Metabolic effects of inhibitors of two enzymes of the branched-chain amino acid pathway in Salmonella typhimurium

Journal of Bacteriology

Volumn 178, Issue 4, 1996, Pages 1187-1196

  Epelbaum, Sabine ^a   Chipman, David M ^a   Barak, Ze'ev ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOLACTATE SYNTHASE; BRANCHED CHAIN AMINO ACID; ISOLEUCINE; VALINE;

AMINO ACID SYNTHESIS; ARTICLE; ENZYME INHIBITION; GROWTH INHIBITION; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

EID: 0030025785     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.178.4.1187-1196.1996     Document Type: Article

References (51)

1. Abell, L. M., and J. V. Schloss. 1991. Oxygenase side reactions of acetolactate synthase and other carbanion-forming enzymes. Biochemistiy 30:7883-7887.
2. Aulabaugh, A., and J. V. Schloss. 1988 The kinetic mechanism of ketol-acid reductoisomerase. J. Cell Biol. 107:402A.
3. Aulabaugh, A., and J. V. Schloss. 1990. Oxalyl hydroxamates as reaction-intermediate analogues for ketol-acid reductoisomerase. Biochemistry 29: 2824-2830.
4. Bradford, M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248-254.
5. Burns, R. O. 1971 L-Threonine deaminase-biosynthetic Salmonella typhimurium. Methods Enzymol. 178:555-560.
6. Danchin, A., L. Dondon, and J. Daniel. 1984. Metabolic alterations mediated by 2-ketobutyrate in Escherichia coli K-12. Mol Gen. Genet. 193:473-478.
7. Daniel, J., L. Dondon, and A. Danchin. 1983. 2-Ketobutyrate, a putative alarmone of Escherichia coli Mol. Gen. Genet. 190:452-458.
8. Daniel, J., E. Joseph, and A. Danchin. 1984. Role of 2-ketobutyrate as an alarmone in Escherichia coli K-12. inhibition of adenylate cyclase activity mediated by the phosphoenol pyruvate glucose phosphotransferase transport system. Mol. Gen. Genet 193:467-472.
9. Dumas, R., C. Cornillion Bertrand, P. Gulgue Talet, P. Genix, R. Douce, and D. Job. 1994. Interactions of plant acetohydroxy acid isomeroreductase with reaction intermediate analogues: correlation of the slow, competitive, inhibition kinetics of enzyme activity and herbicidal effects. Biochem. J. 301: 813-820.
10. Epelbaum, S., D. M. Chipman, and Z. Barak. 1990. Determination of products of acetohydroxy acid synthase by the colorimetric method, revisited. Anal. Biochem. 191:96-99.
11. Gollop, N., Z. Barak, and D. M. Chipman. 1987. A method for simultaneous determination of the two possible products of acetohydroxy acid synthase Anal. Biochem. 160:323-331.
12. Gollop, N., Z. Barak, and D. M. Chipman. 1988. Assay of products of acetolactate synthase. Methods Enzymol. 166:234-240.
13. Gollop, N., B. Damri, Z. Barak, and D. M. Chipman. 1989. Kinetics and mechanism of acetohydroxy acid synthase isozyme III from Escherichia coli. Biochemistry 28:6310-6317.
14. Goodsell, D. S. 1991. Inside a living cell Trends Biochem. Sci 16:203-206.
15. Holms, W. H. 1986. The central metabolic pathways of Escherichia coli: relationship between flux and control at a branch point, efficiency of conversion to biomass, and excretion of acetate. Curr. Top. Cell. Regul. 28:69-105.
16. Johnsen, K., S. Molin, O. Karlström, and O. Maaløe. 1977. Control of protein synthesis in Escherichia coli. analysis of an energy source shift-down. J. Bacteriol. 131:18-29.
17. Julliard, J. H. 1994. Purification and characterization of oxopantoyl lactone reductase from higher plants: role in pantothenate synthesis. Bot. Acta 107:191-200.
18. Kishor, G. M., and D. M. Shah. 1988. Amino acid biosynthesis inhibitors as herbicides. Annu. Rev. Biochem. 57:627-663.
19. Kisumi, N., M. Siguira, and I. Chibata. 1976. Biosynthesis of norvaline, norleucine, and homoisoleucine in Serratta marcescens. J. Biochem 80:333-339.
20. Klingenberg, M., and E. PfafF. 1967 Means of terminating reactions. Methods Enzymol. 10:680-684.
21. Krampitz, L. O. 1948. Preparation and determination of 2-acetolactic acid Arch Biochem. 17:81.
22. Landstein, D., S. Epelbaum, S. Arad (Malis), Z. Barak, and D. M. Chipman. 1995. Metabolic response of Chlorella emersonu to the herbicide sulfometuron methyl. Planta 197:219-224
23. LaRossa, R. A., and J. V. Schloss. 1984. The sulfonylurea herbicide sulfometuron methyl is an extremely potent and selective inhibitor of acetolactate synthase in Salmonella typhimurium. J. Biol. Chem. 259:8753-8757.
24. LaRossa, R. A., and T. K. Van Dyk. 1989. Leaky pantothenate and thiamin mutations of Salmonella typhimurium conferring sulfometuron methyl sensitivity. J. Gen Microbiol. 135:2209-2222.
25. LaRossa, R. A., T. K. Van Dyk, and D. R. Smulski. 1987 Toxic accumulation of α-ketobutyrate caused by inhibition of the branched-chain amino acid biosynthetic enzyme acetolactate synthase in Salmonella typhimurium. J. Bacteriol. 169:1372-1378.
26. Levin, G. 1983. Agricultural sulfonamides. U.S. patent 4,394,506.
