-
1
-
-
70350133628
-
Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals
-
Abi-Gerges A, Richter W, Lefebvre F, Mateo P, Varin A, Heymes C, Samuel JL, Lugnier C, Conti M, Fischmeister R, Vandecasteele G. Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals. Circ Res 105: 784-792, 2009.
-
(2009)
Circ Res
, vol.105
, pp. 784-792
-
-
Abi-Gerges, A.1
Richter, W.2
Lefebvre, F.3
Mateo, P.4
Varin, A.5
Heymes, C.6
Samuel, J.L.7
Lugnier, C.8
Conti, M.9
Fischmeister, R.10
Vandecasteele, G.11
-
2
-
-
0027058138
-
Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate
-
Allbritton NL, Meyer T, Stryer L. Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate. Science 258: 1812-1815, 1992.
-
(1992)
Science
, vol.258
, pp. 1812-1815
-
-
Allbritton, N.L.1
Meyer, T.2
Stryer, L.3
-
3
-
-
0037036135
-
a role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains
-
Anderson RG, Jacobson K. a role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science 296: 1821-1825, 2002.
-
(2002)
Science
, vol.296
, pp. 1821-1825
-
-
Anderson, R.G.1
Jacobson, K.2
-
4
-
-
10344242415
-
Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation
-
Ariga M, Neitzert B, Nakae S, Mottin G, Bertrand C, Pruniaux MP, Jin SL, Conti M. Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation. J Immunol 173: 7531-7538, 2004.
-
(2004)
J Immunol
, vol.173
, pp. 7531-7538
-
-
Ariga, M.1
Neitzert, B.2
Nakae, S.3
Mottin, G.4
Bertrand, C.5
Pruniaux, M.P.6
Jin, S.L.7
Conti, M.8
-
6
-
-
14844303317
-
Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium
-
Barnes AP, Livera G, Huang P, Sun C, O'Neal WK, Conti M, Stutts MJ, Milgram SL. Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium. J Biol Chem 280: 7997-8003, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 7997-8003
-
-
Barnes, A.P.1
Livera, G.2
Huang, P.3
Sun, C.4
O'Neal, W.K.5
Conti, M.6
Stutts, M.J.7
Milgram, S.L.8
-
7
-
-
0016294374
-
Activation of protein kinase by physiological concentrations of cyclic AMP
-
Beavo JA, Bechtel PJ, Krebs EG. Activation of protein kinase by physiological concentrations of cyclic AMP. Proc Natl Acad Sci USA 71: 3580-3583, 1974.
-
(1974)
Proc Natl Acad Sci USA
, vol.71
, pp. 3580-3583
-
-
Beavo, J.A.1
Bechtel, P.J.2
Krebs, E.G.3
-
8
-
-
79953329375
-
PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts
-
Blackman BE, Heimann J, Horner K, Wang D, Richter W, Rich TC, Conti M. PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts. J Biol Chem 286: 12590-12601, 2011.
-
(2011)
J Biol Chem
, vol.286
, pp. 12590-12601
-
-
Blackman, B.E.1
Heimann, J.2
Horner, K.3
Wang, D.4
Richter, W.5
Rich, T.C.6
Conti, M.7
-
9
-
-
0025271564
-
The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes
-
Bridge JH, Smolley JR, Spitzer KW. The relationship between charge movements associated with ICa and INa-Ca in cardiac myocytes. Science 248: 376-378, 1990.
-
(1990)
Science
, vol.248
, pp. 376-378
-
-
Bridge, J.H.1
Smolley, J.R.2
Spitzer, K.W.3
-
12
-
-
0025018116
-
The magnitude, time course and spatial distribution of current induced in salamander rods by cyclic guanine nucleotides
-
Cameron DA, Pugh EN Jr. The magnitude, time course and spatial distribution of current induced in salamander rods by cyclic guanine nucleotides. J Physiol 430: 419-439, 1990.
-
(1990)
J Physiol
, vol.430
, pp. 419-439
-
-
Cameron, D.A.1
Pugh Jr., E.N.2
-
13
-
-
33646795266
-
Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes
-
Castro LR, Verde I, Cooper DM, Fischmeister R. Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes. Circulation 113: 2221-2228, 2006.
-
(2006)
Circulation
, vol.113
, pp. 2221-2228
-
-
Castro, L.R.1
Verde, I.2
Cooper, D.M.3
Fischmeister, R.4
-
14
-
-
77957796510
-
Fluidization and resolidification of the human bladder smooth muscle cell in response to transient stretch
-
Chen C, Krishnan R, Zhou E, Ramachandran A, Tambe D, Rajendran K, Adam RM, Deng L, Fredberg JJ. Fluidization and resolidification of the human bladder smooth muscle cell in response to transient stretch. PLoS One 5: e12035, 2010.
-
(2010)
PLoS One
, vol.5
-
-
Chen, C.1
Krishnan, R.2
Zhou, E.3
Ramachandran, A.4
Tambe, D.5
Rajendran, K.6
Adam, R.M.7
Deng, L.8
Fredberg, J.J.9
-
15
-
-
0033056636
-
Cyclic AMP diffusion coefficient in frog olfactory cilia
-
Chen CH, Nakamura T, Koutalos Y. Cyclic AMP diffusion coefficient in frog olfactory cilia. Biophys J 76: 2861-2867, 1999.
