Inhibitors of branched-chain amino acid biosynthesis as potential antituberculosis agents

Journal of Antimicrobial Chemotherapy

Volumn 42, Issue 4, 1998, Pages 475-482

  Grandoni, Jerry A ^a,c   Marta, Peter T ^a   Schloss, John V ^b  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c IMMUNETICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOLACTATE SYNTHASE; BACTERIAL ENZYME; BRANCHED CHAIN AMINO ACID; HERBICIDE; KETOL; LEUCINE; PROTEIN SYNTHESIS INHIBITOR; SULFOMETURON METHYL; TUBERCULOSTATIC AGENT;

AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUXOTROPHY; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG TARGETING; GROWTH INHIBITION; LUNG; MOUSE; MYCOBACTERIUM BOVIS; NONHUMAN; SPLEEN;

ACETOLACTATE SYNTHASE; ALCOHOL OXIDOREDUCTASES; AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; ANTITUBERCULAR AGENTS; COLONY COUNT, MICROBIAL; ENZYME INHIBITORS; HERBICIDES; KETOL-ACID REDUCTOISOMERASE; LUNG; MICE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; SPLEEN; TUBERCULOSIS;

EID: 0031718499     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/42.4.475     Document Type: Article

References (31)

1. Collins, F. M. (1993). Tuberculosis: the return of an old enemy. Critical Reviews in Microbiology 19, 1-16.
2. Jacobs, R. F. (1994). Multiple-drug-resistant tuberculosis. Clinical Infectious Disease 19, 1-10.
3. Allaudeen, H. S. & Ramakrishnan, T. (1968). Biosynthesis of isoleucine and valine in Mycobacterium tuberculosis H37Rv. Archives of Biochemistry and Biophysics 125, 199-209.
4. Chaleff, R. S. & Mauvais, J. (1984). Acetolactate synthase is the site of action of two sulfonylurea herbicides in higher plants. Science 224, 1443-5.
5. LaRossa, R. A. & Schloss, J. V. (1984). The sulfonylrea herbicide sulfometuron methyl is an extremely potent and selective inhibitor of acetolactate synthase in Salmonella typhimurium. Journal of Biological Chemistry 259, 8753-7.
6. Ray, T. B. (1984). Site of action of chlorsulfuron: inhibition of valine and isoleucine biosynthesis in plants. Plant Physiology 75, 827-31.
7. Hawkes, T. R., Howard, J. L. & Poutin, S. F. (1989). Herbicides that inhibit the biosynthesis of branched-chain amino acids. In Herbicides in Plant Metabolism, (Dodge, A. D., Ed.), pp. 113-37. Cambridge University Press, Cambridge.
8. Shaner, D. L., Anderson, P. C. & Stidham, M. A. (1984). Imidazolinones: potent inhibitors of acetohydroxyacid synthase. Plant Physiology 76, 545-6.
9. Schloss, J. V., Ciskanik, L. M. & Van Dyk, D. E. (1988). Origin of the herbicide binding site of acetolactate synthase. Nature 331, 360-2.
10. Schloss, J. V. & Aulabaugh, A. (1990). Acetolactate synthase and ketol-acid reductoisomerase: a search for a reason and a reason for a search. In Biosynthesis of Branched Chain Amino Acids, (Barak, Z., Chipman, D. & Schloss, J. V., Eds), pp. 329-56. VCH, Weinheim, Germany.
11. Aulabaugh, A. & Schloss, J. V. (1990). Oxalyl hydroxamates as reaction-intermediate analogues for ketol-acid reductoisomerase. Biochemistry 29, 2824-30.
12. Schulz, A., Sponemann, P., Kocher, H. & Wengenmayer, F. (1988). The herbicidally active experimental compound Hoe 704 is a potent inhibitor of the enzyme acetolactate reductoisomerase. FEBS Letters 238, 375-8.
13. McAdam, R. A., Weisbrod, T. R., Martin, J., Scuderi, J. D., Brown, A. M., Cirillo, J. D. et al. (1995). In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis. Infection and Immunity 63, 1004-12.
