Bacterial acetohydroxyacid synthase and its inhibitors - A summary of their structure, biological activity and current status

FEBS Journal

Volumn 279, Issue 6, 2012, Pages 946-963

  Gedi, Vinayakumar ^a   Yoon, Moon Young ^a  

^a Hanyang University   (South Korea)

Author keywords

acetohydroxyacid synthase; antimicrobial target; bacterial; flavin adenine dinucleotide; herbicides; high throughput screening; inhibitors; protein structure; regulatory subunit; ThDP dependent enzyme

Indexed keywords

ACETOHYDROXYACID SYNTHASE I; ACETOHYDROXYACID SYNTHASE III; ACETOLACTATE SYNTHASE; ENZYME INHIBITOR; HERBICIDE; UNCLASSIFIED DRUG;

ACETOHYDROXYACID SYNTHASE GENE; BACTERIAL GENE; BACTERIAL GENETICS; CATALYSIS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; FEEDBACK SYSTEM; GENETIC CONSERVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ACETOLACTATE SYNTHASE; AMINO ACIDS, BRANCHED-CHAIN; ANTI-INFECTIVE AGENTS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; ENZYME INHIBITORS; HERBICIDES; MODELS, MOLECULAR; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

ALGAE; ANIMALIA; BACTERIA (MICROORGANISMS); FUNGI; MAMMALIA;

EID: 84858439204     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2012.08505.x     Document Type: Review

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