Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages

Infection and Immunity

Volumn 64, Issue 5, 1996, Pages 1794-1799

  Bange, Franz Christoph ^a   Brown, Amanda M ^a   Jacobs Jr , William R ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; LEUCINE;

ARTICLE; AUXOTROPHY; BACTERIAL GROWTH; CELL DIVISION; GENETIC COMPLEMENTATION; GROWTH INHIBITION; GROWTH REGULATION; HUMAN; HUMAN CELL; MACROPHAGE FUNCTION; MYCOBACTERIUM BOVIS; PHAGOCYTOSIS; PRIORITY JOURNAL;

EID: 0029944435     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.5.1794-1799.1996     Document Type: Article

References (36)

1. Ahmed, Z. U., M. R. Sarker, and D. A. Sack. 1990. Protection of adult rabbits and monkeys from lethal shigellosis by oral immunization with a thymine-requiring and temperature sensitive mutant of Shigella flexneri Y. Vaccine 8:153-158.
2. Armstrong, J. A., and P. DArcy Hart. 1971. Response of cultured macro phages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomes. J. Exp. Med. 134:713-740.
3. Armstrong, J. A., and P. DArcy Hart. 1975 Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. J. Exp. Med. 142:1-16.
4. Auwerx, J. 1991. The human leukemia cell line, THP-1: a multifacetted model for the study of monocytic-macrophage differentiation. Experientia 47:22-31.
5. Bacon, G. A., T. W. Burrows, and M. Yates. 1950. The effects of biochemical mutations on the virulence of Bacterium typhosum: the virulence of mutants Br. J. Exp. Pathol. 31:714-724.
6. Bacon, G. A., T. W. Burrows, and M. Yates. 1951. The effects of biochemical mutation on the virulence of Bacterium typhosum: the loss of virulence of certain mutants. Br. J. Exp. Pathol. 32:85-96.
7. Balasubramanian, V., M. S. Pavelka, Jr., S. S. Bardarov, J. Martin, T. R. Weisbrod, R. A. McAdam, B. R. Bloom, and W. R. Jacobs, Jr. 1996. Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates. J. Bacteriol. 178:273-279.
8. Bloom, B. R., and P. E. M. Fine. 1994. The BCG experience: implications for future vaccines against tuberculosis, p. 531-557. In B. R. Bloom (ed.), Tuberculosis. Pathogenesis, protection, and control. American Society for Microbiology, Washington, D.C.
9. Chan, J., and S. H. E. Kaufmann. 1994. Immune mechanism of protection, p. 389-415. In B. R. Bloom (ed.), Tuberculosis. Pathogenesis, protection, and control. American Society for Microbiology, Washington, D.C
10. Clemens, D. L., and M. A. Horwitz. 1995. Characterization of the Mycobacterium tuberculosis phagosome and evidence that the phagosomal maturation is inhibited. J. Exp. Med. 181:257-270.
11. Crowle, J. A., and M. H. May. 1983. Replication of lyophilized and cultured BCG in human macrophages Am. Rev. Respir. Dis. 128:673-679
12. D'Arcy Hart, P., M. R. Young, M. M. Jordon, W. J. Perkins, and M. J. Geisow. 1983. Chemical inhibition of phagosome-lysosome fusion in cultured macrophages also inhibits saltatory lysosomal movements. A combined microscopic and computer study. J. Exp. Med. 158:477-492
13. Desai, S. A., D. J. Krogstad, and E. W. McCleskey. 1993. A nutrient-permeable channel on the intraerythrocytic malaria parasite Nature (London) 362:643-646.
14. Fields, P. I., R. V. Swanson, C. G. Haidaris, and F. Heffron. 1986. Mutants of Salmonella typlumurium that cannot survive within the macrophage are avirulent. Proc. Natl. Acad. Sci. USA 83:5189-5193.
15. Friedland, J. S., D. Remick, R. J. Shattock, and G. E. Griffin. 1992. Secretion of interleukin-8 following phagocytosis of Mycobacterium tuberculosis by human monocyte cell lines. Eur. J. Immunol. 22:1373-1378
16. Gaillard, J. L., P. Berche, J. Mounier, S. Richard, and P. J. Sansonetti. 1987 In vitro model of penetration and intracellular growth of Listeria monocytogenes in the human enterocyte-like cell line Caco-2. Infect. Immun. 55:2822-2829.
17. Gordon, A. H., P. D'Arcy Hart, and M. R. Young. 1980. Ammonia inhibits phagosome-lysosome fusion in macrophages. Nature (London) 286:79-81.