-
(1999)
Biophys J
, vol.76
, pp. 2861-2867
-
-
Chen, C.H.1
Nakamura, T.2
Koutalos, Y.3
-
16
-
-
0037166934
-
Dominant regulation of interendothelial cell gap formation by calcium-inhibited type 6 adenylyl cyclase
-
Cioffi DL, Moore TM, Schaack J, Creighton JR, Cooper DM, Stevens T. Dominant regulation of interendothelial cell gap formation by calcium-inhibited type 6 adenylyl cyclase. J Cell Biol 157: 1267-1278, 2002.
-
(2002)
J Cell Biol
, vol.157
, pp. 1267-1278
-
-
Cioffi, D.L.1
Moore, T.M.2
Schaack, J.3
Creighton, J.R.4
Cooper, D.M.5
Stevens, T.6
-
17
-
-
34447265905
-
Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling
-
Conti M, Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem 76: 481-551, 2007.
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 481-551
-
-
Conti, M.1
Beavo, J.2
-
18
-
-
0017684387
-
Compartmentalization of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphatedependent protein kinase in heart tissue
-
Corbin JD, Sugden PH, Lincoln TM, Keely SL. Compartmentalization of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphatedependent protein kinase in heart tissue. J Biol Chem 252: 3854-3861, 1977.
-
(1977)
J Biol Chem
, vol.252
, pp. 3854-3861
-
-
Corbin, J.D.1
Sugden, P.H.2
Lincoln, T.M.3
Keely, S.L.4
-
19
-
-
39449120833
-
Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation
-
Creighton J, Zhu B, Alexeyev M, Stevens T. Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation. J Cell Sci 121: 110-119, 2008.
-
(2008)
J Cell Sci
, vol.121
, pp. 110-119
-
-
Creighton, J.1
Zhu, B.2
Alexeyev, M.3
Stevens, T.4
-
20
-
-
0038440545
-
i depletion and Na buffering
-
i depletion and Na buffering. Biophys J 84: 4157-4166, 2003.
-
(2003)
Biophys J
, vol.84
, pp. 4157-4166
-
-
Despa, S.1
Bers, D.M.2
-
21
-
-
0030736715
-
The catalytic mechanism of mammalian adenylyl cyclase equilibrium binding and kinetic analysis of P-site inhibition
-
Dessauer CW, Gilman AG. The catalytic mechanism of mammalian adenylyl cyclase equilibrium binding and kinetic analysis of P-site inhibition. J Biol Chem 272: 27787-27795, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 27787-27795
-
-
Dessauer, C.W.1
Gilman, A.G.2
-
22
-
-
25644452031
-
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
-
Dodge-Kafka KL, Soughayer J, Pare GC, Carlisle Michel JJ, Langeberg LK, Kapiloff MS, Scott JD. The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature 437: 574-578, 2005.
-
(2005)
Nature
, vol.437
, pp. 574-578
-
-
Dodge-Kafka, K.L.1
Soughayer, J.2
Pare, G.C.3
Carlisle Michel, J.J.4
Langeberg, L.K.5
Kapiloff, M.S.6
Scott, J.D.7
-
23
-
-
77951985322
-
AKAP79 interacts with multiple adenylyl cyclase (AC) isoforms and scaffolds AC5 and -6 to alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors
-
Efendiev R, Samelson BK, Nguyen BT, Phatarpekar PV, Baameur F, Scott JD, Dessauer CW. AKAP79 interacts with multiple adenylyl cyclase (AC) isoforms and scaffolds AC5 and -6 to alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors. J Biol Chem 285: 14450-14458, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 14450-14458
-
-
Efendiev, R.1
Samelson, B.K.2
Nguyen, B.T.3
Phatarpekar, P.V.4
Baameur, F.5
Scott, J.D.6
Dessauer, C.W.7
-
26
-
-
0034713937
-
2+ entry requires localization in cholesterol-rich domains
-
2+ entry requires localization in cholesterol-rich domains. J Biol Chem 275: 26530-26537, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 26530-26537
-
-
Fagan, K.A.1
Smith, K.E.2
Cooper, D.M.F.3
-
27
-
-
0032848914
-
Cyclic nucleotide-dependent protein kinases: Intracellular receptors for cAMP and cGMP action
-
Francis S, Corbin JD. Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action. Crit Rev Clin Lab Sci 36: 275-328, 1999.
-
(1999)
Crit Rev Clin Lab Sci
, vol.36
, pp. 275-328
-
-
Francis, S.1
Corbin, J.D.2
-
28
-
-
0033003990
-
Controversial issues in vertebrate olfactory transduction
-
Gold GH. Controversial issues in vertebrate olfactory transduction. Annu Rev Physiol 61: 857-871, 1999.
-
(1999)
Annu Rev Physiol
, vol.61
, pp. 857-871
-
-
Gold, G.H.1
-
29
-
-
0033198658
-
Longitudinal spread of second messenger signals in isolated rod outer segments of lizards
-
Gray-Keller M, Denk W, Shraiman B, Detwiler PB. Longitudinal spread of second messenger signals in isolated rod outer segments of lizards. J Physiol 513: 679-692, 1999.
