Non-viral gene delivery of the GDNF, either alone or fused to the C-fragment of tetanus toxin protein, prolongs survival in a mouse ALS model

Restorative Neurology and Neuroscience

Volumn 30, Issue 1, 2012, Pages 69-80

  Moreno Igoa, María ^a   Calvo, Ana Cristina ^a   Ciriza, Jesús ^a,b   Muñoz, María Jesús ^a   Zaragoza, Pilar ^a   Osta, Rosario ^a  

^a UNIVERSIDAD DE ZARAGOZA   (Spain)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amyotrophic lateral sclerosis (ALS); C fragment tetanus toxin (TTC); Glial cell line derived neurotrophic factor (GDNF); neuronal apoptosis; SODG93A mouse model

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NAKED DNA; PLASMID VECTOR; TETANUS TOXIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SURVIVAL;

AGE FACTORS; AGE OF ONSET; AMYOTROPHIC LATERAL SCLEROSIS; ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; CASPASE 3; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE GROWTH FACTORS; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-AKT; SUPEROXIDE DISMUTASE; TETANUS TOXIN;

EID: 84858256486     PISSN: 09226028     EISSN: 18783627     Source Type: Journal    
DOI: 10.3233/RNN-2011-0621     Document Type: Article

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