcelle ^b   Pfarr, Kenneth ^a   Mand, Sabine ^a   Fimmers, Rolf ^a   Marfo Debrekyei, Yeboah ^c   Konadu, Peter ^d   Debrah, Alexander Yaw ^a,c,d   Bandi, Claudio ^e   Brattig, Norbert ^b   Albers, Anna ^a   Larbi, John ^c,d   Batsa, Linda ^c   Taylor, Mark J ^f   Adjei, Ohene ^c,d   Büttner, Dietrich W ^b  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^c Kumasi Centre for Collaborative Research   (Ghana)

^d KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^e UNIVERSITY OF MILAN   (Italy)

^f LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Doxycycline; Ghana; Ivermectin; Macrofilaricidal; Onchocerca volvulus; Wolbachia

Indexed keywords

ANTIINFECTIVE AGENT; DIETHYLCYARBAMAZINE; DOXYCYCLINE; IVERMECTIN; METRONIDAZOLE; PLACEBO; SURAMIN;

ADULT; ARTICLE; BLOODY DIARRHEA; CLINICAL FEATURE; CLINICAL TRIAL; COLITIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPLETION; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG RESEARCH; DRUG WITHDRAWAL; EMBRYO DEVELOPMENT; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOLOGY; MAJOR CLINICAL STUDY; MALE; MICROFILARIA; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCHOCERCIASIS; PERFORATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN NODULE; UNSPECIFIED SIDE EFFECT; WOLBACHIA;

EID: 44549084895     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00430-007-0072-z     Document Type: Erratum

References (47)