-
(1999)
J Physiol
, vol.513
, pp. 679-692
-
-
Gray-Keller, M.1
Denk, W.2
Shraiman, B.3
Detwiler, P.B.4
-
30
-
-
0019468019
-
Morphometric study of rat lung cells. I. Numerical and dimensional characteristics of parenchymal cell population
-
Haies DM, Gil J, Weibel ER. Morphometric study of rat lung cells. I. Numerical and dimensional characteristics of parenchymal cell population. Am Rev Respir Dis 123: 533-541, 1981.
-
(1981)
Am Rev Respir Dis
, vol.123
, pp. 533-541
-
-
Haies, D.M.1
Gil, J.2
Weibel, E.R.3
-
31
-
-
0018386027
-
Organization of acetylcholine receptors in quick-frozen, deep-etched, and rotary-replicated Torpedo postsynaptic membrane
-
Heuser JE, Salpeter SR. Organization of acetylcholine receptors in quick-frozen, deep-etched, and rotary-replicated Torpedo postsynaptic membrane. J Cell Biol 82: 150-173, 1979.
-
(1979)
J Cell Biol
, vol.82
, pp. 150-173
-
-
Heuser, J.E.1
Salpeter, S.R.2
-
32
-
-
0031601339
-
The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: Intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions
-
Houslay MD, Sullivan M, Bolger GB. The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions. Adv Pharmacol 44: 225-342, 1998.
-
(1998)
Adv Pharmacol
, vol.44
, pp. 225-342
-
-
Houslay, M.D.1
Sullivan, M.2
Bolger, G.B.3
-
33
-
-
34247570952
-
Compartmentation of cAMP signaling in cardiac myocytes: A computational study
-
Iancu RV, Jones SW, Harvey RD. Compartmentation of cAMP signaling in cardiac myocytes: a computational study. Biophys J 92: 3317-3331, 2007.
-
(2007)
Biophys J
, vol.92
, pp. 3317-3331
-
-
Iancu, R.V.1
Jones, S.W.2
Harvey, R.D.3
-
34
-
-
0017109857
-
Transformation of cytoplasmic actin. Importance for the organization of the contractile gel reticulum and the contraction-relasation cycle of cytoplasmic actomyosin
-
Isenberg G, Wohlfarth-Bottermann KE. Transformation of cytoplasmic actin. Importance for the organization of the contractile gel reticulum and the contraction-relasation cycle of cytoplasmic actomyosin. Cell Tissue Res 173: 495-528, 1976.
-
(1976)
Cell Tissue Res
, vol.173
, pp. 495-528
-
-
Isenberg, G.1
Wohlfarth-Bottermann, K.E.2
-
35
-
-
0032584673
-
Subcellular localization of rolipram-sensitive, cAMP phosphodiesterases
-
Jin SLC, Bushnik T, Lan L, Conti M. Subcellular localization of rolipram-sensitive, cAMP phosphodiesterases. J Biol Chem 273: 19672-19678, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 19672-19678
-
-
Jin, S.L.C.1
Bushnik, T.2
Lan, L.3
Conti, M.4
-
38
-
-
77955900382
-
Modeling capping protein FRAP and CALI experiments reveals in vivo regulation of actin dynamics
-
Kapustina M, Vitriol E, Elston TC, Loew LM, Jacobson K. Modeling capping protein FRAP and CALI experiments reveals in vivo regulation of actin dynamics. Cytoskeleton 67: 519-534, 2010.
-
(2010)
Cytoskeleton
, vol.67
, pp. 519-534
-
-
Kapustina, M.1
Vitriol, E.2
Elston, T.C.3
Loew, L.M.4
Jacobson, K.5
-
39
-
-
0036710588
-
Peering inside lipid rafts and caveolae
-
Kenworthy A. Peering inside lipid rafts and caveolae. Trends Biochem Sci 27: 435-438, 2002.
-
(2002)
Trends Biochem Sci
, vol.27
, pp. 435-438
-
-
Kenworthy, A.1
-
40
-
-
43049176242
-
Giving space to cell signaling
-
Kholodenko BN, Kolch W. Giving space to cell signaling. Cell 133: 566-567, 2008.
-
(2008)
Cell
, vol.133
, pp. 566-567
-
-
Kholodenko, B.N.1
Kolch, W.2
-
41
-
-
65549116438
-
Reinforcement versus fluidization in cytoskeletal mechanoresponsiveness
-
Krishnan R, Park CY, Lin YC, Mead J, Jaspers RT, Trepat X, Lenormand G, Tambe D, Smolensky AV, Knoll AH, Butler JP, Fredberg JJ. Reinforcement versus fluidization in cytoskeletal mechanoresponsiveness. PLoS One 4: e5486, 2009.
-
(2009)
PLoS One
, vol.4
-
-
Krishnan, R.1
Park, C.Y.2
Lin, Y.C.3
Mead, J.4
Jaspers, R.T.5
Trepat, X.6
Lenormand, G.7
Tambe, D.8
Smolensky, A.V.9
Knoll, A.H.10
Butler, J.P.11
Fredberg, J.J.12
-
42
-
-
0014665355
-
Ionic mobility in muscle cells
-
Kushmerick MJ, Podolsky RJ. Ionic mobility in muscle cells. Science 166: 1297-1298, 1969.
