Reaction mechanisms of thiamin diphosphate enzymes: New insights into the role of a conserved glutamate residue

FEBS Journal

Volumn 276, Issue 9, 2009, Pages 2447-2453

  Shaanan, Boaz ^a   Chipman, David M ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

3D structure; Aminopyrimidine iminopyrimidine tautomerization; Carboligation; Conserved glutamate; Effective dielectric constant; Glyoxylate carboligase; Thiamin; Thiamin diphosphate dependent enzyme

Indexed keywords

4' AMINOPYRIMIDINE; ACETOLACTATE SYNTHASE; GLUTAMIC ACID; LIGASE; PYRIMIDINE DERIVATIVE; TARTRONATE SEMIALDEHYDE SYNTHASE; THIAMINE PYROPHOSPHATASE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VALINE;

CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME MECHANISM; HYDROGEN BOND; IONIZATION; ISOMERIZATION; MOLECULAR STABILITY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; SHORT SURVEY; SITE DIRECTED MUTAGENESIS; SPECTROSCOPY; TAUTOMERIC SHIFT;

CRYSTALLOGRAPHY, X-RAY; GLUTAMIC ACID; KINETICS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; THIAMINE PYROPHOSPHATE;

EID: 64149085016     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.06965.x     Document Type: Short Survey

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