18. Guiholt, C., I. Otal, I. van Rompaey, C. Martin, and B. Giquel. 1994. Efficient transposition in mycobacteria: construction of Mycobacterium smegmatis insertional mutant libraries. J. Bacteriol. 176:535-539.
19. Hinshelwood, S., and N. G. Stoker. 1992. Cloning of mycobacterial histidine synthesis genes by complementation of a Mycobacterium smegmatis auxotroph. Mol. Microbiol. 6:2887-2895.
20. Joiner, K. A., C. J. Beckers, D. Bermundes, P. N. Ossorio, J. C. Schwab, and J. F. Dubremetz. 1994. Structure and function of the parasitophorous vacuole membrane surrounding Toxoplasma gondii. Ann. N. Y. Acad. Sci. 730:1-6.
21. Leão, S. C., C. L. Rocha, L. A. Murillo, C. A. Parra, and M. E. Patarroyo. 1995. A species-specific nucleotide sequence of Mycobacterium tuberculosis encodes a protein that exhibits hemolytic activity when expressed in Escherichia coli Infect. Immun. 63:4301-4306.
22. Leung, K. Y., and B. B. Finlay. 1991. Intracellular replication is essential for the virulence of Salmonella typhimurium. Proc. Natl. Acad. Sci. USA 88: 11470-11474.
23. Mahan, M. J., J. M. Slauch, and J. J. Mekalanos. 1993. Selection of bacterial virulence genes that are specifically induced in host tissues. Science 259:686-688.
24. m24. Marquis, H., H. G. A. Bouwer, D. J. Hinrichs, and D. A. Portnoy. 1993 Intracytoplasmatic growth and virulence of Listeria monocytogenes auxotrophic mutants Infect. Immun. 61:3756-3760.
25. McAdam, R. A., T. R. Weisbrod, J. Martin, J. D. Scuderi, A. M. Brown, J. D. Cirillo, B. R. Bloom, and W. R. Jacobs, Jr. 1995. In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis. Infect. Immun. 63:1004-1012.
26. McDonough, K. A., Y. Kress, and B. R. Bloom. 1993 Pathogenesis of tuberculosis: interaction of Mycobacterium tuberculosis with macrophages. Infect. Immun 61:2763-2773.
27. Mintz, C. S., J. Chen, and H. A. Shuman. 1988. Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes. Infect. Immun 56:1449-1455.
28. Myrvik, Q. N., E. S. Leake, and M. J. Wright. 1984. Disruption of phagosomal membranes of normal alveolar macrophages by the H37Rv strain of Mycobacterium tuberculosis. Am. Rev. Respir. Dis. 129:322-328
29. North, R. J., and A. A. Izzo. 1993. Mycobacterial virulence. Virulent strains of Mycobacterium tuberculosis have faster in vivo doubling times and are better equipped to resist growth-inhibiting functions of macrophages in the presence and absence of the specific immunity. I. Exp Med. 177:1723-1733.
30. Okada, N., C. Sasakawa, T. Tobe, M. Yamada, S. Nagai, K. A. Talukder, K. Komatsu, S. Kanegasuki, and M. Yoshikawa. 1991. Virulence-associated chromosomal loci of Shigella flexneri identified by random Tn5 insertion mutagenesis. Mol. Microbiol. 5:187-195.
31. Permaratne, R. J., W.-J. Lin, and E. A. Johnson. 1991. Development of an improved chemically denned minimal medium for Listeria moncytogenes. Appl. Environ Microbiol. 57:3046-3048.
32. Portnoy, D. A., P. S. Jacks, and U. J. Hinrichs. 1988 Role of hemolysin for the intracellular growth of Listeria monocytogenes. J. Exp. Med. 167:1459-1471.
33. Sansonetti, P. J., A. Ryter, P. Clerc, A. T. Maurelli, and J. Mounier. 1986. Multiplication of Shigella flexncri within HeLa cells: lysis of the phagocytic vacuole and plasmid-mediated contact hemolysis Infect. Immun 51:461-469.
34. Shattock, R. J., J. S. Friedland, and G. E. Griffin. 1993. Modulation of HIV transcription in and release from human monocytic cells following phagocytosis of Mycobacterium tuberculosis. Res. Virol. 144:7-12.
35. Sturgill-Koszycki, S., P. H. Schlesinger, P. Chakraborty, P. L. Haddix, H. L. Collins, A. K. Fok, R. D. Allen, S. L. Gluck, J. Heuser, and D. G. Russell. 1994. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase Science 363:678-681.
36. Xu, S., A. Cooper, S. Sturgill-Koszycki, T. van Heyningen, D. Chatterjee, I. Orme, and D. G. Russell. 1994. Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages. J Immunol. 153:2568-2578.