-
(1969)
Science
, vol.166
, pp. 1297-1298
-
-
Kushmerick, M.J.1
Podolsky, R.J.2
-
43
-
-
0026734726
-
Signal flow in visual transduction
-
Lagnado L, Baylor DA. Signal flow in visual transduction. Neuron 8: 995-1002, 1992.
-
(1992)
Neuron
, vol.8
, pp. 995-1002
-
-
Lagnado, L.1
Baylor, D.A.2
-
44
-
-
0025272685
-
Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum
-
Leblanc N, Hume JR. Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum. Science 248: 372-376, 1990.
-
(1990)
Science
, vol.248
, pp. 372-376
-
-
Leblanc, N.1
Hume, J.R.2
-
45
-
-
0033680726
-
The gain of rod phototransduction: Reconciliation of biochemical and electrophysiological measurements
-
Leskov IB, Klenchin VA, Handy JW, Whitlock GG, Govardovskii VI, Bownds MD, Lamb TD, Pugh EN Jr, Arshavsky VY. The gain of rod phototransduction: reconciliation of biochemical and electrophysiological measurements. Neuron 27: 525-537, 2000.
-
(2000)
Neuron
, vol.27
, pp. 525-537
-
-
Leskov, I.B.1
Klenchin, V.A.2
Handy, J.W.3
Whitlock, G.G.4
Govardovskii, V.I.5
Bownds, M.D.6
Lamb, T.D.7
Pugh Jr., E.N.8
Arshavsky, V.Y.9
-
46
-
-
0033537946
-
Phosphorylation-mediated activation and translocation of the cyclic AMP-specific phosphodiesterase PDE4D3 by cyclic AMP-dependent protein kinase and mitogen-activated protein kinases. A potential mechanism allowing for the coordinated regulation of PDE4D activity and targeting
-
Liu H, Maurice DH. Phosphorylation-mediated activation and translocation of the cyclic AMP-specific phosphodiesterase PDE4D3 by cyclic AMP-dependent protein kinase and mitogen-activated protein kinases. A potential mechanism allowing for the coordinated regulation of PDE4D activity and targeting. J Biol Chem 274: 10557-10565, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 10557-10565
-
-
Liu, H.1
Maurice, D.H.2
-
47
-
-
0027491955
-
Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells
-
Lowe G, Gold GH. Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells. Nature 366: 283-286, 1993.
-
(1993)
Nature
, vol.366
, pp. 283-286
-
-
Lowe, G.1
Gold, G.H.2
-
49
-
-
0347552472
-
Diffusion of a small molecule in the cytoplasm of mammalian cells
-
Mastro AM, Babich MA, Taylor WD, Keith AD. Diffusion of a small molecule in the cytoplasm of mammalian cells. Proc Natl Acad Sci USA 81: 3414-3418, 1984.
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 3414-3418
-
-
Mastro, A.M.1
Babich, M.A.2
Taylor, W.D.3
Keith, A.D.4
-
50
-
-
0032421235
-
Photoreceptor membrane proteins, phototransduction, and retinal degenerative diseases: The Friedenwald Lecture
-
Molday RS. Photoreceptor membrane proteins, phototransduction, and retinal degenerative diseases: The Friedenwald Lecture. Invest Ophthalmol Vis Sci 39: 2493-2513, 1998.
-
(1998)
Invest Ophthalmol Vis Sci
, vol.39
, pp. 2493-2513
-
-
Molday, R.S.1
-
51
-
-
3142723295
-
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases
-
Mongillo M, McSorley T, Evellin S, Sood A, Lissandron V, Terrin A, Huston E, Hannawacker A, Lohse MJ, Pozzan T, Houslay MD, Zaccolo M. Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ Res 95: 67-75, 2004.
-
(2004)
Circ Res
, vol.95
, pp. 67-75
-
-
Mongillo, M.1
McSorley, T.2
Evellin, S.3
Sood, A.4
Lissandron, V.5
Terrin, A.6
Huston, E.7
Hannawacker, A.8
Lohse, M.J.9
Pozzan, T.10
Houslay, M.D.11
Zaccolo, M.12
-
52
-
-
0029152783
-
Immunohistochemical localization of adenylyl cyclase in rat brain indicates a highly selective concentration at synapses
-
Mons N, Harry A, Dubourg P, Premont RT, Iyengar R, Cooper DMF. Immunohistochemical localization of adenylyl cyclase in rat brain indicates a highly selective concentration at synapses. Proc Natl Acad Sci USA 92: 8473-8477, 1995.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8473-8477
-
-
Mons, N.1
Harry, A.2
Dubourg, P.3
Premont, R.T.4
Iyengar, R.5
Cooper, D.M.F.6
-
53
-
-
84858238106
-
The interplay of multiple molecular and cellular components is necessary for compartmentalization of cAMP. Focus on "Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells"
-
January 11, doi:10.1152/ajpcell.00012.2012
-
Murray F. The interplay of multiple molecular and cellular components is necessary for compartmentalization of cAMP. Focus on "Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells." Am J Physiol Cell Physiol (January 11, 2012). doi:10.1152/ajpcell.00012.2012.
