The interplay of multiple molecular and cellular components is necessary for compartmentalization of cAMP. focus on "Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells"

American Journal of Physiology - Cell Physiology

Volumn 302, Issue 6, 2012, Pages

  Murray, Fiona ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYTOCHALASIN D; F ACTIN;

BIOSENSOR; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CYTOSOL; EDITORIAL; HUMAN; MATHEMATICAL MODEL; MICROVASCULAR ENDOTHELIAL CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CELL COMPARTMENTATION; CYCLIC AMP; ENDOTHELIAL CELLS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION;

EID: 84858238106     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00012.2012     Document Type: Editorial

References (10)

1. Blackman BE, Horner K, Heidmann J, Wang D, Richter W, Rich TC, Conti M. PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts. J Biol Chem 286: 12590-12601, 2011.
2. Carnegie GK, Means CK, Scott JD. A-kinase anchoring proteins: from protein complexes to physiology and disease. IUBMB Life 61: 394-406, 2009.
3. Feinstein WP, Zhu B, Leavesley SJ, Sayner SL, Rich TC. Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells. Am J Physiol Cell Physiol (November 23, 2011). doi:10.1152/ajpcell.00361.2011.
4. Hill SJ, Williams C, May LT. Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies. Br J Pharmacol 161: 1266-1275, 2010.
5. Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R. Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell 133: 666-680, 2008.
6. Oliveira RF, Terrin A, Di Benedetto G, Cannon RC, Koh W, Kim M, Zaccolo M, Blackwell KT. The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations. Plos One 5: e11725, 2010.
7. Rich TC, Xin W, Mehats C, Hassell KA, Piggott LA, Le X, Karpen JW, Conti M. Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells. Am J Physiol Cell Physiol 292: C319-C331, 2007.
8. Rochais F, Abi-Gerges A, Horner K, Lefebvre F, Cooper DM, Conti M, Fischmeister R, Vandecasteele G. A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes. Circ Res 98: 1081-1088, 2006.
9. Sayner SL. Emerging themes of cAMP regulation of the pulmonary endothelial barrier. Am J Physiol Lung Cell Mol Physiol 300: L667-L678, 2011.
10. Zaccolo M. Spatial control of cAMP signalling in health and disease. Curr Opin Pharmacol 11: 649-655, 2011.