1. WHO (1995) Onchocerciasis and its control. WHO Tech Rep Ser 852:1-103
2. Habbema JDF, Plaisier AP, van Oortmarssen GJ, Remme J (1990) Prospective evaluation of onchocerciasis control strategies. Acta Leiden 59:387-398
3. Little MP, Breitling LP, Basanez MG, Alley ES, Boatin BA (2004) Association between microfilarial load and excess mortality in onchocerciasis: an epidemiological study. Lancet 363:1514-1521
4. Basanez MG, Pion SD, Churcher TS, Breitling LP, Little MP, Boussinesq M (2006) River blindness: a success story under threat? PLoS Med 3:e371
5. Boatin BA, Richards FO Jr (2006) Control of onchocerciasis. Adv Parasitol 61:349-394
6. Awadzi K, Attah SK, Addy ET, Opoku NO, Quartey BT (1999) The effects of high-dose ivermectin regimens on Onchocerca volvulus in onchocerciasis patients. Trans R Soc Trop Med Hyg 93:189-194
7. Kläger SL, Whitworth JA, Downham MD (1996) Viability and fertility of adult Onchocerca volvulus after 6 years of treatment with ivermectin. Trop Med Int Health 1:581-589
8. Kläger S, Whitworth JA, Post RJ, Chavasse DC, Downham MD (1993) How long do the effects of ivermectin on adult Onchocerca volvulus persist? Trop Med Parasitol 44:305-310
9. Duke BO (2005) Evidence for macrofilaricidal activity of ivermectin against female Onchocerca volvulus: further analysis of a clinical trial in the Republic of Cameroon indicating two distinct killing mechanisms. Parasitology 130:447-453
10. Cupp EW, Cupp MS (2005) Short report: impact of ivermectin community-level treatments on elimination of adult Onchocerca volvulus when individuals receive multiple treatments per year. Am J Trop Med Hyg 73:1159-1161
11. Dadzie Y, Neira M, Hopkins D (2003) Final report of the Conference on the Eradicability of Onchocerciasis. Filaria J 2:2
12. Awadzi K, Boakye DA, Edwards G, Opoku NO, Attah SK, Osei-Atweneboana MY, Lazdins-Helds JK, Ardrey AE, Addy ET, Quartey BT, Ahmed K, Boatin BA, Soumbey-Alley EW (2004) An investigation of persistent microfilaridermias despite multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana. Ann Trop Med Parasitol 98:231-249
13. Awadzi K, Attah SK, Addy ET, Opoku NO, Quartey BT, Lazdins-Helds JK, Ahmed K, Boatin BA, Boakye DA, Edwards G (2004) Thirty-month follow-up of sub-optimal responders to multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana. Ann Trop Med Parasitol 98:359-370
14. Osei-Atweneboana MY, Eng JK, Boakye DA, Gyapong JO, Prichard RK (2007) Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study. Lancet 369:2021-2029
15. Hoerauf A, Nissen-Pähle K, Schmetz C, Henkle-Dührsen K, Blaxter ML, Büttner DW, Gallin MY, Al-Qaoud KM, Lucius R, Fleischer B (1999) Tetracycline therapy targets intracellular bacteria in the filarial nematode Litomosoides sigmodontis and results in filarial infertility. J Clin Invest 103:11-18
16. Hoerauf A, Volkmann L, Hamelmann C, Adjei O, Autenrieth IB, Fleischer B, Büttner DW (2000) Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis. Lancet 355:1242-1243
17. Hoerauf A, Mand S, Adjei O, Fleischer B, Büttner DW (2001) Depletion of Wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment. Lancet 357:1415-1416
18. Hoerauf A, Mand S, Volkmann L, Büttner M, Marfo-Debrekyei Y, Taylor M, Adjei O, Büttner DW (2003) Doxycycline in the treatment of human onchocerciasis: kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms. Microbes Infect 5:261-273
19. Taylor MJ, Makunde WH, McGarry HF, Turner JD, Mand S, Hoerauf A (2005) Macrofilaricidal activity following doxycycline treatment of Wuchereria bancrofti: a double-blind randomised controlled trial. Lancet 365:2116-2121
20. Debrah AY, Mand S, Specht S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Larbi J, Lawson B, Taylor M, Adjei O, Hoerauf A (2006) Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis. PLOS Pathogens 2(9):e92
21. Kutin K, Kruppa TF, Brenya R, Garms R (2004) Efficiency of Simulium sanctipauli as a vector of Onchocerca volvulus in the forest zone of Ghana. Med Vet Entomol 18:167-173
22. Albiez EJ, Büttner DW, Duke BO (1988) Diagnosis and extirpation of nodules in human onchocerciasis. Trop Med Parasitol 39:331-346
23. Büttner DW, Albiez EJ, von Essen J, Erichsen J (1988) Histological examination of adult Onchocerca volvulus and comparison with the collagenase technique. Trop Med Parasitol 39:390-417