-
(2012)
Am J Physiol Cell Physiol
-
-
Murray, F.1
-
54
-
-
0026649940
-
Calcium gradients and buffers in bovine chromaffin cells
-
Neher E, Augustine GJ. Calcium gradients and buffers in bovine chromaffin cells. J Physiol 450: 273-301, 1992.
-
(1992)
J Physiol
, vol.450
, pp. 273-301
-
-
Neher, E.1
Augustine, G.J.2
-
55
-
-
43049156015
-
Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks
-
Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru I, Iyengar R. Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell 133: 666-680, 2008.
-
(2008)
Cell
, vol.133
, pp. 666-680
-
-
Neves, S.R.1
Tsokas, P.2
Sarkar, A.3
Grace, E.A.4
Rangamani, P.5
Taubenfeld, S.M.6
Alberini, C.M.7
Schaff, J.C.8
Blitzer, R.D.9
Moraru, I.10
Iyengar, R.11
-
56
-
-
68949119721
-
Diffusion in cytoplasm: Effects of excluded volume due to internal membranes and cytoskeletal structures
-
Novak IL, Kraikivski P, Slepchenko BM. Diffusion in cytoplasm: effects of excluded volume due to internal membranes and cytoskeletal structures. Biophys J 97: 758-767, 2009.
-
(2009)
Biophys J
, vol.97
, pp. 758-767
-
-
Novak, I.L.1
Kraikivski, P.2
Slepchenko, B.M.3
-
57
-
-
77955374442
-
The role of type 4 phosphodiesterases in generating microdomains of cAMP: Large scale stochastic simulations
-
Oliveira RF, Terrin A, Di Benedetto G, Cannon RC, Koh W, Kim M, Zaccolo M, Blackwell KT. The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations. PLoS One 5: e11725, 2010.
-
(2010)
PLoS One
, vol.5
-
-
Oliveira, R.F.1
Terrin, A.2
di Benedetto, G.3
Cannon, R.C.4
Koh, W.5
Kim, M.6
Zaccolo, M.7
Blackwell, K.T.8
-
58
-
-
0027301276
-
Diffusion coefficient of cyclic GMP in salamander rod outer segments estimated with two fluorescent probes
-
Olson A, Pugh EN Jr. Diffusion coefficient of cyclic GMP in salamander rod outer segments estimated with two fluorescent probes. Biophys J 65: 1335-1352, 1993.
-
(1993)
Biophys J
, vol.65
, pp. 1335-1352
-
-
Olson, A.1
Pugh Jr., E.N.2
-
59
-
-
0036839744
-
Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: Expression in caveolin-rich and noncaveolin domains
-
Ostrom RS, Liu X, Head BP, Gregorian C, Seasholtz TM, Insel PA. Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: expression in caveolin-rich and noncaveolin domains. Mol Pharmacol 62: 983-992, 2002.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 983-992
-
-
Ostrom, R.S.1
Liu, X.2
Head, B.P.3
Gregorian, C.4
Seasholtz, T.M.5
Insel, P.A.6
-
60
-
-
0021845642
-
Odorant-sensitive adenylate cyclase may mediate olfactory reception
-
Pace U, Hanski E, Salomon Y, Lancet D. Odorant-sensitive adenylate cyclase may mediate olfactory reception. Nature 316: 255-258, 1985.
-
(1985)
Nature
, vol.316
, pp. 255-258
-
-
Pace, U.1
Hanski, E.2
Salomon, Y.3
Lancet, D.4
-
61
-
-
65549095446
-
Spatial distribution of protein kinase A activity during cell migration is mediated by A-kinase anchoring protein AKAP Lbc
-
Paulucci-Holthauzen AA, Vergara LA, Bellot LJ, Canton D, Scott JD, O'Connor KL. Spatial distribution of protein kinase A activity during cell migration is mediated by A-kinase anchoring protein AKAP Lbc. J Biol Chem 284: 5956-5967, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 5956-5967
-
-
Paulucci-Holthauzen, A.A.1
Vergara, L.A.2
Bellot, L.J.3
Canton, D.4
Scott, J.D.5
O'Connor, K.L.6
-
62
-
-
33745646054
-
Natriuretic peptides and nitric oxide stimulate cGMP synthesis in different cellular compartments
-
Piggott LA, Hassell KA, Berkova Z, Morris AP, Silberbach M, Rich TC. Natriuretic peptides and nitric oxide stimulate cGMP synthesis in different cellular compartments. J Gen Physiol 128: 3-14, 2006.
-
(2006)
J Gen Physiol
, vol.128
, pp. 3-14
-
-
Piggott, L.A.1
Hassell, K.A.2
Berkova, Z.3
Morris, A.P.4
Silberbach, M.5
Rich, T.C.6
-
63
-
-
0029132693
-
Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes
-
Post SR, Hilal-Dandan R, Urasawa K, Brunton LL, Insel PA. Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes. Biochem J 311: 75-80, 1995.
