Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G

Immunity

Volumn 12, Issue 2, 2000, Pages 201-210

  Tkalcevic, Josephine ^a,c   Novelli, Marco ^b   Phylactides, Marios ^a   Iredale, John P ^a,d   Segal, Anthony W ^a   Roes, Jürgen ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Rayne Institute ^*  (United Kingdom)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN G; ELASTASE; REACTIVE OXYGEN METABOLITE;

ARTICLE; ENZYME ACTIVITY; HUMAN; INFECTION RESISTANCE; INFECTION SENSITIVITY; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK;

EID: 0034144636     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80173-9     Document Type: Article

References (59)

1. Bancroft, J.D., and Cook, H.C. (1998). Manual of Biological Techniques (London: Churchill Livingstone).
2. Belaaouaj, A., Walsh, B.C., Jenkins, N.A., Copeland, N.G., and Shapiro, S.D. (1997). Characterization of the mouse neutrophil elastase gene and localization to chromosome 10. Mamm. Genome 8, 5-8.
3. Belaaouaj, A., McCarthy, R., Baumann, M., Gao, Z., Ley, T.J., Abraham, S.N., and Shapiro, S.D. (1998). Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat. Med. 4, 615-618.
4. Beutler, B., and Cerami, A. (1988). Tumor necrosis, cachexia, shock, and inflammation: A common mediator. Annu. Rev. Biochem. 57, 505-518.
5. Beutler, B., and Cerami, A. (1989). The biology of cachectin/TNF - A primary mediator of the host response. Annu. Rev. Immunol. 7, 625-655.
6. Cai, T.Q., and Wright, S.D. (1996). Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) and modulates polymorphonuclear leukocyte adhesion. J. Exp. Med. 184, 1213-1223.
7. Caughey, G.H., Schaumberg, T.H., Zerweck, E.H., Butterfield, J.H., Hanson, R.D., Silverman, G.A., and Ley, T.J. (1993). The human mast cell chymase gene (CMA1): Mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression. Genomics 15, 614-620.
8. Chertov, O., Ueda, H., Xu, L.L, Tani, K., Murphy, W.J., Wang, J.M., Howard, O.M., Sayers, T.J., and Oppenheim, J.J. (1997). Identification of human neutrophil-derived cathepsin G and azurocidin/CAP37 as chemoattractants for mononuclear cells and neutrophils. J. Exp. Med. 186, 739-747.
9. Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
10. Church, G.M., and Gilbert, W. (1984). Genomic sequencing. Proc. Natl. Acad. Sci. USA 81, 1991-1995.
11. Diamond, R.D., and Clark, R.A. (1982). Damage to Aspergillus fumigatus and Rhizopus oryzae hyphae by oxidative and nonoxidative microbicidal products of human neutrophils in vitro. Infect. Immunol. 38, 487-495.
12. Emmendörffer, A., Hecht, M., Lohmann-Matthes, M.L., and Roesler, J. (1990). A fast and easy method to determine the production of reactive oxygen intermediates by human and murine phagocytes using dihydrorhodamine 123. J. Immunol. Methods 131, 269-275.
13. Fouret, P., du Bois, R.M., Bernaudin, J.F., Takahashi, H., Ferrans, V.J., and Crystal, R.G. (1989). Expression of the neutrophil elastase gene during human bone marrow cell differentiation. J. Exp. Med. 169, 833-845.
14. Gabay, J.E., and Almeida, R.P. (1993). Antibiotic peptides and serine protease homologs in human polymorphonuclear leukocytes: Defensins and azurocidin. Curr. Opin. Immunol. 5, 97-102.
15. Galanos, C., Freudenberg, M.A., and Reutter, W. (1979). Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc. Natl. Acad. Sci. USA 76, 5939-5943.
16. Garcia, R., Gusmani, L., Murgia, R., Guarnaccia, C., Cinco, M., and Rottini, G. (1998). Elastase is the only human neutrophil granule protein that alone is responsible for in vitro killing of Borrelia burgdorferi. Infect. Immunol. 66, 1408-1412.
17. Gray, P.W., Flaggs, G., Leong, S.R., Gumina, R.J., Weiss, J., Ooi, C.E., and Elsbach, P. (1989). Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations. J. Biol. Chem. 264, 9505-9509.
