Characterization of acetohydroxyacid synthase from Mycobacterium tuberculosis and the identification of its new inhibitor from the screening of a chemical library

FEBS Letters

Volumn 579, Issue 21, 2005, Pages 4903-4910

  Choi, Kyoung Jae ^a   Yeon, Gyu Yu ^b   Hoh, Gyu Hahn ^c   Choi, Jung Do ^d   Yoon, Moon Young ^a  

^a Hanyang University   (South Korea)

^b Kookmin University   (South Korea)

^c Korea Institute of Science and Technology   (South Korea)

^d Chungbuk National University   (South Korea)

Author keywords

Acetohydroxyacid synthase; Antibacterial target; Antimycobacterial activity; Inhibitor screening

Indexed keywords

ACETOLACTATE SYNTHASE; BACTERIAL ENZYME; ENZYME INHIBITOR; HERBICIDE; KHG 20612; KHG 20613; KHG 20614; KHG 20616; PYRAZOSULFURON ETHYL; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG IDENTIFICATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PURIFICATION; ESCHERICHIA COLI; GENE OVEREXPRESSION; GROWTH INHIBITION; KINETICS; MOLECULAR CLONING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SCREENING;

ACETOLACTATE SYNTHASE; AMINO ACIDS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BIOLOGICAL ASSAY; DRUG DESIGN; HERBICIDES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PYRAZOLES; PYRIMIDINES;

MYCOBACTERIUM TUBERCULOSIS;

EID: 24044548711     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.07.055     Document Type: Article

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