-
(1995)
Biochem J
, vol.311
, pp. 75-80
-
-
Post, S.R.1
Hilal-Dandan, R.2
Urasawa, K.3
Brunton, L.L.4
Insel, P.A.5
-
65
-
-
0000413412
-
Formation of a cyclic adenine ribonucleotide by tissue particles
-
Rall TW, Sutherland EW. Formation of a cyclic adenine ribonucleotide by tissue particles. J Biol Chem 232: 1065-1076, 1958.
-
(1958)
J Biol Chem
, vol.232
, pp. 1065-1076
-
-
Rall, T.W.1
Sutherland, E.W.2
-
66
-
-
0023088944
-
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors
-
Reeves ML, Leigh BK, England PJ. The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors. Biochem J 241: 535-541, 1987.
-
(1987)
Biochem J
, vol.241
, pp. 535-541
-
-
Reeves, M.L.1
Leigh, B.K.2
England, P.J.3
-
67
-
-
0033895842
-
Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion
-
Rich TC, Fagan KA, Nakata H, Schaack J, Cooper DMF, Karpen JW. Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion. J Gen Physiol 116: 147-161, 2000.
-
(2000)
J Gen Physiol
, vol.116
, pp. 147-161
-
-
Rich, T.C.1
Fagan, K.A.2
Nakata, H.3
Schaack, J.4
Cooper, D.M.F.5
Karpen, J.W.6
-
68
-
-
0035818473
-
A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell
-
Rich TC, Fagan KA, Tse TE, Schaack J, Cooper DMF, Karpen JW. A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell. Proc Natl Acad Sci USA 98: 13049-13054, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13049-13054
-
-
Rich, T.C.1
Fagan, K.A.2
Tse, T.E.3
Schaack, J.4
Cooper, D.M.F.5
Karpen, J.W.6
-
69
-
-
33846305048
-
Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells
-
Rich TC, Xin W, Hassell KA, Piggott LA, Le X, Karpen JW, Conti M. Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells. Am J Physiol Cell Physiol 292: C319-C331, 2007.
-
(2007)
Am J Physiol Cell Physiol
, vol.292
-
-
Rich, T.C.1
Xin, W.2
Hassell, K.A.3
Piggott, L.A.4
Le, X.5
Karpen, J.W.6
Conti, M.7
-
70
-
-
21744442922
-
Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue
-
Richter W, Jin SL, Conti M. Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue. Biochem J 388: 803-811, 2005.
-
(2005)
Biochem J
, vol.388
, pp. 803-811
-
-
Richter, W.1
Jin, S.L.2
Conti, M.3
-
71
-
-
33646776455
-
A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes
-
Rochais F, Abi-Gerges A, Horner K, Lefebvre F, Cooper DMF, Conti M, Fischmeister R, Vandecasteele G. A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes. Circ Res 98: 1081-1088, 2006.
-
(2006)
Circ Res
, vol.98
, pp. 1081-1088
-
-
Rochais, F.1
Abi-Gerges, A.2
Horner, K.3
Lefebvre, F.4
Cooper, D.M.F.5
Conti, M.6
Fischmeister, R.7
Vandecasteele, G.8
-
72
-
-
0346850834
-
Modeling beta-adrenergic control of cardiac myocyte contractility in silico
-
Saucerman JJ, Brunton LL, Michailova AP, McCulloch AD. Modeling beta-adrenergic control of cardiac myocyte contractility in silico. J Biol Chem 278: 47997-48003, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 47997-48003
-
-
Saucerman, J.J.1
Brunton, L.L.2
Michailova, A.P.3
McCulloch, A.D.4
-
73
-
-
2442587536
-
Mechanistic systems models of cell signaling networks: A case study of myocyte adrenergic regulation
-
Saucerman JJ, McCulloch AD. Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation. Prog Biophys Mol Biol 85: 261-278, 2004.
-
(2004)
Prog Biophys Mol Biol
, vol.85
, pp. 261-278
-
-
Saucerman, J.J.1
McCulloch, A.D.2
-
74
-
-
33748054283
-
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
-
Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD. Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proc Natl Acad Sci USA 103: 12923-12928, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 12923-12928
-
-
Saucerman, J.J.1
Zhang, J.2
Martin, J.C.3
Peng, L.X.4
Stenbit, A.E.5
Tsien, R.Y.6
McCulloch, A.D.7
-
75
-
-
79959985241
-
Filamin A is a phosphorylation target of plasma membrane but not cytosolic adenylyl cyclase activity
-
Sayner S, Balczon R, Frank D, Cooper D, Stevens T. Filamin A is a phosphorylation target of plasma membrane but not cytosolic adenylyl cyclase activity. Am J Physiol Lung Cell Mol Physiol 301: L117-L124, 2011.
-
(2011)
Am J Physiol Lung Cell Mol Physiol
, vol.301
-
-
Sayner, S.1
Balczon, R.2
Frank, D.3
Cooper, D.4
Stevens, T.5
-
76
-
-
84858219123
-
Bicarbonate disruption of the pulmonary endothelial cell barrier by activation of the endogenous soluble adenylyl cyclase
-
Sayner S, Kunstadt R, Daigle J. Bicarbonate disruption of the pulmonary endothelial cell barrier by activation of the endogenous soluble adenylyl cyclase. Am J Respir Crit Care Med 183: A4178, 2011.