18. Gu, H., Zou, Y.R., and Rajewsky, K. (1993). Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-IoxP-mediated gene targeting. Cell 73, 1155-1164.
19. Haslett, C., and Condliffe, A. (1996). Neutrophil granulocytes. In The Integrated Immune System, L.A. Herzenberg, D.M. Weir, L.A. Herzenberg, and C. Blackwell, eds. (Cambridge, MA: Blackwell Science), pp. 157.1-157.12.
20. Heusel, J.W., Scarpati, E.M., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Shapiro, S.D., and Ley, T.J. (1993). Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene. Blood 81, 1614-1623.
21. Jackson, S.H., Gallin, J.I., and Holland, S.M. (1995). The p47phox mouse knock-out model of chronic granulomatous disease. J. Exp. Med. 182, 751-758.
22. Kaw, S., Hecker, M., and Vane, J.R. (1992). The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes. Proc. Natl. Acad. Sci. USA 89, 6886-6890.
23. Klebanoff, S.J., Vadas, M.A., Harlan, J.M., Sparks, L.H., Gamble, J.R., Agosti, J.M., and Waltersdorph, A.M. (1986). Stimulation of neutrophils by tumor necrosis factor. J. Immunol. 136, 4220-4225.
24. Laird, P.W., Zijderveld, A., Linders, K., Rudnicki, M.A., Jaenisch, R., and Berns, A. (1991). Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19, 4293.
25. Leff, J., and Repine, J. (1993). Neutrophil-mediated tissue injury. In The Neutrophil, J.S. Abramson and J.G. Wheeler, eds. (Oxford: IRL Press), pp. 229-262.
26. Lehrer, R.I., and Ganz, T. (1990). Antimicrobial polypeptides of human neutrophils. Blood 76, 2169-2181.
27. Malech, H.L., and Gallin, J.I. (1987). Current concepts: Immunology. Neutrophils in human diseases. N. Engl. J. Med. 317, 687-694.
28. Marino, M.W., Dunn, A., Grail, D., Inglese, M., Noguchi, Y., Richards, E., Jungbluth, A., Wada, H., Moore, M., Williamson, B., et al. (1997). Characterization of tumor necrosis factor-deficient mice. Proc. Natl. Acad. Sci. USA 94, 8093-8098.
29. Mills, E.L., and Noya, F.J.D. (1993). Congenital neutrophil deficiencies. In The Neutrophil, J.S. Abramson and J.G. Wheeler, eds. (Oxford: IRL Press), pp. 183-227.
30. Morgenstern, D.E., Gifford, M.A., Li, L.L., Doerschuk, C.M., and Dinauer, M.C. (1997). Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus. J. Exp. Med. 185, 207-218.
31. Neeman, N., Lahav, M., and Ginsburg, I. (1974). The effect of leukocyte hydrolases on bacteria. II. The synergistic action of lysozyme and extracts of PMN, macrophages, lymphocytes, and platelets in bacteriolysis. Proc. Soc. Exp. Biol. Med. 146, 1137-1145.
32. Nicholson, S.C., Grobmyer, S.R., Shiloh, M.U., Brause, J.E., Potter, S., MacMicking, J.D., Dinauer, M.C., and Nathan, C.F. (1999). Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both. Shock 11, 253-258.
33. Odeberg, H., and Olsson, I. (1976). Microbicidal mechanisms of human granulocytes: Synergistic effects of granulocyte elastase and myeloperoxidase or chymotrypsin-like cationic protein. Infect. Immunol. 14, 1276-1283.
34. Parrillo, J.E. (1993). Pathogenetic mechanisms of septic shock. N. Engl. J. Med. 328, 1471-1477.
35. Pasparakis, M., Alexopoulou, L., Episkopou, V., and Kollias, G. (1996). Immune and inflammatory responses in TNF alpha-deficient mice: A critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J. Exp. Med. 184, 1397-1411.
36. Patrignani, P., Del Maschio, A., Bazzoni, G., Daffonchio, L., Hernandez, A., Modica, R., Montesanti, L., Volpi, D., Patrone, C., and DeJana, E. (1991). Inactivation of endothelin by polymorphonuclear leukocyte-derived lytic enzymes. Blood 78, 2715-2720.
37. Paul, N.L., and Ruddle, N.H. (1988). Lymphotoxin. Annu. Rev. Immunol. 6, 407-438.
