Identification and characterization of inhibitors of Haemophilus influenzae acetohydroxyacid synthase

Enzyme and Microbial Technology

Volumn 49, Issue 1, 2011, Pages 1-5

  Gedi, Vinayakumar ^a   Moon, Ji Young ^a   Lim, Won Mook ^a   Lee, Mi Young ^a   Lee, Sang Choon ^a   Koo, Bon Sung ^b   Govindwar, Sanjay ^c   Yoon, Moon Young ^a  

^a Hanyang University   (South Korea)

^b National Institute of Animal Science   (South Korea)

^c SHIVAJI UNIVERSITY   (India)

Author keywords

AHAS; Docking; Haemophilus influenzae; High throughput screening

Indexed keywords

ACETOHYDROXYACID SYNTHASE; ACTIVE SITE; AHAS; ANTI-MICROBIAL AGENT; BINDING MODES; CATALYTIC SUBUNITS; DRUG-RESISTANT BACTERIA; GENE CODING; HAEMOPHILUS INFLUENZAE; HIGH-THROUGHPUT; HIGH-THROUGHPUT SCREENING; IN-VITRO; INHIBITION MECHANISMS; MICROMOLAR RANGE; MOLECULAR DOCKING; NOVEL ANTIBIOTICS; SCREENING COMPOUNDS; STRUCTURAL CLASS;

AMINO ACIDS; BINDING ENERGY; BIOCHEMISTRY; CARBOXYLIC ACIDS; DOCKING; ESCHERICHIA COLI; GENES; NAPHTHALENE; POLYMER BLENDS; SCAFFOLDS;

CHEMICAL COMPOUNDS;

ACETOLACTATE SYNTHASE; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; KHG 25056; KHG 25229; KHG 25386; OXA 1 THIA 4 AZACYCLOPENTA[B]NAPHTHALENE; PHENYL 2,3 DIHYDROISOTHIAZOLE; PHENYLPYRROLIDINE 3 CARBOXYLIC ACID PHENYLAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DRUG POTENCY; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PURIFICATION; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; MOLECULAR CLONING; MOLECULAR DOCKING; NONHUMAN;

ACETOLACTATE SYNTHASE; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DRUG DISCOVERY; ENZYME INHIBITORS; HAEMOPHILUS INFLUENZAE; HIGH-THROUGHPUT SCREENING ASSAYS; KINETICS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; THIA;

EID: 79957569727     PISSN: 01410229     EISSN: 18790909     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2011.04.004     Document Type: Article

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