-
(2011)
Am J Respir Crit Care Med
, vol.183
-
-
Sayner, S.1
Kunstadt, R.2
Daigle, J.3
-
77
-
-
33645287748
-
Soluble adenylyl cyclase reveals the significance of cAMP compartmentation on pulmonary microvascular endothelial cell barrier
-
Sayner SL, Alexeyev M, Dessauer CW, Stevens T. Soluble adenylyl cyclase reveals the significance of cAMP compartmentation on pulmonary microvascular endothelial cell barrier. Circ Res 98: 675-681, 2006.
-
(2006)
Circ Res
, vol.98
, pp. 675-681
-
-
Sayner, S.L.1
Alexeyev, M.2
Dessauer, C.W.3
Stevens, T.4
-
78
-
-
3343017244
-
Paradoxical cAMP-induced lung endothelial hyperpermeability revealed by Pseudomonas aeruginosa ExoY
-
Sayner SL, Frank DW, King J, Chen H, VandeWaa J, Stevens T. Paradoxical cAMP-induced lung endothelial hyperpermeability revealed by Pseudomonas aeruginosa ExoY. Circ Res 95: 196-203, 2004.
-
(2004)
Circ Res
, vol.95
, pp. 196-203
-
-
Sayner, S.L.1
Frank, D.W.2
King, J.3
Chen, H.4
Vandewaa, J.5
Stevens, T.6
-
79
-
-
0030739712
-
A general computational framework for modeling cellular structure and function
-
Schaff J, Fink CC, Slepchenko B, Carson JH, Loew LM. A general computational framework for modeling cellular structure and function. Biophys J 73: 1135-1146, 1997.
-
(1997)
Biophys J
, vol.73
, pp. 1135-1146
-
-
Schaff, J.1
Fink, C.C.2
Slepchenko, B.3
Carson, J.H.4
Loew, L.M.5
-
80
-
-
0036085765
-
Computational cell biology: Spatiotemporal simulation of cellular events
-
Slepchenko BM, Schaff JC, Carson JH, Loew LM. Computational cell biology: spatiotemporal simulation of cellular events. Annu Rev Biophys Biomol Struct 31: 423-441, 2002.
-
(2002)
Annu Rev Biophys Biomol Struct
, vol.31
, pp. 423-441
-
-
Slepchenko, B.M.1
Schaff, J.C.2
Carson, J.H.3
Loew, L.M.4
-
82
-
-
0032768780
-
Control of cAMP in lung endothelial cell phenotypes. Implications for control of barrier function
-
Stevens T, Creighton J, Thompson WJ. Control of cAMP in lung endothelial cell phenotypes. Implications for control of barrier function. Am J Physiol Lung Cell Mol Physiol 277: L119-L126, 1999.
-
(1999)
Am J Physiol Lung Cell Mol Physiol
, vol.277
-
-
Stevens, T.1
Creighton, J.2
Thompson, W.J.3
-
84
-
-
0001559662
-
Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles
-
Sutherland EW, Rall TW. Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles. J Biol Chem 232: 1077-1092, 1958.
-
(1958)
J Biol Chem
, vol.232
, pp. 1077-1092
-
-
Sutherland, E.W.1
Rall, T.W.2
-
85
-
-
0030023673
-
Direct measurement of coupling between dendritic spines and shafts
-
Svoboda K, Tank DW, Denk W. Direct measurement of coupling between dendritic spines and shafts. Science 272: 716-719, 1996.
-
(1996)
Science
, vol.272
, pp. 716-719
-
-
Svoboda, K.1
Tank, D.W.2
Denk, W.3
-
86
-
-
0032585513
-
A new class of synaptic response involving calcium release in dendritic spines
-
Takechi H, Eilers J, Konnerth A. A new class of synaptic response involving calcium release in dendritic spines. Nature 396: 757-760, 1998.
-
(1998)
Nature
, vol.396
, pp. 757-760
-
-
Takechi, H.1
Eilers, J.2
Konnerth, A.3
-
87
-
-
33750720277
-
1 stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: Role of compartmentalized phosphodiesterases
-
1 stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. J Cell Biol 175: 441-451, 2006.
-
(2006)
J Cell Biol
, vol.175
, pp. 441-451
-
-
Terrin, A.1
di Benedetto, G.2
Pertegato, V.3
Cheung, Y.F.4
Baillie, G.5
Lynch, M.J.6
Elvassore, N.7
Prinz, A.8
Herberg, F.W.9
Houslay, M.D.10
Zaccolo, M.11
-
88
-
-
0015231739
-
Multiple cyclic nucleotide phosphodiesterase activities from rat brain
-
Thompson WJ, Appleman MM. Multiple cyclic nucleotide phosphodiesterase activities from rat brain. Biochemistry 10: 311-316, 1971.
-
(1971)
Biochemistry
, vol.10
, pp. 311-316
-
-
Thompson, W.J.1
Appleman, M.M.2
-
89
-
-
0037085012
-
Regulation of cyclic AMP in rat pulmonary microvascular endothelial cells by rolipram-sensitive cyclic AMP phosphodiesterase (PDE4)
-
Thompson WJ, Ashikaga T, Kelly JJ, Liu L, Zhu B, Vemavarapu L, Strada SJ. Regulation of cyclic AMP in rat pulmonary microvascular endothelial cells by rolipram-sensitive cyclic AMP phosphodiesterase (PDE4). Biochem Pharmacol 63: 797-807, 2002.