38. Pfeffer, K., Matsuyama, T., Kündig, T.M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P.S., Krönke, M., and Mak, T.W. (1993). Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73, 457-467.
39. Pollock, J.D., Williams, D.A., Gifford, M.A., Li, L.L., Du, X., Fisherman, J., Orkin, S.H., Doerschuk, C.M., and Dinauer, M.C. (1995). Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat. Genet. 9, 202-209.
40. Rajewsky, K., Gu, H., Kühn, R., Betz, U.A., Müller, W., Roes, J., and Schwenk, F. (1996). Conditional gene targeting. J. Clin. Invest. 98, 600-603.
41. Rest, R.F. (1988). Human neutrophil and mast cell proteases implicated in inflammation. Methods Enzymol. 163, 309-327.
42. Rickert, R.C., Rajewsky, K., and Roes, J. (1995). Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376, 352-355.
43. Roberts, A.W., Kim, C., Zhen, L., Lowe, J.B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J.D., Borneo, J.B., Bradford, G.B., et al. (1999). Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity 10, 183-196.
44. Roes, J., and Rajewsky, K. (1993). Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells. J. Exp. Med. 177, 45-55.
45. Roos, D. (1994). The genetic basis of chronic granulomatous disease. Immunol. Rev. 138, 121-157.
46. Rothe, J., Lesslauer, W., Lötscher, H., Lang, Y., Koebel, P., Köntgen, F., Althage, A., Zinkernagel, R., Steinmetz, M., and Bluethmann, H. (1993). Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediatedtoxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364, 798-802.
47. Sauer, B., and Henderson, N. (1988). Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc. Natl. Acad. Sci. (USA) 85, 5166-5170.
48. Scuderi, P., Nez, P.A., Duerr, M.L., Wong, B.J., and Valdez, C.M. (1991). Cathepsin-G and leukocyte elastase inactivate human tumor necrosis factor and lymphotoxin. Cell. Immunol. 135, 299-313.
49. Segal, A.W., and Abo, A. (1993). The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem. Sci. 18, 43-47.
50. Segal, A.W., Geisow, M., Garcia, R., Harper, A., and Miller, R. (1981). The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH. Nature 290, 406-409.
51. Shapiro, S.D., Campbell, E.J., Senior, R.M., and Welgus, H.G. (1991). Proteinases secreted by human mononuclear phagocytes. J. Rheumatol. Suppl. 27, 95-98.
52. Smedly, L.A., Tonnesen, M.G., Sandhaus, R.A., Haslett, C., Guthrie, L.A., Johnston, R.B.J., Henson, P.M., and Worthen, G.S. (1986). Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase. J. Clin. Invest. 77, 1233-1243.
53. Sturrock, A., Franklin, K.F., Wu, S., and Hoidal, J.R. (1998). Characterization and localization of the genes for mouse proteinase-3 (Prtn3) and neutrophil elastase (Ela2). Cytogenet. Cell Genet. 83, 104-108.
54. Tanaka, H., Sugimoto, H., Yoshioka, T., and Sugimoto, T. (1991). Role of granulocyte elastase in tissue injury in patients with septic shock complicated by multiple-organ failure. Ann. Surgery 213, 81-85.
55. Thorne, K.J., Oliver, R.C., and Barrett, A.J. (1976). Lysis and killing of bacteria by lysosomal proteinases. Infect. Immunol. 14, 555-563.
56. Tiegs, G., Wolter, M., and Wendel, A. (1989). Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. Biochem. Pharmacol. 38, 627-631.
57. Tracey, K.J., Beutler, B., Lowery, S.F., Merryweather, J., Wolpe, S., Milsark, I.W., Hariri, R. J., Fahey III, T.J., Zentella, A., Albert, J.D., et al. (1986). Shock and tissue injury induced by recombinant human cachectin. Science 234, 470-474.
58. Vassalli, P. (1992). The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10, 411-552.
59. Zimmer, M., Medcalf, R.L., Fink, T.M., Mattmann, C., Lichter, P., and Jenne, D.E. (1992). Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. Proc. Natl. Acad. Sci. USA 89, 8215-8219.