14. Inderleid, C. B. & Nash, K. A. (1996). Antimycobacterial agents: in vitro susceptibility testing, spectra of activity, mechanisms of action and resistance, and assays for activity in biological fluids. In Antibiotics in Laboratory Medicine, 4th edn, (Lorian, V., Ed.), pp. 127-75. Williams & Wilkins, Baltimore.
15. Inderleid, C. B. & Salfinger, M. (1995). Antimicrobial agents and susceptibility tests: mycobacteria. In Manual of Clinical Microbiology, 6th edn, (Murray, P. R., Baron, E. J., Pfaller, M. A., Tenover, F. C. & Yolken, R. H., Eds), pp. 1385-404. American Society for Microbiology, Washington, DC.
16. Klemens, S. P., Sharpe, C. A., Rogge, M. C. & Cynamon, M. H. (1994). Activity of levofloxacin in a murine model of tuberculosis. Antimicrobial Agents and Chemotherapy 38, 1476-9.
17. Siegel, S. (1956). Nonparametric Statistics for the Behavioral Sciences. McGraw Hill, New York.
18. Wallace, R. J. J., Nash, D. R., Steele, L. C. & Steingrube, V. (1986). Suseptibility testing of slowly growing mycobacteria by a microdilution MIC method with 7H9 broth. Journal of Clinical Microbiology 24, 976-81.
19. Gaillard, J. L., Berche, P., Mounier, J., Richard, S. & Sansonetti, P. (1987). In vitro model of penetration and intracellular growth of Listeria monocytogenes in the human enterocyte-like cell line Caco-2. Infection and Immunity 55, 2822-9.
20. Premaratne, R. J., Lin, W. J. & Johnson, E. A. (1991). Development of an improved chemically defined minimal medium for Listeria monocytogenes. Applied and Environmental Microbiology 57, 3046-8.
21. Marquis, H., Bouwer, H. G., Hinrichs, D. J. & Portnoy, D. A. (1993). Intracytoplasmic growth and virulence of Listeria monocytogenes auxotrophic mutants. Infection and Immunity 61, 3756-60.
22. Moreira, A. L., Wang, J., Tsenova-Berkova, L., Hellmann, W., Freedman, V. H. & Kaplan, G. (1997). Sequestration of Mycobacterium tuberculosis in tight vacuoles in vivo in lung macrophages of mice infected by the respiratory route. Infection and Immunity 65, 305-8.
23. Fields, P. I., Swanson, R. V., Haidaris, C. G. & Heffron, F. (1986). Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent. Proceedings of the National Academy of Sciences of the USA 83, 5189-93.
24. Leung, K. Y. & Finlay, B. B. (1991). Intracellular replication is essential for the virulence of Salmonella typhimurium. Proceedings of the National Academy of Sciences of the USA 88, 11470-4.
25. McFarland, W. C. & Stocker, B. A. (1987). Effect of different purine auxotrophic mutations on mouse-virulence of Vi-positive strain of Salmonella dublin and of two strains of Salmonella typhimurium. Microbial Pathogenesis 3, 129-41.
26. Horwitz, M. A. (1983). The legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes. Journal of Experimental Medicine 158, 2108-26.
27. Tesh, M. J. & Miller, R. D. (1981). Amino acid requirements for Legionella pneumophila growth. Journal of Clinical Microbiology 13, 865-9.
28. Bange, F.-C., Brown, A. M. & Jacobs, W. R. (1996). Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages. Infection and Immunity 64, 1794-9.
29. Moulder, J. W. (1985). Comparative biology of intracellular parasitism. Microbiological Reviews 49, 298-337.
30. Schloss, J. V. (1994). Recent advances in understanding the mechanism and inhibition of acetolactate synthase. In Chemistry of Plant Protection. Herbicides Inhibiting Branched-Chain Amino Acid Biosynthesis, (Stetter, J., Ed.), pp. 3-14. Springer-Verlag, Berlin.
31. Wittenbach, V. A., Aulabaugh, A. & Schloss, J. V. (1991). Examples of extraneous site inhibitors and reaction intermediate analogs: acetolactate synthase and ketol-acid reductoisomerase. In Pesticide Chemistry, (Frehse, H., Ed.), pp. 151-60. VCH, Weinheim, Germany.