24. Awadzi K, Addy ET, Opoku NO, Plenge-Bönig A, Büttner DW (1995) The chemotherapy of onchocerciasis XX: ivermectin in combination with albendazole. Trop Med Parasitol 46:213-220
25. Awadzi K, Hero M, Opoku NO, Addy ET, Büttner DW, Ginger CD (1995) The chemotherapy of onchocerciasis XVIII. Aspects of treatment with suramin. Trop Med Parasitol 46:19-26
26. Bazzocchi C, Jamnongluk W, O'Neill SL, Anderson TJ, Genchi C, Bandi C (2000) wsp gene sequences from the Wolbachia of filarial nematodes. Curr Microbiol 41:96-100
27. Jolodar A, Fischer P, Büttner DW, Miller DJ, Schmetz C, Brattig NW (2004) Onchocerca volvulus: expression and immunolocalization of a nematode cathepsin D-like lysosomal aspartic protease. Exp Parasitol 107:145-156
28. Gardon J, Boussinesq M, Kamgno J, Gardon-Wendel N, Demanga N, Duke BO (2002) Effects of standard and high doses of ivermectin on adult worms of Onchocerca volvulus: a randomised controlled trial. Lancet 360:203-210
29. Duke BO, Marty AM, Peett DL, Gardo J, Pion SD, Kamgno J, Boussinesq M (2002) Neoplastic change in Onchocerca volvulus and its relation to ivermectin treatment. Parasitology 125:431-444
30. Albiez EJ, Walter G, Kaiser A, Ranque P, Newland HS, White AT, Greene BM, Taylor HR, Büttner DW (1988) Histological examination of onchocercomata after therapy with ivermectin. Trop Med Parasitol 39:93-99
31. Duke BO, Zea-Flores G, Munoz B (1991) The embryogenesis of Onchocerca volvulus over the first year after a single dose of ivermectin. Trop Med Parasitol 42:175-180
32. Gilbert J, Nfon CK, Makepeace BL, Njongmeta LM, Hastings IM, Pfarr KM, Renz A, Tanya VN, Trees AJ (2005) Antibiotic chemotherapy of onchocerciasis: in a bovine model, killing of adult parasites requires a sustained depletion of endosymbiotic bacteria (Wolbachia species). J Infect Dis 192:1483-1493
33. Meijerink J, Mandigers C, van de Locht L, Tonnissen E, Goodsaid F, Raemaekers J (2001) A novel method to compensate for different amplification efficiencies between patient DNA samples in quantitative real-time PCR. J Mol Diagn 3:55-61
34. Remme J, Ba O, Dadzie KY, Karam M (1986) A force-of-infection model for onchocerciasis and its applications in the epidemiological evaluation of the Onchocerciasis Control Programme in the Volta River basin area. Bull World Health Organ 64:667-681
35. Debrah AY, Mand S, Marfo-Debrekyei Y, Larbi J, Adjei O, Hoerauf A (2006) Assessment of microfilarial loads in the skin of onchocerciasis patients after treatment with different regimens of doxycycline plus ivermectin. Filaria J 5:1
36. Awadzi K (2003) Clinical picture and outcome of serious adverse events in the treatment of onchocerciasis. Filaria J 2(Suppl 1):S6
37. Kipp W, Bamhuhiiga J, Rubaale T, Büttner DW (2003) Adverse reactions to ivermectin treatment in Simulium neavei-transmitted onchocerciasis. Am J Trop Med Hyg 69:621-623
38. Carey V, Zeger SL, Diggle P (1993) Modelling multivariate binary data with alternating logistic regressions. Biometrika 80:517-526
39. ® 9.1.2. SAS Institute Inc., Cary
40. Awadzi K, Dadzie KY, Schulz-Key H, Haddock DR, Gilles HM, Aziz MA (1985) The chemotherapy of onchocerciasis X. An assessment of four single dose treatment regimes of MK-933 (ivermectin) in human onchocerciasis. Ann Trop Med Parasitol 79:63-78
41. WHO (1995) Drugs used in parasitic diseases, 2nd edn. WHO, Geneva
42. Franz M (1988) The morphology of adult Onchocerca volvulus based on electron microscopy. Trop Med Parasitol 39:359-366
43. Schulz-Key H (1988) The collagenase technique: how to isolate and examine adult Onchocerca volvulus for the evaluation of drug effects. Trop Med Parasitol 39:423-440
44. Duke BO (1991) Observations and reflections on the immature stages of Onchocerca volvulus in the human host. Ann Trop Med Parasitol 85:103-110
45. Wildenburg G, Henkle-Dührsen K (1999) Onchocerca volvulus: immunolocalization of the extracellular CuZn superoxide dismutase using antibodies raised against a 15-mer epitope of this enzyme. Exp Parasitol 91:1-6
46. WHO (2007) Meeting of the international task force for disease eradication. Wkly Epidem Rec 82:197-208
47. Hoerauf A, Pfarr K (2007) Wolbachia Endosymbionts: an achilles' heel of filarial nematodes. In: Hoerauf A, Rao R (eds) Wolbachia: a bug's life in another bug. Karger, Basel, pp 31-51