27. McAdam, R. A., T. R. Weisbrod, J. Martin, J. D. Scuderi, A. M. Brown, J. D. Cirillo, B. R. Bloom, and W. R. Jacobs. 1995. In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis. Infect. Immun. 63:1004-1017.
28. Miller, J. H. 1972. Experiments in molecular genetics, p 352-356. Cold Spring Harbor Laboratory. Cold Spring Harbor, N.Y
29. Miller, J. H. 1972. Experiments in molecular genetics, p 433 Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
30. Muhitch, M. J., D. L. Shaner, and M. A. Stidham. 1987. Imidazolinones and acetohydroxyacid synthase from higher plants. Properties of the enzyme from maize suspension culture cells and evidence for the binding of imazapyr to acetohydroxyacid synthase in vivo. Plant Physiol. 83:451-456.
31. Neidhardt, F. C. 1987. Chemical composition of Escherichia coli, p. 3-6 In J. L Ingraham, K. B Losy, B. Magasanik, M. Schaechter, and H E. Umbarger (ed.), Escherichia coli and Salmonella typhimurium: cellular and molecular biology. American Society for Microbiology, Washington, D.C.
32. Neidhardt, F. C., P. L. Bloch, and D. F. Smith. 1974. Culture medium for enterobacteria. J. Bacteriol 119:736-747
33. Palmer, D. T., P. H. Blum, and S. W. Artz. 1983 Effects of the hisT mutation in Salmonella typhimurium on translation elongation rate. J Bacteriol. 153: 357-363.
34. Payne, S. M., and B. N. Ames. 1982 A procedure for rapid extraction and high-pressure liquid chromatographic separation of the nucleotides and other small molecules from bacterial cells Anal. Biochem 123:151-162.
35. Powers, S. G., and E. E. Snell. 1976 Ketopantoate hydroxymethyltransferase. 2. Physical catalytic and regulatory properties. J. Biol. Chem. 251: 3786-3793
36. Primerano, D. A., and R. O. Burns. 1983. Role of acetohydroxy acid isomeroreductase in biosynthesis of pantothenic acid in Salmonella typhimurium. J Bacteriol. 153:259-269.
37. Putnam, S. L., and A. L. Koch. 1975. Complications in the simplest cellular enzyme assay: lysis of Escherichia coli for the assay of β-galactosidase Anal. Biochem 53:350-350.
38. Ratzkin, B., S. Arfin, and H. E. Umbarger. 1972 Isoleucine and valine metabolism in Escherichia coli. XVMII. Induction of acetohydroxy acid isomeroreductase. J. Bacteriol. 112:131-141.
39. Ray, T. B. 1984. Site of action of chlorosulfuron. Plant Physiol 75:827-831.
40. Schloss, J. V., and A. Aulabaugh. 1990 Acetolactate synthase and ketol-acid reductoisomerase: targets for herbicides obtained by screening and de novo design Z. Naturforsch. 45c:544-551.
41. Schloss, J. V., and A. Aulabaugh. 1990. Acetolactate synthase and ketol-acid reductoisomerase: a search for reason and a reason for search, p. 329-356. In Z. Barak, D. M. Chipman, and J. V. Schloss (ed.), Biosynthesis of branched chain amino acids. VCH, Weinheim, Germany.
42. Schulz, A., P. Spoenemann, H. Koecher, and F. Wengemayer. 1988. The herbicidally active experimental compound Hoe 704 is a potent inhibitor of the enzyme acetolactate reductoisomerase. FEBS Lett. 238:375-378.
43. Shaner, D. L., and B. K. Singh. 1993. Phytotoxicity of acetohydroxyacid synthase inhibitors is not due to accumulation of 2-ketobutyrate and/or 2-aminobutyrate. Plant Physiol. 103:1221-1226.
44. Singer, P. A., M. Levinthal, and L. S. Williams. 1984. Synthesis of the isoleucyl- and valyl-tRNA synthetases and the isoleucine-valine biosynthetic enzymes in a threonine deaminase regulatory mutant of Escherichia coli K-12. J. Mol. Biol. 175:39-55.
45. Tse, J. M. T., and J. V. Schloss. 1993. The oxygenase reaction of acetolactate synthase. Biochemistry 32:10398-10403.
46. Van Dyk, T. K., and R. A. LaRossa. 1986. Sensitivity of a Salmonella typhimurium aspC mutant to sulfometuron methyl, a potent inhibitor of acetolactate synthase II. J. Bacteriol. 165:386-392.
47. Van Dyk, T. K., and R. A. LaRossa. 1990. Prevention of endogenous 2-ketobutyrate toxicity in Salmonella typhimurium, p 123-130. In Z. Barak, D. M Chipman, and J. V. Schloss (ed.), Biosynthesis of branched chain amino acids. VCH, Wemheim, Germany.
48. Wang, Z.-J., K. Zaitsu, and Y. Ohkura. 1988. High-performance liquid chromatographic determination of 2-ketoacids in human serum and urine using 1,2-diamino-4,5-methylenedioxybenzene as a precolumn fluorescence derivatisation reagent. J. Chromatogr. 430:223-231.
49. Westerfeld, W. W. 1945 A colorimetric determination of blood acetoin. J Biol. Chem. 161:495-502.
50. Wittenbach, V. A., A. Aulabaugh, and J. V. Schloss. 1991. Examples of extraneous site inhibitors and reaction intermediate analogs: acetolactate synthase and ketol-acid reductoisomerase, p. 151-160. In H. Frehse (ed.), Pesticide chemistry. VCH, Weinheim, Germany.
51. Zaritzky, A., C. L. Woldringh, C. E. Helmstetter, and N. B. Grover. 1993. Dimensional rearrangement of Escherichia coli B/r cells during a nutritional shift down. J. Gen. Microbiol. 139:2711-2714.