-
(2002)
Biochem Pharmacol
, vol.63
, pp. 797-807
-
-
Thompson, W.J.1
Ashikaga, T.2
Kelly, J.J.3
Liu, L.4
Zhu, B.5
Vemavarapu, L.6
Strada, S.J.7
-
91
-
-
0016756490
-
The relationship between enzyme activity, cell geometry, and fitness in Saccharomyces cerevisiae
-
Weiss RL, Kukora JR, Adams J. The relationship between enzyme activity, cell geometry, and fitness in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 72: 794-798, 1975.
-
(1975)
Proc Natl Acad Sci USA
, vol.72
, pp. 794-798
-
-
Weiss, R.L.1
Kukora, J.R.2
Adams, J.3
-
92
-
-
33646787840
-
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
-
Willoughby D, Wong W, Schaack J, Scott JD, Cooper DMF. An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. EMBO J 25: 2051-2061, 2006.
-
(2006)
EMBO J
, vol.25
, pp. 2051-2061
-
-
Willoughby, D.1
Wong, W.2
Schaack, J.3
Scott, J.D.4
Cooper, D.M.F.5
-
93
-
-
33846556075
-
Longitudinal diffusion of a polar tracer in the outer segments of rod photoreceptors from different species
-
Wu Q, Chen C, Koutalos Y. Longitudinal diffusion of a polar tracer in the outer segments of rod photoreceptors from different species. Photochem Photobiol 82: 1447-1451, 2006.
-
(2006)
Photochem Photobiol
, vol.82
, pp. 1447-1451
-
-
Wu, Q.1
Chen, C.2
Koutalos, Y.3
-
94
-
-
41649095080
-
Functional roles of GRK and PDE activities in the regulation of beta2 adrenergic signaling
-
Xin W, Tran TM, Richter W, Clark RB, Rich TC. Functional roles of GRK and PDE activities in the regulation of beta2 adrenergic signaling. J Gen Physiol 134: 349-364, 2008.
-
(2008)
J Gen Physiol
, vol.134
, pp. 349-364
-
-
Xin, W.1
Tran, T.M.2
Richter, W.3
Clark, R.B.4
Rich, T.C.5
-
96
-
-
0033591233
-
The RACK1 signaling scaffold protein selectively interacts with the cAMPspecific phosphodiesterase PDE4D5 isoform
-
Yarwood SJ, Steele MR, Scotland G, Houslay MD, Bolger GB. The RACK1 signaling scaffold protein selectively interacts with the cAMPspecific phosphodiesterase PDE4D5 isoform. J Biol Chem 274: 14909-14917, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 14909-14917
-
-
Yarwood, S.J.1
Steele, M.R.2
Scotland, G.3
Houslay, M.D.4
Bolger, G.B.5
-
97
-
-
0028118719
-
Phototransduction mechanism in retinal rods and cones: The Friedenwald Lecture
-
Yau KW. Phototransduction mechanism in retinal rods and cones: The Friedenwald Lecture. Invest Ophthalmol Vis Sci 35: 9-32, 1994.
-
(1994)
Invest Ophthalmol Vis Sci
, vol.35
, pp. 9-32
-
-
Yau, K.W.1
-
98
-
-
0019321610
-
2+ control of actin gelation. Interaction of gelsolin with actin filaments and regulation of actin gelation
-
T.P.S
-
2+ control of actin gelation. Interaction of gelsolin with actin filaments and regulation of actin gelation. J Biol Chem 255: 9494-9500, 1980.
-
(1980)
J Biol Chem
, vol.255
, pp. 9494-9500
-
-
Yin, H.L.1
Zaner, K.S.2
-
99
-
-
0027295771
-
Mobile and immobile calcium buffers in bovine adrenal chromaffin cells
-
Zhou Z, Neher E. Mobile and immobile calcium buffers in bovine adrenal chromaffin cells. J Physiol 469: 245-273, 1993.
-
(1993)
J Physiol
, vol.469
, pp. 245-273
-
-
Zhou, Z.1
Neher, E.2
-
100
-
-
3042819132
-
Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells
-
Zhu B, Kelly J, Vemavarapu L, Thompson WJ, Strada SJ. Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells. Biochem Pharmacol 68: 479-491, 2004.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 479-491
-
-
Zhu, B.1
Kelly, J.2
Vemavarapu, L.3
Thompson, W.J.4
Strada, S.J.5
-
101
-
-
0034714206
-
Activation of the particulate and not the soluble guanylate cyclase leads to the inhibition of Ca2_ extrusion through localized elevation of cGMP
-
Zolle O, Lawrie AM, Simpson AWM. Activation of the particulate and not the soluble guanylate cyclase leads to the inhibition of Ca2_ extrusion through localized elevation of cGMP. J Biol Chem 275: 25892-25899, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 25892-25899
-
-
Zolle, O.1
Lawrie, A.M.2
Simpson, A.W.M.3
|