A new class of synaptic response involving calcium release in dendritic spines

Nature

Volumn 396, Issue 6713, 1998, Pages 757-760

  Takechi, Hajime ^a   Eilers, Jens ^a   Konnerth, Arthur ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; AMPA RECEPTOR; CALCIUM ION; INOSITOL 1,4,5 TRISPHOSPHATE; METABOTROPIC RECEPTOR;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; FLUORESCENCE; MOUSE; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL PLASTICITY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PURKINJE CELL; SYNAPTIC TRANSMISSION;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; CALCIUM; CALCIUM SIGNALING; CEREBELLUM; DENDRITES; EXCITATORY AMINO ACID ANTAGONISTS; MICE; NERVE FIBERS; PURKINJE CELLS; SYNAPSES;

EID: 0032585513     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/25547     Document Type: Article

References (17)

1. Eilers, J. & Konnerth, A. Dendritic signal integration. Curr. Opin. Neurobiol. 7, 385-390 (1997).
2. Sladeczek, F., Pin, J.-P., Récasens, M., Bockaert, J. & Weiss, S. Glutamate stimulates inositol phosphate formation in striatal neurons. Nature 317, 717-719 (1985).
3. Masu, M., Tanabe, Y., Tsuchida, K., Shigemoto, R. & Nakanishi, S. Sequence and expression of a metabotropic glutamate receptor. Nature 349, 760-765 (1991).
4. Conn, P. J. & Pin, J. P. Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37, 205-237 (1997).
5. Berridge, M. Inositol trisphosphate and calcium signalling. Nature 361, 315-325 (1993).
6. Furuichi,T., Kohda, K., Miyawaki, A. & Mikoshiba, K. Intracellular channels. Curr. Opin. Neurobiol 4, 294-303 (1994).
7. Ito, M. The Cerebellum and Neuronal Control (Raven, New York, 1984).
8. Kano, M. & Kato, M. Quisqualate receptors are specifically involved in cerebellar synaptic plasticity. Nature 325, 276-279 (1987).
9. Linden, D. J., Dickinson, M. H., Smeyne, M. & Connor, J. A. A long-term depression of AMPA currents in cultured cerebellar Purkinje neurons. Neuron 7, 81-89 (1991).
10. Konnerth, A., Llano, I. & Armstrong, C. M. Synaptic currents in cerebellar Purkinje cells. Proc. Natl Acad. Sci. USA 87, 2662-2665 (1990).
11. 2+ signalling in fine dendrites and spines of cerebellar Purkinje neurons. Nature 373, 155-158 (1995).
12. Denk, W., Sugimori, M. & Llinás, R. Two types of calcium responses limited to single spines in cerebellar Purkinje cells. Proc, Natl Acad. Sci. USA 92, 8279-8282 (1995).
13. Batchelor, A. & Garthwaite, J. Novel synaptic potentials in cerebellar Purkinje cells: probable mediation by metabotropic glutamate receptors. Neuropharmacol. 32, 11-20 (1993).
14. Batchelor, A. & Garthwaite, J. Frequency detection and temporally dispersed synaptic signal association through a metabotropic glutamate receptor pathway. Nature 385, 74-77 (1997).
15. Eilers, J., Batchelor, A., Garthwaite, J. & Konnerth, A. Synaptic activation of metabotropic glutamate receptors produces dendritic calcium transients in cerebellar Purkinje cells. Pflügers Arch. 433 (Suppl.), 549 (1997).
16. Martin, L J., Blackstone, C. D., Huganir, R. L. & Price, D. L Cellular localization of a metabotropic glutamate receptor in rat brain. Neuron 9, 259-270 (1992).
17. Shigemoto, R., Nakanishi, S. & Mizuno, N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat. J. Comp. Neurol 322, 121-135 (1992).